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Stephen A. Huang, MD


  • Guo C, Chen X, Song H, Maynard MA, Zhou Y, Lobanov AV, Gladyshev VN, Ganis JJ, Wiley D, Jugo RH, Lee NY, Castroneves LA, Zon LI, Scanlan TS, Feldman HA, Huang SA.Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.Endocrinology. 2014 Oct;155(10):4069-80.
  • Castroneves LA, Jugo RH, Maynard MA, Lee JS, Wassner AJ, Dorfman D, Bronson RT, Ukomadu C, Agoston AT, Ding L, Luongo C, Guo C, Song H, Demchev V, Lee NY, Feldman HA, Vella KR, Peake RW, Hartigan C, Kellogg MD, Desai A, Salvatore D, Dentice M, Huang SA.Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis.Endocrinology. 2014 Oct;155(10):4061-8.
  • Maynard MA, Huang SA.Thyroid hormone inactivation in gastrointestinal stromal tumors.N Engl J Med. 2014 Jul 3;371(1):86-7.
  • Maynard MA, Marino-Enriquez A, Fletcher JA, Dorfman DM, Raut CP, Yassa L, Guo C, Wang Y, Dorfman C, Feldman HA, Frates MC, Song H, Jugo RH, Taguchi T, Hershman JM, Larsen PR, Huang SA.Thyroid hormone inactivation in gastrointestinal stromal tumors.N Engl J Med. 2014 Apr 3;370(14):1327-34.
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Muyide F, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Martins Y, Burmeister K, Kozakewich H, Hollowell M, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA.How are childhood thyroid nodules discovered: opportunities for improving early detection.J Pediatr. 2014 Mar;164(3):658-60.
  • Gupta A, Ly S, Castroneves LA, Frates MC, Benson CB, Feldman HA, Wassner AJ, Smith JR, Marqusee E, Alexander EK, Barletta J, Doubilet PM, Peters HE, Webb S, Modi BP, Paltiel HJ, Kozakewich H, Cibas ES, Moore FD, Shamberger RC, Larsen PR, Huang SA.A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults.J Clin Endocrinol Metab. 2013 Aug;98(8):3238-45.
  • Ben-Shachar R, Eisenberg M, Huang SA, DiStefano JJ.Simulation of post-thyroidectomy treatment alternatives for triiodothyronine or thyroxine replacement in pediatric thyroid cancer patients.Thyroid. 2012 Jun;22(6):595-603.
  • Scholz S, Smith JR, Chaignaud B, Shamberger RC, Huang SA.Thyroid surgery at Children's Hospital Boston: a 35-year single-institution experience.J Pediatr Surg. 2011 Mar;46(3):437-42.
  • Smith JR, Marqusee E, Webb S, Nose V, Fishman SJ, Shamberger RC, Frates MC, Huang SA.Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor Syndrome.J Clin Endocrinol Metab. 2011 Jan;96(1):34-7.
  • Marsili A, Ramadan W, Harney JW, Mulcahey M, Castroneves LA, Goemann IM, Wajner SM, Huang SA, Zavacki AM, Maia AL, Dentice M, Salvatore D, Silva JE, Larsen PR.Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.Endocrinology. 2010 Dec;151(12):5952-60.
  • Aerts G, Arrojo E Drigo R, Van Herck SL, Sammels E, Mirebeau-Prunier D, Gereben B, Zeöld A, Harney JW, Huang SA, Mulcahey MA, Van der Geyten S, Van den Bergh G, Arckens L, Darras VM, Zavacki AM.Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells.Endocrinology. 2009 Nov;150(11):5171-80.
  • Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW.Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.Endocrinology. 2009 Apr;150(4):1976-83.
  • Huang SA.Deiodination and cellular proliferation: parallels between development, differentiation, tumorigenesis, and now regeneration.Endocrinology. 2009 Jan;150(1):3-4.
  • Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC.Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.Endocr. Rev. 2008 Dec;29(7):898-938. Review.
  • Capelo LP, Beber EH, Huang SA, Zorn TM, Bianco AC, Gouveia CH.Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.Bone. 2008 Nov;43(5):921-30.
  • Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeöld A, Curcio-Morelli C, Harney JW, Luongo C, Mulcahey MA, Larsen PR, Huang SA, Bianco AC.The thyroid hormone-inactivating deiodinase functions as a homodimer.Mol Endocrinol. 2008 Jun;22(6):1382-93.
  • Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA.Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.J Clin Invest. 2008 Mar;118(3):975-83.
  • Huang SA, Bianco AC.Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.Nat Clin Pract Endocrinol Metab. 2008 Mar;4(3):148-55. Review.
  • Huang SA, Mulcahey MA, Crescenzi A, Chung M, Kim BW, Barnes C, Kuijt W, Turano H, Harney J, Larsen PR.Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase.Mol Endocrinol. 2005 Dec;19(12):3126-36.
  • Kuijt WJ, Huang SA.Children with differentiated thyroid cancer achieve adequate hyperthyrotropinemia within 14 days of levothyroxine withdrawal.J Clin Endocrinol Metab. 2005 Nov;90(11):6123-5.
  • Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR.Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.J Clin Invest. 2005 Sep;115(9):2524-33.
  • Huang SA, Dorfman DM, Genest DR, Salvatore D, Larsen PR.Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.J Clin Endocrinol Metab. 2003 Mar;88(3):1384-8.
  • Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR.A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase.J Clin Endocrinol Metab. 2002 Oct;87(10):4457-61.
  • Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, Fishman SJ, Larsen PR.Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas.N Engl J Med. 2000 Jul 20;343(3):185-9.