Alfred L. Goldberg, PhD

Publications

Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL.ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.Cell. 2011 Feb 18;144(4):526-38.
21335235
Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B.Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.J Biol Chem. 2010 Dec 17;285(51):39597-608.
20940294
Peth A, Uchiki T, Goldberg AL.ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation.Mol Cell. 2010 Nov 24;40(4):671-81.
21095592
Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC.Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.Hum Mol Genet. 2010 Dec 1;19(23):
20829225
Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, Lacey DL, Goldberg AL, Han HQ.Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.Cell. 2010 Aug 20;142(4):531-43.
20723755
Tai HC, Besche H, Goldberg AL, Schuman EM.Characterization of the Brain 26S Proteasome and its Interacting Proteins.Front Mol Neurosci. 2010;3.
20717473
Brault JJ, Jespersen JG, Goldberg AL.Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.J Biol Chem. 2010 Jun 18;285(25):19460
20404331
Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y.Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.EMBO J. 2010 Feb 3;29(3):692-702.
20019667
Lee do H, Goldberg AL.Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1056-61.
19995551
Peth A, Besche HC, Goldberg AL.Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.Mol Cell. 2009 Dec 11;36(5):794-804.
20005843
Besche HC, Peth A, Goldberg AL.Getting to first base in proteasome assembly.Cell. 2009 Jul 10;138(1):25-8. Review.
19596233
Kim HT, Kim KP, Uchiki T, Gygi SP, Goldberg AL.S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.EMBO J. 2009 Jul 8;28(13):1867-77.
19387488
Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL.During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.J Cell Biol. 2009 Jun 15;185(6):1083-95.
19506036
Medicherla B, Goldberg AL.Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.J Cell Biol. 2008 Aug 25;182(4):663-73.
18725537
Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL.Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.Mol Cell. 2007 Sep 7;27(5):731-44.
17803938
Rock KL, York IA, Goldberg AL.Post-proteasomal antigen processing for major histocompatibility complex class I presentation.Nat Immunol. 2004 Jul;5(7):670-7.
15224092
Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL.Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.Cell. 2004 Apr 30;117(3):399-412
15109499

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Alfred L. Goldberg, PhD Publications Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL.ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.Cell. 2011 Feb 18;144(4):526-38. 21335235 Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B.Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.J Biol Chem. 2010 Dec 17;285(51):39597-608. 20940294 Peth A, Uchiki T, Goldberg AL.ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation.Mol Cell. 2010 Nov 24;40(4):671-81. 21095592 Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC.Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.Hum Mol Genet. 2010 Dec 1;19(23): 20829225 Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, Lacey DL, Goldberg AL, Han HQ.Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.Cell. 2010 Aug 20;142(4):531-43. 20723755 Tai HC, Besche H, Goldberg AL, Schuman EM.Characterization of the Brain 26S Proteasome and its Interacting Proteins.Front Mol Neurosci. 2010;3. 20717473 Brault JJ, Jespersen JG, Goldberg AL.Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.J Biol Chem. 2010 Jun 18;285(25):19460 20404331 Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y.Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.EMBO J. 2010 Feb 3;29(3):692-702. 20019667 Lee do H, Goldberg AL.Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1056-61. 19995551 Peth A, Besche HC, Goldberg AL.Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.Mol Cell. 2009 Dec 11;36(5):794-804. 20005843 Besche HC, Peth A, Goldberg AL.Getting to first base in proteasome assembly.Cell. 2009 Jul 10;138(1):25-8. Review. 19596233 Kim HT, Kim KP, Uchiki T, Gygi SP, Goldberg AL.S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.EMBO J. 2009 Jul 8;28(13):1867-77. 19387488 Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL.During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.J Cell Biol. 2009 Jun 15;185(6):1083-95. 19506036 Medicherla B, Goldberg AL.Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.J Cell Biol. 2008 Aug 25;182(4):663-73. 18725537 Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL.Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.Mol Cell. 2007 Sep 7;27(5):731-44. 17803938 Rock KL, York IA, Goldberg AL.Post-proteasomal antigen processing for major histocompatibility complex class I presentation.Nat Immunol. 2004 Jul;5(7):670-7. 15224092 Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL.Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.Cell. 2004 Apr 30;117(3):399-412 15109499
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