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Catherine T. Yan


  • Chen Z, Yan CT, Dou Y, Viboolsittiseri SS, Wang JH.The role of a newly identified SET domain-containing protein, SETD3, inoncogenesis.Haematologica. 2012 Oct 12.
  • Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.J Immunol. 2011 Feb 15;186(4):2336-43.
  • Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT.Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3024-9.
  • Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9.
  • Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Nature. 2009 Dec 10;462(7274):803-7.
  • Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.Mechanisms promoting translocations in editing and switching peripheral B cells.Nature. 2009 Jul 9;460(7252):231-6.
  • Wang JH,Alt FW,Gostissa M,Datta A,Murphy M,Alimzhanov MB,Coakley KM,Rajewsky K,Manis JP,Yan CT.Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.J Exp Med. 2008 Dec 22;205(13):3079-90.
  • Xie A,Hartlerode A,Stucki M,Odate S,Puget N,Kwok A,Nagaraju G,Yan C,Alt FW,Chen J,Jackson SP,Scully R.Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.Mol Cell. 2007 Dec 28;28(6):1045-57.
  • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.IgH class switching and translocations use a robust non-classical end-joining pathway.Nature. 2007 Sep 27;449(7161):478-82.
  • Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW.Evolution of the immunoglobulin heavy chain class switch recombination mechanism.Adv Immunol. 2007;94:157-214. Review.
  • Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW.XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83.
  • Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.Mol Cell. 2006 Jan 20;21(2):201-14.
  • Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.EMBO J. 2003 Jul 15;22(14):3602-12.
  • Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8.