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Peter Sorger, PhD

Publications

  • Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma'ayan A.LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.Nucleic Acids Res. 2014 Jun 6.
    24906883
  • Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, Sorger PK.Analysis of growth factor signaling in genetically diverse breast cancer lines.BMC Biol. 2014;12(1):20.
    24655548
  • Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, Eils R.Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Sci Signal. 2014 Mar 11;7(316):ra23.
    24619646
  • Koch Y, Wolf T, Sorger PK, Eils R, Brors B.Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states.PLoS ONE. 2013;8(12):e82593.
    24367526
  • Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, Stuart JM.Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE).Bioinformatics. 2013 Nov 1;29(21):2757-64.
    23986566
  • Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK.Metrics other than potency reveal systematic variation in responses to cancer drugs.Nat Chem Biol. 2013 Nov;9(11):708-14.
    24013279
  • Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, Sorger PK.Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines.Sci Signal. 2013 Sep 24;6(294):ra84.
    24065145
  • Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G.S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase.Cell. 2013 Aug 29;154(5):1127-39.
    23993100
  • Flusberg DA, Roux J, Spencer SL, Sorger PK.Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes.Mol Biol Cell. 2013 Jul;24(14):2186-200.
    23699397
  • Flusberg DA, Sorger PK.Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging.Phys Biol. 2013 Jun;10(3):035002.
    23735516
  • Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R.Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.Nat Commun. 2013;4:1504.
    23422672
  • Sorger PK, Schoeberl B.An expanding role for cell biologists in drug discovery and pharmacology.Mol Biol Cell. 2012 Nov;23(21):4162-4.
    23112228
  • Spencer SL, Sorger PK.Measuring and modeling apoptosis in single cells.Cell. 2011 Mar 18;144(6):926-39.
    21414484
  • Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA.Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.PLoS Comput. Biol. 2011 Mar;7(3):e1001099.
    21408212
  • Luckert K, Goetschel F, Sorger PK, Hecht A, Joos TO, Poetz O.Snapshots of protein dynamics and posttranslational modifications in one experiment - [beta]-catenin and its functions.Mol Cell Proteomics. 2011 Mar 4.
    21378377
  • Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS.Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line.Mol Biosyst. 2010 Oct 1;6(10):1956-72.
    20617251
  • Chen WW, Niepel M, Sorger PK.Classic and contemporary approaches to modeling biochemical reactions.Genes Dev. 2010 Sep 1;24(17):1861-75. Review.
    20810646
  • Alexopoulos LG, Saez Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK.Networks inferred from biochemical data reveal profound differences in TLR and inflammatory signaling between normal and transformed hepatocytes.Mol Cell Proteomics. 2010 Sep;9(9):1849-65.
    20460255
  • Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA.Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.Mol Biosyst. 2010 Jul 15;6(7):1195-206.
    20361094
  • Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim do H.Systematic calibration of a cell signaling network model.BMC Bioinformatics. 2010;11:202.
    20416044
  • Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA.Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations.Cancer Res. 2010 May 1;70(9):3843-50.
    20406974
  • Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA.Logic-based models for the analysis of cell signaling networks.Biochemistry. 2010 Apr 20;49(15):3216-24. Review.
    20225868
  • Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G.Towards a rigorous assessment of systems biology models: the DREAM3 challenges.PLoS ONE. 2010;5(2):e9202.
    20186320
  • Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK.Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.Mol Syst Biol. 2009;5:331.
    19953085
  • Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK.Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.Nature. 2009 May 21;459(7245):428-32.
    19363473
  • Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK.Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.Mol Syst Biol. 2009;5:239.
    19156131
  • Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK.Modeling a snap-action, variable-delay switch controlling extrinsic cell death.PLoS Biol. 2008 Dec 2;6(12):2831-52.
    19053173
  • Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK.Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.Mol Cell. 2008 Apr 11;30(1):11-25.
    18406323
  • Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK.The response of human epithelial cells to TNF involves an inducible autocrine cascade.Cell. 2006 Mar 24;124(6):1225-39.
    16564013
  • Meraldi P, Draviam VM, Sorger PK.Timing and checkpoints in the regulation of mitotic progression.Dev Cell. 2004 Jul;7(1):45-60.
    15239953