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Andrius Kazlauskas, PhD

Publications

  • Jacobo SM, Kazlauskas A.
    Insulin-like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels.
    J Biol Chem. 2015 Mar 6;290(10):6349-60.
    25564613
  • Lei H, Qian C, Lei J, Haddock LJ, Mukai S, Kazlauskas A.
    RasGAP antagonizes signaling, cellular responses and pathology driven by indirectly activated PDGFR.
    Mol Cell Biol. 2015 Mar 2.
    25733681
  • Pennock S, Haddock LJ, Eliott D, Mukai S, Kazlauskas A.
    Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?.
    Prog Retin Eye Res. 2014 May;40C:16-34.
    24412519
  • Lei H, Kazlauskas A.
    A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.
    Mol Cell Biol. 2014 Jan;34(1):110-22.
    24190966
  • Ruan GX, Kazlauskas A.
    Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.
    J Biol Chem. 2013 Jul 19;288(29):21161-72.
    23754286
  • Ruan GX, Kazlauskas A.
    VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt.
    Cell Cycle. 2012 Jun 1;11(11):2047-8.
    22647379
  • Lei H, Velez G, Kazlauskas A.
    Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53.
    Mol Cell Biol. 2011 Feb 28.
    21357737
  • Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A.
    The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms.
    Cancer Res. 2010 May 15;70(10):4195-203.
    20442296
  • Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.
    PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.
    Mol Cell Biol. 2010 May;30(10):2401-10.
    20231358
  • Lei H, Rheaume MA, Kazlauskas A.
    Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy.
    Exp Eye Res. 2010 Mar;90(3):376-81. Review.
    19931527
  • Romeo GR, Kazlauskas A.
    Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.
    J Biol Chem. 2008 Apr 11;283(15):9595-605.
    18230613
  • Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A.
    Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.
    Invest Ophthalmol Vis Sci. 2008 Jan;49(1):42-8.
    18172073
  • Motiejunaite R, Kazlauskas A.
    Pericytes and ocular diseases.
    Exp Eye Res. 2008 Feb;86(2):171-7. Review.
    18078933
  • Lei H, Kazlauskas A.
    Focus on Molecules: Platelet-derived growth factor C, PDGF-C.
    Exp Eye Res. 2008 May;86(5):711-2. Review.
    17904120
  • Im E, Kazlauskas A.
    Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway.
    J Biol Chem. 2007 Oct 5;282(40):29122-9.
    17684019
  • Barcia RN, Dana MR, Kazlauskas A.
    Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL.
    Am J Transplant. 2007 Sep;7(9):2082-9.
    17614980
  • Romeo GR, Moulton KS, Kazlauskas A.
    Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.
    Circ Res. 2007 Aug 17;101(4):357-67.
    17615372
  • Im E, Kazlauskas A.
    PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis.
    Expert Opin Ther Targets. 2007 Apr;11(4):443-51. Review.
    17373875
  • Im E, Kazlauskas A.
    New insights regarding vessel regression.
    Cell Cycle. 2006 Sep;5(18):2057-9. Review.
    16969103
  • Im E, Kazlauskas A.
    Regulating angiogenesis at the level of PtdIns-4,5-P2.
    EMBO J. 2006 May 17;25(10):2075-82.
    16628216
  • Kazlauskas A.
    The priming/completion paradigm to explain growth factor-dependent cell cycle progression.
    Growth Factors. 2005 Sep;23(3):203-10.
    16243712
  • Im E, Venkatakrishnan A, Kazlauskas A.
    Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
    Mol Biol Cell. 2005 Aug;16(8):3488-500.
    15901832
  • Tallquist M, Kazlauskas A.
    PDGF signaling in cells and mice.
    Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13.
    15207812
  • Jones SM, Kazlauskas A.
    Growth-factor-dependent mitogenesis requires two distinct phases of signalling.
    Nat Cell Biol. 2001 Feb;3(2):165-72.
    11175749
  • Jones SM, Kazlauskas A.
    Connecting signaling and cell cycle progression in growth factor-stimulated cells.
    Oncogene. 2000 Nov 20;19(49):5558-67.
    11114735
  • Balciunaite E, Jones S, Toker A, Kazlauskas A.
    PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition.
    Curr Biol. 2000 Mar 9;10(5):261-7.
    10712903
  • Fambrough D, McClure K, Kazlauskas A, Lander ES.
    Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.
    Cell. 1999 Jun 11;97(6):727-41.
    10380925
  • Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A.
    PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.
    Curr Biol. 1999 May 20;9(10):512-21.
    10339426
  • DeMali KA, Whiteford CC, Ulug ET, Kazlauskas A.
    Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.
    J Biol Chem. 1997 Apr 4;272(14):9011-8.
    9083025
  • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.
    The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
    Cell. 1995 Jun 2;81(5):727-36.
    7774014
  • Valius M, Secrist JP, Kazlauskas A.
    The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.
    Mol Cell Biol. 1995 Jun;15(6):3058-71.
    7760802
  • Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J.
    PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.
    Nature. 1994 Jul 7;370(6484):71-5.
    8015612
  • Joly M, Kazlauskas A, Fay FS, Corvera S.
    Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.
    Science. 1994 Feb 4;263(5147):684-7.
    8303278
  • Kazlauskas A, Feng GS, Pawson T, Valius M.
    The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
    Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6939-43.
    7688466
  • Valius M, Kazlauskas A.
    Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.
    Cell. 1993 Apr 23;73(2):321-34.
    7682895