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Alec Kimmelman, MD, PhD

Publications

  • Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC.Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations.Cancer Discovery. 2014 Aug(8):905-13.
    24875860
  • Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G.Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.Nat Med. 2014 Jun;20(6):599-606.
    24813251
  • Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS, McCleary NJ, Meyerhardt JA, Ng K, Schrag D, Sikora AL, Spicer BA, Killion L, Mamon H, Kimmelman AC.Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma.Oncologist. 2014 Jun;19(6):637-8.
    24821822
  • Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC.Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.Nature. 2014 May 1(7498):105-9.
    24695223
  • Sousa CM, Kimmelman AC.The Complex Landscape of Pancreatic Cancer Metabolism.Carcinogenesis. 2014 Apr 17.
    24743516
  • Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG, Bardeesy N, Wong KK.D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.Genes Dev. 2014 Mar 1;28(5):479-90.
    24589777
  • Bryant KL, Mancias JD, Kimmelman AC, Der CJ.KRAS: feeding pancreatic cancer proliferation.Trends Biochem Sci. 2014 Feb;39(2):91-100.
    24388967
  • Wallner PE, Anscher MS, Barker CA, Bassetti M, Bristow RG, Cha YI, Dicker AP, Formenti SC, Graves EE, Hahn SM, Hei TK, Kimmelman AC, Kirsch DG, Kozak KR, Lawrence TS, Marples B, McBride WH, Mikkelsen RB, Park CC, Weidhaas JB, Zietman AL, Steinberg M.Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary.Int J Radiat Oncol Biol Phys. 2014 Jan 1;88(1):11-7.
    24246724
  • Shimamura T, Chen Z, Soucheray M, Carretero J, Kikuchi E, Tchaicha JH, Gao Y, Cheng KA, Cohoon TJ, Qi J, Akbay E, Kimmelman AC, Kung AL, Bradner JE, Wong KK.Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer.Clin Cancer Res. 2013 Nov 15;19(22):6183-92.
    24045185
  • Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK.Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.Cancer Discovery. 2013 Aug;3(8):870-9.
    23715154
  • Lyssiotis CA, Son J, Cantley LC, Kimmelman AC.Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance.Cell Cycle. 2013 Jul 1;12(13):1987-8.
    23759579
  • Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC.SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.Cancer Cell. 2013 Apr 15;23(4):450-63.
    23562301
  • O'Connor KW, Dejsuphong D, Park E, Nicolae CM, Kimmelman AC, D'Andrea AD, Moldovan GL.PARI Overexpression Promotes Genomic Instability and Pancreatic Tumorigenesis.Cancer Res. 2013 Apr 15;73(8):2529-39.
    23436799
  • Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, Depinho RA, Cantley LC, Kimmelman AC.Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.Nature. 2013 Mar 27.
    23535601
  • Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM.DNA Damage Enhancement from Gold Nanoparticles for Clinical MV Photon Beams.Radiat Res. 2012 Nov 13.
    23148509
  • Li YH, Wang X, Pan Y, Lee DH, Chowdhury D, Kimmelman AC.Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response.PLoS ONE. 2012;7(6):e39588.
    22724027
  • Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.Pancreatic cancers require autophagy for tumor growth.Genes Dev. 2011 Apr 1;25(7):717-29.
    21406549
  • Kimmelman AC,Hezel AF,Aguirre AJ,Zheng H,Paik JH,Ying H,Chu GC,Zhang JX,Sahin E,Yeo G,Ponugoti A,Nabioullin R,Deroo S,Yang S,Wang X,McGrath JP,Protopopova M,Ivanova E,Zhang J,Feng B,Tsao MS,Redston M,Protopopov A,Xiao Y,Futreal PA,Hahn WC,Klimstra DS,Chin L,DePinho RA.Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19372-7.
    19050074
  • Zheng H,Ying H,Yan H,Kimmelman AC,Hiller DJ,Chen AJ,Perry SR,Tonon G,Chu GC,Ding Z,Stommel JM,Dunn KL,Wiedemeyer R,You MJ,Brennan C,Wang YA,Ligon KL,Wong WH,Chin L,DePinho RA.p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.Nature. 2008 Oct 23;455(7216):1129-33.
    18948956
  • Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA.Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.Cancer Res. 2007 Nov 15;67(22):10736-43.
    18006816
  • Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA.Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.Science. 2007 Oct 12;318(5848):287-90.
    17872411
  • Chu GC, Kimmelman AC, Hezel AF, Depinho RA.Stromal biology of pancreatic cancer.J Cell Biochem. 2007 Jul 1;101(4):887-907. Review.
    17266048
  • Nuñez Rodriguez N, Lee IN, Banno A, Qiao HF, Qiao RF, Yao Z, Hoang T, Kimmelman AC, Chan AM.Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.Mol Cell Biol. 2006 Oct;26(19):7145-54.
    16980617
  • Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA.Genetics and biology of pancreatic ductal adenocarcinoma.Genes Dev. 2006 May 15;20(10):1218-49. Review.
    16702400
  • Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD, Nuñez Rodriguez N, Liang BC, Guha A, Martignetti JA, Friedman SL, Chan AM.Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.Oncogene. 2004 Jun 24;23(29):5077-83.
    15064720
  • Kimmelman AC, Nuñez Rodriguez N, Chan AM.R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.Mol Cell Biol. 2002 Aug;22(16):5946-61.
    12138204
  • Chan TO, Rodeck U, Chan AM, Kimmelman AC, Rittenhouse SE, Panayotou G, Tsichlis PN.Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.Cancer Cell. 2002 Mar;1(2):181-91.
    12086876