• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Bakhos A. Tannous, PhD


  • Teng J, Hejazi S, Badr CE, Tannous BA.Systemic anticancer neural stem cells in combination with a cardiac glycoside for glioblastoma therapy.Stem Cells. 2014 May 6.
  • Hiddingh L, Tannous BA, Teng J, Tops B, Jeuken J, Hulleman E, Boots-Sprenger SH, Vandertop WP, Noske DP, Kaspers GJ, Wesseling P, Wurdinger T.EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma.Oncotarget. 2014 Jan 30;5(2):363-74.
  • Elman JS, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B.Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells.PLoS ONE. 2014;9(2):e89882.
  • Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire CA, Chen JW, Tannous BA, Breakefield XO.Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter.ACS Nano. 2014 Jan 28;8(1):483-94.
  • Bovenberg MS, Degeling MH, Hejazi S, Amante RJ, van Keulen M, Jeuken JW, Akbaripanahi S, Vleggeert-Lankamp CL, Tannous M, Wesseling P, Wurdinger T, Tannous BA.Multiplex blood reporters for simultaneous monitoring of cellular processes.Anal Chem. 2013 Nov 5;85(21):10205-10.
  • Lai CP, Tannous BA, Breakefield XO.Noninvasive in vivo monitoring of extracellular vesicles.Methods Mol Biol. 2014;1098:249-58.
  • Lewandrowski GK, Magee CN, Mounayar M, Tannous BA, Azzi J.Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase.Methods Mol Biol. 2014;1098:211-27.
  • Tannous BA, Kerami M, Van der Stoop PM, Kwiatkowski N, Wang J, Zhou W, Kessler AF, Lewandrowski G, Hiddingh L, Sol N, Lagerweij T, Wedekind L, Niers JM, Barazas M, Nilsson RJ, Geerts D, De Witt Hamer PC, Hagemann C, Vandertop WP, Van Tellingen O, Noske DP, Gray NS, Würdinger T.Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.Journal of the National Cancer Institute. 2013 Sep 4;105(17):1322-31.
  • Maguire CA, Bovenberg MS, Crommentuijn MH, Niers JM, Kerami M, Teng J, Sena-Esteves M, Badr CE, Tannous BA.Triple bioluminescence imaging for in vivo monitoring of cellular processes.Mol Ther Nucleic Acids. 2013;2:e99.
  • Bovenberg MS, Degeling MH, Tannous BA.Cell-based Immunotherapy Against Gliomas: From Bench to Bedside.Mol Ther. 2013 May 7.
  • Bovenberg MS, Degeling MH, Tannous BA.Advances in stem cell therapy against gliomas.Trends Mol Med. 2013 Mar 25.
  • Badr CE, Van Hoppe S, Dumbuya H, Tjon-Kon-Fat LA, Tannous BA.Targeting Cancer Cells With the Natural Compound Obtusaquinone.Journal of the National Cancer Institute. 2013 Mar 11.
  • van Rijn S, Nilsson J, Noske DP, Vandertop WP, Tannous BA, Würdinger T.Functional multiplex reporter assay using tagged Gaussia luciferase.Sci Rep. 2013;3:1046.
  • Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK.Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3119-27.
  • Niers JM, Chen JW, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA.Single reporter for targeted multimodal in vivo imaging.J Am Chem Soc. 2012 Mar 21;134(11):5149-56.
  • Tannous BA, Teng J.Secreted blood reporters: Insights and applications.Biotechnol Adv. 2011 Nov;29(6):997-1003.
  • Badr CE, Tannous BA.Bioluminescence imaging: progress and applications.Trends Biotechnol. 2011 Jul 23.
  • Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA.Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway.Neuro Oncology. 2011 Jul 13.
  • Niers JM, Chen JW, Weissleder R, Tannous BA.Enhanced in vivo imaging of metabolically biotinylated cell surface reporters.Anal Chem. 2011 Feb 1;83(3):994-9.
  • Niers JM, Kerami M, Pike L, Lewandrowski G, Tannous BA.Multimodal In Vivo Imaging and Blood Monitoring of Intrinsic and Extrinsic Apoptosis.Mol Ther. 2011 Feb 22.
  • Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA, Würdinger T.miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.Oncotarget. 2010 Dec;1(8):710-20.
  • Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, Cloos J, Breakefield XO, Krichevsky AM, Noske DP, Tannous BA, Würdinger T.Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.PLoS ONE. 2011;6(1):e16282.
  • Badr CE, Wurdinger T, Tannous BA.Functional Drug Screening Assay Reveals Potential Glioma Therapeutics.Assay And Drug Development Technologies. 2010 Dec 27.
  • Mir SE, De Witt Hamer PC, Krawczyk PM, Balaj L, Claes A, Niers JM, Van Tilborg AA, Zwinderman AH, Geerts D, Kaspers GJ, Peter Vandertop W, Cloos J, Tannous BA, Wesseling P, Aten JA, Noske DP, Van Noorden CJ, Würdinger T.In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.Cancer Cell. 2010 Sep 14;18(3):244-57.
  • Sharma R, Tsuchiya M, Skobe Z, Tannous BA, Bartlett JD.The acid test of fluoride: how pH modulates toxicity.PLoS ONE. 2010;5(5):e10895.
  • Maguire CA, Deliolanis NC, Pike L, Niers JM, Tjon-Kon-Fat LA, Sena-Esteves M, Tannous BA.Gaussia luciferase variant for high-throughput functional screening applications.Anal Chem. 2009 Aug 15;81(16):7102-6.
  • Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO.Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter.Cancer Gene Ther. 2010 Apr;17(4):266-74.
  • Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK.Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.PLoS ONE. 2009;4(12):e8316.
  • Saydam O, Shen Y, Würdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, Breakefield XO.Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway.Mol Cell Biol. 2009 Nov;29(21):5923-40.
  • Badr CE, Niers JM, Tjon-Kon-Fat LA, Noske DP, Wurdinger T, Tannous BA.Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models.Mol Imaging.;8(5):278-90.
  • Deliolanis NC, Dunham J, Wurdinger T, Figueiredo JL, Bakhos T, Ntziachristos V.In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography.J Biomed Opt.;14(3):030509.
  • van Vuurden DG, Yazdani M, Bosma I, Broekhuizen AJ, Postma TJ, Heimans JJ, van der Valk P, Aronica E, Tannous BA, Würdinger T, Kaspers GJ, Cloos J.Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment.PLoS ONE. 2009;4(6):e5953.
  • Würdinger T, Tannous BA.Glioma angiogenesis: Towards novel RNA therapeutics.Cell Adh Migr. 2009 Apr;3(2):230-5. Review.
  • Tannous BA.Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo.Nat Protoc. 2009;4(4):582-91.
  • Tannous BA,Christensen AP,Pike L,Wurdinger T,Perry KF,Saydam O,Jacobs AH,Garcia-Anoveros J,Weissleder R,Sena-Esteves M,Corey DP,Breakefield XO.Mutant sodium channel for tumor therapy.Mol Ther. 2009 May;17(5):810-9.
  • Tannous B, Lee-Lewandrowski E, Sharples C, Brugge W, Bigatello L, Thompson T, Benzer T, Lewandrowski K.Comparison of conventional guaiac to four immunochemical methods for fecal occult blood testing: implications for clinical practice in hospital and outpatient settings.Clin Chim Acta. 2009 Feb;400(1-2):120-2.
  • Deliolanis NC,Kasmieh R,Wurdinger T,Tannous BA,Shah K,Ntziachristos V.Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications.J Biomed Opt. 2008 Jul-Aug;13(4):044008.
  • Wurdinger T,Tannous BA,Saydam O,Skog J,Grau S,Soutschek J,Weissleder R,Breakefield XO,Krichevsky AM.miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.Cancer Cell. 2008 Nov 4;14(5):382-93.
  • Lewandrowski K, Flood J, Finn C, Tannous B, Farris AB, Benzer TI, Lee-Lewandrowski E.Implementation of point-of-care rapid urine testing for drugs of abuse in the emergency department of an academic medical center: impact on test utilization and ED length of stay.Am J Clin Pathol. 2008 May;129(5):796-801.
  • Hewett JW, Nery FC, Niland B, Ge P, Tan P, Hadwiger P, Tannous BA, Sah DW, Breakefield XO.siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells.Hum Mol Genet. 2008 May 15;17(10):1436-45.
  • Wurdinger T,Badr C,Pike L,de Kleine R,Weissleder R,Breakefield XO,Tannous BA.A secreted luciferase for ex vivo monitoring of in vivo processes.Nat Methods. 2008 Feb;5(2):171-3.
  • Lee-Lewandrowski E, Januzzi JL, Green SM, Tannous B, Wu AH, Smith A, Wong A, Murakami MM, Kaczmarek J, Apple FS, Miller WL, Hartman K, Jaffe AS.Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay.Clin Chim Acta.;386(1-2):20-4.
  • Badr CE, Hewett JW, Breakefield XO, Tannous BA.A highly sensitive assay for monitoring the secretory pathway and ER stress.PLoS ONE. 2007;2(6):e571.
  • Hewett JW, Tannous B, Niland BP, Nery FC, Zeng J, Li Y, Breakefield XO.Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7271-6.
  • Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO.Metabolic biotinylation of cell surface receptors for in vivo imaging.Nat Methods. 2006 May;3(5):391-6.
  • Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo.Mol Ther. 2005 Mar;11(3):435-43.