Andrius Kazlauskas, PhD

Publications

Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY.SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.J Clin Invest. 2011 Feb 14.
21393858
Lei H, Velez G, Kazlauskas A.Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53.Mol Cell Biol. 2011 Feb 28.
21357737
Ruan GX, Kazlauskas A.Focus on Molecules: Akt (PKB).Exp Eye Res. 2010 Jun 23.
20599963
Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A.The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms.Cancer Res. 2010 May 15;70(10):4195-203.
20442296
Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.Mol Cell Biol. 2010 May;30(10):2401-10
20231358
Lei H, Rheaume MA, Kazlauskas A.Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy.Exp Eye Res. 2010 Mar;90(3):376-81. Review.
19931527
Romeo GR, Kazlauskas A.Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.J Biol Chem. 2008 Apr 11;283(15):9595-605.
18230613
Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A.Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.Invest Ophthalmol Vis Sci. 2008 Jan;49(1):42-8.
18172073
Heikkinen LS, Kazlauskas A, Melen K, Wagner R, Ziegler T, Julkunen I, Saksela K.Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.J Biol Chem. 2008 Feb 29;283(9):5719-27.
18165234
Motiejunaite R, Kazlauskas A.Pericytes and ocular diseases.Exp Eye Res. 2008 Feb;86(2):171-7. Review.
18078933
Lei H, Kazlauskas A.Focus on Molecules: Platelet-derived growth factor C, PDGF-C.Exp Eye Res. 2008 May;86(5):711-2. Review.
17904120
Im E, Kazlauskas A.Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway.J Biol Chem. 2007 Oct 5;282(40):29122-9.
17684019
Romeo GR, Moulton KS, Kazlauskas A.Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.Circ Res. 2007 Aug 17;101(4):357-67.
17615372
Barcia RN, Dana MR, Kazlauskas A.Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL.Am J Transplant. 2007 Sep;7(9):2082-9.
17614980
Singh PK, Wen Y, Swanson BJ, Shanmugam K, Kazlauskas A, Cerny RL, Gendler SJ, Hollingsworth MA.Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells.Cancer Res. 2007 Jun 1;67
17545600
Im E, Kazlauskas A.PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis.Expert Opin Ther Targets. 2007 Apr;11(4):443-51. Review.
17373875
Im E, Kazlauskas A.New insights regarding vessel regression.Cell Cycle. 2006 Sep;5(18):2057-9. Review.
16969103
Im E, Kazlauskas A.The role of cathepsins in ocular physiology and pathology.Exp Eye Res. 2007 Mar;84(3):383-8. Review.
16893541
Im E, Kazlauskas A.Regulating angiogenesis at the level of PtdIns-4,5-P2.EMBO J. 2006 May 17;25(10):2075-82.
16628216
Kazlauskas A.The priming/completion paradigm to explain growth factor-dependent cell cycle progression.Growth Factors. 2005 Sep;23(3):203-10.
16243712
Im E, Venkatakrishnan A, Kazlauskas A.Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.Mol Biol Cell. 2005 Aug;16(8):3488-500.
15901832
Calera MR, Venkatakrishnan A, Kazlauskas A.VE-cadherin increases the half-life of VEGF receptor 2.Exp Cell Res. 2004 Oct 15;300(1):248-56.
15383331
Tallquist M, Kazlauskas A.PDGF signaling in cells and mice.Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13.
15207812
Jones SM, Kazlauskas A.Growth-factor-dependent mitogenesis requires two distinct phases of signalling.Nat Cell Biol. 2001 Feb;3(2):165-72.
11175749
Jones SM, Kazlauskas A.Connecting signaling and cell cycle progression in growth factor-stimulated cells.Oncogene. 2000 Nov 20;19(49):5558-67.
11114735
Balciunaite E, Jones S, Toker A, Kazlauskas A.PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition.Curr Biol. 2000 Mar 9;10(5):261-7.
10712903
Fambrough D, McClure K, Kazlauskas A, Lander ES.Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.Cell. 1999 Jun 11;97(6):727-41.
10380925
Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A.PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.Curr Biol. 1999 May 20;9(10):512-21.
10339426
DeMali KA, Whiteford CC, Ulug ET, Kazlauskas A.Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.J Biol Chem. 1997 Apr 4;272(14):9011-8.
9083025
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.Cell. 1995 Jun 2;81(5):727-36.
7774014
Valius M, Secrist JP, Kazlauskas A.The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Mol Cell Biol. 1995 Jun;15(6):3058-71.
7760802
Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J.PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.Nature. 1994 Jul 7;370(6484):71-5.
8015612
Joly M, Kazlauskas A, Fay FS, Corvera S.Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.Science. 1994 Feb 4;263(5147):684-7.
8303278
Kazlauskas A, Feng GS, Pawson T, Valius M.The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6939-
7688466
Valius M, Kazlauskas A.Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.Cell. 1993 Apr 23;73(2):321-34.
7682895

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Andrius Kazlauskas, PhD Publications Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY.SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.J Clin Invest. 2011 Feb 14. 21393858 Lei H, Velez G, Kazlauskas A.Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53.Mol Cell Biol. 2011 Feb 28. 21357737 Ruan GX, Kazlauskas A.Focus on Molecules: Akt (PKB).Exp Eye Res. 2010 Jun 23. 20599963 Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A.The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms.Cancer Res. 2010 May 15;70(10):4195-203. 20442296 Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.Mol Cell Biol. 2010 May;30(10):2401-10 20231358 Lei H, Rheaume MA, Kazlauskas A.Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy.Exp Eye Res. 2010 Mar;90(3):376-81. Review. 19931527 Romeo GR, Kazlauskas A.Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.J Biol Chem. 2008 Apr 11;283(15):9595-605. 18230613 Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A.Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.Invest Ophthalmol Vis Sci. 2008 Jan;49(1):42-8. 18172073 Heikkinen LS, Kazlauskas A, Melen K, Wagner R, Ziegler T, Julkunen I, Saksela K.Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.J Biol Chem. 2008 Feb 29;283(9):5719-27. 18165234 Motiejunaite R, Kazlauskas A.Pericytes and ocular diseases.Exp Eye Res. 2008 Feb;86(2):171-7. Review. 18078933 Lei H, Kazlauskas A.Focus on Molecules: Platelet-derived growth factor C, PDGF-C.Exp Eye Res. 2008 May;86(5):711-2. Review. 17904120 Im E, Kazlauskas A.Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway.J Biol Chem. 2007 Oct 5;282(40):29122-9. 17684019 Romeo GR, Moulton KS, Kazlauskas A.Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.Circ Res. 2007 Aug 17;101(4):357-67. 17615372 Barcia RN, Dana MR, Kazlauskas A.Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL.Am J Transplant. 2007 Sep;7(9):2082-9. 17614980 Singh PK, Wen Y, Swanson BJ, Shanmugam K, Kazlauskas A, Cerny RL, Gendler SJ, Hollingsworth MA.Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells.Cancer Res. 2007 Jun 1;67 17545600 Im E, Kazlauskas A.PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis.Expert Opin Ther Targets. 2007 Apr;11(4):443-51. Review. 17373875 Im E, Kazlauskas A.New insights regarding vessel regression.Cell Cycle. 2006 Sep;5(18):2057-9. Review. 16969103 Im E, Kazlauskas A.The role of cathepsins in ocular physiology and pathology.Exp Eye Res. 2007 Mar;84(3):383-8. Review. 16893541 Im E, Kazlauskas A.Regulating angiogenesis at the level of PtdIns-4,5-P2.EMBO J. 2006 May 17;25(10):2075-82. 16628216 Kazlauskas A.The priming/completion paradigm to explain growth factor-dependent cell cycle progression.Growth Factors. 2005 Sep;23(3):203-10. 16243712 Im E, Venkatakrishnan A, Kazlauskas A.Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.Mol Biol Cell. 2005 Aug;16(8):3488-500. 15901832 Calera MR, Venkatakrishnan A, Kazlauskas A.VE-cadherin increases the half-life of VEGF receptor 2.Exp Cell Res. 2004 Oct 15;300(1):248-56. 15383331 Tallquist M, Kazlauskas A.PDGF signaling in cells and mice.Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13. 15207812 Jones SM, Kazlauskas A.Growth-factor-dependent mitogenesis requires two distinct phases of signalling.Nat Cell Biol. 2001 Feb;3(2):165-72. 11175749 Jones SM, Kazlauskas A.Connecting signaling and cell cycle progression in growth factor-stimulated cells.Oncogene. 2000 Nov 20;19(49):5558-67. 11114735 Balciunaite E, Jones S, Toker A, Kazlauskas A.PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition.Curr Biol. 2000 Mar 9;10(5):261-7. 10712903 Fambrough D, McClure K, Kazlauskas A, Lander ES.Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.Cell. 1999 Jun 11;97(6):727-41. 10380925 Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A.PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.Curr Biol. 1999 May 20;9(10):512-21. 10339426 DeMali KA, Whiteford CC, Ulug ET, Kazlauskas A.Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.J Biol Chem. 1997 Apr 4;272(14):9011-8. 9083025 Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.Cell. 1995 Jun 2;81(5):727-36. 7774014 Valius M, Secrist JP, Kazlauskas A.The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Mol Cell Biol. 1995 Jun;15(6):3058-71. 7760802 Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J.PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.Nature. 1994 Jul 7;370(6484):71-5. 8015612 Joly M, Kazlauskas A, Fay FS, Corvera S.Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.Science. 1994 Feb 4;263(5147):684-7. 8303278 Kazlauskas A, Feng GS, Pawson T, Valius M.The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6939- 7688466 Valius M, Kazlauskas A.Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.Cell. 1993 Apr 23;73(2):321-34. 7682895
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