Levi A. Garraway, MD, PhD

Publications

• Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Ch
  22817889
• Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI.The histone m
  21430779
• Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowia
  21430775
• Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA.Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling.J Clin Oncol. 2011 Mar 7.
  21383288
• Kiessling MK, Oberholzer PA, Mondal C, Karpova MB, Zipser MC, Lin WM, Girardi M, Macconaill LE, Kehoe SM, Hatton C, French LE, Garraway LA, Polier G, Süss D, Klemke CD, Krammer PH, Gülow K, Dummer R.High-throughput mutation profiling of CTCL samples rev
  21209378
• Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, Fennell T, Parkin M, Saksena G, Voet D, Ramos AH, Pugh TJ, Wilkinson J, Fisher S,
  21307934
• Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE,
  21107320
• Akavia UD, Litvin O, Kim J, Sanchez-Garcia F, Kotliar D, Causton HC, Pochanard P, Mozes E, Garraway LA, Pe'er D.An Integrated Approach to Uncover Drivers of Cancer.Cell. 2010 Dec 10;143(6):1005-1017.
  21129771
• Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD.Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in
  21109473
• Macconaill LE, Garraway LA.Clinical Implications of the Cancer Genome.J Clin Oncol. 2010 Dec 10;28(35):5219-28.
  20975063
• Vasudevan KM, Garraway LA.AKT Signaling in Physiology and Disease.Curr Top Microbiol Immunol. 2011;347:105-33.
  20549472
• Berger MF, Lawrence MS, Demichelis F, Cibulskis K, Sivachenko A, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter S, Drier Y, Ambrogio L, Fenne T, Parkin M, Gordon S, Voet D, Ramos A, Pugh T, Wilkinson J, Fisher S, Winckler W, Mahan S, Ardlie
• Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ.Recurrent BRAF mutations in Langerhans cell histiocytosis.Blood. 2010 Sep 1
  20519626
• Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofri
  20601955
• Garraway LA, Hahn WC.On or off target: mutations, models, and predictions.Sci Transl Med. 2010 Jun 9;2(35):35ps28.
  20538617
• Berger MF, Levin JZ, Vijayendran K, Sivachenko A, Adiconis X, Maguire J, Johnson LA, Robinson J, Verhaak RG, Sougnez C, Onofrio RC, Ziaugra L, Cibulskis K, Laine E, Barretina J, Winckler W, Fisher DE, Getz G, Meyerson M, Jaffe DB, Gabriel SB, Lander ES, D
  20179022
• Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA.An oncogenic role for ETV1 in melanoma.Cancer Res. 2010 Mar 1;70(5):2075-84.
  20160028
• Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Lo
  20164920
• Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA.Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NC
  20124458
• Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, MacConaill LE, Zhang J, Gray NS, Sellers WR, Dummer R, Garraway LA.MEK1 mutations confer resistance to MEK and B-RAF inhibition.Proc Natl Acad Sc
  19915144
• Levin JZ, Berger MF, Adiconis X, Rogov P, Melnikov A, Fennell T, Nusbaum C, Garraway LA, Gnirke A.Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts.Genome Biol. 2009;10(10):R
  19835606
• MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasan
  19924296
• Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR.p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.Mol Cell Biol. 2009 Oct;29(19):5377-88.
  19635806
• Modrek B, Ge L, Pandita A, Lin E, Mohan S, Yue P, Guerrero S, Lin WM, Pham T, Modrusan Z, Seshagiri S, Stern HM, Waring P, Garraway LA, Chant J, Stokoe D, Cavet G.Oncogenic activating mutations are associated with local copy gain.Mol Cancer Res. 2009 Aug;
  19671679
• Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gon
  19573809
• Nare B,Garraway LA,Vickers TJ,Beverley SM.PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.Curr Genet. 2009 Jun;55(3):287-99.
  19396443
• Berger MF,Garraway LA.Applications of genomics in melanoma oncogene discovery.Hematol Oncol Clin North Am. 2009 Jun;23(3):397-414, vii. Review.
  19464593
• Sos ML,Michel K,Zander T,Weiss J,Frommolt P,Peifer M,Li D,Ullrich R,Koker M,Fischer F,Shimamura T,Rauh D,Mermel C,Fischer S,Stuckrath I,Heynck S,Beroukhim R,Lin W,Winckler W,Shah K,LaFramboise T,Moriarty WF,Hanna M,Tolosi L,Rahnenfuhrer J,Verhaak R,Chiang
  19451690
• Sos ML,Koker M,Weir BA,Heynck S,Rabinovsky R,Zander T,Seeger JM,Weiss J,Fischer F,Frommolt P,Michel K,Peifer M,Mermel C,Girard L,Peyton M,Gazdar AF,Minna JD,Garraway LA,Kashkar H,Pao W,Meyerson M,Thomas RK.PTEN loss contributes to erlotinib resistance in
  19351834
• Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J, Wik E, Greulich H, Bø TH, Jonassen I, Thomas RK, Zander T, Garraway LA, Oyan AM, Sellers WR, Kalland KH, Meyerson M, Akslen LA, Beroukhim R.In
  19261849
• Linja M,Garraway LA.Stepping on the GAS: a brake pedal for melanoma metastasis?.Pigment Cell Melanoma Res. 2009 Feb;22(1):8-9.
  19154234
• The Cancer Genome Atlas Research Network.Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature.;455(7216):1061-8.
• Li C, Beroukhim R, Weir BA, Winckler W, Garraway LA, Sellers WR, Meyerson M.Major copy proportion analysis of tumor samples using SNP arrays.BMC Bioinformatics. 2008;9:204.
  18426588
• Demichelis F, Greulich H, Macoska JA, Beroukhim R, Sellers WR, Garraway L, Rubin MA.SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines.Nucleic Acids Res. 2008 Apr;36(7):2446-56.
  18304946
• Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA.Modeling genomic diversity and tumor dependency
  18245465
• Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S, Prensner J, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mische
  18077431
• Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M
  17982442
• Hill AD, Chang BS, Hill RS, Garraway LA, Bodell A, Sellers WR, Walsh CA.A 2-Mb critical region implicated in the microcephaly associated with terminal 1q deletion syndrome.Am J Med Genet A. 2007 Aug 1;143A(15):1692-8.
  17603806
• Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Rober
  17574021
• Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Thomas RK, Garraway LA, Jänne PA, Johnson BE, Chin L, Wong KK.Mutations in BRAF and KRAS converge on activation of the
  17510423
• Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C,
  17293865
• Chin L, Garraway LA, Fisher DE.Malignant melanoma: genetics and therapeutics in the genomic era.Genes Dev. 2006 Aug 15;20(16):2149-82. Review.
  16912270
• Garraway LA, Weir BA, Zhao X, Widlund H, Beroukhim R, Berger A, Rimm D, Rubin MA, Fisher DE, Meyerson ML, Sellers WR."Lineage Addiction" in Human Cancer: Lessons from Integrated Genomics.Cold Spring Harb Symp Quant Biol. 2005;70:25-34.
  16869735
• Garraway LA, Sellers WR.Lineage dependency and lineage-survival oncogenes in human cancer.Nat Rev Cancer. 2006 Aug;6(8):593-602. Review.
  16862190
• Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Broc
  16799556
• Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M.Androgen-dependent regulation of Her-2/neu in prostate cancer cells.Cancer Res. 2006 Jun 1;66(11):5723-8.
  16740710
• Beroukhim R, Lin M, Park Y, Hao K, Zhao X, Garraway LA, Fox EA, Hochberg EP, Mellinghoff IK, Hofer MD, Descazeaud A, Rubin MA, Meyerson M, Wong WH, Sellers WR, Li C.Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide S
  16699594
• Garraway LA, Sellers WR.From integrated genomics to tumor lineage dependency.Cancer Res. 2006 Mar 1;66(5):2506-8. Review.
  16510564
• Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N.BRAF mutation predicts sensitivity to MEK inhibition.Nature. 2006 Jan 19;439(7074):358-62.
  16273091
• Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR.Integrative genomic analyses identify MITF as a lineage survival onc
  16001072
• Späth GF, Garraway LA, Turco SJ, Beverley SM.The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9536-41.
  12869694
• Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, Bhattacharya N, Loda M.Intermediate basal cells of the prostate: in vitro and in vivo characterization.Prostate. 2003 May 15;55(3):206-18.
  12692787
• Garraway LA, Chabner B.MDR1 inhibition: less resistance or less relevance?.Eur J Cancer. 2002 Dec;38(18):2337-40.
  12460776
• Garraway LA, Tosi LR, Wang Y, Moore JB, Dobson DE, Beverley SM.Insertional mutagenesis by a modified in vitro Ty1 transposition system.Gene. 1997 Oct 1;198(1-2):27-35.
  9370261
• Pimenta PF, Saraiva EM, Rowton E, Modi GB, Garraway LA, Beverley SM, Turco SJ, Sacks DL.Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophos
  8090785
• Ryan KA, Garraway LA, Descoteaux A, Turco SJ, Beverley SM.Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8609-13.
  8378337
• Gerard NP, Garraway LA, Eddy RL, Shows TB, Iijima H, Paquet JL, Gerard C.Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones.Biochemistry. 1991 Nov 5;30(44):10640-6.
  1657150