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Arnold S. Freedman, MD
Publications
- Furman RR, Grossbard ML, Johnson JL, Pecora AL, Cassileth PA, Jung SH, Peterson BA, Nadler LM, Freedman A, Bayer RL, Bartlett NL, Hurd DD, Cheson BD, For The Cancer Leukemia Group B And Eastern Cooperative Oncology Group .A phase III study of anti-B4-bloc
21275630 - Sweetenham JW, Freedman AS.Early initial therapy of advanced follicular lymphoma: the need for vigilance.Leuk Lymphoma. 2011 Mar;52(3):355-7.
21323517 - Setlur SR, Ihm C, Tchinda J, Shams S, Werner L, Cho EK, Thompson C, Phillips K, Rassenti LZ, Kipps TJ, Neuberg D, Freedman AS, Lee C, Brown JR.Comparison of familial and sporadic chronic lymphocytic leukaemia using high resolution array comparative genomi
20812997 - Yoon SO, Zhang X, Freedman AS, Zahrieh D, Lossos IS, Li L, Choi YS.Down-regulation of CD9 expression and its correlation to tumor progression in B lymphomas.Am J Pathol. 2010 Jul;177(1):377-86.
20566742 - Pozdnyakova O, Spieler PJ, Abraham J, Freedman AS, Kutok JL.Epstein-barr virus-associated diffuse large B-cell lymphoma in an immunocompetent woman.J Clin Oncol. 2010 Feb 10;28(5):e75-8.
19917837 - Brown JR,Friedberg JW,Feng Y,Scofield S,Phillips K,Dal Cin P,Joyce R,Takvorian RW,Fisher DC,Fisher RI,Liesveld J,Marquis D,Neuberg D,Freedman AS.A phase 2 study of concurrent fludarabine and rituximab for the treatment of marginal zone lymphomas.British J
19344412 - Friedberg JW, Kelly JL, Neuberg D, Peterson DR, Kutok JL, Salloum R, Brenn T, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Sims P, Rothberg PG, Liesveld J, Fisher RI, Coffman R, Mosmann T, Freedman AS.Phase II study of a TLR-9 agonist (1018 ISS) with
19519691 - Brown JR, Freedman AS.ASCT in follicular lymphoma.Nat Rev Clin Oncol. 2009 Jul;6(7):380-2.
19561632 - Luthy SK,Ng AK,Silver B,Degnan KO,Fisher DC,Freedman AS,Mauch PM.Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphoma.Ann Oncol. 2008 Dec;19(12):2043-7.
18647962 - Armand P,Gannamaneni S,Kim HT,Cutler CS,Ho VT,Koreth J,Alyea EP,LaCasce AS,Jacobsen ED,Fisher DC,Brown JR,Canellos GP,Freedman AS,Soiffer RJ,Antin JH.Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis afte
19001324 - Brown JR, Levine RL, Thompson C, Basile G, Gilliland DG, Freedman AS.Systematic genomic screen for tyrosine kinase mutations in CLL.Leukemia. 2008 Oct;22(10):1966-9.
18754031 - Brown JR,Neuberg D,Phillips K,Reynolds H,Silverstein J,Clark JC,Ash M,Thompson C,Fisher DC,Jacobsen E,LaCasce AS,Freedman AS.Prevalence of familial malignancy in a prospectively screened cohort of patients with lymphoproliferative disorders.British Journa
18729853 - Friedberg J, Jacobsen E, Neuberg D, Kutok J, Munoz O, Boussiotis V, Reynolds H, Fisher D, Szot A, Van Den Abbeele A, Freedman A.Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept.Leuk Lymphoma. 2008 May;49(5):9
18464109 - Lacasce AS, Freedman AS.Antibody and Immunomodulatory Agents in the Treatment of Indolent Non-Hodgkin's Lymphoma.Semin Hematol. 2008 Apr;45(2):85-9. Review.
18381102 - Armand P, Kim HT, Ho VT, Cutler CS, Koreth J, Antin JH, LaCasce AS, Jacobsen ED, Fisher DC, Brown JR, Canellos GP, Freedman AS, Soiffer RJ, Alyea EP.Allogeneic transplantation with reduced-intensity conditioning for Hodgkin and non-Hodgkin lymphoma: impor
18342784 - Brown JR, Feng Y, Gribben JG, Neuberg D, Fisher DC, Mauch P, Nadler LM, Freedman AS.Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission.Biol Blood Marrow Transplant. 2007 Sep;13(9):1057-65.
17697968 - Rohatiner AZ, Nadler L, Davies AJ, Apostolidis J, Neuberg D, Matthews J, Gribben JG, Mauch PM, Lister TA, Freedman AS.Myeloablative Therapy With Autologous Bone Marrow Transplantation for Follicular Lymphoma at the Time of Second or Subsequent Remission:
17515573 - Zubair AC, Kao G, Daley H, Schott D, Freedman A, Ritz J.CD34(+) CD38(-) and CD34(+) HLA-DR(-) cells in BM stem cell grafts correlate with short-term engraftment but have no influence on long-term hematopoietic reconstitution after autologous transplantati
16923616 - Friedberg JW, Freedman AS.Antibody and immunomodulatory agents in treatment of indolent non-Hodgkin's lymphoma.Curr Treat Options Oncol. 2006 Jul;7(4):276-84. Review.
16916488 - Freedman AS.Non-transplant-related treatment options in follicular lymphoma.Biol Blood Marrow Transplant. 2006 Jan;12(1 Suppl 1):53-8. Review.
16399586 - Gribben JG, Zahrieh D, Stephans K, Bartlett-Pandite L, Alyea EP, Fisher DC, Freedman AS, Mauch P, Schlossman R, Sequist LV, Soiffer RJ, Marshall B, Neuberg D, Ritz J, Nadler LM.Autologous and allogeneic stem cell transplantations for poor-risk chronic lym
16131571 - Brown JR, Yeckes H, Friedberg JW, Neuberg D, Kim H, Nadler LM, Freedman AS.Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin'
15753460 - Jacobsen E, Freedman A.B-cell purging in autologous stem-cell transplantation for non-Hodgkin lymphoma.Lancet Oncol. 2004 Dec;5(12):711-7.
15581541 - Munoz O, Fend F, de Beaumont R, Husson H, Astier A, Freedman AS.TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferation.Leukemia. 2004 Dec;18(12):2015-25.
15470494 - Friedberg JW, Kim H, McCauley M, Hessel EM, Sims P, Fisher DC, Nadler LM, Coffman RL, Freedman AS.Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducibl
15358617 - Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM.Small molecule blockade of transcriptional coactivation of the hypoxia-
15261140 - Brown JR, Weng AP, Freedman AS.Hodgkin disease associated with T-cell non-Hodgkin lymphomas: case reports and review of the literature.Am J Clin Pathol. 2004 May;121(5):701-8.
15151210 - Brown JR, Gaudet G, Friedberg JW, Neuberg D, Mauch P, Kutok JL, Takvorian T, Fisher DC, Gribben JG, Kim H, Nadler LM, Freedman AS.Autologous bone marrow transplantation for marginal zone non-Hodgkin's lymphoma.Leuk Lymphoma. 2004 Feb;45(2):315-20.
15101717 - Zubair AC, Zahrieh D, Daley H, Schott D, Gribben JG, Alyea EP, Schlossman R, Freedman A, Antin JH, Soiffer RJ, Neuberg D, Ritz J.Engraftment of autologous and allogeneic marrow HPCs after myeloablative therapy.Transfusion. 2004 Feb;44(2):253-61.
14962317 - Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA.Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukem
14654078 - Friedberg JW, Kim H, Li S, Neuberg D, Boyd K, Daley H, Fisher DC, Gribben JG, Spitzer T, Freedman AS.Ex vivo B cell depletion using the Eligix B Cell SC system and autologous peripheral blood stem cell transplantation in patients with follicular non-Hodgk
13130315 - Lestou VS, Gascoyne RD, Sehn L, Ludkovski O, Chhanabhai M, Klasa RJ, Husson H, Freedman AS, Connors JM, Horsman DE.Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data a
12930384 - Zubair A, Zahrieh D, Daley H, Schott D, Gribben JG, Freedman A, Ritz J.Early neutrophil engraftment following autologous BMT provides a functional predictor of long-term hematopoietic reconstitution.Transfusion. 2003 May;43(5):614-21.
12702183 - Alyea EP, Weller E, Fisher DC, Freedman AS, Gribben JG, Lee S, Schlossman RL, Stone RM, Friedberg J, DeAngelo D, Liney D, Windawi S, Ng A, Mauch P, Antin JH, Soiffer RJ.Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogenei
12463479 - Husson H, Freedman AS, Cardoso AA, Schultze J, Munoz O, Strola G, Kutok J, Carideo EG, De Beaumont R, Caligaris-Cappio F, Ghia P.CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells.Br J Haematol. 2002 Nov
12406091 - Astier AL, Xu R, Svoboda M, Hinds E, Munoz O, de Beaumont R, Crean CD, Gabig T, Freedman AS.Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival.Blood. 200
12393420 - Webb IJ, Friedberg W, Gribben JG, Fisher DC, Spitzer T, Neuberg D, Jallow H, Kim H, Houde H, Monroy R, Schmittling R, Freedman AS.Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparti
12234168 - Friedberg JW, Neuberg D, Gribben JG, Fisher DC, Canning C, Koval M, Poor CM, Green LM, Daley J, Soiffer R, Ritz J, Freedman AS.Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non-Hodgkin's
12060117 - Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ.Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5367-72.
11959990 - Alyea E, Neuberg D, Mauch P, Marcus K, Freedman A, Webb I, Anderson K, Schlossman R, Fisher D, Gribben J, Ritz J, Soiffer R.Effect of total body irradiation dose escalation on outcome following T-cell-depleted allogeneic bone marrow transplantation.Biol B
11939603 - Gaudet G, Friedberg JW, Weng A, Pinkus GS, Freedman AS.Breast lymphoma associated with breast implants: two case-reports and a review of the literature.Leuk Lymphoma. 2002 Jan;43(1):115-9.
11908714 - Husson H, Carideo EG, Neuberg D, Schultze J, Munoz O, Marks PW, Donovan JW, Chillemi AC, O'Connell P, Freedman AS.Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays.Blood. 2002 Jan 1;99(1):282-9.
11756183 - Husson H, Carideo EG, Cardoso AA, Lugli SM, Neuberg D, Munoz O, de Leval L, Schultze J, Freedman AS.MCP-1 modulates chemotaxis by follicular lymphoma cells.Br J Haematol. 2001 Dec;115(3):554-62.
11736935 - Friedberg JW, Neuberg D, Monson E, Jallow H, Nadler LM, Freedman AS.The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma.Biol Blood Marrow Transplant. 2001;7(8):446-53.
11569890 - Soiffer RJ, Weller E, Alyea EP, Mauch P, Webb IL, Fisher DC, Freedman AS, Schlossman RL, Gribben J, Lee S, Anderson KC, Marcus K, Stone RM, Antin JH, Ritz J.CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in pa
11181681 - Robinson SN, Freedman AS, Neuberg DS, Nadler LM, Mauch PM.Loss of marrow reserve from dose-intensified chemotherapy results in impaired hematopoietic reconstitution after autologous transplantation: CD34(+), CD34(+)38(-), and week-6 CAFC assays predict po
11146154 - Husson H, Lugli SM, Ghia P, Cardoso A, Roth A, Brohmi K, Carideo EG, Choi YS, Browning J, Freedman AS.Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells.Cell Immunol. 2000 Aug 1;203(2):134-43.
11006011 - Freedman AS, Neuberg D, Mauch P, Soiffer RJ, Anderson KC, Fisher DC, Schlossman R, Alyea EP, Takvorian T, Jallow H, Kuhlman C, Ritz J, Nadler LM, Gribben JG.Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular
10552941 - Friedberg JW, Neuberg D, Stone RM, Alyea E, Jallow H, LaCasce A, Mauch PM, Gribben JG, Ritz J, Nadler LM, Soiffer RJ, Freedman AS.Outcome in patients with myelodysplastic syndrome after autologous bone marrow transplantation for non-Hodgkin's lymphoma
10506609 - Grossbard ML, Multani PS, Freedman AS, O'Day S, Gribben JG, Rhuda C, Neuberg D, Nadler LM.A Phase II study of adjuvant therapy with anti-B4-blocked ricin after autologous bone marrow transplantation for patients with relapsed B-cell non-Hodgkin's
10499609 - Friedberg JW, Neuberg D, Gribben JG, Mauch P, Anderson KC, Soiffer RJ, Takvorian T, Fisher DC, Schlossman R, Jallow H, Kuhlman C, Ritz J, Freedman AS.Autologous bone marrow transplantation after histologic transformation of indolent B cell malignancies.Bi
10465106 - Soiffer RJ, Freedman AS, Neuberg D, Fisher DC, Alyea EP, Gribben J, Schlossman RL, Bartlett-Pandite L, Kuhlman C, Murray C, Freeman A, Mauch P, Anderson KC, Nadler LM, Ritz J.CD6+ T cell-depleted allogeneic bone marrow transplantation for non-Hodgkin'
9674848 - Mach-Pascual S, Legare RD, Lu D, Kroon M, Neuberg D, Tantravahi R, Stone RM, Freedman AS, Nadler LM, Gribben JG, Gilliland DG.Predictive value of clonality assays in patients with non-Hodgkin's lymphoma undergoing autologous bone marrow transplant: a
9616144 - Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS.Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lympho
9498705 - Ghia P, Boussiotis VA, Schultze JL, Cardoso AA, Dorfman DM, Gribben JG, Freedman AS, Nadler LM.Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival.Blood. 1998 Jan 1;91(1):244-51.
9414291 - Freedman AS, Neuberg D, Gribben JG, Mauch P, Soiffer RJ, Fisher DC, Anderson KC, Andersen N, Schlossman R, Kroon M, Ritz J, Aster J, Nadler LM.High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in
9440717 - Andersen NS, Donovan JW, Borus JS, Poor CM, Neuberg D, Aster JC, Nadler LM, Freedman AS, Gribben JG.Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease.Blood. 1997 Nov 15;90(10
9354694 - Astier A, Manié SN, Avraham H, Hirai H, Law SF, Zhang Y, Golemis EA, Fu Y, Druker BJ, Haghayeghi N, Freedman AS, Avraham S.The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1.J Biol Chem. 199
9242628 - Manié SN, Astier A, Haghayeghi N, Canty T, Druker BJ, Hirai H, Freedman AS.Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2.J Biol Chem. 1997 Jun 20;272(25):15636-41.
9188452 - Soiffer RJ, Fairclough D, Robertson M, Alyea E, Anderson K, Freedman A, Bartlett-Pandite L, Fisher D, Schlossman RL, Stone R, Murray C, Freeman A, Marcus K, Mauch P, Nadler L, Ritz J.CD6-depleted allogeneic bone marrow transplantation for acute leukemia i
9108425 - Soiffer RJ, Mauch P, Fairclough D, Alyea E, Anderson K, Fisher D, Freedman A, Bartlett-Pandite L, Robertson M, Schlossman R, Gollob J, Marcus K, Murray C, Kuhlman C, Freeman A, Nadler L, Ritz J.CD6+ T cell depleted allogeneic bone marrow transplantation f
9209736 - Astier A, Avraham H, Manie SN, Groopman J, Canty T, Avraham S, Freedman AS.The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas.J Biol Chem. 1997 Jan 3;272(1):228-32.
8995252 - Manié SN, Sattler M, Astier A, Phifer JS, Canty T, Morimoto C, Druker BJ, Salgia R, Griffin JD, Freedman AS.Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.Exp Hematol. 1997 Jan;25(1):45
8989906 - Freedman AS, Gribben JG, Neuberg D, Mauch P, Soiffer RJ, Anderson KC, Pandite L, Robertson MJ, Kroon M, Ritz J, Nadler LM.High-dose therapy and autologous bone marrow transplantation in patients with follicular lymphoma during first remission.Blood. 1996
8839876 - Manie SN, Astier A, Wang D, Phifer JS, Chen J, Lazarovits AI, Morimoto C, Freedman AS.Stimulation of tyrosine phosphorylation after ligation of beta7 and beta1 integrins on human B cells.Blood. 1996 Mar 1;87(5):1855-61.
8634433 - Huang MJ, Osborn L, Svahn J, Schiffer SB, Eliseo L, Zhou LJ, Rhynhart K, Benjamin CD, Freedman AS.Expression of vascular cell adhesion molecule-1 by follicular dendritic cells.Leuk Lymphoma. 1995 Jul;18(3-4):259-64.
8535191 - Stone RM, Neuberg D, Soiffer R, Takvorian T, Whelan M, Rabinowe SN, Aster JC, Leavitt P, Mauch P, Freedman AS.Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma.J Clin Oncol. 199
7989927 - Freedman AS, Saporito L, Rhynhart K, Morimoto C, Nadler LM.Adhesion of follicular lymphoma cells to lymphoid germinal centers--a potential mechanism of tumor cell homing following autologous transplantation.Leuk Lymphoma. 1994 Mar;13(1-2):47-52.
8025523 - Freedman AS, Rhynhart K, Nojima Y, Svahn J, Eliseo L, Benjamin CD, Morimoto C, Vivier E.Stimulation of protein tyrosine phosphorylation in human B cells after ligation of the beta 1 integrin VLA-4.J Immunol. 1993 Mar 1;150(5):1645-52.
7679689 - Freedman AS, Munro JM, Rhynhart K, Schow P, Daley J, Lee N, Svahn J, Eliseo L, Nadler LM.Follicular dendritic cells inhibit human B-lymphocyte proliferation.Blood. 1992 Sep 1;80(5):1284-8.
1515644 - Freedman AS, Munro JM, Morimoto C, McIntyre BW, Rhynhart K, Lee N, Nadler LM.Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1.Blood.
1370204 - Freedman AS, Munro JM, Rice GE, Bevilacqua MP, Morimoto C, McIntyre BW, Rhynhart K, Pober JS, Nadler LM.Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110.Science. 1990 Aug 31;249(4972):1030-3.
1697696 - Freedman AS, Freeman G, Horowitz JC, Daley J, Nadler LM.B7, a B-cell-restricted antigen that identifies preactivated B cells.J Immunol. 1987 Nov 15;139(10):3260-7.
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