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Joseph Avruch, MD


  • Oshiro N, Rapley J, Avruch J.Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.J Biol Chem. 2014 Jan 31;289(5):2658-74.
  • Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D.The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.Cell Rep. 2013 May 30;3(5):1663-77.
  • Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ.Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas.Gastroenterology. 2013 Feb 27.
  • Avruch J, Zhou D, Fitamant J, Bardeesy N, Mou F, Barrufet LR.Protein kinases of the Hippo pathway: Regulation and substrates.Semin Cell Dev Biol. 2012 Sep;23(7):770-84.
  • Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD.Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation.Cell. 2011 Mar 4;144(5):782-95.
  • Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB.Tumor suppressor Ras-association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.J Biol Chem. 2010 Nov 5;285(45):35029-38.
  • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.Cancer Cell. 2009 Nov 6;16(5):425-38.
  • Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F.Rassf family of tumor suppressor polypeptides.J Biol Chem. 2009 Apr 24;284(17):11001-5. Review.
  • Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N.Amino acid regulation of TOR complex 1.Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. Review.
  • Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, Kasir J, Cybulski N, Avruch J, Rüegg MA, Hall MN, Meyuhas O.The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.Mol Cell Biol. 2009 Feb;29(3):640-9.
  • Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U.Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.Biochem Soc Trans. 2009 Feb;37(Pt 1):223-6. Review.
  • Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J.The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6.
  • Rapley J, Nicolàs M, Groen A, Regué L, Bertran MT, Caelles C, Avruch J, Roig J.The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.J Cell Sci. 2008 Dec 1;121(Pt 23):3912-21.
  • Anguera MC,Liu M,Avruch J,Lee JT.Characterization of two Mst1-deficient mouse models.Dev Dyn. 2008 Nov;237(11):3424-34.
  • Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP.A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.Mol Cell Biol. 2008 Jul;28(13):4215-26.
  • Praskova M, Xia F, Avruch J.MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.Curr Biol. 2008 Mar 11;18(5):311-21.