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Alfred L. Goldberg, PhD


  • Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL.Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates.EMBO J. 2014 May 16;33(10):1159-76.
  • Cohen S, Lee D, Zhai B, Gygi SP, Goldberg AL.Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.J Cell Biol. 2014 Mar 3;204(5):747-58.
  • Piccirillo R, Demontis F, Perrimon N, Goldberg AL.Mechanisms of muscle growth and atrophy in mammals and Drosophila.Dev Dyn. 2014 Feb;243(2):201-15.
  • Demontis F, Piccirillo R, Goldberg AL, Perrimon N.The influence of skeletal muscle on systemic aging and lifespan.Aging Cell. 2013 Dec;12(6):943-9.
  • Lee D, Goldberg AL.SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.J Biol Chem. 2013 Oct 18;288(42):30515-26.
  • Peth A, Nathan JA, Goldberg AL.The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.J Biol Chem. 2013 Oct 4;288(40):29215-22.
  • Han HQ, Zhou X, Mitch WE, Goldberg AL.Myostatin/activin pathway antagonism: molecular basis and therapeutic potential.Int J Biochem Cell Biol. 2013 Oct;45(10):2333-47.
  • Goldberg AL.Development of proteasome inhibitors as research tools and cancer drugs.J Cell Biol. 2012 Nov 12;199(4):583-8.
  • Berko D, Tabachnick-Cherny S, Shental-Bechor D, Cascio P, Mioletti S, Levy Y, Admon A, Ziv T, Tirosh B, Goldberg AL, Navon A.The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini.Mol Cell. 2012 Oct 3.
  • Raju RM, Goldberg AL, Rubin EJ.Bacterial proteolytic complexes as therapeutic targets.Nat Rev Drug Discov. 2012 Oct;11(10):777-89.
  • Cohen S, Zhai B, Gygi SP, Goldberg AL.Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy.J Cell Biol. 2012 Aug 20;198(4):575-89.
  • Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC.Cancer vulnerabilities unveiled by genomic loss.Cell. 2012 Aug 17;150(4):842-54.
  • Piccirillo R, Goldberg AL.The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.EMBO J. 2012 Aug 1;31(15):3334-50.
  • Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL.ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.Cell. 2011 Feb 18;144(4):526-38.
  • Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B.Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.J Biol Chem. 2010 Dec 17;285(51):39597-608.
  • Peth A, Uchiki T, Goldberg AL.ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation.Mol Cell. 2010 Nov 24;40(4):671-81.
  • Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC.Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.Hum Mol Genet. 2010 Dec 1;19(23):4573-86.
  • Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, Lacey DL, Goldberg AL, Han HQ.Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.Cell. 2010 Aug 20;142(4):531-43.
  • Tai HC, Besche H, Goldberg AL, Schuman EM.Characterization of the Brain 26S Proteasome and its Interacting Proteins.Front Mol Neurosci. 2010;3.
  • Brault JJ, Jespersen JG, Goldberg AL.Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.J Biol Chem. 2010 Jun 18;285(25):19460-71.
  • Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y.Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.EMBO J. 2010 Feb 3;29(3):692-702.
  • Lee do H, Goldberg AL.Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1056-61.
  • Peth A, Besche HC, Goldberg AL.Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.Mol Cell. 2009 Dec 11;36(5):794-804.
  • Besche HC, Peth A, Goldberg AL.Getting to first base in proteasome assembly.Cell. 2009 Jul 10;138(1):25-8. Review.
  • Kim HT, Kim KP, Uchiki T, Gygi SP, Goldberg AL.S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.EMBO J. 2009 Jul 8;28(13):1867-77.
  • Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL.During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.J Cell Biol. 2009 Jun 15;185(6):1083-95.
  • Medicherla B, Goldberg AL.Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.J Cell Biol. 2008 Aug 25;182(4):663-73.
  • Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL.Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.Mol Cell. 2007 Sep 7;27(5):731-44.
  • Rock KL, York IA, Goldberg AL.Post-proteasomal antigen processing for major histocompatibility complex class I presentation.Nat Immunol. 2004 Jul;5(7):670-7.
  • Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL.Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.Cell. 2004 Apr 30;117(3):399-412.