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Martin E. Hemler, PhD


  • Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi Y, Zhou P, Stipp CS, Kaetzel DM, Hemler ME, Yang XH.Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.Neoplasia. 2012 Aug;14(8):678-89.
  • Wang HX, Li Q, Sharma C, Knoblich K, Hemler ME.Tetraspanin protein contributions to cancer.Biochem Soc Trans. 2011 Apr 1;39(2):547-52.
  • Yang XH, Flores LM, Li Q, Zhou P, Xu F, Krop IE, Hemler ME.Disruption of Laminin-Integrin-CD151-Focal Adhesion Kinase Axis Sensitizes Breast Cancer Cells to ErbB2 Antagonists.Cancer Res. 2010 Mar 15;70(6):2256-63.
  • Xu D, Sharma C, Hemler ME.Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.FASEB J. 2009 Nov;23(11):3674-81.
  • Lafleur MA,Xu D,Hemler ME.Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis.Mol Biol Cell. 2009 Apr;20(7):2030-40.
  • Kolesnikova TV,Kazarov AR,Lemieux ME,Lafleur MA,Kesari S,Kung AL,Hemler ME.Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo.Neoplasia. 2009 Jan;11(1):77-86, 4p following 86.
  • Fiorentino M,Zadra G,Palescandolo E,Fedele G,Bailey D,Fiore C,Nguyen PL,Migita T,Zamponi R,Di Vizio D,Priolo C,Sharma C,Xie W,Hemler ME,Mucci L,Giovannucci E,Finn S,Loda M.Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer.Lab Invest. 2008 Dec;88(12):1340-8.
  • Hemler ME.Targeting of tetraspanin proteins--potential benefits and strategies.Nat Rev Drug Discov. 2008 Sep;7(9):747-58. Review.
  • Sharma C,Yang XH,Hemler ME.DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.Mol Biol Cell. 2008 Aug;19(8):3415-25.
  • Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME.CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.Cancer Res. 2008 May 1;68(9):3204-13.
  • Kovalenko OV, Yang XH, Hemler ME.A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9.Mol Cell Proteomics. 2007 Nov;6(11):1855-67.
  • Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME.Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.Blood. 2007 Feb 15;109(4):1524-32.
  • Wunschmann S, Muller HM, Stipp CS, Hemler ME, Stapleton JT.In vitro interaction between hepatitis C virus (HCV) envelope glycoprotein E2 and serum lipoproteins (LPs) results in enhanced cellular binding of both HCV E2 and LPs.J Infect Dis. 2006 Oct 15;194(8):1058-67.
  • Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME.Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.J Biol Chem. 2006 May 5;281(18):12976-85.
  • Kovalenko OV, Metcalf DG, DeGrado WF, Hemler ME.Structural organization and interactions of transmembrane domains in tetraspanin proteins.BMC Struct Biol. 2005 Jun 28;5:11.
  • Xu D, Hemler ME.Metabolic activation-related CD147-CD98 complex.Mol Cell Proteomics. 2005 Aug;4(8):1061-71.
  • Yang X, Kovalenko OV, Tang W, Claas C, Stipp CS, Hemler ME.Palmitoylation supports assembly and function of integrin-tetraspanin complexes.J Cell Biol. 2004 Dec 20;167(6):1231-40.
  • Tang W, Chang SB, Hemler ME.Links between CD147 function, glycosylation, and caveolin-1.Mol Biol Cell. 2004 Sep;15(9):4043-50.
  • Little KD, Hemler ME, Stipp CS.Dynamic Regulation of a GPCR-Tetraspanin-G Protein Complex on Intact Cells: Central Role of CD81 in Facilitating GPR56-G{alpha}q/11 Association.Mol Biol Cell. 2004 May;15(5):2375-87.
  • Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME.EWI-2 modulates lymphocyte integrin {alpha}4{beta}1 functions.Blood. 2004 Apr 15;103(8):3013-3019.
  • Tang W, Hemler ME.Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering.J Biol Chem. 2004 Mar 19;279(12):11112-8.
  • Stipp CS, Kolesnikova TV, Hemler ME.EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5.J Cell Biol. 2003 Dec 8;163(5):1167-77.
  • Hemler ME.Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain.Annu Rev Cell Dev Biol. 2003;19:397-422.
  • Kovalenko OV, Yang X, Kolesnikova TV, Hemler ME.Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking.Biochem J. 2004 Jan 15;377(Pt 2):407-17.
  • Lammerding J, Kazarov AR, Huang H, Lee RT, Hemler ME.Tetraspanin CD151 regulates alpha6beta1 integrin adhesion strengthening.Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7616-21.
  • Stipp CS, Kolesnikova TV, Hemler ME.Functional domains in tetraspanin proteins.Trends Biochem Sci. 2003 Feb;28(2):106-12.
  • Kazarov AR, Yang X, Stipp CS, Sehgal B, Hemler ME.An extracellular site on tetraspanin CD151 determines alpha 3 and alpha 6 integrin-dependent cellular morphology.J Cell Biol. 2002 Sep 30;158(7):1299-309.
  • Yang X, Claas C, Kraeft SK, Chen LB, Wang Z, Kreidberg JA, Hemler ME.Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.Mol Biol Cell. 2002 Mar;13(3):767-81.
  • Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME.Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.Mol Biol Cell. 2002 Jan;13(1):1-11.
  • Hemler ME.Specific tetraspanin functions.J Cell Biol. 2001 Dec 24;155(7):1103-7.
  • Hemler ME.Retooling of the beta 4 integrin in tumor cells--ligands lost and kinase gained.Dev Cell. 2001 Dec;1(6):728-30.
  • Kolesnikova TV, Mannion BA, Berditchevski F, Hemler ME.Beta1 integrins show specific association with CD98 protein in low density membranes.BMC Biochem. 2001;2(1):10.
  • Stipp CS, Kolesnikova TV, Hemler ME.EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.J Biol Chem. 2001 Nov 2;276(44):40545-54.
  • Zhang XA, Bontrager AL, Hemler ME.Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins.J Biol Chem. 2001 Jul 6;276(27):25005-13.
  • Sun J, Hemler ME.Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions.Cancer Res. 2001 Mar 1;61(5):2276-81.
  • Zhang XA, Bontrager AL, Stipp CS, Kraeft SK, Bazzoni G, Chen LB, Hemler ME.Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.Mol Biol Cell. 2001 Feb;12(2):351-65.
  • Claas C, Stipp CS, Hemler ME.Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts.J Biol Chem. 2001 Mar 16;276(11):7974-84.
  • Stipp CS, Orlicky D, Hemler ME.FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein.J Biol Chem. 2001 Feb 16;276(7):4853-62.
  • Yauch RL, Hemler ME.Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase.Biochem J. 2000 Nov 1;351 Pt 3:629-37.
  • Stipp CS, Hemler ME.Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth.J Cell Sci. 2000 Jun;113 ( Pt 11):1871-82.
  • Tachibana I, Hemler ME.Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance.J Cell Biol. 1999 Aug 23;146(4):893-904.
  • Zhang XA, Hemler ME.Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein.J Biol Chem. 1999 Jan 1;274(1):11-9.
  • Mannion BA, Kolesnikova TV, Lin SH, Wang S, Thompson NL, Hemler ME.The light chain of CD98 is identified as E16/TA1 protein.J Biol Chem. 1998 Dec 11;273(50):33127-9.
  • Yauch RL, Berditchevski F, Harler MB, Reichner J, Hemler ME.Highly stoichiometric, stable, and specific association of integrin alpha3beta1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration.Mol Biol Cell. 1998 Oct;9(10):2751-65.
  • Pujades C, Alon R, Yauch RL, Masumoto A, Burkly LC, Chen C, Springer TA, Lobb RR, Hemler ME.Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding.Mol Biol Cell. 1997 Dec;8(12):2647-57.
  • Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME.NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.J Biol Chem. 1997 Nov 14;272(46):29181-9.
  • Yauch RL, Felsenfeld DP, Kraeft SK, Chen LB, Sheetz MP, Hemler ME.Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding.J Exp Med. 1997 Oct 20;186(8):1347-55.
  • Berditchevski F, Tolias KF, Wong K, Carpenter CL, Hemler ME.A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.J Biol Chem. 1997 Jan 31;272(5):2595-8.
  • Weitzman JB, Pujades C, Hemler ME.Integrin alpha chain cytoplasmic tails regulate "antibody-redirected" cell adhesion, independently of ligand binding.Eur J Immunol. 1997 Jan;27(1):78-84.
  • Bazzoni G, Carlesso N, Griffin JD, Hemler ME.Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.J Clin Invest. 1996 Jul 15;98(2):521-8.
  • Hemler ME, Mannion BA, Berditchevski F.Association of TM4SF proteins with integrins: relevance to cancer.Biochim Biophys Acta. 1996 Jun 7;1287(2-3):67-71.
  • Berditchevski F, Zutter MM, Hemler ME.Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins).Mol Biol Cell. 1996 Feb;7(2):193-207.
  • Bazzoni G, Shih DT, Buck CA, Hemler ME.Monoclonal antibody 9EG7 defines a novel beta 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium.J Biol Chem. 1995 Oct 27;270(43):25570-7.
  • Berditchevski F, Bazzoni G, Hemler ME.Specific association of CD63 with the VLA-3 and VLA-6 integrins.J Biol Chem. 1995 Jul 28;270(30):17784-90.
  • Kassner PD, Alon R, Springer TA, Hemler ME.Specialized functional properties of the integrin alpha 4 cytoplasmic domain.Mol Biol Cell. 1995 Jun;6(6):661-74.
  • Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA.The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.J Cell Biol. 1995 Mar;128(6):1243-53.
  • Lobb RR, Hemler ME.The pathophysiologic role of alpha 4 integrins in vivo.J Clin Invest. 1994 Nov;94(5):1722-8.
  • Kassner PD, Kawaguchi S, Hemler ME.Minimum alpha chain cytoplasmic tail sequence needed to support integrin-mediated adhesion.J Biol Chem. 1994 Aug 5;269(31):19859-67.
  • Masumoto A, Hemler ME.Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin.J Cell Biol. 1993 Oct;123(1):245-53.
  • Kawaguchi S, Hemler ME.Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2.J Biol Chem. 1993 Aug 5;268(22):16279-85.
  • Bergelson JM, Chan BM, Finberg RW, Hemler ME.The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms.J Clin Invest. 1993 Jul;92(1):232-9.
  • Chan BM, Hemler ME.Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.J Cell Biol. 1993 Jan;120(2):537-43.
  • Bergelson JM, Shepley MP, Chan BM, Hemler ME, Finberg RW.Identification of the integrin VLA-2 as a receptor for echovirus 1.Science. 1992 Mar 27;255(5052):1718-20.
  • Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME.Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains.Cell. 1992 Mar 20;68(6):1051-60.
  • Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR.VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.Cell. 1990 Feb 23;60(4):577-84.
  • Hemler ME.VLA proteins in the integrin family: structures, functions, and their role on leukocytes.Annu Rev Immunol. 1990;8:365-400.
  • Hemler ME, Huang C, Takada Y, Schwarz L, Strominger JL, Clabby ML.Characterization of the cell surface heterodimer VLA-4 and related peptides.J Biol Chem. 1987 Aug 25;262(24):11478-85.
  • Takada Y, Huang C, Hemler ME.Fibronectin receptor structures in the VLA family of heterodimers.Nature. 1987 Apr 9-15;326(6113):607-9.