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Franziska Michor, PhD

Publications

  • Podlaha O, De S, Gonen M, Michor F.Histone modifications are associated with transcript isoform diversity in normal and cancer cells.PLoS Comput. Biol. 2014 Jun;10(6):e1003611.
    24901363
  • Guancial EA, Werner L, Bellmunt J, Bamias A, Choueiri TK, Ross R, Schutz FA, Park RS, O'Brien RJ, Hirsch MS, Barletta JA, Berman DM, Lis R, Loda M, Stack EC, Garraway LA, Riester M, Michor F, Kantoff PW, Rosenberg JE.FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.Cancer Med. 2014 May 21.
    24846059
  • Riester M, Wei W, Waldron L, Culhane AC, Trippa L, Oliva E, Kim SH, Michor F, Huttenhower C, Parmigiani G, Birrer MJ.Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.Journal of the National Cancer Institute. 2014 May(5).
    24700803
  • Foo J, Michor F.Evolution of acquired resistance to anti-cancer therapy.J Theor Biol. 2014 Mar 25;355C:10-20.
    24681298
  • Michor F, Weaver VM.Understanding tissue context influences on intratumour heterogeneity.Nat Cell Biol. 2014 Apr 1;16(4):301-2.
    24691256
  • Riester M, Werner L, Bellmunt J, Selvarajah S, Guancial EA, Weir BA, Stack EC, Park RS, O'Brien R, Schutz FA, Choueiri TK, Signoretti S, Lloreta J, Marchionni L, Gallardo E, Rojo F, Garcia DI, Chekaluk Y, Kwiatkowski DJ, Bochner BH, Hahn WC, Ligon AH, Barletta JA, Loda M, Berman DM, Kantoff PW, Michor F, Rosenberg JE.Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.Clin Cancer Res. 2014 Apr 1;20(7):1873-83.
    24486590
  • Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich R.Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.Blood. 2014 Mar 13;123(11):1699-708.
    24385541
  • Almendro V, Kim HJ, Cheng YK, Gönen M, Itzkovitz S, Argani P, van Oudenaarden A, Sukumar S, Michor F, Polyak K.Genetic and phenotypic diversity in breast tumor metastases.Cancer Res. 2014 Mar 1;74(5):1338-48.
    24448237
  • Almendro V, Cheng YK, Randles A, Itzkovitz S, Marusyk A, Ametller E, Gonzalez-Farre X, Muñoz M, Russnes HG, Helland A, Rye IH, Borresen-Dale AL, Maruyama R, van Oudenaarden A, Dowsett M, Jones RL, Reis-Filho J, Gascon P, Gönen M, Michor F, Polyak K.Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.Cell Rep. 2014 Feb 13;6(3):514-27.
    24462293
  • Leder K, Pitter K, Laplant Q, Hambardzumyan D, Ross BD, Chan TA, Holland EC, Michor F.Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules.Cell. 2014 Jan 30;156(3):603-16.
    24485463
  • Gallipoli P, Stobo J, Heaney N, Nicolini FE, Clark R, Wilson G, Tighe J, McLintock L, Hughes T, Michor F, Paul J, Drummond M, Holyoake TL.Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up.British Journal of Haematology. 2013 Dec;163(5):674-6.
    24032404
  • Jia P, Jin H, Meador CB, Xia J, Ohashi K, Liu L, Pirazzoli V, Dahlman KB, Politi K, Michor F, Zhao Z, Pao W.Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.Genome Res. 2013 Sep;23(9):1434-45.
    23733853
  • Haeno H, Maruvka YE, Iwasa Y, Michor F.Stochastic Tunneling of Two Mutations in a Population of Cancer Cells.PLoS ONE. 2013;8(6):e65724.
    23840359
  • Choudhury S, Almendro V, Merino VF, Wu Z, Maruyama R, Su Y, Martins FC, Fackler MJ, Bessarabova M, Kowalczyk A, Conway T, Beresford-Smith B, Macintyre G, Cheng YK, Lopez-Bujanda Z, Kaspi A, Hu R, Robens J, Nikolskaya T, Haakensen VD, Schnitt SJ, Argani P, Ethington G, Panos L, Grant M, Clark J, Herlihy W, Lin SJ, Chew G, Thompson EW, Greene-Colozzi A, Richardson AL, Rosson GD, Pike M, Garber JE, Nikolsky Y, Blum JL, Au A, Hwang ES, Tamimi RM, Michor F, Haviv I, Liu XS, Sukumar S, Polyak K.Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.Cell Stem Cell. 2013 Jul 3;13(1):117-30.
    23770079
  • Zhao R, Michor F.Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.PLoS Comput. Biol. 2013;9(6):e1003082.
    23785264
  • , Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.A physical sciences network characterization of non-tumorigenic and metastatic cells.Sci Rep. 2013 Apr 25;3:1449.
    23618955
  • Ohashi K, Maruvka YE, Michor F, Pao W.Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease.J Clin Oncol. 2013 Mar 10;31(8):1070-80.
    23401451
  • Liu L, De S, Michor F.DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.Nat Commun. 2013;4:1502.
    23422670
  • De S, Shaknovich R, Riester M, Elemento O, Geng H, Kormaksson M, Jiang Y, Woolcock B, Johnson N, Polo JM, Cerchietti L, Gascoyne RD, Melnick A, Michor F.Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.PLoS Genet. 2013 Jan;9(1):e1003137.
    23326238
  • De S, Michor F.Analyzing the association of SCNA boundaries with replication timing.Nat Biotechnol. 2012 Nov;30(11):1045-6.
    23138296
  • Foo J, Chmielecki J, Pao W, Michor F.Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer.J Thorac Oncol. 2012 Oct;7(10):1583-93.
    22982659
  • Martins FC, De S, Almendro V, Gönen M, Park SY, Blum JL, Herlihy W, Ethington G, Schnitt SJ, Tung N, Garber JE, Fetten K, Michor F, Polyak K.Evolutionary pathways in BRCA1-associated breast tumors.Cancer Discovery. 2012 Jun;2(6):503-11.
    22628410
  • Iwasa Y, Michor F.Evolutionary dynamics of intratumor heterogeneity.PLoS ONE. 2011;6(3):e17866.
    21479218
  • Durrett R, Foo J, Leder K, Mayberry J, Michor F.Intratumor Heterogeneity in Evolutionary Models of Tumor Progression.Genetics. 2011 Mar 15.
    21406679
  • Foo J, Leder K, Michor F.Stochastic dynamics of cancer initiation.Phys Biol. 2011 Feb;8(1):015002.
    21301064
  • De Vargas Roditi L, Michor F.Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis.J Theor Biol. 2011 Mar 21;273(1):207-15.
    21194536
  • Leder K, Holland EC, Michor F.The therapeutic implications of plasticity of the cancer stem cell phenotype.PLoS ONE. 2010;5(12):e14366.
    21179426
  • Michor F, Polyak K.The Origins and Implications of Intratumor Heterogeneity.Cancer Prev Res (Phila Pa). 2010 Nov;3(11):1361-4.
    20959519
  • Attolini CS, Cheng YK, Beroukhim R, Getz G, Abdel-Wahab O, Levine RL, Mellinghoff IK, Michor F.A mathematical framework to determine the temporal sequence of somatic genetic events in cancer.Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17604-9.
    20864632
  • Danielson LS, Menendez S, Attolini CS, Guijarro MV, Bisogna M, Wei J, Socci ND, Levine DA, Michor F, Hernando E.A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy.Am J Pathol. 2010 Aug;177(2):908-17.
    20558575
  • Durrett R, Foo J, Leder K, Mayberry J, Michor F.Evolutionary dynamics of tumor progression with random fitness values.Theor Popul Biol. 2010 Aug;78(1):54-66.
    20488197
  • Riester M, Stephan-Otto Attolini C, Downey RJ, Singer S, Michor F.A differentiation-based phylogeny of cancer subtypes.PLoS Comput. Biol. 2010 May;6(5):e1000777.
    20463876
  • Foo J, Michor F.Evolution of resistance to anti-cancer therapy during general dosing schedules.J Theor Biol. 2010 Mar 21;263(2):179-88.
    20004211
  • Haeno H, Michor F.The evolution of tumor metastases during clonal expansion.J Theor Biol. 2010 Mar 7;263(1):30-44.
    19917298
  • Park SY, Gönen M, Kim HJ, Michor F, Polyak K.Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.J Clin Invest. 2010 Feb 1;120(2):636-44.
    20101094
  • Foo J, Michor F.Evolution of resistance to targeted anti-cancer therapies during continuous and pulsed administration strategies.PLoS Comput. Biol. 2009 Nov;5(11):e1000557.
    19893626
  • Haeno H, Levine RL, Gilliland DG, Michor F.A progenitor cell origin of myeloid malignancies.Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16616-21.
    19805346
  • Michor F, Iwasa Y, Nowak MA.The age incidence of chronic myeloid leukemia can be explained by a one-mutation model.Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14931-4.
    17001000
  • Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, Sawyers CL, Nowak MA.Dynamics of chronic myeloid leukaemia.Nature. 2005 Jun 30;435(7046):1267-70.
    15988530