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David Kozono, MD, PhD


  • Parikh RB, Cronin AM, Kozono DE, Oxnard GR, Mak RH, Jackman DM, Lo PC, Baldini EH, Johnson BE, Chen AB.Definitive Primary Therapy in Patients Presenting With Oligometastatic Non-Small Cell Lung Cancer.Int J Radiat Oncol Biol Phys. 2014 May 24.
  • Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC.Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.Oncotarget. 2014 Feb 28;5(4):882-93.
  • Coroller TP, Mak RH, Lewis JH, Baldini EH, Chen AB, Colson YL, Hacker FL, Hermann G, Kozono D, Mannarino E, Molodowitch C, Wee JO, Sher DJ, Killoran JH.Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry.PLoS ONE. 2014;9(4):e94859.
  • Gazula A, Baldini EH, Chen A, Kozono D.Comparison of once and twice daily radiotherapy for limited stage small-cell lung cancer.Lung. 2014 Feb;192(1):151-8.
  • Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, Rameseder J, Chen CC, D'Andrea AD, Kozono D.Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer.PLoS ONE. 2013;8(9):e73710.
  • Morgan EA, Kozono DE, Wang Q, Mery CM, Butrynski JE, Baldini EH, George S, Nascimento AF, Raut CP.Cutaneous radiation-associated angiosarcoma of the breast: poor prognosis in a rare secondary malignancy.Ann Surg Oncol. 2012 Nov;19(12):3801-8.
  • Nehs MA, Lin CI, Kozono DE, Whang EE, Cho NL, Zhu K, Moalem J, Moore FD, Ruan DT.Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers.Surgery. 2011 Dec;150(6):1032-9.
  • Sturla LM, Zinn PO, Ng K, Nitta M, Kozono D, Chen CC, Kasper EM.Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma.Br J Cancer. 2011 Oct 11;105(8):1235-43.
  • Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC.Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.PLoS ONE. 2010;5(5):e10767.
  • Kahle KT, Kozono D, Ng K, Hsieh G, Zinn PO, Nitta M, Chen CC.Functional genomics to explore cancer cell vulnerabilities.Neurosurg Focus. 2010 Jan;28(1):E5.
  • Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM.Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18932-7.
  • Palanivelu DV, Kozono DE, Engel A, Suda K, Lustig A, Agre P, Schirmer T.Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals.J Mol Biol. 2006 Jan 27;355(4):605-11.
  • Liu K, Kozono D, Kato Y, Agre P, Hazama A, Yasui M.Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution.Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2192-7.
  • King LS, Kozono D, Agre P.From structure to disease: the evolving tale of aquaporin biology.Nat Rev Mol Cell Biol. 2004 Sep;5(9):687-98. Review.
  • Agre P, Kozono D.Aquaporin water channels: molecular mechanisms for human diseases.FEBS Lett. 2003 Nov 27;555(1):72-8. Review.
  • Kozono D, Ding X, Iwasaki I, Meng X, Kamagata Y, Agre P, Kitagawa Y.Functional expression and characterization of an archaeal aquaporin. AqpM from methanothermobacter marburgensis.J Biol Chem. 2003 Mar 21;278(12):10649-56.
  • Carbrey JM, Gorelick-Feldman DA, Kozono D, Praetorius J, Nielsen S, Agre P.Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2945-50.
  • Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M.Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63.J Biol Chem. 2002 Oct 18;277(42):39873-9.
  • Hazama A, Kozono D, Guggino WB, Agre P, Yasui M.Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation.J Biol Chem. 2002 Aug 9;277(32):29224-30.
  • Kozono D, Yasui M, King LS, Agre P.Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine.J Clin Invest. 2002 Jun;109(11):1395-9. Review.
  • Saparov SM, Kozono D, Rothe U, Agre P, Pohl P.Water and ion permeation of aquaporin-1 in planar lipid bilayers. Major differences in structural determinants and stoichiometry.J Biol Chem. 2001 Aug 24;276(34):31515-20.
  • Borgnia MJ, Kozono D, Calamita G, Maloney PC, Agre P.Functional reconstitution and characterization of AqpZ, the E. coli water channel protein.J Mol Biol. 1999 Sep 3;291(5):1169-79.