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Cristina Ferrone, MD


  • Marchegiani G, Mino-Kenudson M, Ferrone CR, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C.
    Oncocytic-Type Intraductal Papillary Mucinous Neoplasms: A Unique Malignant Pancreatic Tumor with Good Long-Term Prognosis.
    J Am Coll Surg. 2015 Feb 11.
  • Marchegiani G, Mino-Kenudson M, Ferrone CR, Morales-Oyarvide V, Warshaw AL, Lillemoe KD, Castillo CF.
    Patterns of Recurrence After Resection of IPMN: Who, When, and How?.
    Ann Surg. 2015 Mar 19.
  • Ferrone CR, Ting DT, Shahid M, Konstantinidis IT, Sabbatino F, Goyal L, Rice-Stitt T, Mubeen A, Arora K, Bardeesey N, Miura J, Gamblin TC, Zhu AX, Borger D, Lillemoe KD, Rivera MN, Deshpande V.
    The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology.
    Ann Surg Oncol. 2014 Dec 18.
  • Dias-Santos D, Ferrone CR, Zheng H, Lillemoe KD, Castillo CF.
    The Charlson age comorbidity index predicts early mortality after surgery for pancreatic cancer.
    Surgery. 2015 Feb 20.
  • Moy AP, Shahid M, Ferrone CR, Borger DR, Zhu AX, Ting D, Deshpande V.
    Microsatellite instability in gallbladder carcinoma.
    Virchows Arch. 2015 Feb 14.
  • Ferrone CR, Marchegiani G, Hong TS, Ryan DP, Deshpande V, McDonnell EI, Sabbatino F, Santos DD, Allen JN, Blaszkowsky LS, Clark JW, Faris JE, Goyal L, Kwak EL, Murphy JE, Ting DT, Wo JY, Zhu AX, Warshaw AL, Lillemoe KD, Fernández-del Castillo C.
    Radiological and surgical implications of neoadjuvant treatment with FOLFIRINOX for locally advanced and borderline resectable pancreatic cancer.
    Ann Surg. 2015 Jan;261(1):12-7.
  • Fong ZV, Correa-Gallego C, Ferrone CR, Veillette GR, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C.
    Early Drain Removal-The Middle Ground Between the Drain Versus No Drain Debate in Patients Undergoing Pancreaticoduodenectomy: A Prospective Validation Study.
    Ann Surg. 2015 Jan 12.
  • Zhu AX, Borger DR, Kim Y, Cosgrove D, Ejaz A, Alexandrescu S, Groeschl RT, Deshpande V, Lindberg JM, Ferrone C, Sempoux C, Yau T, Poon R, Popescu I, Bauer TW, Gamblin TC, Gigot JF, Anders RA, Pawlik TM.
    Genomic Profiling of Intrahepatic Cholangiocarcinoma: Refining Prognosis and Identifying Therapeutic Targets.
    Ann Surg Oncol. 2014 Jun 3.
  • Wo JY, Childs SK, Szymonifka J, Mamon HJ, Ryan DP, Blaszkowsky LS, Kwak EL, Ferrone CR, Allen JN, Zhu AX, Wolpin BM, Chan JA, Abrams TA, McCleary NJ, Fernandez-Del Castillo C, Hong TS.
    Delaying chemoradiation until after completion of adjuvant chemotherapy for pancreatic cancer may not impact local control.
    Practical Radiation Oncology.;4(2):e117-23.
  • Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG.
    A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
    Int J Radiat Oncol Biol Phys. 2014 May 24.
  • Yoon SS, Aloia TA, Haynes AB, Kambadakone A, Kaur H, Vauthey JN, Ferrone CR, Zhu AX, Wo JY, Crane C, Hong TS.
    Surgical placement of biologic mesh spacers to displace bowel away from unresectable liver tumors followed by delivery of dose-intense radiation therapy.
    Practical Radiation Oncology.;4(3):167-73.
  • Sabbatino F, Wang Y, Wang X, Flaherty KT, Yu L, Pepin D, Scognamiglio G, Pepe S, Kirkwood JM, Cooper ZA, Frederick DT, Wargo JA, Ferrone S, Ferrone CR.
    PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
    Oncotarget. 2014 Mar 31.
  • Borger DR, Goyal L, Yau T, Poon RT, Ancukiewicz M, Deshpande V, Christiani DC, Liebman HM, Yang H, Kim H, Yen K, Faris JE, Iafrate AJ, Kwak EL, Clark JW, Allen JN, Blaszkowsky LS, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Bardeesy N, Straley KS, Agresta S, Schenkein DP, Ellisen LW, Ryan DP, Zhu AX.
    Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.
    Clin Cancer Res. 2014 Apr 1;20(7):1884-90.
  • Wo JY, Mamon HJ, Ferrone CR, Ryan DP, Blaszkowsky LS, Kwak EL, Tseng YD, Napolitano BN, Ancukiewicz M, Swanson RS, Lillemoe KD, Fernandez-del Castillo C, Hong TS.
    Phase I study of neoadjuvant accelerated short course radiation therapy with photons and capecitabine for resectable pancreatic cancer.
    Radiother Oncol. 2014 Jan;110(1):160-4.
  • Hyder O, Marques H, Pulitano C, Marsh JW, Alexandrescu S, Bauer TW, Gamblin TC, Sotiropoulos GC, Paul A, Barroso E, Clary BM, Aldrighetti L, Ferrone CR, Zhu AX, Popescu I, Gigot JF, Mentha G, Feng S, Pawlik TM.
    A Nomogram to Predict Long-term Survival After Resection for Intrahepatic Cholangiocarcinoma: An Eastern and Western Experience.
    JAMA Surg. 2014 Mar 5.
  • Fernandez-del Castillo CF, Thayer SP, Ferrone CR, Wargo J.
    Surgery for small and asymptomatic branch-duct IPMNs.
    Ann Surg. 2014 Mar;259(3):e47.
  • Ferrone CR.
    Lymphadenectomy for pancreatic neuroendocrine tumors: is that the relevant debate?.
    Ann Surg. 2014 Feb;259(2):213-4.
  • Fong ZV, Ferrone CR, Thayer SP, Wargo JA, Sahora K, Seefeld KJ, Warshaw AL, Lillemoe KD, Hutter MM, Fernández-Del Castillo C.
    Understanding hospital readmissions after pancreaticoduodenectomy: can we prevent them?: a 10-year contemporary experience with 1,173 patients at the Massachusetts General Hospital.
    J Gastrointest Surg. 2014 Jan;18(1):137-44; discussion 144-5.
  • Sabbatino F, Wang Y, Wang X, Ferrone S, Ferrone CR.
    Emerging BRAF inhibitors for melanoma.
    Expert Opin Emerg Drugs. 2013 Dec;18(4):431-43.
  • Cai S, Hong TS, Goldberg SI, Fernandez-del Castillo C, Thayer SP, Ferrone CR, Ryan DP, Blaszkowsky LS, Kwak EL, Willett CG, Lillemoe KD, Warshaw AL, Wo JY.
    Updated long-term outcomes and prognostic factors for patients with unresectable locally advanced pancreatic cancer treated with intraoperative radiotherapy at the Massachusetts General Hospital, 1978 to 2010.
    Cancer. 2013 Dec 1;119(23):4196-204.
  • Sahora K, Mino-Kenudson M, Brugge W, Thayer SP, Ferrone CR, Sahani D, Pitman MB, Warshaw AL, Lillemoe KD, Fernandez-del Castillo CF.
    Branch duct intraductal papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical analysis of the revised international consensus guidelines in a large single-institutional series.
    Ann Surg. 2013 Sep;258(3):466-75.
  • Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA, Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP, Murphy JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernandez-Del Castillo C, Ryan DP, Hong TS.
    FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience.
    Oncologist. 2013 May 8.
  • Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, Depinho RA, Cantley LC, Kimmelman AC.
    Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
    Nature. 2013 Mar 27.
  • Hyder O, Hatzaras I, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, Aldrighetti L, Ferrone CR, Zhu AX, Bauer TW, Walters DM, Groeschl R, Gamblin TC, Marsh JW, Nguyen KT, Turley R, Popescu I, Hubert C, Meyer S, Choti MA, Gigot JF, Mentha G, Pawlik TM.
    Recurrence after operative management of intrahepatic cholangiocarcinoma.
    Surgery. 2013 Mar 15.
  • Gupta R, Khosroshahi A, Shinagare S, Fernandez C, Ferrone C, Lauwers GY, Stone JH, Deshpande V.
    Does autoimmune pancreatitis increase the risk of pancreatic carcinoma?: a retrospective analysis of pancreatic resections.
    Pancreas. 2013 Apr;42(3):506-10.
  • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA.
    BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
    Clin Cancer Res. 2013 Mar 1;19(5):1225-31.
  • Valsangkar NP, Bush DM, Michaelson JS, Ferrone CR, Wargo JA, Lillemoe KD, Fernández-del Castillo C, Warshaw AL, Thayer SP.
    N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma.
    J Gastrointest Surg. 2013 Feb;17(2):257-66.
  • Khor TS, Badizadegan K, Ferrone C, Fernández-Del Castillo C, Desai GS, Saenz A, Le L, Lauwers GY, Deshpande V.
    Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodules.
    Am J Surg Pathol. 2012 Nov;36(11):1579-91.
  • Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK.
    Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
    Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15101-8.
  • Konstantinidis IT, Warshaw AL, Allen JN, Blaszkowsky LS, Fernandez-Del Castillo C, Deshpande V, Hong TS, Kwak EL, Lauwers GY, Ryan DP, Wargo JA, Lillemoe KD, Ferrone CR.
    Pancreatic Ductal Adenocarcinoma: Is There a Survival Difference for R1 Resections Versus Locally Advanced Unresectable Tumors? What Is a "True" R0 Resection?.
    Ann Surg. 2012 Sep 10.
  • Fernández-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR, Thayer SP, Lillemoe KD, Warshaw AL.
    Evolution of the Whipple procedure at the Massachusetts General Hospital.
    Surgery. 2012 Sep;152(3 Suppl 1):S56-63.
  • Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernández-del Castillo C.
    851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital.
    Surgery. 2012 Sep;152(3 Suppl 1):S4-12.
  • Cogdill AP, Frederick DT, Cooper ZA, Garber HR, Ferrone CR, Fiedler A, Rosenberg L, Thayer SP, Warshaw AL, Wargo JA.
    Targeting the MAGE A3 antigen in pancreatic cancer.
    Surgery. 2012 Sep;152(3 Suppl 1):S13-8.
  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C, Lillemoe KD, Warshaw AL.
    Pancreatic ductal adenocarcinoma: long-term survival does not equal cure.
    Surgery. 2012 Sep;152(3 Suppl 1):S43-9.
  • Nehra D, Oyarvide VM, Mino-Kenudson M, Thayer SP, Ferrone CR, Wargo JA, Muzikansky A, Finkelstein D, Warshaw AL, Castillo CF.
    Intraductal papillary mucinous neoplasms: does a family history of pancreatic cancer matter?.
  • Halvey PJ, Ferrone CR, Liebler DC.
    GeLC-MRM quantitation of mutant KRAS oncoprotein in complex biological samples.
    J Proteome Res. 2012 Jul 6;11(7):3908-13.
  • Ferrone CR, Konstantinidis IT, Sahani DV, Wargo JA, Fernandez-Del Castillo C, Warshaw AL.
    Twenty-Three Years of the Warshaw Operation for Distal Pancreatectomy with Preservation of the Spleen.
    Ann Surg. 2011 Mar 9.
  • Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C, Warshaw AL, Ferrone CR.
    Metastatic tumors in the pancreas in the modern era.
    J Am Coll Surg. 2010 Dec;211(6):749-53.
  • Ferrone C, Dranoff G.
    Dual roles for immunity in gastrointestinal cancers.
    J Clin Oncol. 2010 Sep 10;28(26):4045-51. Review.
  • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA.
    Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.
    Cancer Res. 2010 Jul 1;70(13):5213-9.
  • Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M.
    Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.
    N Engl J Med. 2010 Jun 24;362(25):2411-9.
  • Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-Del Castillo C.
    Incidental pancreatic cysts: do we really know what we are watching?.
    Pancreatology. 2010;10(2-3):144-50.
  • Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S, Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R.
    Invasive intraductal papillary mucinous carcinomas of the pancreas: predictors of survival and the role of lymph node ratio.
    Ann Surg. 2010 Mar;251(3):477-82.
  • Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR.
    Does the mechanism of lymph node invasion affect survival in patients with pancreatic ductal adenocarcinoma?.
    J Gastrointest Surg. 2010 Feb;14(2):261-7.
  • Ogino S, Nosho K, Irahara N, Meyerhardt JA, Baba Y, Shima K, Glickman JN, Ferrone CR, Mino-Kenudson M, Tanaka N, Dranoff G, Giovannucci EL, Fuchs CS.
    Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype.
    Clin Cancer Res. 2009 Oct 15;15(20):6412-20.
  • Yoon LS,Catalano OA,Fritz S,Ferrone CR,Hahn PF,Sahani DV.
    Another dimension in magnetic resonance cholangiopancreatography: comparison of 2- and 3-dimensional magnetic resonance cholangiopancreatography for the evaluation of intraductal papillary mucinous neoplasm of the pancreas.
    J Comput Assist Tomogr. 2009 May-Jun;33(3):363-8.
  • Ferrone CR,Correa-Gallego C,Warshaw AL,Brugge WR,Forcione DG,Thayer SP,Fernandez-del Castillo C.
    Current trends in pancreatic cystic neoplasms.
    Arch Surg. 2009 May;144(5):448-54.
  • Konstantinidis IT,Deshpande V,Genevay M,Berger D,Fernandez-del Castillo C,Tanabe KK,Zheng H,Lauwers GY,Ferrone CR.
    Trends in presentation and survival for gallbladder cancer during a period of more than 4 decades: a single-institution experience.
    Arch Surg. 2009 May;144(5):441-7; discussion 447.
  • Ferrone CR,Levine DA,Tang LH,Allen PJ,Jarnagin W,Brennan MF,Offit K,Robson ME.
    BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.
    J Clin Oncol. 2009 Jan 20;27(3):433-8.
  • Canter RJ,Qin LX,Ferrone CR,Maki RG,Singer S,Brennan MF.
    Why do patients with low-grade soft tissue sarcoma die?.
    Ann Surg Oncol. 2008 Dec;15(12):3550-60.
  • Ferrone CR,Warshaw AL,Rattner DW,Berger D,Zheng H,Rawal B,Rodriguez R,Thayer SP,Fernandez-del Castillo C.
    Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates.
    J Gastrointest Surg. 2008 Oct;12(10):1691-7; discussion 1697-8.