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Andrius Kazlauskas, PhD


  • Pennock S, Haddock LJ, Eliott D, Mukai S, Kazlauskas A.Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?.Prog Retin Eye Res. 2014 May;40C:16-34.
  • Lei H, Kazlauskas A.A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.Mol Cell Biol. 2014 Jan;34(1):110-22.
  • Ruan GX, Kazlauskas A.Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.J Biol Chem. 2013 Jul 19;288(29):21161-72.
  • Ruan GX, Kazlauskas A.VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt.Cell Cycle. 2012 Jun 1;11(11):2047-8.
  • Lei H, Velez G, Kazlauskas A.Pathological signaling via PDGFR{alpha} involves chronic activation of Akt and suppression of p53.Mol Cell Biol. 2011 Feb 28.
  • Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A.The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms.Cancer Res. 2010 May 15;70(10):4195-203.
  • Im E, Motiejunaite R, Aranda J, Park EY, Federico L, Kim TI, Clair T, Stracke ML, Smyth S, Kazlauskas A.PLC{gamma} activation drives increased production of autotaxin in endothelial cells and LPA-dependent regression.Mol Cell Biol. 2010 May;30(10):2401-10.
  • Lei H, Rheaume MA, Kazlauskas A.Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy.Exp Eye Res. 2010 Mar;90(3):376-81. Review.
  • Romeo GR, Kazlauskas A.Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.J Biol Chem. 2008 Apr 11;283(15):9595-605.
  • Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A.Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy.Invest Ophthalmol Vis Sci. 2008 Jan;49(1):42-8.
  • Motiejunaite R, Kazlauskas A.Pericytes and ocular diseases.Exp Eye Res. 2008 Feb;86(2):171-7. Review.
  • Lei H, Kazlauskas A.Focus on Molecules: Platelet-derived growth factor C, PDGF-C.Exp Eye Res. 2008 May;86(5):711-2. Review.
  • Im E, Kazlauskas A.Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway.J Biol Chem. 2007 Oct 5;282(40):29122-9.
  • Barcia RN, Dana MR, Kazlauskas A.Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL.Am J Transplant. 2007 Sep;7(9):2082-9.
  • Romeo GR, Moulton KS, Kazlauskas A.Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.Circ Res. 2007 Aug 17;101(4):357-67.
  • Im E, Kazlauskas A.PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis.Expert Opin Ther Targets. 2007 Apr;11(4):443-51. Review.
  • Im E, Kazlauskas A.New insights regarding vessel regression.Cell Cycle. 2006 Sep;5(18):2057-9. Review.
  • Im E, Kazlauskas A.Regulating angiogenesis at the level of PtdIns-4,5-P2.EMBO J. 2006 May 17;25(10):2075-82.
  • Kazlauskas A.The priming/completion paradigm to explain growth factor-dependent cell cycle progression.Growth Factors. 2005 Sep;23(3):203-10.
  • Im E, Venkatakrishnan A, Kazlauskas A.Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.Mol Biol Cell. 2005 Aug;16(8):3488-500.
  • Tallquist M, Kazlauskas A.PDGF signaling in cells and mice.Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13.
  • Jones SM, Kazlauskas A.Growth-factor-dependent mitogenesis requires two distinct phases of signalling.Nat Cell Biol. 2001 Feb;3(2):165-72.
  • Jones SM, Kazlauskas A.Connecting signaling and cell cycle progression in growth factor-stimulated cells.Oncogene. 2000 Nov 20;19(49):5558-67.
  • Balciunaite E, Jones S, Toker A, Kazlauskas A.PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition.Curr Biol. 2000 Mar 9;10(5):261-7.
  • Fambrough D, McClure K, Kazlauskas A, Lander ES.Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.Cell. 1999 Jun 11;97(6):727-41.
  • Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A.PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.Curr Biol. 1999 May 20;9(10):512-21.
  • DeMali KA, Whiteford CC, Ulug ET, Kazlauskas A.Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.J Biol Chem. 1997 Apr 4;272(14):9011-8.
  • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.Cell. 1995 Jun 2;81(5):727-36.
  • Valius M, Secrist JP, Kazlauskas A.The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.Mol Cell Biol. 1995 Jun;15(6):3058-71.
  • Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J.PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.Nature. 1994 Jul 7;370(6484):71-5.
  • Joly M, Kazlauskas A, Fay FS, Corvera S.Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.Science. 1994 Feb 4;263(5147):684-7.
  • Kazlauskas A, Feng GS, Pawson T, Valius M.The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6939-43.
  • Valius M, Kazlauskas A.Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal.Cell. 1993 Apr 23;73(2):321-34.