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Christos S. Mantzoros, MD, DSc, PhD h.c. mult.


  • Moon HS, Mantzoros CS.Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines.Metabolism. 2014 Feb;63(2):188-93.
  • Dalamaga M, Karmaniolas K, Chamberland J, Nikolaidou A, Lekka A, Dionyssiou-Asteriou A, Mantzoros CS.Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome.Metabolism. 2013 Dec;62(12):1830-9.
  • Moon HS, Mantzoros CS.Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer.Endocr. Relat. Cancer. 2013;20(6):849-59.
  • Vamvini MT, Aronis KN, Panagiotou G, Huh JY, Chamberland JP, Brinkoetter MT, Petrou M, Christophi CA, Kales SN, Christiani DC, Mantzoros CS.Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.European Journal Of Endocrinology / European Federation Of Endocrine Societies. 2013;169(6):829-34.
  • Aronis KN, Chamberland JP, Mantzoros CS.GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways.Metabolism. 2013 Sep;62(9):1279-86.
  • Huffman DM, Augenlicht LH, Zhang X, Lofrese JJ, Atzmon G, Chamberland JP, Mantzoros CS.Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.Cancer Prev Res (Phila Pa). 2013 Mar;6(3):177-87.
  • Dalamaga M, Diakopoulos KN, Mantzoros CS.The role of adiponectin in cancer: a review of current evidence.Endocr. Rev. 2012 Aug;33(4):547-94.
  • Petridou ET, Sergentanis TN, Antonopoulos CN, Dessypris N, Matsoukis IL, Aronis K, Efremidis A, Syrigos C, Mantzoros CS.Insulin resistance: an independent risk factor for lung cancer?.Metabolism. 2011 Jan 18.
  • Baur DM, Klotsche J, Hamnvik OP, Sievers C, Pieper L, Wittchen HU, Stalla GK, Schmid RM, Kales SN, Mantzoros CS.Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort.Metabolism. 2010 Nov 15.
  • Nagel JM, Kriegl L, Horst D, Engel J, Gautam S, Mantzoros CS, Kirchner T, Göke B, Kolligs FT.γ-Catenin is an independent prognostic marker in early stage colorectal cancer.Int J Colorectal Dis. 2010 Nov;25(11):1301-9.
  • Dalamaga M, Crotty BH, Fargnoli J, Papadavid E, Lekka A, Triantafilli M, Karmaniolas K, Migdalis I, Dionyssiou-Asteriou A, Mantzoros CS.B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case-control study in Greece.Cancer Causes Control. 2010 Sep;21(9):1451-9.
  • Kotsopoulos J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willett WC, Hankinson SE, Eliassen AH.Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies.Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):938-46.
  • Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Mantzoros CS, Hu FB.Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels.Hum Mol Genet. 2010 May 1;19(9):1846-55.
  • Ligibel JA,Giobbie-Hurder A,Olenczuk D,Campbell N,Salinardi T,Winer EP,Mantzoros CS.Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors.Cancer Causes Control. 2009 Oct;20(8):1523-8.
  • Fargnoli JL, Sun Q, Olenczuk D, Qi L, Zhu Y, Hu FB, Mantzoros CS.Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function.European Journal Of Endocrinology / European Federation Of Endocrine Societies. 2010 Feb;162(2):281-8.
  • Petridou ET, Sergentanis TN, Dessypris N, Vlachantoni IT, Tseleni-Balafouta S, Pourtsidis A, Moschovi M, Polychronopoulou S, Athanasiadou-Piperopoulou F, Kalmanti M, Mantzoros CS.Serum adiponectin as a predictor of childhood non-Hodgkin's lymphoma: a nationwide case-control study.J Clin Oncol. 2009 Oct 20;27(30):5049-55.
  • Dalamaga M, Migdalis I, Fargnoli JL, Papadavid E, Bloom E, Mitsiades N, Karmaniolas K, Pelecanos N, Tseleni-Balafouta S, Dionyssiou-Asteriou A, Mantzoros CS.Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study.Cancer Causes Control. 2009 Jul;20(5):625-33.
  • Scheer FA, Hilton MF, Mantzoros CS, Shea SA.Adverse metabolic and cardiovascular consequences of circadian misalignment.Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4453-8.
  • Heidemann C,Schulze MB,Franco OH,van Dam RM,Mantzoros CS,Hu FB.Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women.Circulation. 2008 Jul 15;118(3):230-7.
  • Kaklamani VG, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, Ahsan H, Pasche B, Mantzoros C.Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk.Cancer Res. 2008 May 1;68(9):3178-84.
  • Petridou ET, Mitsiades N, Gialamas S, Angelopoulos M, Skalkidou A, Dessypris N, Hsi A, Lazaris N, Polyzos A, Syrigos C, Brennan AM, Tseleni-Balafouta S, Mantzoros CS.Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies.Oncology. 2007;73(3-4):261-9.
  • Williams CJ, Mitsiades N, Sozopoulos E, Hsi A, Wolk A, Nifli AP, Tseleni-Balafouta S, Mantzoros CS.Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.Endocr. Relat. Cancer. 2008 Mar;15(1):289-99.
  • Barb D, Williams CJ, Neuwirth AK, Mantzoros CS.Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence.Am J Clin Nutr. 2007 Sep;86(3):s858-66. Review.
  • Körner A, Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Williams CJ, Kaprara A, Bullen J, Neuwirth A, Tseleni S, Mitsiades N, Kiess W, Mantzoros CS.Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies.J Clin Endocrinol Metab. 2007 Mar;92(3):1041-8.
  • Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, Giannopoulos A, Mantzoros CS.Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study.Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):308-13.
  • Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CS, .Low adiponectin levels are associated with renal cell carcinoma: a case-control study.Int J Cancer. 2007 Apr 1;120(7):1573-8.
  • Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros CS, Hankinson SE.Plasma adiponectin concentrations and risk of incident breast cancer.J Clin Endocrinol Metab. 2007 Apr;92(4):1510-6.
  • Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS.Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study.J Natl Cancer Inst. 2005 Nov 16;97(22):1688-94.