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Xu Wu, PhD

Publications

  • Bassilana F, Carlson A, DaSilva JA, Grosshans B, Vidal S, Beck V, Wilmeringwetter B, Llamas LA, Showalter TB, Rigollier P, Bourret A, Ramamurthy A, Wu X, Harbinski F, Plonsky S, Lee L, Ruffner H, Grandi P, Schirle M, Jenkins J, Sailer AW, Bouwmeester T, Porter JA, Myer V, Finan PM, Tallarico JA, Kelleher JF, Seuwen K, Jain RK, Luchansky SJ.Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.Nat Chem Biol. 2014 May;10(5):343-9.
    24633354
  • Chen EY, Deran MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, Lobbardi RM, Brockmann J, Keller C, Wu X, Langenau DM.Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5349-54.
    24706870
  • Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL.Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
    24277854
  • Huang Z, Wu H, Chuai S, Xu F, Yan F, Englund N, Wang Z, Zhang H, Fang M, Wang Y, Gu J, Zhang M, Yang T, Zhao K, Yu Y, Dai J, Yi W, Zhou S, Li Q, Wu J, Liu J, Wu X, Chan H, Lu C, Atadja P, Li E, Wang Y, Hu M.NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.Cancer Res. 2013 Oct 15;73(20):6277-88.
    23980095
  • Zheng B, Deran M, Li X, Liao X, Fukata M, Wu X.2-Bromopalmitate Analogues as Activity-Based Probes To Explore Palmitoyl Acyltransferases.J Am Chem Soc. 2013 May 3.
    23631516
  • Cheng D, Han D, Gao W, Jing Q, Jiang J, Wan Y, Englund NP, Tuntland T, Wu X, Pan S.Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6573-6.
    23036954
  • Miller E, Yang J, DeRan M, Wu C, Su AI, Bonamy GM, Liu J, Peters EC, Wu X.Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.Chem Biol. 2012 Aug 24;19(8):955-62.
    22884261
  • Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG.A stem cell-based approach to cartilage repair.Science. 2012 May 11;336(6082):717-21.
    22491093
  • Skvara H, Kalthoff F, Meingassner JG, Wolff-Winiski B, Aschauer H, Kelleher JF, Wu X, Pan S, Mickel L, Schuster C, Stary G, Jalili A, David OJ, Emotte C, Antunes AM, Rose K, Decker J, Carlson I, Gardner H, Stuetz A, Bertolino AP, Stingl G, De Rie MA.Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor.J Invest Dermatol. 2011 Mar 24.
    21430703
  • Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira SM, García-Echeverría C, Briggs KJ, Watkins DN, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M.Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.Sci Transl Med. 2010 Sep 29;2(51):51ra70.
    20881279
  • Hu XV, Rodrigues TM, Tao H, Baker RK, Miraglia L, Orth AP, Lyons GE, Schultz PG, Wu X.Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15087-92.
    20696907
  • Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X.A genomic screen identifies TYRO3 as a MITF regulator in melanoma.Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17025-30.
    19805117
  • Wu X, Schultz PG.Synthesis at the interface of chemistry and biology.J Am Chem Soc. 2009 Sep 9;131(35):12497-515. Review.
    19689159
  • Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG.A small molecule primes embryonic stem cells for differentiation.Cell Stem Cell. 2009 May 8;4(5):416-26.
    19427291
  • Wang W, Walker JR, Wang X, Tremblay MS, Lee JW, Wu X, Schultz PG.Identification of small-molecule inducers of pancreatic beta-cell expansion.Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32.
    19164755
  • Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, Wu X.Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14982-7.
    17855562