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Benjamin D. Humphreys, MD, PhD


  • Grgic I, Hofmeister AF, Genovese G, Bernhardy AJ, Sun H, Maarouf OH, Bijol V, Pollak MR, Humphreys BD.Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.Kidney Int. 2014 Jun 18.
  • Chang-Panesso M, Humphreys BD.The Seen and the Unseen: Clinical Guidelines and Cost-Effective Care.J Am Soc Nephrol. 2014 May 29.
  • Liu J, Krautzberger AM, Sui SH, Hofmann OM, Chen Y, Baetscher M, Grgic I, Kumar S, Humphreys BD, Hide WA, McMahon AP.Cell-specific translational profiling in acute kidney injury.J Clin Invest. 2014 May 1;124(5):2288.
  • Grgic I, Krautzberger AM, Hofmeister A, Lalli M, Dirocco DP, Fleig SV, Liu J, Duffield JS, McMahon AP, Aronow B, Humphreys BD.Translational Profiles of Medullary Myofibroblasts during Kidney Fibrosis.J Am Soc Nephrol. 2014 Apr 17.
  • Little MH, Brown D, Humphreys BD, McMahon AP, Miner JH, Sands JM, Weisz OA, Mullins C, Hoshizaki D, .Defining kidney biology to understand renal disease.Clin J Am Soc Nephrol. 2014 Apr;9(4):809-11.
  • Kramann R, Tanaka M, Humphreys BD.Fluorescence Microangiography for Quantitative Assessment of Peritubular Capillary Changes after AKI in Mice.J Am Soc Nephrol. 2014 Mar 20.
  • DiRocco DP, Bisi J, Roberts P, Strum J, Wong KK, Sharpless N, Humphreys BD.CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F379-88.
  • Kusaba T, Humphreys BD.Controversies on the origin of proliferating epithelial cells after kidney injury.Pediatr Nephrol. 2014 Apr;29(4):673-9.
  • Kusaba T, Lalli M, Kramann R, Kobayashi A, Humphreys BD.Differentiated kidney epithelial cells repair injured proximal tubule.Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1527-32.
  • Humphreys BD.Kidney structures differentiated from stem cells.Nat Cell Biol. 2014 Jan;16(1):19-21.
  • Kramann R, Dirocco DP, Maarouf OH, Humphreys BD.Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation.Curr Pathobiol Rep. 2013 Dec;1(4).
  • Humphreys BD.Kidney injury, stem cells and regeneration.Curr Opin Nephrol Hypertens. 2014 Jan;23(1):25-31.
  • Kramann R, DiRocco DP, Humphreys BD.Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease.J Pathol. 2013 Nov;231(3):273-89. Review.
  • Humphreys BD, Dirocco DP.Lineage-tracing methods and the kidney.Kidney Int. 2013 Oct 2.
  • Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV.Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.J Clin Invest. 2013 Sep 3;123(9):4023-35.
  • DiRocco DP, Kobayashi A, Taketo MM, McMahon AP, Humphreys BD.Wnt4/β-catenin signaling in medullary kidney myofibroblasts.J Am Soc Nephrol. 2013 Sep;24(9):1399-412.
  • Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB.TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.Sci Signal. 2012 Dec 11;5(254):ra90.
  • Humphreys BD.Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy.Semin Nephrol. 2012 Sep;32(5):463-70.
  • Lam AQ, Humphreys BD.Onco-Nephrology: AKI in the Cancer Patient.Clin J Am Soc Nephrol. 2012 Oct;7(10):1692-700.
  • de Jesus-Gonzalez N, Robinson E, Penchev R, von Mehren M, Heinrich MC, Tap W, Wang Q, Demetri G, George S, Humphreys BD.Regorafenib induces rapid and reversible changes in plasma nitric oxide and endothelin-1.Am J Hypertens. 2012 Oct;25(10):1118-23.
  • de Jesus-Gonzalez N, Robinson E, Moslehi J, Humphreys BD.Management of antiangiogenic therapy-induced hypertension.Hypertension. 2012 Sep;60(3):607-15.
  • Grgic I, Duffield JS, Humphreys BD.The origin of interstitial myofibroblasts in chronic kidney disease.Pediatr Nephrol. 2011 Feb 11.
  • Humphreys BD.Onco-nephrology: kidney disease in the cancer patient: introduction.Semin Nephrol. 2010 Nov;30(6):531-3.
  • Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD.Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker.Semin Nephrol. 2010 Nov;30(6):591-601. Review.
  • Cohen LJ, Rennke HG, Laubach JP, Humphreys BD.The Spectrum of Kidney Involvement in Lymphoma: A Case Report and Review of the Literature.Am J Kidney Dis. 2010 Dec;56(6):1191-6. Review.
  • Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA, Humphreys BD.Suppression of the Nitric Oxide Pathway in Metastatic Renal Cell Carcinoma Patients Receiving Vascular Endothelial Growth Factor-Signaling Inhibitors.Hypertension. 2010 Dec;56(6):1131-6.
  • Heher EC, Goes NB, Spitzer TR, Raje NS, Humphreys BD, Anderson KC, Richardson PG.Kidney disease associated with plasma cell dyscrasias.Blood. 2010 Sep 2;116(9):1397-404. Review.
  • Robinson ES, Matulonis UA, Ivy P, Berlin ST, Tyburski K, Penson RT, Humphreys BD.Rapid development of hypertension and proteinuria with cediranib, an oral vascular endothelial growth factor receptor inhibitor.Clin J Am Soc Nephrol. 2010 Mar;5(3):477-83.
  • Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS.Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.Am J Pathol. 2010 Jan;176(1):85-97.
  • Humphreys BD.Slow-cycling cells in renal papilla: stem cells awaken?.J Am Soc Nephrol. 2009 Nov;20(11):2277-9.
  • Humphreys BD, Atkins MB.Rapid development of hypertension by sorafenib: toxicity or target?.Clin Cancer Res. 2009 Oct 1;15(19):5947-9.
  • Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV.Intrinsic epithelial cells repair the kidney after injury.Cell Stem Cell. 2008 Mar 6;2(3):284-91.
  • Patel TV, Morgan JA, Demetri GD, George S, Maki RG, Quigley M, Humphreys BD.A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib.Journal of the National Cancer Institute. 2008 Feb 20;100(4):282-4.
  • Humphreys BD, Soiffer RJ, Magee CC.Renal failure associated with cancer and its treatment: an update.J Am Soc Nephrol. 2005 Jan;16(1):151-61.