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Sandro Santagata

Publications

  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, Macconaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL.Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proc Natl Acad Sci U S A. 2013 Apr 30.
    23633565
  • Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Nat Genet. 2013 Mar;45(3):285-9.
    23334667
  • Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG.Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6.
    23300285
  • Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.J Clin Invest. 2012 Oct 1;122(10):3742-54.
    22945628
  • Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S.HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.Cell. 2012 Aug 3;150(3):549-62.
    22863008
  • Whitesell L, Santagata S, Lin NU.Inhibiting HSP90 to treat cancer: a strategy in evolution.Curr Mol Med. 2012 Jul 17.
    22804235
  • Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG, Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH.DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.PLoS ONE. 2012;7(6):e38881.
    22719973
  • Milbury CA, Chen CC, Mamon H, Liu P, Santagata S, Makrigiorgos GM.Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content.J Mol Diagn. 2011 Mar;13(2):220-32.
    21354058
  • Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL.Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome.J Clin Oncol. 2010 Dec 6.
    21098324
  • Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR.Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90.
    20855618
  • McIntire MG, Santagata S, Ligon K, Chirieac LR.Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.Am J Transl Res. 2010;2(3):309-15.
    20589169
  • Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.Cell. 2010 May 28;141(5):872-83.
    20471072
  • Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL.CRX is a diagnostic marker of retinal and pineal lineage tumors.PLoS ONE. 2009;4(11):e7932.
    19936203
  • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA.Profiling critical cancer gene mutations in clinical tumor samples.PLoS ONE. 2009;4(11):e7887.
    19924296
  • Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY.Phase II study of protracted daily temozolomide for low-grade gliomas in adults.Clin Cancer Res. 2009 Jan 1;15(1):330-7.
    19118062
  • Santagata S, Ligon KL, Hornick JL.Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors.Am J Surg Pathol. 2007 Jun;31(6):836-845.
    17527070
  • Santagata S, Hornick JL, Ligon KL.Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.Am J Surg Pathol. 2006 Dec;30(12):1613-8.
    17122519
  • Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD.A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.PLoS Genet. 2005 Jul;1(1):72-80.
    16103922
  • Santagata S,Demichelis F,Riva A,Varambally S,Hofer MD,Kutok JL,Kim R,Tang J,Montie JE,Chinnaiyan AM,Rubin MA,Aster JC.JAGGED1 expression is associated with prostate cancer metastasis and recurrence.Cancer Res. 2004 Oct 1;64(19):6854-7.
    15466172
  • Santagata S,Besmer E,Villa A,Bozzi F,Allingham JS,Sobacchi C,Haniford DB,Vezzoni P,Nussenzweig MC,Pan ZQ,Cortes P.The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination.Mol Cell. 1999 Dec;4(6):935-47.
    10635319