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Thomas Michel, MD, PhD


  • Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, Tavares de Almeida I, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE.Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase-1 Expression.J Biol Chem. 2014 Apr 9.
  • Bretón-Romero R, Kalwa H, Lamas S, Michel T.Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells.Biochim Biophys Acta. 2013 Dec;1833(12):2586-95.
  • Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE.Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.Sci Signal. 2013 Jul 30;6(286):ra64.
  • Maron BA, Michel T.Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase.Circ J. 2012 Oct 25;76(11):2497-512.
  • Jin BY, Lin AJ, Golan DE, Michel T.MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability.Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14864-9.
  • Kalwa H, Sartoretto JL, Sartoretto SM, Michel T.Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium.J Biol Chem. 2012 Aug 17;287(34):29147-58.
  • Kalwa H, Michel T.The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells.J Biol Chem. 2011 Jan 21;286(3):2320-30.
  • Michel T.NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart.Circulation. 2010 Feb 2;121(4):484-6.
  • Michel T, Vanhoutte PM.Cellular signaling and NO production.Pflugers Arch. 2010 Jan 16.
  • Sugiyama T, Michel T.Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways.Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H194-201.
  • Hess CN, Kou R, Johnson RP, Li GK, Michel T.ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.J Biol Chem. 2009 Nov 20;284(47):32209-24.
  • Sartoretto JL, Jin BY, Bauer M, Gertler FB, Liao R, Michel T.Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1697-710.
  • Jin BY, Sartoretto JL, Gladyshev VN, Michel T.Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17343-8.
  • Maegdefessel L, Linde T, Michel T, Hamilton K, Steinseifer U, Friedrich I, Schubert S, Hauroeder B, Raaz U, Buerke M, Werdan K, Schlitt A.Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study.Thromb Haemost. 2009 Jun;101(6):1163-9.
  • Kou R, Sartoretto J, Michel T.Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.J Biol Chem. 2009 May 29;284(22):14734-43.
  • Sugiyama T, Levy BD, Michel T.Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells.J Biol Chem. 2009 May 8;284(19):12691-700.
  • Igarashi J, Michel T.Sphingosine-1-phosphate and modulation of vascular tone.Cardiovasc Res. 2009 May 1;82(2):212-20. Review.
  • Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J.PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice.J Clin Invest. 2009 Jan;119(1):110-24.