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E. T. Hedley-Whyte, MBBS, MD


  • Stein TD, Chae YS, Won N, Lee JH, Hedley-Whyte ET.A 34-year-old man with bitemporal hemianopsia.Brain Pathol. 2014 Jan;24(1):107-10.
  • Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB.Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination.N Engl J Med. 2013 May 8.
  • Aizer AA, Sethi RV, Hedley-Whyte ET, Ebb D, Tarbell NJ, Yock TI, Macdonald SM.Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications.Neuro Oncology. 2013 May 7.
  • Tritos NA, Eppakayala S, Swearingen B, Hedley-Whyte ET, Miller KK, Nachtigall LB, Grinspoon SK, Biller BM, Klibanski A.Pathologic and clinical features of pituitary adenomas showing TSH immunoreactivity.Pituitary. 2012 Aug 7.
  • Venna N, Coyle CM, González RG, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 15-2012. A 48-year-old woman with diplopia, headaches, and papilledema.N Engl J Med. 2012 May 17;366(20):1924-34.
  • David WS, Chad DA, Kambadakone A, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 7-2012. A 79-year-old man with pain and weakness in the legs.N Engl J Med. 2012 Mar 8;366(10):944-54.
  • Katavetin P, Cheunsuchon P, Grant E, Boepple PA, Hedley-Whyte ET, Misra M, Levitsky LL.Rathke's cleft cysts in children and adolescents: association with female puberty.J. Pediatr. Endocrinol. Metab. 2010 Nov;23(11):1175-80.
  • di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK.Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.Cancer Res. 2011 Jan 1;71(1):19-28.
  • McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE.TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.J Neuropathol Exp Neurol. 2010 Sep;69(9):918-29.
  • Katavetin P, Cheunsuchon P, Swearingen B, Hedley-Whyte ET, Misra M, Levitsky LL.Review: Pituitary adenomas in children and adolescents.J. Pediatr. Endocrinol. Metab. 2010 May;23(5):427-31.
  • Deng HX, Klein CJ, Yan J, Shi Y, Wu Y, Fecto F, Yau HJ, Yang Y, Zhai H, Siddique N, Hedley-Whyte ET, Delong R, Martina M, Dyck PJ, Siddique T.Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4.Nat Genet. 2010 Feb;42(2):165-9.
  • Singhal AB, Kimberly WT, Schaefer PW, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 8-2009. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum.N Engl J Med. 2009 Mar 12;360(11):1126-37.
  • Hedley-Whyte ET, Goldman JE, Nedergaard M, Friedman A, Han X, Schmidt RE, Powers JM.Hyaline protoplasmic astrocytopathy of neocortex.J Neuropathol Exp Neurol. 2009 Feb;68(2):136-47.
  • Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD.Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations.Brain Pathol. 2009 Jan;19(1):39-47.
  • Freeman SH,Kandel R,Cruz L,Rozkalne A,Newell K,Frosch MP,Hedley-Whyte ET,Locascio JJ,Lipsitz LA,Hyman BT.Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.J Neuropathol Exp Neurol. 2008 Dec;67(12):1205-12.
  • Gejman R, Batista DL, Zhong Y, Zhou Y, Zhang X, Swearingen B, Stratakis CA, Hedley-Whyte ET, Klibanski A.Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas.J Clin Endocrinol Metab. 2008 Oct;93(10):4119-25.
  • Staley KJ,Sims KB,Grant PE,Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia.N Engl J Med. 2008 Sep 11;359(11):1156-67.
  • Hedley-Whyte ET.On being a pathologist: how does one plan a career, or does one?.Hum Pathol. 2008 Sep;39(9):1269-74.
  • Seton M, Pless M, Fishman JA, Caruso PA, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 18-2008. A 68-year-old man with headache and visual changes after liver transplantation.N Engl J Med. 2008 Jun 12;358(24):2619-28.
  • Gejman R, Swearingen B, Hedley-Whyte ET.Role of Ki-67 proliferation index and p53 expression in predicting progression of pituitary adenomas.Hum Pathol. 2008 May;39(5):758-66.
  • Greer DM, Cagliero E, Krakauer EL, Gonzalez RG, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 21-2007. A 58-year-old woman with headaches, weakness, and strokelike episodes.N Engl J Med. 2007 Jul 12;357(2):164-73.
  • Vallat JM, Cros DP, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 9-2007. A 27-year-old woman with pain and swelling of the legs.N Engl J Med. 2007 Mar 22;356(12):1252-9.
  • Cha JH, Furie K, Kay J, Walensky RP, Mullins ME, Hedley-Whyte ET.Case records of the Massachusetts General Hospital. Case 39-2006. A 24-year-old woman with systemic lupus erythematosus, seizures, and right arm weakness.N Engl J Med. 2006 Dec 21;355(25):2678-89.
  • Vucic S, Tian D, Chong PS, Cudkowicz ME, Hedley-Whyte ET, Cros D.Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology.Brain. 2006 Dec;129(Pt 12):3384-90.
  • Batista DL, Zhang X, Gejman R, Ansell PJ, Zhou Y, Johnson SA, Swearingen B, Hedley-Whyte ET, Stratakis CA, Klibanski A.The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas.J Clin Endocrinol Metab. 2006 Nov;91(11):4482-8.
  • Saenz A, Mandal R, Kradin R, Hedley-Whyte ET.Nephrogenic fibrosing dermopathy with involvement of the dura mater.Virchows Arch. 2006 Sep;449(3):389-91.
  • Chou RC, Henson JW, Tian D, Hedley-Whyte ET, Reginato AM.Successful treatment of rheumatoid meningitis with cyclophosphamide but not infliximab.Ann Rheum Dis. 2006 Aug;65(8):1114-6.
  • Wüthrich C, Kesari S, Kim WK, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ.Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells.J Neurovirol. 2006 Apr;12(2):116-28.
  • Gaviani P, Mullins ME, Braga TA, Hedley-Whyte ET, Halpern EF, Schaefer PS, Henson JW.Improved detection of metastatic melanoma by T2*-weighted imaging.AJNR Am J Neuroradiol. 2006 Mar;27(3):605-8.
  • Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch MP, Growdon JH, McLean PJ, Hyman BT.Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.Acta Neuropathol. 2006 Feb;111(2):101-8.
  • Dahiya S, Sarkar C, Hedley-Whyte ET, Sharma MC, Zervas NT, Sridhar E, Louis DN.Spindle cell oncocytoma of the adenohypophysis: report of two cases.Acta Neuropathol. 2005 Jul;110(1):97-9.
  • Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC.Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain.Neurology. 2004 Mar 23;62(6):925-31.
  • Gilles FH, Tavaré CJ, Leviton A, Hedley-Whyte ET, Sotrel A, Adelman L, Davis RL, Rorke LB,.Prognostic limitations of the Daumas-Duport grading scheme in infratentorial neuroglial tumors in children.Pediatr Dev Pathol. 2004 Mar-Apr;7(2):138-47.
  • Gilles FH, Leviton A, Tavaré CJ, Adelman L, Rorke LB, Sobel EL, Hedley-Whyte ET, Davis RL.Clinical and survival covariates of eight classes of childhood supratentorial neuroglial tumors.Cancer. 2002 Sep 15;95(6):1302-10.
  • Shibata N, Hirano A, Hedley-Whyte ET, Dal Canto MC, Nagai R, Uchida K, Horiuchi S, Kawaguchi M, Yamamoto T, Kobayashi M.Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.Acta Neuropathol. 2002 Aug;104(2):171-8.
  • Fitzek MM, Thornton AF, Harsh G, Rabinov JD, Munzenrider JE, Lev M, Ancukiewicz M, Bussiere M, Hedley-Whyte ET, Hochberg FH, Pardo FS.Dose-escalation with proton/photon irradiation for Daumas-Duport lower-grade glioma: results of an institutional phase I/II trial.Int J Radiat Oncol Biol Phys. 2001 Sep 1;51(1):131-7.
  • Hug EB, Devries A, Thornton AF, Munzenride JE, Pardo FS, Hedley-Whyte ET, Bussiere MR, Ojemann R.Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy.J Neurooncol. 2000 Jun;48(2):151-60.
  • Danila DC, Zhang X, Zhou Y, Dickersin GR, Fletcher JA, Hedley-Whyte ET, Selig MK, Johnson SR, Klibanski A.A human pituitary tumor-derived folliculostellate cell line.J Clin Endocrinol Metab. 2000 Mar;85(3):1180-7.
  • Danila DC, Inder WJ, Zhang X, Alexander JM, Swearingen B, Hedley-Whyte ET, Klibanski A.Activin effects on neoplastic proliferation of human pituitary tumors.J Clin Endocrinol Metab. 2000 Mar;85(3):1009-15.
  • Gilles FH, Leviton A, Tavaré CJ, Adelman L, Rorke LB, Sobel EL, Hedley-Whyte ET, Davis RL.Definitive classes of childhood supratentorial neuroglial tumors. The Childhood Brain Tumor Consortium.Pediatr Dev Pathol. 2000 Mar-Apr;3(2):126-39.
  • Fitzek MM, Thornton AF, Rabinov JD, Lev MH, Pardo FS, Munzenrider JE, Okunieff P, Bussière M, Braun I, Hochberg FH, Hedley-Whyte ET, Liebsch NJ, Harsh GR.Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial.J Neurosurg. 1999 Aug;91(2):251-60.
  • Shafqat S, Hedley-Whyte ET, Henson JW.Age-dependent rate of anaplastic transformation in low-grade astrocytoma.Neurology. 1999 Mar 10;52(4):867-9.
  • Brown WD, Gilles FH, Tavaré CJ, Rorke LB, Davis RL, Adelman L, Hedley-Whyte ET, Leviton A.Prognostic limitations of the Daumas-Duport grading scheme in childhood supratentorial astroglial tumors.J Neuropathol Exp Neurol. 1998 Nov;57(11):1035-40.
  • Maxwell M, Allegra C, MacGillivray J, Hsu DW, Hedley-Whyte ET, Riskind P, Madsen JR, Black PM.Functional transplantation of the rat pituitary gland.Neurosurgery. 1998 Nov;43(5):1157-63.
  • Maxwell M, Shih SD, Galanopoulos T, Hedley-Whyte ET, Cosgrove GR.Familial meningioma: analysis of expression of neurofibromatosis 2 protein Merlin. Report of two cases.J Neurosurg. 1998 Mar;88(3):562-9.
  • Chae YS, Flotte T, Hsu DW, Preffer F, Hedley-Whyte ET.Flow cytometric DNA ploidy and cells phase fractions in recurrent human pituitary adenomas. A correlative study of flow cytometric analysis and the expression of proliferating cell nuclear antigen.Gen Diagn Pathol. 1996 Oct;142(2):89-95.
  • Gilles FH, Sobel EL, Tavaré CJ, Leviton A, Hedley-Whyte ET.Age-related changes in diagnoses, histological features, and survival in children with brain tumors: 1930-1979. The Childhood Brain Tumor Consortium.Neurosurgery. 1995 Dec;37(6):1056-68.
  • Hsu DW, Efird JT, Hedley-Whyte ET.Prognostic role of urokinase-type plasminogen activator in human gliomas.Am J Pathol. 1995 Jul;147(1):114-23.
  • Gilles FH, Leviton A, Hedley-Whyte ET, Sobel E, Tavaré CJ, Sobel RS, Rorke LB.Childhood brain tumors that occupy more than one compartment at presentation. Multiple compartment tumors.J Neurooncol. 1992 Sep;14(1):45-56.
  • Gilles FH, Sobel E, Leviton A, Hedley-Whyte ET, Tavare CJ, Adelman LS, Sobel RA.Epidemiology of seizures in children with brain tumors. The Childhood Brain Tumor Consortium.J Neurooncol. 1992 Jan;12(1):53-68.
  • Chung R, Whaley J, Kley N, Anderson K, Louis D, Menon A, Hettlich C, Freiman R, Hedley-Whyte ET, Martuza R.TP53 gene mutations and 17p deletions in human astrocytomas.Genes Chromosomes Cancer. 1991 Sep;3(5):323-31.
  • de la Monte SM, Gabuzda DH, Ho DD, Brown RH, Hedley-Whyte ET, Schooley RT, Hirsch MS, Bhan AK.Peripheral neuropathy in the acquired immunodeficiency syndrome.Ann Neurol. 1988 May;23(5):485-92.