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Keith T. Flaherty, MD

Publications

  • Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, Flaherty KT, Wargo JA, Tamayo P, Garraway LA.A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.Cancer Discovery. 2014 Jul(7):816-27.
    24771846
  • Hodi FS, Lawrence D, Lezcano C, Wu X, Zhou J, Sasada T, Zeng W, Giobbie-Hurder A, Atkins MB, Ibrahim N, Friedlander P, Flaherty KT, Murphy GF, Rodig S, Velazquez EF, Mihm MC, Russell S, DiPiro PJ, Yap JT, Ramaiya N, Van den Abbeele AD, Gargano M, McDermott D.Bevacizumab plus ipilimumab in patients with metastatic melanoma.Cancer Immunol Res. 2014 Jul(7):632-42.
    24838938
  • Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA.Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.Cancer Immunol Res. 2014 Jul(7):643-54.
    24903021
  • Ackerman A, Klein O, McDermott DF, Wang W, Ibrahim N, Lawrence DP, Gunturi A, Flaherty KT, Hodi FS, Kefford R, Menzies AM, Atkins MB, Long GV, Sullivan RJ.Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors.Cancer. 2014 Jun 1(11):1695-701.
    24577748
  • Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, Ramaswamy S, Toner M, Fisher DE, Maheswaran S, Haber DA.Isolation and molecular characterization of circulating melanoma cells.Cell Rep. 2014 May 8(3):645-53.
    24746818
  • Shtivelman E, Davies MQ, Hwu P, Yang J, Lotem M, Oren M, Flaherty KT, Fisher DE.Pathways and therapeutic targets in melanoma.Oncotarget. 2014 Apr 8.
    24743024
  • Miller DM, Flaherty KT, Tsao H.Commentary: Molecular testing in melanoma.J Am Acad Dermatol. 2014 May;70(5):863-70.
    24534656
  • Sabbatino F, Wang Y, Wang X, Flaherty KT, Yu L, Pepin D, Scognamiglio G, Pepe S, Kirkwood JM, Cooper ZA, Frederick DT, Wargo JA, Ferrone S, Ferrone CR.PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.Oncotarget. 2014 Mar 31.
    24732172
  • Miller DM, Flaherty KT.Cyclin-dependent kinases as therapeutic targets in melanoma.Pigment Cell Melanoma Res. 2014 May;27(3):351-65.
    24405945
  • Wilson MA, Zhao F, Letrero R, D'Andrea K, Rimm DL, Kirkwood JM, Kluger HM, Lee SJ, Schuchter LM, Flaherty KT, Nathanson KL.Correlation of somatic mutations and clinical outcome in melanoma patients treated with carboplatin, paclitaxel, and sorafenib.Clin Cancer Res. 2014 Apr 8.
    24714776
  • Park JJ, Hawryluk EB, Tahan SR, Flaherty K, Kim CC.Cutaneous granulomatous eruption and successful response to potent topical steroids in patients undergoing targeted BRAF inhibitor treatment for metastatic melanoma.JAMA Dermatol. 2014 Mar;150(3):307-11.
    24352115
  • Padmanabhan RK, Somasundar VH, Griffith SD, Zhu J, Samoyedny D, Tan KS, Hu J, Liao X, Carin L, Yoon SS, Flaherty KT, Dipaola RS, Heitjan DF, Lal P, Feldman MD, Roysam B, Lee WM.An active learning approach for rapid characterization of endothelial cells in human tumors.PLoS ONE. 2014;9(3):e90495.
    24603893
  • Flaherty KT, Hennig M, Lee SJ, Ascierto PA, Dummer R, Eggermont AM, Hauschild A, Kefford R, Kirkwood JM, Long GV, Lorigan P, Mackensen A, McArthur G, O'Day S, Patel PM, Robert C, Schadendorf D.Surrogate endpoints for overall survival in metastatic melanoma: a meta-analysis of randomised controlled trials.Lancet Oncol. 2014 Mar;15(3):297-304.
    24485879
  • McArthur GA, Chapman PB, Robert C, Larkin J, Haanen JB, Dummer R, Ribas A, Hogg D, Hamid O, Ascierto PA, Garbe C, Testori A, Maio M, Lorigan P, Lebbé C, Jouary T, Schadendorf D, O'Day SJ, Kirkwood JM, Eggermont AM, Dréno B, Sosman JA, Flaherty KT, Yin M, Caro I, Cheng S, Trunzer K, Hauschild A.Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.Lancet Oncol. 2014 Mar;15(3):323-32.
    24508103
  • Balch CM, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC, Morton DL, Atkins MB, Flaherty KT, Sondak VK.Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.Ann Surg Oncol. 2014 Apr;21(4):1075-81.
    24531700
  • Flaherty L, Hamid O, Linette G, Schuchter L, Hallmeyer S, Gonzalez R, Cowey CL, Pavlick A, Kudrik F, Curti B, Lawson D, Chapman PB, Margolin K, Ribas A, McDermott D, Flaherty K, Cranmer L, Hodi FS, Day BM, Linke R, Hainsworth J.A single-arm, open-label, expanded access study of vemurafenib in patients with metastatic melanoma in the United States.Cancer J.;20(1):18-24.
    24445759
  • Wagle N, Van Allen EM, Treacy DJ, Frederick DT, Cooper ZA, Taylor-Weiner A, Rosenberg M, Goetz EM, Sullivan RJ, Farlow DN, Friedrich DC, Anderka K, Perrin D, Johannessen CM, McKenna A, Cibulskis K, Kryukov G, Hodis E, Lawrence DP, Fisher S, Getz G, Gabriel SB, Carter SL, Flaherty KT, Wargo JA, Garraway LA.MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.Cancer Discovery. 2014 Jan;4(1):61-8.
    24265154
  • Ciunci CA, Perini RF, Avadhani AN, Kang HC, Sun W, Redlinger M, Harlacker K, Flaherty KT, Giantonio BJ, Rosen MA, Divgi CR, Song HK, Englander S, Troxel A, Schnall M, O'Dwyer PJ.Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer.Cancer. 2014 Jan 1;120(1):77-85.
    24108668
  • O'Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, Indig FE, Flaherty KT, Wargo JA, Frederick DT, Cooper ZA, Nair S, Amaravadi RK, Schuchter LM, Karakousis GC, Xu W, Xu X, Weeraratna AT.Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.Cancer Discovery. 2013 Dec;3(12):1378-93.
    24104062
  • Johannessen CM, Johnson LA, Piccioni F, Townes A, Frederick DT, Donahue MK, Narayan R, Flaherty KT, Wargo JA, Root DE, Garraway LA.A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.Nature. 2013 Dec 5;504(7478):138-42.
    24185007
  • Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT, Wargo JA.BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes.Oncoimmunology. 2013 Oct 1;2(10):e26615.
    24251082
  • Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Coit DG, Atkins MB, Ding S, Cochran AJ, Eggermont AM, Flaherty KT, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, McMasters KM, Mihm MC, Morton DL, Ross MI, Sondak VK.Age as a prognostic factor in patients with localized melanoma and regional metastases.Ann Surg Oncol. 2013 Nov;20(12):3961-8.
    23838920
  • Luke JJ, Callahan MK, Postow MA, Romano E, Ramaiya N, Bluth M, Giobbie-Hurder A, Lawrence DP, Ibrahim N, Ott PA, Flaherty KT, Sullivan RJ, Harding JJ, D'Angelo S, Dickson M, Schwartz GK, Chapman PB, Wolchok JD, Hodi FS, Carvajal RD.Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.Cancer. 2013 Oct 15;119(20):3687-95.
    23913718
  • Sullivan RJ, Lorusso PM, Flaherty KT.The intersection of immune-directed and molecularly targeted therapy in advanced melanoma: where we have been, are, and will be.Clin Cancer Res. 2013 Oct 1;19(19):5283-91.
    24089441
  • Fridlyand J, Simon RM, Walrath JC, Roach N, Buller R, Schenkein DP, Flaherty KT, Allen JD, Sigal EV, Scher HI.Considerations for the successful co-development of targeted cancer therapies and companion diagnostics.Nat Rev Drug Discov. 2013 Oct;12(10):743-55.
    24008432
  • Hodi FS, Corless CL, Giobbie-Hurder A, Fletcher JA, Zhu M, Marino-Enriquez A, Friedlander P, Gonzalez R, Weber JS, Gajewski TF, O'Day SJ, Kim KB, Lawrence D, Flaherty KT, Luke JJ, Collichio FA, Ernstoff MS, Heinrich MC, Beadling C, Zukotynski KA, Yap JT, Van den Abbeele AD, Demetri GD, Fisher DE.Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.J Clin Oncol. 2013 Sep 10;31(26):3182-90.
    23775962
  • Ji Z, Kumar R, Taylor M, Rajadurai A, Marzuka-Alcalá A, Chen YE, Njauw CN, Flaherty K, Jönsson G, Tsao H.Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.Clin Cancer Res. 2013 Aug 15;19(16):4383-91.
    23812671
  • Jilaveanu LB, Zhao F, Zito CR, Kirkwood JM, Nathanson KL, D'Andrea K, Wilson M, Rimm DL, Flaherty KT, Lee SJ, Kluger HM.Expression of drug targets in patients treated with sorafenib, Carboplatin and Paclitaxel.PLoS ONE. 2013;8(8):e69748.
    23936348
  • Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Piris A, Nazarian RM, Brown RD, Godfrey JT, Winokur D, Walsh J, Mino-Kenudson M, Maheswaran S, Settleman J, Wargo JA, Flaherty KT, Haber DA, Engelman JA.TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma.Sci Transl Med. 2013 Jul 31;5(196):196ra98.
    23903755
  • Postow MA, Luke JJ, Bluth MJ, Ramaiya N, Panageas KS, Lawrence DP, Ibrahim N, Flaherty KT, Sullivan RJ, Ott PA, Callahan MK, Harding JJ, D'Angelo SP, Dickson MA, Schwartz GK, Chapman PB, Gnjatic S, Wolchok JD, Hodi FS, Carvajal RD.Ipilimumab for patients with advanced mucosal melanoma.Oncologist. 2013 Jun;18(6):726-32.
    23716015
  • Salas Fragomeni RA, Chung HW, Landesman Y, Senapedis W, Saint-Martin JR, Tsao H, Flaherty KT, Shacham S, Kauffman M, Cusack JC.CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF mutant melanoma.Mol Cancer Ther. 2013 Apr 24.
    23615632
  • Trunzer K, Pavlick AC, Schuchter L, Gonzalez R, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Kim KB, Weber JS, Hersey P, Long GV, Lawrence D, Ott PA, Amaravadi RK, Lewis KD, Puzanov I, Lo RS, Koehler A, Kockx M, Spleiss O, Schell-Steven A, Gilbert HN, Cockey L, Bollag G, Lee RJ, Joe AK, Sosman JA, Ribas A.Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma.J Clin Oncol. 2013 Apr 8.
    23569304
  • Sullivan RJ, Flaherty KT.Resistance to BRAF-targeted therapy in melanoma.Eur J Cancer. 2013 Apr;49(6):1297-304.
    23290787
  • Desai BM, Villanueva J, Nguyen TT, Lioni M, Xiao M, Kong J, Krepler C, Vultur A, Flaherty KT, Nathanson KL, Smalley KS, Herlyn M.The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling.PLoS ONE. 2013;8(3):e59588.
    23527225
  • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA.BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.Clin Cancer Res. 2013 Mar 1;19(5):1225-31.
    23307859
  • Flaherty KT, Lee SJ, Zhao F, Schuchter LM, Flaherty L, Kefford R, Atkins MB, Leming P, Kirkwood JM.Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma.J Clin Oncol. 2013 Jan 20;31(3):373-9.
    23248256
  • Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, Scialabba VL, Batten JM, Borger DR, Iafrate AJ, Heist RS, Lawrence DP, Flaherty KT, Bendell JC, Deschler D, Li Y, Wirth LJ, Dias-Santagata D.Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.Clin Cancer Res. 2013 Jan 15;19(2):480-90.
    23186780
  • Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, Chen JQ, Li HS, Watowich SS, Yang Y, Tompers Frederick D, Cooper ZA, Mbofung RM, Whittington M, Flaherty KT, Woodman SE, Davies MA, Radvanyi LG, Overwijk WW, Lizée G, Hwu P.BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.Clin Cancer Res. 2013 Jan 15;19(2):393-403.
    23204132
  • Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, Rini BI, Srinivas S, Stein MN, Adams LM, Ottesen LH, Laubscher KH, Sherman L, McDermott DF, Haas NB, Flaherty KT, Ross R, Eisenberg P, Meltzer PS, Merino MJ, Bottaro DP, Linehan WM, Srinivasan R.Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma.J Clin Oncol. 2013 Jan 10;31(2):181-6.
    23213094
  • Kang HC, Tan KS, Keefe SM, Heitjan DF, Siegelman ES, Flaherty KT, O'Dwyer PJ, Rosen MA.MRI assessment of early tumor response in metastatic renal cell carcinoma patients treated with sorafenib.AJR Am J Roentgenol. 2013 Jan;200(1):120-6.
    23255750
  • Cho DC, Hutson TE, Samlowski W, Sportelli P, Somer B, Richards P, Sosman JA, Puzanov I, Michaelson MD, Flaherty KT, Figlin RA, Vogelzang NJ.Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal cell carcinoma after progression on vascular endothelial growth factor-targeted therapy.Cancer. 2012 Dec 15;118(24):6055-62.
    22674198
  • Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messaien L, Bronson RT, McMahon M, Granter S, Flaherty KT, Wargo JA, Marais R, Cichowski K.Elucidating distinct roles for NF1 in melanomagenesis.Cancer Discovery. 2012 Nov 21.
    23171796
  • Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J.Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.N Engl J Med. 2012 Nov;367(18):1694-703.
    23020132
  • Flaherty KT.Dividing and conquering: controlling advanced melanoma by targeting oncogene-defined subsets.Clin Exp Metastasis. 2012 Oct;29(7):841-6.
    22661223
  • Flaherty KT.Throwing the kitchen sink at melanoma drug development.Pigment Cell Melanoma Res. 2012 Sep;25(5):543-4.
    22812391
  • Belden S, Flaherty KT.MEK and RAF inhibitors for BRAF-mutated cancers.Expert Rev Mol Med. 2012;14:e17.
    23058743
  • Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L.Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.Nat Med. 2012 Oct;18(10):1503-10.
    22983396
  • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, Davis A, Mongare MM, Gould J, Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A, Lo RS, Flaherty KT, Ogino S, Wargo JA, Golub TR.Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.Nature. 2012 Jul 26;487(7408):500-4.
    22763439
  • Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, Milhem M, Demidov LV, Hassel JC, Rutkowski P, Mohr P, Dummer R, Trefzer U, Larkin JM, Utikal J, Dreno B, Nyakas M, Middleton MR, Becker JC, Casey M, Sherman LJ, Wu FS, Ouellet D, Martin AM, Patel K, Schadendorf D, .Improved survival with MEK inhibition in BRAF-mutated melanoma.N Engl J Med. 2012 Jul 12;367(2):107-14.
    22663011
  • Ascierto PA, Grimaldi AM, Curti B, Faries MB, Ferrone S, Flaherty K, Fox BA, Gajewski TF, Gershenwald JE, Gogas H, Grossmann K, Hauschild A, Hodi FS, Kefford R, Kirkwood JM, Leachmann S, Maio M, Marais R, Palmieri G, Morton DL, Ribas A, Stroncek DF, Stewart R, Wang E, Mozzillo N, Marincola FM.Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".J Transl Med. 2012;10:83.
    22551296
  • Kong Y, Si L, Zhu Y, Xu X, Corless CL, Flaherty KT, Li L, Li H, Sheng X, Cui C, Chi Z, Li S, Han M, Mao L, Lu A, Guo J.Large-Scale Analysis of KIT Aberrations in Chinese Patients with Melanoma.Clin Cancer Res. 2011 Apr 1;17(7):1684-91.
    21325067
  • Flaherty KT.Is It Good or Bad to Find a BRAF Mutation?.J Clin Oncol. 2011 Apr 1;29(10):1229-30.
    21343552
  • Puzanov I, Burnett P, Flaherty KT.Biological challenges of BRAF inhibitor therapy.Mol Oncol. 2011 Feb 16.
    21393075
  • Flaherty KT, Lathia C, Frye RF, Schuchter L, Redlinger M, Rosen M, O'Dwyer PJ.Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.Cancer Chemother Pharmacol. 2011 Feb 25.
    21350850
  • Flaherty KT.Taking stock of translational research in melanoma at the 2010 Society for Melanoma Research Congress.Pigment Cell Melanoma Res. 2011 Feb;24(1):107-9.
    21232025
  • Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.Nature. 2010 Dec 16;468(7326):968-72.
    21107320
  • Puzanov I, Flaherty KT.Targeted molecular therapy in melanoma.Seminars In Cutaneous Medicine And Surgery. 2010 Sep;29(3):196-201.
    21051014
  • Flaherty KT.Narrative review: BRAF opens the door for therapeutic advances in melanoma.Ann Intern Med. 2010 Nov 2;153(9):587-91. Review.
    21041578
  • Flaherty KT, McArthur G.BRAF, a target in melanoma: implications for solid tumor drug development.Cancer. 2010 Nov 1;116(21):4902-13.
    20629085
  • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K.Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.Nature. 2010 Sep 30;467(7315):596-9.
    20823850
  • Agarwala SS, di Pietro A, Flaherty KT, Garbe C, Grob JJ, Kashani-Sabet M, Kirkwood JM, Leachman S, Messina J, O'Day S, Ribas A, Sondak V.Meeting report from the Third Global Workshop on Melanoma.Pigment Cell Melanoma Res. 2010 Oct;23(5):e1-7.
    20718940
  • Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB.Inhibition of mutated, activated BRAF in metastatic melanoma.N Engl J Med. 2010 Aug 26;363(9):809-19.
    20818844
  • Flaherty KT, Puzanov I.Building on a foundation of VEGF and mTOR targeted agents in renal cell carcinoma.Biochem Pharmacol. 2010 Sep 1;80(5):638-46. Review.
    20382128
  • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA.Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.Cancer Res. 2010 Jul 1;70(13):5213-9.
    20551059
  • Flaherty KT, Hodi FS, Bastian BC.Mutation-driven drug development in melanoma.Curr Opin Oncol. 2010 May;22(3):178-83. Review.
    20401974
  • Ji Z, Flaherty KT, Tsao H.Molecular therapeutic approaches to melanoma.Mol Aspects Med. 2010 Apr;31(2):194-204. Review.
    20176049
  • Traynor AM, Hewitt M, Liu G, Flaherty KT, Clark J, Freedman SJ, Scott BB, Leighton AM, Watson PA, Zhao B, O'Dwyer PJ, Wilding G.Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors.Cancer Chemother Pharmacol. 2010 Apr 13.
    20386909
  • Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM.Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care.Lancet Oncol. 2010 Apr;11(4):373-82. Review.
    20171141
  • Mehnert JM, McCarthy MM, Jilaveanu L, Flaherty KT, Aziz S, Camp RL, Rimm DL, Kluger HM.Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays.Hum Pathol. 2010 Mar;41(3):375-84.
    20004943
  • Pacey S, Ratain MJ, Flaherty KT, Kaye SB, Cupit L, Rowinsky EK, Xia C, O'Dwyer PJ, Judson IR.Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial.Invest New Drugs. 2009 Dec 18.
    20016927
  • Flaherty KT.Where does the combination of sorafenib and interferon in renal cell carcinoma stand?.Cancer. 2010 Jan 1;116(1):4-7.
    19890962
  • Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC, Morton DL, Ross MI, Sober AJ, Sondak VK.Final version of 2009 AJCC melanoma staging and classification.J Clin Oncol. 2009 Dec 20;27(36):6199-206.
    19917835
  • Flaherty KT, Brose MS.Sorafenib-Related Hand-Foot Skin Reaction Improves, Not Worsens, with Continued Treatment.Clin Cancer Res. 2009 Dec 15;15(24):7749.
    20008857
  • Amaravadi RK, Schuchter LM, McDermott DF, Kramer A, Giles L, Gramlich K, Carberry M, Troxel AB, Letrero R, Nathanson KL, Atkins MB, O'Dwyer PJ, Flaherty KT.Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases.Clin Cancer Res. 2009 Dec 15;15(24):7711-7718.
    19996224
  • Flaherty KT, Smalley KS.Preclinical and clinical development of targeted therapy in melanoma: attention to schedule.Pigment Cell Melanoma Res. 2009 Oct;22(5):529-31.
    19619259
  • Agarwala SS, Becker JC, Eggermont AM, Flaherty KT, Garbe C, Goldstein AM, Halpern A, Kashani-Sabet M, Hauschild A, Kirkwood JM, Leachman S, Lorigan P, McMahon M, Messina J, Ribas A, Samlowski WE, Schadendorf D, Sondak VK.Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.Pigment Cell Melanoma Res. 2009 Oct;22(5):532-43.
    19659612
  • Smalley KS, Flaherty KT.Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment.Future Oncol. 2009 Aug;5(6):775-8.
    19663727
  • Carpenter EL, Mick R, Rech AJ, Beatty GL, Colligon TA, Rosenfeld MR, Kaplan DE, Chang KM, Domchek SM, Kanetsky PA, Fecher LA, Flaherty KT, Schuchter LM, Vonderheide RH.Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers.Clin Cancer Res. 2009 Jul 1;15(13):4277-87.
    19549767
  • Smalley KS, Nathanson KL, Flaherty KT.Genetic subgrouping of melanoma reveals new opportunities for targeted therapy.Cancer Res. 2009 Apr 15;69(8):3241-4. Review.
    19351826
  • Jilaveanu L,Zito C,Lee SJ,Nathanson KL,Camp RL,Rimm DL,Flaherty KT,Kluger HM.Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib.Clin Cancer Res. 2009 Feb 1;15(3):1076-85.
    19188183
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