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David Langenau, PhD

Publications

  • Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM.Optimized cell transplantation using adult rag2 mutant zebrafish.Nat Methods. 2014 Jul 20.
    25042784
  • Abraham J, Nuñez-Álvarez Y, Hettmer S, Carrió E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansoor A, Chen Y, Suelves M, Rubin BP, Keller C.Lineage of origin in rhabdomyosarcoma informs pharmacological response.Genes Dev. 2014 Jul 15;28(14):1578-91.
    25030697
  • Blackburn JS, Langenau DM.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Dis Model Mech. 2014 Jul;7(7):755-762.
    24973745
  • Chen EY, Deran MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM.Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54.
    24706870
  • Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT.Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.British Journal of Haematology. 2014 Apr 2.
    24690081
  • Blackburn JS, Liu S, Wilder JL, Dobrinski KP, Lobbardi R, Moore FE, Martinez SA, Chen EY, Lee C, Langenau DM.Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.Cancer Cell. 2014 Mar 17;25(3):366-78.
    24613413
  • Langenau DM.Pten regulates zebrafish hematopoiesis.Blood. 2014 Jan 9;123(2):149-50.
    24408201
  • Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Chen JY, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM.Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.PLoS Genet. 2013 Aug;9(8):e1003727.
    24009521
  • Storer NY, White RM, Uong A, Price E, Nielsen GP, Langenau DM, Zon LI.Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.Development. 2013 Jul;140(14):3040-50.
    23821038
  • Sokolowski E, Turina CB, Kikuchi K, Langenau DM, Keller C.Proof-of-concept rare cancers in drug development: the case for rhabdomyosarcoma.Oncogene. 2013 May 13.
    23665679
  • Le X, Pugach EK, Hettmer S, Storer NY, Liu J, Wills AA, Dibiase A, Chen EY, Ignatius MS, Poss KD, Wagers AJ, Langenau DM, Zon LI.A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.Development. 2013 Apr 24.
    23615277
  • Moore FE, Langenau DM.Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish.Adv Hematol. 2012;2012:478164.
    22829834
  • Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM.Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).PLoS ONE. 2012;7(5):e37877.
    22655075
  • Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM.In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.Cancer Cell. 2012 May 15;21(5):680-93.
    22624717
  • Blackburn JS, Liu S, Raimondi AR, Ignatius MS, Salthouse CD, Langenau DM.High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.Nat Protoc. 2011 Feb;6(2):229-41.
    21293462
  • Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK.Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).Nat Methods. 2011 Jan;8(1):67-9.
    21151135
  • Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.Cancer Cell. 2010 Oct 19;18(4):353-66.
    20951945
  • Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM.High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.Blood. 2010 Apr 22;115(16):3296-303.
    20056790
  • Blackburn JS, Langenau DM.aMAZe-ing tools for mosaic analysis in zebrafish.Nat Methods. 2010 Mar;7(3):188-90.
    20195251
  • Ignatius MS, Langenau DM.Zebrafish as a model for cancer self-renewal.Zebrafish. 2009 Dec;6(4):377-87.
    19954344
  • Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI.Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.Oncogene. 2008 Jul 10;27(30):4242-8.
    18345029
  • Le X, Langenau DM, Keefe MD, Kutok JL, Neuberg DS, Zon LI.Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.Proc Natl Acad Sci U S A. 2007 May 29;104(22):9410-5.
    17517602
  • Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI.Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Genes Dev. 2007 Jun 1;21(11):1382-1395.
    17510286
  • Langenau DM, Feng H, Berghmans S, Kanki JP, Kutok JL, Look AT.Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6068-73.
    15827121
  • Langenau DM,Zon LI.The zebrafish: a new model of T-cell and thymic development.Nat Rev Immunol. 2005 Apr;5(4):307-17.
    15803150
  • Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, Kanki JP, Zon LI, Look AT, Trede NS.In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.Proc Natl Acad Sci U S A. 2004 May 11;101(19):7369-74.
    15123839
  • Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.Myc-induced T cell leukemia in transgenic zebrafish.Science. 2003 Feb 7;299(5608):887-90.
    12574629