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Sandro Santagata

Publications

  • Santagata S, Ince TA.Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy.Expert Rev Anticancer Ther. 2014 Sep 27:1-5.
    25263303
  • Cryan JB, Haidar S, Ramkissoon LA, Bi WL, Knoff DS, Schultz N, Abedalthagafi M, Brown L, Wen PY, Reardon DA, Dunn IF, Folkerth RD, Santagata S, Lindeman NI, Ligon AH, Beroukhim R, Hornick JL, Alexander BM, Ligon KL, Ramkissoon SH.Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas.Oncotarget. 2014 Aug 12.
    25257301
  • Calligaris D, Caragacianu D, Liu X, Norton I, Thompson CJ, Richardson AL, Golshan M, Easterling ML, Santagata S, Dillon DA, Jolesz FA, Agar NY.Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis.Proc Natl Acad Sci U S A. 2014 Sep 22.
    25246570
  • Lee EQ, Ruland S, LeBoeuf NR, Wen PY, Santagata S.Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy.J Clin Oncol. 2014 Aug 4.
    25092772
  • Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S.The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.Cell. 2014 Jul 31;158(3):564-78.
    25083868
  • Santagata S, Eberlin LS, Norton I, Calligaris D, Feldman DR, Ide JL, Liu X, Wiley JS, Vestal ML, Ramkissoon SH, Orringer DA, Gill KK, Dunn IF, Dias-Santagata D, Ligon KL, Jolesz FA, Golby AJ, Cooks RG, Agar NY.Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11121-6.
    24982150
  • Aizer AA, Arvold ND, Catalano P, Claus EB, Golby AJ, Johnson MD, Al-Mefty O, Wen PY, Reardon DA, Lee EQ, Nayak L, Rinne ML, Beroukhim R, Weiss SE, Ramkissoon SH, Abedalthagafi M, Santagata S, Dunn IF, Alexander BM.Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma.Neuro Oncology. 2014 Jun 2.
    24891451
  • Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN.Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.Proteomics. 2014 Mar 13.
    24634066
  • Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA.Structure-Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response.J Med Chem. 2014 Mar 25.
    24625088
  • Wen PY, Chang SM, Lamborn KR, Kuhn JG, Norden AD, Cloughesy TF, Robins HI, Lieberman FS, Gilbert MR, Mehta MP, Drappatz J, Groves MD, Santagata S, Ligon AH, Yung WK, Wright JJ, Dancey J, Aldape KD, Prados MD, Ligon KL.Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02.Neuro Oncology. 2014 Apr;16(4):567-78.
    24470557
  • Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J.The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.PLoS Pathog. 2014 Feb;10(2):e1003904.
    24516381
  • Santagata S, Thakkar A, Ergonul A, Wang B, Woo T, Hu R, Harrell JC, McNamara G, Schwede M, Culhane AC, Kindelberger D, Rodig S, Richardson A, Schnitt SJ, Tamimi RM, Ince TA.Taxonomy of breast cancer based on normal cell phenotype predicts outcome.J Clin Invest. 2014 Feb 3;124(2):859-70.
    24463450
  • Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S.Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.Nat Genet. 2014 Feb;46(2):161-5.
    24413733
  • Calligaris D, Norton I, Feldman DR, Ide JL, Dunn IF, Eberlin LS, Cooks RG, Jolesz FA, Golby AJ, Santagata S, Agar NY.Mass spectrometry imaging as a tool for surgical decision-making.J Mass Spectrom. 2013 Nov;48(11):1178-87.
    24259206
  • Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY.Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.Sci Rep. 2013;3:2859.
    24091529
  • Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS.Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.Sci Transl Med. 2013 Sep 4;5(201):201ra119.
    24005159
  • Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S.Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Science. 2013 Jul 19;341(6143):1238303.
    23869022
  • Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S.Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.Nat Biotechnol. 2013 Jul;31(7):630-7.
    23811600
  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL.Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
    23633565
  • Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R.Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Nat Genet. 2013 Mar;45(3):285-9.
    23334667
  • Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG.Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6.
    23300285
  • Silverman MA, Misasi J, Smole S, Feldman HA, Cohen AB, Santagata S, McManus M, Ahmed AA.Eastern equine encephalitis in children, Massachusetts and New Hampshire,USA, 1970-2010.Emerg Infect Dis. 2013 Feb;19(2):194-201; quiz 352.
    23343480
  • Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.J Clin Invest. 2012 Oct 1;122(10):3742-54.
    22945628
  • Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S.HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.Cell. 2012 Aug 3;150(3):549-62.
    22863008
  • Whitesell L, Santagata S, Lin NU.Inhibiting HSP90 to treat cancer: a strategy in evolution.Curr Mol Med. 2012 Jul 17.
    22804235
  • Craig JM, Vena N, Ramkissoon S, Idbaih A, Fouse SD, Ozek M, Sav A, Hill DA, Margraf LR, Eberhart CG, Kieran MW, Norden AD, Wen PY, Loda M, Santagata S, Ligon KL, Ligon AH.DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.PLoS ONE. 2012;7(6):e38881.
    22719973
  • Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA.Using the heat-shock response to discover anticancer compounds that target protein homeostasis.ACS Chem Biol. 2012 Feb 17;7(2):340-9.
    22050377
  • Eberlin LS, Norton I, Dill AL, Golby AJ, Ligon KL, Santagata S, Cooks RG, Agar NY.Classifying human brain tumors by lipid imaging with mass spectrometry.Cancer Res. 2012 Feb 1;72(3):645-54.
    22139378
  • Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA.High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83.
    22042860
  • Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NY, Cooks RG.Desorption Electrospray Ionization then MALDI Mass Spectrometry Imaging of Lipid and Protein Distributions in Single Tissue Sections.Anal Chem. 2011 Oct 18.
    21975048
  • Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL.Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pediatric Low-Grade Gliomas.J Mol Diagn. 2011 Nov;13(6):669-77.
    21884820
  • Mahta A, Qu Y, Nastic D, Sundstrom M, Kim RY, Saria M, Santagata S, Kesari S.Relapsing Tumefactive Lesion in an Adult with Medulloblastoma Previously Treated with Chemoradiotherapy and Stem Cell Transplant.Pathol Oncol Res. 2011 Sep 28.
    21953324
  • Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, Batchelor TT, Ligon KL, Iafrate AJ, Ligon AH, Louis DN, Santagata S.BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.PLoS ONE. 2011;6(3):e17948.
    21479234
  • Milbury CA, Chen CC, Mamon H, Liu P, Santagata S, Makrigiorgos GM.Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content.J Mol Diagn. 2011 Mar;13(2):220-32.
    21354058
  • Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL.Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome.J Clin Oncol. 2010 Dec 6.
    21098324
  • McMillan HJ, Santagata S, Shapiro F, Batish SD, Couchon L, Donnelly S, Kang PB.Novel MPZ mutations and congenital hypomyelinating neuropathy.Neuromuscular Disorders : Nmd. 2010 Nov;20(11):725-9.
    20621479
  • Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR.Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90.
    20855618
  • McIntire MG, Santagata S, Ligon K, Chirieac LR.Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.Am J Transl Res. 2010;2(3):309-15.
    20589169
  • Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.Cell. 2010 May 28;141(5):872-83.
    20471072
  • Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL.CRX is a diagnostic marker of retinal and pineal lineage tumors.PLoS ONE. 2009;4(11):e7932.
    19936203
  • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA.Profiling critical cancer gene mutations in clinical tumor samples.PLoS ONE. 2009;4(11):e7887.
    19924296
  • Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S.Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.Nat Chem Biol. 2009 Sep;5(9):655-63.
    19597508
  • Kesari S,Schiff D,Drappatz J,LaFrankie D,Doherty L,Macklin EA,Muzikansky A,Santagata S,Ligon KL,Norden AD,Ciampa A,Bradshaw J,Levy B,Radakovic G,Ramakrishna N,Black PM,Wen PY.Phase II study of protracted daily temozolomide for low-grade gliomas in adults.Clin Cancer Res. 2009 Jan 1;15(1):330-7.
    19118062
  • Wabulya A, Imitola J, Santagata S, Kesari S.Mycosis fungoides with leptomeningeal involvement.J Clin Oncol. 2007 Dec 10;25(35):5658-61.
    18065739
  • Santagata S, Ligon KL, Hornick JL.Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors.Am J Surg Pathol. 2007 Jun;31(6):836-845.
    17527070
  • Santagata S, van Horne C, Sallan SE, McLaughlin ME, Ramakrishna NR.Post-irradiation meningioma with sarcoidosis.J. Neurooncol. 2007 May;82(3):271-2.
    17361337
  • Santagata S, Kesari S, Black PM, Chan JA.Anaplastic variant of medulloblastoma mimicking a vestibular schwannoma.J Neurooncol. 2007 Jan;81(1):49-51.
    17146596
  • Santagata S, Hornick JL, Ligon KL.Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG.Am J Surg Pathol. 2006 Dec;30(12):1613-8.
    17122519
  • Santagata S, Tuli S, Wiese DE, Day A, De Girolami U.Intramedullary neuroma of the cervicomedullary junction. Case report.J Neurosurg Spine. 2006 Oct;5(4):362-6.
    17048775
  • Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD.A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.PLoS Genet. 2005 Jul;1(1):72-80.
    16103922
  • Santagata S, Kinney HC.Mechanism of JCV entry into oligodendrocytes.Science. 2005 Jul 15;309(5733):381-2.
    16020715
  • Santagata S,Demichelis F,Riva A,Varambally S,Hofer MD,Kutok JL,Kim R,Tang J,Montie JE,Chinnaiyan AM,Rubin MA,Aster JC.JAGGED1 expression is associated with prostate cancer metastasis and recurrence.Cancer Res. 2004 Oct 1;64(19):6854-7.
    15466172
  • Santagata S,Besmer E,Villa A,Bozzi F,Allingham JS,Sobacchi C,Haniford DB,Vezzoni P,Nussenzweig MC,Pan ZQ,Cortes P.The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination.Mol Cell. 1999 Dec;4(6):935-47.
    10635319