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Rebecca S. Heist, MD, MPH


  • Hata AN, Yeo A, Faber AC, Lifshits E, Chen Z, Cheng KA, Walton Z, Sarosiek KA, Letai A, Heist RS, Mino-Kenudson M, Wong KK, Engelman JA.Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.Cancer Res. 2014 Jun 1(11):3146-56.
  • Pu X, Hildebrandt MA, Lu C, Roth JA, Stewart DJ, Zhao Y, Heist RS, Ye Y, Chang DW, Su L, Minna JD, Lippman SM, Spitz MR, Christiani DC, Wu X.Inflammation-related Genetic Variations and Survival for Advanced Non-Small Cell Lung Cancer Receiving First-line Chemotherapy.Clin Pharmacol Ther. 2014 Apr 22.
  • Heist RS, Wang X, Hodgson L, Otterson GA, Stinchcombe TE, Gandhi L, Villalona-Calero MA, Watson P, Vokes EE, Socinski MA, .CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer.J Thorac Oncol. 2014 Feb;9(2):214-21.
  • Brunner AM, Costa DB, Heist RS, Garcia E, Lindeman NI, Sholl LM, Oxnard GR, Johnson BE, Hammerman PS.Treatment-related toxicities in a phase II trial of dasatinib in patients with squamous cell carcinoma of the lung.J Thorac Oncol. 2013 Nov;8(11):1434-7.
  • Renouf DJ, Zhai R, Sun B, Xu W, Cheung WY, Heist RS, Kulke MH, Cescon D, Asomaning K, Marshall AL, Li S, Christiani DC, Liu G.Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma.J Gastroenterol Hepatol. 2013 Sep;28(9):1482-8.
  • Izar B, Sequist L, Lee M, Muzikansky A, Heist R, Iafrate J, Dias-Santagata D, Mathisen D, Lanuti M.The impact of EGFR mutation status on outcomes in patients with resected stage I non-small cell lung cancers.Ann Thorac Surg. 2013 Sep;96(3):962-8.
  • Goldberg SB, Willers H, Heist RS.Multidisciplinary management of small cell lung cancer.Surg Oncol Clin N Am. 2013 Apr;22(2):329-43.
  • Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, Scialabba VL, Batten JM, Borger DR, Iafrate AJ, Heist RS, Lawrence DP, Flaherty KT, Bendell JC, Deschler D, Li Y, Wirth LJ, Dias-Santagata D.Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.Clin Cancer Res. 2013 Jan 15;19(2):480-90.
  • Elena JW, Travis LB, Simonds NI, Ambrosone CB, Ballard-Barbash R, Bhatia S, Cerhan JR, Hartge P, Heist RS, Kushi LH, Lash TL, Morton LM, Onel K, Pierce JP, Robison LL, Rowland JH, Schrag D, Sellers TA, Seminara D, Shu XO, Thomas NE, Ulrich CM, Freedman AN.Leveraging epidemiology and clinical studies of cancer outcomes: recommendations and opportunities for translational research.Journal of the National Cancer Institute. 2013 Jan 16;105(2):85-94. Review.
  • Kalemkerian GP, Akerley W, Bogner P, Borghaei H, Chow LQ, Downey RJ, Gandhi L, Ganti AK, Govindan R, Grecula JC, Hayman J, Heist RS, Horn L, Jahan T, Koczywas M, Loo BW, Merritt RE, Moran CA, Niell HB, O'Malley J, Patel JD, Ready N, Rudin CM, Williams CC, Gregory K, Hughes M.Small cell lung cancer.J Natl Compr Canc Netw. 2013 Jan 1;11(1):78-98.
  • Heist RS, Mino-Kenudson M, Sequist LV, Tammireddy S, Morrissey L, Christiani DC, Engelman JA, Iafrate AJ.FGFR1 amplification in squamous cell carcinoma of the lung.J Thorac Oncol. 2012 Dec;7(12):1775-80.
  • Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M.Tumor Islands in Resected Early-stage Lung Adenocarcinomas are Associated With Unique Clinicopathologic and Molecular Characteristics and Worse Prognosis.Am J Surg Pathol. 2012 Oct 19.
  • Goldberg SB, Supko JG, Neal JW, Muzikansky A, Digumarthy S, Fidias P, Temel JS, Heist RS, Shaw AT, McCarthy PO, Lynch TJ, Sharma S, Settleman JE, Sequist LV.A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer.J Thorac Oncol. 2012 Oct;7(10):1602-8.
  • Heist RS, Sequist LV, Engelman JA.Genetic changes in squamous cell lung cancer: a review.J Thorac Oncol. 2012 May;7(5):924-33. Review.
  • Heist RS, Engelman JA.SnapShot: Non-Small Cell Lung Cancer.Cancer Cell. 2012 Mar 20;21(3):448-448.e2.
  • Pirl WF, Greer JA, Traeger L, Jackson V, Lennes IT, Gallagher ER, Perez-Cruz P, Heist RS, Temel JS.Depression and Survival in Metastatic Non-Small-Cell Lung Cancer: Effects of Early Palliative Care.J Clin Oncol. 2012 Mar 19.
  • Cheung WY, Zhai R, Bradbury P, Hopkins J, Kulke MH, Heist RS, Asomaning K, Ma C, Xu W, Wang Z, Hooshmand S, Su L, Christiani DC, Liu G.Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.Int J Cancer. 2012 Mar 16.
  • Greer JA, Pirl WF, Jackson VA, Muzikansky A, Lennes IT, Heist RS, Gallagher ER, Temel JS.Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer.J Clin Oncol. 2012 Feb 1;30(4):394-400.
  • Mak RH, Alexander BM, Asomaning K, Heist RS, Liu CY, Su L, Zhai R, Ancukiewicz M, Napolitano B, Niemierko A, Willers H, Choi NC, Christiani DC.A single-nucleotide polymorphism in the MTHFR (methylene tetrahydrofolate reductase) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.Cancer. 2011 Dec 5.
  • Huang YT, Lin X, Chirieac LR, McGovern R, Wain JC, Heist RS, Skaug V, Zienolddiny S, Haugen A, Su L, Christiani DC.Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer.PLoS ONE. 2011;6(8):e22961.
  • Zhai R, Zhao Y, Liu G, Ter-Minassian M, Wu IC, Wang Z, Su L, Asomaning K, Chen F, Kulke MH, Lin X, Heist RS, Wain JC, Christiani DC.Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study.Cancer. 2011 Jul 12.
  • Wu IC, Zhao Y, Zhai R, Liu G, Ter-Minassian M, Asomaning K, Su L, Liu CY, Chen F, Kulke MH, Heist RS, Christiani DC.Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.Neoplasia. 2011 Apr;13(4):386-92.
  • Wu IC, Zhao Y, Zhai R, Liu CY, Chen F, Ter-Minassian M, Asomaning K, Su L, Heist RS, Kulke MH, Liu G, Christiani DC.Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk.Carcinogenesis. 2011 Apr;32(4):502-6.
  • Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M, Engelman JA.Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors.Sci Transl Med. 2011 Mar 23;3(75):75ra26.
  • Yin M, Yan J, Voutsina A, Tibaldi C, Christiani DC, Heist RS, Rosell R, Booton R, Wei Q.No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: A meta-analysis.Lung Cancer. 2010 Nov 12.
  • Neal JW, Heist RS, Fidias P, Temel JS, Huberman M, Marcoux JP, Muzikansky A, Lynch TJ, Sequist LV.Cetuximab Monotherapy in Patients with Advanced Non-small Cell Lung Cancer After Prior Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy.J Thorac Oncol. 2010 Nov;5(11):1855-8.
  • Heist RS, Fain J, Chinnasami B, Khan W, Molina JR, Sequist LV, Temel JS, Fidias P, Brainerd V, Leopold L, Lynch TJ.Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer.J Thorac Oncol. 2010 Oct;5(10):1637-43.
  • Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC.A Large Scale Genetic Association Study of Esophageal Adenocarcinoma Risk.Carcinogenesis. 2010 Jul;31(7):1259-63.
  • Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC.Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.J Clin Oncol. 2010 May 10;28(14):2445-51.
  • Temel JS, Greer JA, Admane S, Solis J, Cashavelly BJ, Doherty S, Heist R, Pirl WF.Code status documentation in the outpatient electronic medical records of patients with metastatic cancer.J Gen Intern Med. 2010 Feb;25(2):150-3.
  • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ.Clinical Features and Outcome of Patients With Non-Small-Cell Lung Cancer Who Harbor EML4-ALK.J Clin Oncol. 2009 Sep 10;27(26):4247-53.
  • Sequist LV, Fidias P, Heist RS, Ostler P, Muzikansky A, Lynch TJ.Brief report of biweekly pemetrexed and gemcitabine in elderly patients with non-small cell lung cancer.J Thorac Oncol. 2009 Sep;4(9):1170-3.
  • Cheung WY, Zhai R, Kulke MH, Heist RS, Asomaning K, Ma C, Wang Z, Su L, Lanuti M, Tanabe KK, Christiani DC, Liu G.Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk.Carcinogenesis. 2009 Aug;30(8):1363-7.
  • Bradbury PA, Kulke MH, Heist RS, Zhou W, Ma C, Xu W, Marshall AL, Zhai R, Hooshmand SM, Asomaning K, Su L, Shepherd FA, Lynch TJ, Wain JC, Christiani DC, Liu G.Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes.Pharmacogenet Genomics. 2009 Aug;19(8):613-25.
  • Bradbury PA, Zhai R, Ma C, Xu W, Hopkins J, Kulke MJ, Asomaning K, Wang Z, Su L, Heist RS, Lynch TJ, Wain JC, Christiani D, Liu G.Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.Clin Cancer Res. 2009 Jul 15;15(14):4680-5.
  • Huang YT,Heist RS,Chirieac LR,Lin X,Skaug V,Zienolddiny S,Haugen A,Wu MC,Wang Z,Su L,Asomaning K,Christiani DC.Genome-wide analysis of survival in early-stage non-small-cell lung cancer.J Clin Oncol. 2009 Jun 1;27(16):2660-7.
  • Cescon DW,Bradbury PA,Asomaning K,Hopkins J,Zhai R,Zhou W,Wang Z,Kulke M,Su L,Ma C,Xu W,Marshall AL,Heist RS,Wain JC,Lynch TJ Jr,Christiani DC,Liu G.p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis.Clin Cancer Res. 2009 May 1;15(9):3103-9.
  • Bradbury PA,Zhai R,Hopkins J,Kulke MH,Heist RS,Singh S,Zhou W,Ma C,Xu W,Asomaning K,Ter-Minassian M,Wang Z,Su L,Christiani DC,Liu G.Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.Carcinogenesis. 2009 May;30(5):793-8.
  • Heist RS, Christiani D.EGFR-targeted therapies in lung cancer: predictors of response and toxicity.Pharmacogenomics. 2009 Jan;10(1):59-68. Review.
  • Heist RS,Zhou W,Wang Z,Liu G,Neuberg D,Su L,Asomaning K,Hollis BW,Lynch TJ,Wain JC,Giovannucci E,Christiani DC.Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer.J Clin Oncol. 2008 Dec 1;26(34):5596-602.
  • Heist RS,Fidias P,Huberman M,Ardman B,Sequist LV,Temel JS,Lynch TJ.A phase II study of oxaliplatin, pemetrexed, and bevacizumab in previously treated advanced non-small cell lung cancer.J Thorac Oncol. 2008 Oct;3(10):1153-8.
  • Zhai R,Liu G,Asomaning K,Su L,Kulke MH,Heist RS,Nishioka NS,Lynch TJ,Wain JC,Lin X,Christiani DC.Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.Carcinogenesis. 2008 Dec;29(12):2330-4.
  • Ter-Minassian M,Zhai R,Asomaning K,Su L,Zhou W,Liu G,Heist RS,Lynch TJ,Wain JC,Lin X,De Vivo I,Christiani DC.Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.Carcinogenesis. 2008 Nov;29(11):2147-52.
  • Asomaning K,Reid AE,Zhou W,Heist RS,Zhai R,Su L,Kwak EL,Blaszkowsky L,Zhu AX,Ryan DP,Christiani DC,Liu G.MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.Clin Cancer Res. 2008 Jun 15;14(12):4010-5.
  • Tse D,Zhai R,Zhou W,Heist RS,Asomaning K,Su L,Lynch TJ,Wain JC,Christiani DC,Liu G.Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk.Cancer Causes Control. 2008 Dec;19(10):1077-83.
  • Liu G, Gurubhagavatula S, Zhou W, Wang Z, Yeap BY, Asomaning K, Su L, Heist R, Lynch TJ, Christiani DC.Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib.Pharmacogenomics J. 2008 Apr;8(2):129-38.
  • Pennell NA, Daniels GH, Haddad RI, Ross DS, Evans T, Wirth LJ, Fidias PH, Temel JS, Gurubhagavatula S, Heist RS, Clark JR, Lynch TJ.A Phase II Study of Gefitinib in Patients with Advanced Thyroid Cancer.Thyroid. 2008 Mar;18(3):317-23.
  • Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC.VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.J Clin Oncol. 2008 Feb 20;26(6):856-62.
  • Fruh M, Zhou W, Zhai R, Su L, Heist RS, Wain JC, Nishioka NS, Lynch TJ, Shepherd FA, Christiani DC, Liu G.Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.Br J Cancer. 2008 Feb 26;98(4):689-92.
  • Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC.Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer.Clin Cancer Res. 2008 Jan 15;14(2):612-7.
  • Bradbury PA, Heist RS, Kulke MH, Zhou W, Marshall AL, Miller DP, Su L, Park S, Temel J, Fidias P, Sequist L, Lynch TJ, Wain JC, Shepherd FA, Christiani DC, Liu G.A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic outcomes from observational studies.Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):204-11.
  • Liu G, Wheatley-Price P, Zhou W, Park S, Heist RS, Asomaning K, Wain JC, Lynch TJ, Su L, Christiani DC.Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.Int J Cancer. 2008 Feb 15;122(4):915-8.
  • Heist RS, Liu G, Zhou W.Should oncologists measure the mRNA and protein expression levels of ERCC1 and RRM1 in non-small-cell lung cancer?.Nat Clin Pract Oncol. 2007 Oct;4(10):564-5.
  • Heist RS, Zhou W, Chirieac LR, Cogan-Drew T, Liu G, Su L, Neuberg D, Lynch TJ, Wain JC, Christiani DC.MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer.J Clin Oncol. 2007 Jun 1;25(16):2243-7.
  • Zhou W, Heist RS, Liu G, Asomaning K, Neuberg DS, Hollis BW, Wain JC, Lynch TJ, Giovannucci E, Su L, Christiani DC.Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients.J Clin Oncol. 2007 Feb 10;25(5):479-85.
  • Zhou W, Heist RS, Liu G, Asomaning K, Miller DP, Neuberg DS, Wain JC, Lynch TJ, Christiani DC.Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients.Clin Cancer Res. 2006 Dec 1;12(23):7187-93.
  • Zhou W, Heist RS, Liu G, Neuberg DS, Asomaning K, Su L, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Polymorphisms of vitamin d receptor and survival in early-stage non-small cell lung cancer patients.Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2239-45.
  • Heist RS, Marshall AL, Liu G, Zhou W, Su L, Neuberg D, Lynch TJ, Wain J, Christiani DC.Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.Clin Cancer Res. 2006 Sep 15;12(18):5448-53.
  • Zhou W, Heist RS, Liu G, Park S, Neuberg DS, Asomaning K, Wain JC, Lynch TJ, Christiani DC.Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients.Lung Cancer. 2006 Sep;53(3):375-80.
  • Suk R, Gurubhagavatula S, Park S, Zhou W, Su L, Lynch TJ, Wain JC, Neuberg D, Liu G, Christiani DC.Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients.Clin Cancer Res. 2005 Feb 15;11(4):1534-8.
  • Wu X, Zhao H, Suk R, Christiani DC.Genetic susceptibility to tobacco-related cancer.Oncogene. 2004 Aug 23;23(38):6500-23.