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Bradley E. Bernstein, MD, PhD

Publications

  • Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE.Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.Science. 2014 Jun 12.
    24925914
  • Attanasio C, Nord AS, Zhu Y, Blow MJ, Biddie SC, Mendenhall EM, Dixon J, Wright C, Hosseini R, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Afzal V, Ren B, Bernstein BE, Rubin EM, Visel A, Pennacchio LA.Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesis.Genome Res. 2014 Apr 28.
    24752179
  • Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE.Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.Cell. 2014 Apr 24;157(3):580-94.
    24726434
  • Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos JA, Weng Z, White KP, Hardison RC.Defining functional DNA elements in the human genome.Proc Natl Acad Sci U S A. 2014 Apr 23.
    24753594
  • Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE.An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Nat Genet. 2014 Apr;46(4):364-70.
    24584072
  • Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK.Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.Nat Biotechnol. 2013 Dec;31(12):1137-42.
    24108092
  • Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE.Locus-specific editing of histone modifications at endogenous enhancers.Nat Biotechnol. 2013 Dec;31(12):1133-6.
    24013198
  • Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, Pandey S, Shin JY, Telis L, Liu J, Bhatt PK, Monette S, Zhao X, Mason CE, Park CY, Bernstein BE, Aifantis I, Levine RL.Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.J Exp Med. 2013 Nov 18;210(12):2641-59.
    24218140
  • Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK.In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.Nucleic Acids Res. 2013 Oct;41(19):e181.
    23945932
  • Isono K, Endo TA, Ku M, Yamada D, Suzuki R, Sharif J, Ishikura T, Toyoda T, Bernstein BE, Koseki H.SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.Dev Cell. 2013 Sep 30;26(6):565-77.
    24091011
  • Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A.Charting a dynamic DNA methylation landscape of the human genome.Nature. 2013 Aug 22;500(7463):477-81.
    23925113
  • Rheinbay E, Suvà ML, Gillespie SM, Wakimoto H, Patel AP, Shahid M, Oksuz O, Rabkin SD, Martuza RL, Rivera MN, Louis DN, Kasif S, Chi AS, Bernstein BE.An aberrant transcription factor network essential for wnt signaling and stem cell maintenance in glioblastoma.Cell Rep. 2013 May 30;3(5):1567-79.
    23707066
  • Suvà ML, Riggi N, Bernstein BE.Epigenetic reprogramming in cancer.Science. 2013 Mar 29;339(6127):1567-70. Review.
    23539597