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Huiyan Zeng, PhD


  • Zhao S, Zhou L, Niu G, Li Y, Zhao D, Zeng H.Differential regulation of orphan nuclear receptor TR3 transcript variants by novel vascular growth factor signaling pathways.FASEB J. 2014 Jul 11.
  • Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP.Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation.PLoS ONE. 2013;8(5):e64227.
  • Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H.The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.Blood. 2013 Mar 14;121(11):2154-64.
  • Ismail H, Mofarrahi M, Echavarria R, Harel S, Verdin E, Lim HW, Jin ZG, Sun J, Zeng H, Hussain SN.Angiopoietin-1 and vascular endothelial growth factor regulation of leukocyte adhesion to endothelial cells: role of nuclear receptor-77.Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1707-16.
  • Zhao D, Qin L, Bourbon PM, James L, Dvorak HF, Zeng H.Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions.Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12066-71.
  • Liu X, Zhao D, James L, Li J, Zeng H.Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor.FASEB J. 2011 Apr;25(4):1188-97.
  • Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C.Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.J Biol Chem. 2011 Feb 25;286(8):6092-9.
  • Zhao D, Desai S, Zeng H.VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: Role in VEGF-induced angiogenesis.Int J Cancer. 2010 Aug 16.
  • Xiong Y, Huo Y, Chen C, Zeng H, Lu X, Wei C, Ruan C, Zhang X, Hu Z, Shibuya M, Luo J.Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways.J Biol Chem. 2009 Aug 28;284(35):23217-24.
  • An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J.Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor.Circulation. 2009 Aug 18;120(7):617-27.
  • Liu X, Zhao D, Qin L, Li J, Zeng H.Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells.J Biol Chem. 2008 Dec 5;283(49):34159-67.
  • Nagy JA, Benjamin L, Zeng H, Dvorak AM, Dvorak HF.Vascular permeability, vascular hyperpermeability and angiogenesis.Angiogenesis. 2008;11(2):109-19. Review.
  • Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C.Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells.Int J Cancer. 2007 Apr 15;120(8):1652-6.
  • Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.Mol Cancer Res. 2006 Nov;4(11):811-20.
  • Qin L, Zeng H, Zhao D.Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation.J Biol Chem. 2006 Oct 27;281(43):32550-8.
  • Zhao D, Zhan Y, Zeng H, Moyer MP, Mantzoros CS, Pothoulakis C.Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells.J Cell Biochem. 2006 Apr 15;97(6):1317-27.
  • Zeng H, Qin L, Zhao D, Tan X, Manseau EJ, Van Hoang M, Senger DR, Brown LF, Nagy JA, Dvorak HF.Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.J Exp Med. 2006 Mar 20;203(3):719-29.
  • Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C.Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha.Mol Pharmacol. 2005 Jun;67(6):2025-31.
  • Mukhopadhyay D, Zeng H, Bhattacharya R.Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling.Mol Cell Biochem. 2004 Sep;264(1-2):51-61. Review.
  • Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C.Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells.J Biol Chem. 2004 Oct 15;279(42):43547-54.
  • Wang L, Zeng H, Wang P, Soker S, Mukhopadhyay D.Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.J Biol Chem. 2003 Dec 5;278(49):48848-60.
  • Zeng H, Zhao D, Yang S, Datta K, Mukhopadhyay D.Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling.J Biol Chem. 2003 Jun 6;278(23):20738-45.
  • Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C.Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways.Am J Physiol Cell Physiol. 2003 Jun;284(6):C1397-404.
  • Ratts R, Zeng H, Berg EA, Blue C, McComb ME, Costello CE, vanderSpek JC, Murphy JR.The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.J Cell Biol. 2003 Mar 31;160(7):1139-50.
  • Zeng H, Datta K, Neid M, Li J, Parangi S, Mukhopadhyay D.Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line.Biochem Biophys Res Commun. 2003 Feb 28;302(1):46-55.
  • Zeng H, Zhao D, Mukhopadhyay D.KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.J Biol Chem. 2002 Nov 29;277(48):46791-8.
  • Zeng H, Zhao D, Mukhopadhyay D.Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.J Biol Chem. 2002 Feb 8;277(6):4003-9.