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John Iafrate

Publications

  • Chi AS, Batchelor TT, Yang D, Dias-Santagata D, Borger DR, Ellisen LW, Iafrate AJ, Louis DN.BRAF V600E Mutation Identifies a Subset of Low-Grade Diffusely Infiltrating Gliomas in Adults.J Clin Oncol. 2013 Apr 1.
    23547069
  • Ou SH, Bartlett CH, Mino-Kenudson M, Cui J, Iafrate AJ.Crizotinib for the Treatment of ALK-Rearranged Non-Small Cell Lung Cancer: A Success Story to Usher in the Second Decade of Molecular Targeted Therapy in Oncology.Oncologist. 2012;17(11):1351-75.
    22989574
  • Heist RS, Mino-Kenudson M, Sequist LV, Tammireddy S, Morrissey L, Christiani DC, Engelman JA, Iafrate AJ.FGFR1 amplification in squamous cell carcinoma of the lung.J Thorac Oncol. 2012 Dec;7(12):1775-80.
    23154548
  • Nishino M, Klepeis VE, Yeap BY, Bergethon K, Morales-Oyarvide V, Dias-Santagata D, Yagi Y, Mark EJ, Iafrate AJ, Mino-Kenudson M.Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.Mod Pathol. 2012 Nov;25(11):1462-72.
    22743652
  • Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M.Tumor Islands in Resected Early-stage Lung Adenocarcinomas are Associated With Unique Clinicopathologic and Molecular Characteristics and Worse Prognosis.Am J Surg Pathol. 2012 Oct 19.
    23095504
  • Fathi AT, Sadrzadeh H, Borger DR, Ballen KK, Amrein PC, Attar EC, Foster J, Burke M, Lopez HU, Matulis CR, Edmonds KM, Iafrate AJ, Straley KS, Yen KE, Agresta S, Schenkein DP, Hill C, Emadi A, Neuberg DS, Stone RM, Chen YB.Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response.Blood. 2012 Oct 16.
    23074281
  • Le LP, Dias-Santagata D, Pawlak AC, Cosper AK, Nguyen AT, Selim MA, Deng A, Horick NK, Iafrate AJ, Mihm MC, Hoang MP.Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.PLoS ONE. 2012;7(10):e47290.
    23056620
  • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, Riely GJ, Solomon B, Ou SH, Kim DW, Salgia R, Fidias P, Engelman JA, Gandhi L, Jänne PA, Costa DB, Shapiro GI, Lorusso P, Ruffner K, Stephenson P, Tang Y, Wilner K, Clark JW, Shaw AT.Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.Lancet Oncol. 2012 Oct;13(10):1011-9.
    22954507
  • Louissaint A, Ackerman AM, Dias-Santagata D, Ferry JA, Hochberg EP, Huang MS, Iafrate AJ, Lara DO, Pinkus GS, Salaverria I, Siddiquee Z, Siebert R, Weinstein HJ, Zukerberg LR, Harris NL, Hasserjian RP.Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement.Blood. 2012 Sep 20;120(12):2395-404.
    22855608
  • Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ.Prospective, high-throughput molecular profiling of human gliomas.J. Neurooncol. 2012 Oct;110(1):89-98.
    22821383
  • Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K.The challenges posed by cancer heterogeneity.Nat Biotechnol. 2012 Jul;30(7):604-10.
    22781679
  • Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M, Engelman JA.Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors.Sci Transl Med. 2011 Mar 23;3(75):75ra26.
    21430269
  • Growdon WB, Roussel BN, Scialabba VL, Foster R, Dias-Santagata D, Iafrate AJ, Ellisen LW, Tambouret RH, Rueda BR, Borger DR.Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin.Gynecol Oncol. 2011 Apr;121(1):212-7.
    21168197
  • Farris AB, Demicco EG, Le LP, Finberg KE, Miller J, Mandal R, Fukuoka J, Cohen C, Gaissert HA, Zukerberg LR, Lauwers GY, Iafrate AJ, Mino-Kenudson M.Clinicopathologic and Molecular Profiles of Microsatellite Unstable Barrett Esophagus-associated Adenocarcinoma.Am J Surg Pathol. 2011 Mar 18.
    21422910
  • Dias-Santagata D, Lam Q, Bergethon K, Baker GM, Iafrate AJ, Rakheja D, Hoang MP.A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas.Mod Pathol. 2011 Mar 18.
    21423156
  • Camelo-Piragua S, Jansen M, Ganguly A, Kim JC, Cosper AK, Dias-Santagata D, Nutt CL, Iafrate AJ, Louis DN.A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53.J Neuropathol Exp Neurol. 2011 Feb;70(2):110-5.
    21343879
  • Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA.Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.Science. 2011 Feb 4;331(6017):593-6.
    21233348
  • Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA.BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.Sci Signal. 2010;3(149):ra84.
    21098728
  • Ou SH, Bazhenova L, Camidge DR, Solomon BJ, Herman J, Kain T, Bang YJ, Kwak EL, Shaw AT, Salgia R, Maki RG, Clark JW, Wilner KD, Iafrate AJ.Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.J Thorac Oncol. 2010 Dec;5(12):2044-6.
    21102269
  • Sequist LV, Gettinger S, Senzer NN, Martins RG, Jänne PA, Lilenbaum R, Gray JE, Iafrate AJ, Katayama R, Hafeez N, Sweeney J, Walker JR, Fritz C, Ross RW, Grayzel D, Engelman JA, Borger DR, Paez G, Natale R.Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non-Small-Cell Lung Cancer.J Clin Oncol. 2010 Nov 20;28(33):4953-60.
    20940188
  • Lennerz JK, Kuter DJ, Hasserjian R, Iafrate J.Massive hepatomegaly and involvement by Janus kinase 2-positive myeloproliferative neoplasm.Hepatology. 2010 Nov;52(5):1855-6.
    20890944
  • Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Jänne PA, Costa DB, Varella-Garcia M, Kim WH, Lynch TJ, Fidias P, Stubbs H, Engelman JA, Sequist LV, Tan W, Gandhi L, Mino-Kenudson M, Wei GC, Shreeve SM, Ratain MJ, Settleman J, Christensen JG, Haber DA, Wilner K, Salgia R, Shapiro GI, Clark JW, Iafrate AJ.Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.N Engl J Med. 2010 Oct 28;363(18):1693-703.
    20979469
  • Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S.NRAS mutations are rare in colorectal cancer.Diagn Mol Pathol. 2010 Sep;19(3):157-63.
    20736745
  • Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z.Characterization and analysis of human chordoma cell lines.Spine. 2010 Jun 1;35(13):1257-64.
    20461036
  • Dias-Santagata D, Akhavanfard S, David SS, Vernovsky K, Kuhlmann G, Boisvert SL, Stubbs H, McDermott U, Settleman J, Kwak EL, Clark JW, Isakoff SJ, Sequist LV, Engelman JA, Lynch TJ, Haber DA, Louis DN, Ellisen LW, Borger DR, Iafrate AJ.Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.EMBO Mol Med. 2010 May;2(5):146-58.
    20432502
  • Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S.Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.Sci Transl Med. 2010 Mar 31;2(25):25ra23.
    20424012
  • Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ.Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.J Orthop Res. 2010 Jun;28(6):746-52.
    20041488
  • Pino MS, Kikuchi H, Zeng M, Herraiz MT, Sperduti I, Berger D, Park DY, Iafrate AJ, Zukerberg LR, Chung DC.Epithelial to Mesenchymal Transition Is Impaired in Colon Cancer Cells With Microsatellite Instability.Gastroenterology. 2010 Apr;138(4):1406-17.
    20026115
  • Fritz S, Fernández-Del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, Lafemina J, Stirman A, Warshaw AL, Thayer SP.Novel Xenograft and Cell Line Derived From an Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Give New Insights Into Molecular Mechanisms.Pancreas. 2010 Apr;39(3):308-14.
    19924021
  • Mino-Kenudson M, Chirieac LR, Law K, Hornick JL, Lindeman N, Mark EJ, Cohen DW, Johnson BE, Jänne PA, Iafrate AJ, Rodig SJ.A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry.Clin Cancer Res. 2010 Mar 1;16(5):1561-71.
    20179225
  • Barletta JA,Perner S,Iafrate AJ,Yeap BY,Weir BA,Johnson LA,Johnson BE,Meyerson M,Rubin MA,Travis WD,Loda M,Chirieac LR.Clinical Significance of TTF-1 Protein Expression and TTF-1 Gene Amplification in Lung Adenocarcinoma.J Cell Mol Med. 2009 Aug;13(8B):1977-86.
    19040416
  • Turke AB, Zejnullahu K, Wu YL, Song Y, Dias-Santagata D, Lifshits E, Toschi L, Rogers A, Mok T, Sequist L, Lindeman NI, Murphy C, Akhavanfard S, Yeap BY, Xiao Y, Capelletti M, Iafrate AJ, Lee C, Christensen JG, Engelman JA, Jänne PA.Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Cancer Cell. 2010 Jan 19;17(1):77-88.
    20129249
  • Sholl LM, Yeap BY, Iafrate AJ, Holmes-Tisch AJ, Chou YP, Wu MT, Goan YG, Su L, Benedettini E, Yu J, Loda M, Jänne PA, Christiani DC, Chirieac LR.Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers.Cancer Res. 2009 Nov 1;69(21):8341-8.
    19826035
  • Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ.Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.Clin Cancer Res. 2009 Oct 15;15(20):6430-7.
    19808867
  • Sholl LM, Yeap BY, Iafrate AJ, Holmes-Tisch AJ, Chou YP, Wu MT, Goan YG, Su L, Benedettini E, Yu J, Loda M, Jänne PA, Christiani DC, Chirieac LR.Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers.Cancer Res. 2009 Nov 1;69(21):8341-8348.
  • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ.Clinical Features and Outcome of Patients With Non-Small-Cell Lung Cancer Who Harbor EML4-ALK.J Clin Oncol. 2009 Sep 10;27(26):4247-53.
    19667264
  • Pao W, Kris MG, Iafrate AJ, Ladanyi M, Jänne PA, Wistuba II, Miake-Lye R, Herbst RS, Carbone DP, Johnson BE, Lynch TJ.Integration of molecular profiling into the lung cancer clinic.Clin Cancer Res. 2009 Sep 1;15(17):5317-22.
    19706816
  • Rodig SJ, Mino-Kenudson M, Dacic S, Yeap BY, Shaw A, Barletta JA, Stubbs H, Law K, Lindeman N, Mark E, Janne PA, Lynch T, Johnson BE, Iafrate AJ, Chirieac LR.Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population.Clin Cancer Res. 2009 Aug 15;15(16):5216-23.
    19671850
  • Staats PN, Garcia JJ, Dias-Santagata DC, Kuhlmann G, Stubbs H, McCluggage WG, De Nictolis M, Kommoss F, Soslow RA, Iafrate AJ, Oliva E.Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors.Am J Surg Pathol. 2009 Aug;33(8):1206-12.
    19542872
  • Yip S, Miao J, Cahill DP, Iafrate AJ, Aldape K, Nutt CL, Louis DN.MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.Clin Cancer Res. 2009 Jul 15;15(14):4622-9.
    19584161
  • Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z.Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.Anticancer Res. 2009 Jun;29(6):1867-71.
    19528441
  • Maheswaran S,Sequist LV,Nagrath S,Ulkus L,Brannigan B,Collura CV,Inserra E,Diederichs S,Iafrate AJ,Bell DW,Digumarthy S,Muzikansky A,Irimia D,Settleman J,Tompkins RG,Lynch TJ,Toner M,Haber DA.Detection of mutations in EGFR in circulating lung-cancer cells.N Engl J Med. 2008 Jul 24;359(4):366-77.
    18596266
  • Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Janne PA, Joshi VA, McCollum D, Evans TL, Muzikansky A, Kuhlmann GL, Han M, Goldberg JS, Settleman J, Iafrate AJ, Engelman JA, Haber DA, Johnson BE, Lynch TJ.First-Line Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring Somatic EGFR Mutations.J Clin Oncol. 2008 May 20;26(15):2442-9.
    18458038
  • McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J.Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.Cancer Res. 2008 May 1;68(9):3389-95.
    18451166
  • McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA, Settleman J.Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
    18077425
  • Sholl LM, John Iafrate A, Chou YP, Wu MT, Goan YG, Su L, Huang YT, Christiani DC, Chirieac LR.Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma.Mod Pathol. 2007 Oct;20(10):1028-35.
    17673923
  • Han M, Rivera MN, Batten JM, Haber DA, Cin PD, Iafrate AJ.Wilms' tumor with an apparently balanced translocation t(X;18) resulting in deletion of the WTX gene.Genes Chromosomes Cancer. 2007 Oct;46(10):909-13.
    17620295
  • Finberg KE, Sequist LV, Joshi VA, Muzikansky A, Miller JM, Han M, Beheshti J, Chirieac LR, Mark EJ, Iafrate AJ.Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features.J Mol Diagn. 2007 Jul;9(3):320-6.
    17591931
  • Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA.An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.Science. 2007 Feb 2;315(5812):642-5.
    17204608