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Huiyan Zeng, PhD


  • Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H.The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.Blood. 2013 Mar 14;121(11):2154-64.
  • Ismail H, Mofarrahi M, Echavarria R, Harel S, Verdin E, Lim HW, Jin ZG, Sun J, Zeng H, Hussain SN.Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77.Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1707-16.
  • Liu X, Zhao D, James L, Li J, Zeng H.Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor.FASEB J. 2011 Apr;25(4):1188-97.
  • Zhao D, Desai S, Zeng H.VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: Role in VEGF-induced angiogenesis.Int J Cancer. 2010 Aug 16.
  • Xiong Y, Huo Y, Chen C, Zeng H, Lu X, Wei C, Ruan C, Zhang X, Hu Z, Shibuya M, Luo J.Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways.J Biol Chem. 2009 Aug 28;284(35):23217-24.
  • An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J.Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.Circulation. 2009 Aug 18;120(7):617-27.
  • Liu X, Zhao D, Qin L, Li J, Zeng H.Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells.J Biol Chem. 2008 Dec 5;283(49):34159-67.
  • Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.Mol Cancer Res. 2006 Nov;4(11):811-20.
  • Qin L, Zeng H, Zhao D.Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation.J Biol Chem. 2006 Oct 27;281(43):32550-8.
  • Zeng H, Qin L, Zhao D, Tan X, Manseau EJ, Van Hoang M, Senger DR, Brown LF, Nagy JA, Dvorak HF.Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.J Exp Med. 2006 Mar 20;203(3):719-29.
  • Zeng H, Zhao D, Yang S, Datta K, Mukhopadhyay D.Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.J Biol Chem. 2003 Jun 6;278(23):20738-45.
  • Zeng H, Datta K, Neid M, Li J, Parangi S, Mukhopadhyay D.Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line.Biochem Biophys Res Commun. 2003 Feb 28;302(1):46-55.
  • Zeng H, Zhao D, Mukhopadhyay D.KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.J Biol Chem. 2002 Nov 29;277(48):46791-8.
  • Zeng H, Zhao D, Mukhopadhyay D.Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.J Biol Chem. 2002 Feb 8;277(6):4003-9.