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James W. Rocco, MD, PhD


  • Akagi K, Li J, Broutian TR, Padilla-Nash H, Xiao W, Jiang B, Rocco JW, Teknos TN, Kumar B, Wangsa D, He D, Ried T, Symer DE, Gillison ML.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.Genome Res. 2014 Feb;24(2):185-99.
  • Bonilla-Velez J, Mroz EA, Hammon RJ, Rocco JW.Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment.Otolaryngol. Clin. North Am. 2013 Aug;46(4):521-43.
  • Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW.High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma.Cancer. 2013 Aug 15;119(16):3034-42.
  • Puram SV, Hasserjian RP, Faquin WC, Lin HW, Rocco JW.Castleman disease presenting in the neck: Report of a case and review of the literature.Am J Otolaryngol. 2013 Jan 31.
  • Mroz EA, Rocco JW.Gene expression analysis as a tool in early-stage oral cancer management.J Clin Oncol. 2012 Nov 20;30(33):4053-5.
  • Mroz EA, Rocco JW.MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma.Oral Oncol. 2012 Oct 15.
  • Ory B, Ramsey MR, Wilson C, Vadysirisack DD, Forster N, Rocco JW, Rothenberg SM, Ellisen LW.A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.J Clin Invest. 2011 Feb 1;121(2):809-20.
  • Hammon RJ, Lin HW, Sadow PM, Lin DT, Rocco JW.Pathology quiz case 1.Arch. Otolaryngol. Head Neck Surg. 2011 Feb;137(2):198.
  • Silver AL, Farkash EA, Pitman MB, Rocco JW.Rosai-Dorfman disease presenting in the oropharynx.Head Neck. 2010 Jun 11.
  • Nichols AC, Kneuertz PJ, Deschler DG, Lin DT, Emerick KS, Clark JR, Busse PW, Rocco JW.Surgical salvage of the oropharynx after failure of organ-sparing therapy.Head Neck. 2010 Jul 22.
  • Nichols AC, Finkelstein DM, Faquin WC, Westra WH, Mroz EA, Kneuertz P, Begum S, Michaud WA, Busse PM, Clark JR, Rocco JW.Bcl2 and Human Papilloma Virus 16 as Predictors of Outcome following Concurrent Chemoradiation for Advanced Oropharyngeal Cancer.Clin Cancer Res. 2010 Apr 1;16(7):2138-46.
  • Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA.A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.Cancer Res. 2010 Mar 15;70(6):2158-64.
  • Mroz EA, Rocco JW.Functional p53 status as a biomarker for chemotherapy response in oral-cavity cancer.J Clin Oncol. 2010 Feb 10;28(5):715-7.
  • Leuin SC, Faquin WC, Pilch BZ, Rocco JW.Pathology quiz case 2. Sarcoidosis.Arch. Otolaryngol. Head Neck Surg. 2009 Jun;135(6):617, 619-20.
  • Michaud WA,Nichols AC,Mroz EA,Faquin WC,Clark JR,Begum S,Westra WH,Wada H,Busse PM,Ellisen LW,Rocco JW.Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma.Clin Cancer Res. 2009 Mar 1;15(5):1645-54.
  • Nichols AC, Faquin WC, Westra WH, Mroz EA, Begum S, Clark JR, Rocco JW.HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma.Otolaryngology Head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology Head And Neck Surgery. 2009 Feb;140(2):228-34.
  • Mroz EA, Baird AH, Michaud WA, Rocco JW.COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.Cancer Res. 2008 Aug 1;68(15):6049-53.
  • Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ.Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.PLoS Genet. 2006 Nov 17;2(11):e196.
  • Mroz EA, Rocco JW.RNA interference: natural, experimental, and clinical roles in cancer biology.Head Neck. 2006 Dec;28(12):1132-41. Review.
  • Deyoung MP, Johannessen CM, Leong CO, Faquin W, Rocco JW, Ellisen LW.Tumor-Specific p73 Up-regulation Mediates p63 Dependence in Squamous Cell Carcinoma.Cancer Res. 2006 Oct 1;66(19):9362-8.
  • Rocco JW, Ellisen LW.p63 and p73: life and death in squamous cell carcinoma.Cell Cycle. 2006 May;5(9):936-40.
  • Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW.p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.Cancer Cell. 2006 Jan;9(1):45-56.
  • Emerick KS, Mehta A, Pilch BZ, Deschler DG, Busse PM, Rocco JW.Pathology quiz case 1. Adenocarcinoma with features of mucinous adenocarcinoma (MAC) and cystadenocarcinoma (CAC).Arch. Otolaryngol. Head Neck Surg. 2005 Dec;131(12):1120, 1122-3.
  • Cohen EE, Lingen MW, Martin LE, Harris PL, Brannigan BW, Haserlat SM, Okimoto RA, Sgroi DC, Dahiya S, Muir B, Clark JR, Rocco JW, Vokes EE, Haber DA, Bell DW.Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR.Clin Cancer Res. 2005 Nov 15;11(22):8105-8.
  • Amrein PC, Clark JR, Supko JG, Fabian RL, Wang CC, Colevas AD, Posner MR, Deschler DG, Rocco JW, Finkelstein DM, McIntyre JF.Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma.Cancer. 2005 Oct 1;104(7):1418-27.
  • Shin JJ, Katayama T, Michaud WA, Rocco JW.Short hairpin RNA system to inhibit human p16 in squamous cell carcinoma.Arch. Otolaryngol. Head Neck Surg. 2004 Jan;130(1):68-73.
  • Ung F, Rocco JW, Deschler DG.Temporary intraoperative external fixation in mandibular reconstruction.Laryngoscope. 2002 Sep;112(9):1569-73.