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Keith T. Flaherty, MD

Publications

  • Salas Fragomeni RA, Chung HW, Landesman Y, Senapedis W, Saint-Martin JR, Tsao H, Flaherty KT, Shacham S, Kauffman M, Cusack JC.CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma.Mol Cancer Ther. 2013 Apr 24.
    23615632
  • Trunzer K, Pavlick AC, Schuchter L, Gonzalez R, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Kim KB, Weber JS, Hersey P, Long GV, Lawrence D, Ott PA, Amaravadi RK, Lewis KD, Puzanov I, Lo RS, Koehler A, Kockx M, Spleiss O, Schell-Steven A, Gilbert HN, Cockey L, Bollag G, Lee RJ, Joe AK, Sosman JA, Ribas A.Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma.J Clin Oncol. 2013 Apr 8.
    23569304
  • Sullivan RJ, Flaherty KT.Resistance to BRAF-targeted therapy in melanoma.Eur J Cancer. 2013 Apr;49(6):1297-304.
    23290787
  • Desai BM, Villanueva J, Nguyen TT, Lioni M, Xiao M, Kong J, Krepler C, Vultur A, Flaherty KT, Nathanson KL, Smalley KS, Herlyn M.The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling.PLoS ONE. 2013;8(3):e59588.
    23527225
  • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA.BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.Clin Cancer Res. 2013 Mar 1;19(5):1225-31.
    23307859
  • Flaherty KT, Lee SJ, Zhao F, Schuchter LM, Flaherty L, Kefford R, Atkins MB, Leming P, Kirkwood JM.Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma.J Clin Oncol. 2013 Jan 20;31(3):373-9.
    23248256
  • Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, Scialabba VL, Batten JM, Borger DR, Iafrate AJ, Heist RS, Lawrence DP, Flaherty KT, Bendell JC, Deschler D, Li Y, Wirth LJ, Dias-Santagata D.Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.Clin Cancer Res. 2013 Jan 15;19(2):480-90.
    23186780
  • Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, Chen JQ, Li HS, Watowich SS, Yang Y, Tompers Frederick D, Cooper ZA, Mbofung RM, Whittington M, Flaherty KT, Woodman SE, Davies MA, Radvanyi LG, Overwijk WW, Lizée G, Hwu P.BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.Clin Cancer Res. 2013 Jan 15;19(2):393-403.
    23204132
  • Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, Rini BI, Srinivas S, Stein MN, Adams LM, Ottesen LH, Laubscher KH, Sherman L, McDermott DF, Haas NB, Flaherty KT, Ross R, Eisenberg P, Meltzer PS, Merino MJ, Bottaro DP, Linehan WM, Srinivasan R.Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.J Clin Oncol. 2013 Jan 10;31(2):181-6.
    23213094
  • Kang HC, Tan KS, Keefe SM, Heitjan DF, Siegelman ES, Flaherty KT, O'Dwyer PJ, Rosen MA.MRI assessment of early tumor response in metastatic renal cell carcinoma patients treated with sorafenib.AJR Am J Roentgenol. 2013 Jan;200(1):120-6.
    23255750
  • Cho DC, Hutson TE, Samlowski W, Sportelli P, Somer B, Richards P, Sosman JA, Puzanov I, Michaelson MD, Flaherty KT, Figlin RA, Vogelzang NJ.Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal cell carcinoma after progression on vascular endothelial growth factor-targeted therapy.Cancer. 2012 Dec 15;118(24):6055-62.
    22674198
  • Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messaien L, Bronson RT, McMahon M, Granter S, Flaherty KT, Wargo JA, Marais R, Cichowski K.Elucidating distinct roles for NF1 in melanomagenesis.Cancer Discovery. 2012 Nov 21.
    23171796
  • Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J.Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.N Engl J Med. 2012 Nov;367(18):1694-703.
    23020132
  • Flaherty KT.Dividing and conquering: controlling advanced melanoma by targeting oncogene-defined subsets.Clin Exp Metastasis. 2012 Oct;29(7):841-6.
    22661223
  • Flaherty KT.Throwing the kitchen sink at melanoma drug development.Pigment Cell Melanoma Res. 2012 Sep;25(5):543-4.
    22812391
  • Belden S, Flaherty KT.MEK and RAF inhibitors for BRAF-mutated cancers.Expert Rev Mol Med. 2012;14:e17.
    23058743
  • Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L.Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.Nat Med. 2012 Oct;18(10):1503-10.
    22983396
  • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, Davis A, Mongare MM, Gould J, Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A, Lo RS, Flaherty KT, Ogino S, Wargo JA, Golub TR.Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.Nature. 2012 Jul 26;487(7408):500-4.
    22763439
  • Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, Milhem M, Demidov LV, Hassel JC, Rutkowski P, Mohr P, Dummer R, Trefzer U, Larkin JM, Utikal J, Dreno B, Nyakas M, Middleton MR, Becker JC, Casey M, Sherman LJ, Wu FS, Ouellet D, Martin AM, Patel K, Schadendorf D, .Improved survival with MEK inhibition in BRAF-mutated melanoma.N Engl J Med. 2012 Jul 12;367(2):107-14.
    22663011
  • Ascierto PA, Grimaldi AM, Curti B, Faries MB, Ferrone S, Flaherty K, Fox BA, Gajewski TF, Gershenwald JE, Gogas H, Grossmann K, Hauschild A, Hodi FS, Kefford R, Kirkwood JM, Leachmann S, Maio M, Marais R, Palmieri G, Morton DL, Ribas A, Stroncek DF, Stewart R, Wang E, Mozzillo N, Marincola FM.Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".J Transl Med. 2012;10:83.
    22551296
  • Kong Y, Si L, Zhu Y, Xu X, Corless CL, Flaherty KT, Li L, Li H, Sheng X, Cui C, Chi Z, Li S, Han M, Mao L, Lu A, Guo J.Large-Scale Analysis of KIT Aberrations in Chinese Patients with Melanoma.Clin Cancer Res. 2011 Apr 1;17(7):1684-91.
    21325067
  • Flaherty KT.Is It Good or Bad to Find a BRAF Mutation?.J Clin Oncol. 2011 Apr 1;29(10):1229-30.
    21343552
  • Puzanov I, Burnett P, Flaherty KT.Biological challenges of BRAF inhibitor therapy.Mol Oncol. 2011 Feb 16.
    21393075
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ.Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.Cancer Chemother Pharmacol. 2011 Feb 25.
    21350850
  • Flaherty KT.Taking stock of translational research in melanoma at the 2010 Society for Melanoma Research Congress.Pigment Cell Melanoma Res. 2011 Feb;24(1):107-9.
    21232025
  • Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Nature. 2010 Dec 16;468(7326):968-72.
    21107320
  • Puzanov I, Flaherty KT.Targeted molecular therapy in melanoma.Seminars In Cutaneous Medicine And Surgery. 2010 Sep;29(3):196-201.
    21051014
  • Flaherty KT.Narrative review: BRAF opens the door for therapeutic advances in melanoma.Ann Intern Med. 2010 Nov 2;153(9):587-91. Review.
    21041578
  • Flaherty KT, McArthur G.BRAF, a target in melanoma: implications for solid tumor drug development.Cancer. 2010 Nov 1;116(21):4902-13.
    20629085
  • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K.Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.Nature. 2010 Sep 30;467(7315):596-9.
    20823850
  • Agarwala SS, di Pietro A, Flaherty KT, Garbe C, Grob JJ, Kashani-Sabet M, Kirkwood JM, Leachman S, Messina J, O'Day S, Ribas A, Sondak V.Meeting report from the Third Global Workshop on Melanoma.Pigment Cell Melanoma Res. 2010 Oct;23(5):e1-7.
    20718940
  • Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB.Inhibition of mutated, activated BRAF in metastatic melanoma.N Engl J Med. 2010 Aug 26;363(9):809-19.
    20818844
  • Flaherty KT, Puzanov I.Building on a foundation of VEGF and mTOR targeted agents in renal cell carcinoma.Biochem Pharmacol. 2010 Sep 1;80(5):638-46. Review.
    20382128
  • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA.Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.Cancer Res. 2010 Jul 1;70(13):5213-9.
    20551059
  • Flaherty KT, Hodi FS, Bastian BC.Mutation-driven drug development in melanoma.Curr Opin Oncol. 2010 May;22(3):178-83. Review.
    20401974
  • Ji Z, Flaherty KT, Tsao H.Molecular therapeutic approaches to melanoma.Mol Aspects Med. 2010 Apr;31(2):194-204. Review.
    20176049
  • Traynor AM, Hewitt M, Liu G, Flaherty KT, Clark J, Freedman SJ, Scott BB, Leighton AM, Watson PA, Zhao B, O'Dwyer PJ, Wilding G.Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors.Cancer Chemother Pharmacol. 2010 Apr 13.
    20386909
  • Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM.Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care.Lancet Oncol. 2010 Apr;11(4):373-82. Review.
    20171141
  • Mehnert JM, McCarthy MM, Jilaveanu L, Flaherty KT, Aziz S, Camp RL, Rimm DL, Kluger HM.Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays.Hum Pathol. 2010 Mar;41(3):375-84.
    20004943
  • Pacey S, Ratain MJ, Flaherty KT, Kaye SB, Cupit L, Rowinsky EK, Xia C, O'Dwyer PJ, Judson IR.Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial.Invest New Drugs. 2009 Dec 18.
    20016927
  • Flaherty KT.Where does the combination of sorafenib and interferon in renal cell carcinoma stand?.Cancer. 2010 Jan 1;116(1):4-7.
    19890962
  • Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC, Morton DL, Ross MI, Sober AJ, Sondak VK.Final version of 2009 AJCC melanoma staging and classification.J Clin Oncol. 2009 Dec 20;27(36):6199-206.
    19917835
  • Amaravadi RK, Schuchter LM, McDermott DF, Kramer A, Giles L, Gramlich K, Carberry M, Troxel AB, Letrero R, Nathanson KL, Atkins MB, O'Dwyer PJ, Flaherty KT.Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases.Clin Cancer Res. 2009 Dec 15;15(24):7711-7718.
    19996224
  • Flaherty KT, Brose MS.Sorafenib-Related Hand-Foot Skin Reaction Improves, Not Worsens, with Continued Treatment.Clin Cancer Res. 2009 Dec 15;15(24):7749.
    20008857
  • Flaherty KT, Smalley KS.Preclinical and clinical development of targeted therapy in melanoma: attention to schedule.Pigment Cell Melanoma Res. 2009 Oct;22(5):529-31.
    19619259
  • Agarwala SS, Becker JC, Eggermont AM, Flaherty KT, Garbe C, Goldstein AM, Halpern A, Kashani-Sabet M, Hauschild A, Kirkwood JM, Leachman S, Lorigan P, McMahon M, Messina J, Ribas A, Samlowski WE, Schadendorf D, Sondak VK.Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.Pigment Cell Melanoma Res. 2009 Oct;22(5):532-43.
    19659612
  • Smalley KS, Flaherty KT.Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment.Future Oncol. 2009 Aug;5(6):775-8.
    19663727
  • Carpenter EL, Mick R, Rech AJ, Beatty GL, Colligon TA, Rosenfeld MR, Kaplan DE, Chang KM, Domchek SM, Kanetsky PA, Fecher LA, Flaherty KT, Schuchter LM, Vonderheide RH.Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers.Clin Cancer Res. 2009 Jul 1;15(13):4277-87.
    19549767
  • Smalley KS, Nathanson KL, Flaherty KT.Genetic subgrouping of melanoma reveals new opportunities for targeted therapy.Cancer Res. 2009 Apr 15;69(8):3241-4. Review.
    19351826
  • Jilaveanu L,Zito C,Lee SJ,Nathanson KL,Camp RL,Rimm DL,Flaherty KT,Kluger HM.Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib.Clin Cancer Res. 2009 Feb 1;15(3):1076-85.
    19188183
  • Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL.HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.Cancer Cell. 2008 Dec 9;14(6):435-46.
    19061835
  • Smalley KS, Lioni M, Dalla Palma M, Xiao M, Desai B, Egyhazi S, Hansson J, Wu H, King AJ, Van Belle P, Elder DE, Flaherty KT, Herlyn M, Nathanson KL.Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.Mol Cancer Ther. 2008 Sep;7(9):2876-83.
    18790768
  • Flaherty KT, Schiller J, Schuchter LM, Liu G, Tuveson DA, Redlinger M, Lathia C, Xia C, Petrenciuc O, Hingorani SR, Jacobetz MA, Van Belle PA, Elder D, Brose MS, Weber BL, Albertini MR, O'Dwyer PJ.A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel.Clin Cancer Res. 2008 Aug 1;14(15):4836-42.
    18676756
  • Smalley KS, Contractor R, Nguyen TK, Xiao M, Edwards R, Muthusamy V, King AJ, Flaherty KT, Bosenberg M, Herlyn M, Nathanson KL.Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.Cancer Res. 2008 Jul 15;68(14):5743-52.
    18632627
  • Flaherty KT, Rosen MA, Heitjan DF, Gallagher ML, Schwartz B, Schnall MD, O'Dwyer PJ.Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma.Cancer Biol Ther. 2008 Apr;7(4):496-501.
    18219225
  • Vonderheide RH, Flaherty KT, Khalil M, Stumacher MS, Bajor DL, Hutnick NA, Sullivan P, Mahany JJ, Gallagher M, Kramer A, Green SJ, O'Dwyer PJ, Running KL, Huhn RD, Antonia SJ.Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.J Clin Oncol. 2007 Mar 1;25(7):876-83.
    17327609
  • Jiang W, Mikochik PJ, Ra JH, Lei H, Flaherty KT, Winkler JD, Spitz FR.HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest.Cancer Res. 2007 Feb 1;67(3):1221-7.
    17283158
  • Smalley KS, Contractor R, Haass NK, Kulp AN, Atilla-Gokcumen GE, Williams DS, Bregman H, Flaherty KT, Soengas MS, Meggers E, Herlyn M.An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.Cancer Res. 2007 Jan 1;67(1):209-17.
    17210701
  • McCarthy MM, DiVito KA, Sznol M, Kovacs D, Halaban R, Berger AJ, Flaherty KT, Camp RL, Lazova R, Rimm DL, Kluger HM.Expression of tumor necrosis factor--related apoptosis-inducing ligand receptors 1 and 2 in melanoma.Clin Cancer Res. 2006 Jun 15;12(12):3856-63.
    16778114
  • Ratain MJ, Eisen T, Stadler WM, Flaherty KT, Kaye SB, Rosner GL, Gore M, Desai AA, Patnaik A, Xiong HQ, Rowinsky E, Abbruzzese JL, Xia C, Simantov R, Schwartz B, O'Dwyer PJ.Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma.J Clin Oncol. 2006 Jun 1;24(16):2505-12.
    16636341
  • Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M.Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.Mol Cancer Ther. 2006 May;5(5):1136-44.
    16731745
  • Veronese ML, Mosenkis A, Flaherty KT, Gallagher M, Stevenson JP, Townsend RR, O'Dwyer PJ.Mechanisms of hypertension associated with BAY 43-9006.J Clin Oncol. 2006 Mar 20;24(9):1363-9.
    16446323