• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Rachael A. Clark, MD, PhD

Publications

  • Watanabe R, Teague JE, Fisher DC, Kupper TS, Clark RA.Alemtuzumab Therapy for Leukemic Cutaneous T-Cell Lymphoma: Diffuse Erythema as a Positive Predictor of Complete Remission.JAMA Dermatol. 2014 Apr 23.
    24760312
  • Maldonado L, Teague JE, Morrow MP, Jotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL.Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions.Sci Transl Med. 2014 Jan 29;6(221):221ra13.
    24477000
  • Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA.Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.Sci Transl Med. 2014 Jan 15;6(219):219ra8.
    24431112
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Aug(8):1248-53.
    22772464
  • Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA.TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.Clin Cancer Res. 2013 Jul 15;19(14):3755-63.
    23785046
  • Dowlatshahi M, Huang V, Gehad AE, Jiang Y, Calarese A, Teague JE, Dorosario AA, Cheng J, Nghiem P, Schanbacher CF, Thakuria M, Schmults CD, Wang LC, Clark RA.Tumor-Specific T Cells in Human Merkel Cell Carcinomas: A Possible Role for Tregs and T-Cell Exhaustion in Reducing T-Cell Responses.J Invest Dermatol. 2013 Feb 18.
    23419694
  • Gehad AE, Lichtman MK, Schmults CD, Teague JE, Calarese AW, Jiang Y, Watanabe R, Clark RA.Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular e-selectin expression in human squamous cell carcinomas.J Invest Dermatol. 2012 Nov;132(11):2642-51.
    22718118
  • Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS.High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.Blood. 2011 Feb 10;117(6):1966-76.
    21148332
  • Trimble CL, Clark RA, Thoburn C, Hanson NC, Tassello J, Frosina D, Kos F, Teague J, Jiang Y, Barat NC, Jungbluth AA.Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium.J Immunol. 2010 Dec 1;185(11):7107-14.
    21037100
  • de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB.CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire.Nat Immunol. 2010 Dec;11(12):1102-9.
    21037579
  • Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ.Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation.J Immunol. 2010 Oct 15;185(8):4659-72.
    20844192
  • Campbell JJ, Clark RA, Watanabe R, Kupper TS.Sezary syndrome and MF arise from distinct T cell subsets: a biologic rationale for their distinct clinical behaviors.Blood. 2010 Aug 5;116(5):767-71.
    20484084
  • van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J.First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi.Pigment Cell Melanoma Res. 2010 Jun;23(3):375-84.
    20370855
  • Clark RA.Skin-resident T cells: the ups and downs of on site immunity.J Invest Dermatol. 2010 Feb;130(2):362-70. Review.
    19675575
  • Clark RA.Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells.J Invest Dermatol. 2009 Dec;129(12):2747-50.
    19901946
  • Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA.Imiquimod Enhances IFN-gamma Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin.J Invest Dermatol. 2009 Nov;129(11):2676-85.
    19516264
  • Clark RA, Fuhlbrigge RC.Immunology and skin disease 2009: frontiers in cutaneous immunology.J Invest Dermatol. 2009 Aug;129(8):1849-51.
    19603049
  • Clark RA,Huang SJ,Murphy GF,Mollet IG,Hijnen D,Muthukuru M,Schanbacher CF,Edwards V,Miller DM,Kim JE,Lambert J,Kupper TS.Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.J Exp Med. 2008 Sep 29;205(10):2221-34.
    18794336
  • Clark RA, Kupper TS.IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.Blood. 2007 Jan 1;109(1):194-202.
    16968902
  • Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS.The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.J Immunol. 2006 Oct 1;177(7):4488-94.
    16982885
  • Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS.A novel method for the isolation of skin resident T cells from normal and diseased human skin.J Invest Dermatol. 2006 May;126(5):1059-70.
    16484986
  • Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS.The vast majority of CLA+ T cells are resident in normal skin.J Immunol. 2006 Apr 1;176(7):4431-9.
    16547281