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Richard Blumberg, MD

Publications

  • Zeissig S, Olszak T, Melum E, Blumberg RS.Analyzing antigen recognition by Natural Killer T cells.Methods Mol Biol. 2013;960:557-72.
    23329514
  • Nishida A, Nagahama K, Imaeda H, Ogawa A, Lau CW, Kobayashi T, Hisamatsu T, Preffer FI, Mizoguchi E, Ikeuchi H, Hibi T, Fukuda M, Andoh A, Blumberg RS, Mizoguchi A.Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells.J Exp Med. 2012 Dec 17;209(13):2383-94.
    23209314
  • Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS.The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.Immunity. 2012 Nov 16;37(5):930-46.
    23123061
  • Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang Y-H, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS .CEACAM1 dampens anti-timor immunity by downregulation of NKG2D ligand expression on tumor cells and NKG2D function on NK cells.J Exp Med..
  • Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, van den Brink MR.Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation.PLoS ONE. 2011;6(7):e21611.
    21760897
  • Kamat A, Ancuta P, Blumberg RS, Gabuzda D.Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation.PLoS ONE. 2010;5(11):e15533.
    21125014
  • Kaser A, Zeissig S, Blumberg RS.Inflammatory bowel disease.Annu Rev Immunol. 2010 Mar;28:573-621. Review.
    20192811
  • Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, Miura Y, Koyanagi Y, Nakajima A, Blumberg RS, Takahashi H, Hayami M, Igarashi T, Miura T.Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load.J Gen Virol. 2010 Mar;91(Pt 3):773-81.
    19889928
  • Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T.Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.Inflamm Bowel Dis. 2010 Jan;16(1):87-95.
    19572372
  • Blumberg RS.Inflammation in the intestinal tract: pathogenesis and treatment.Dig Dis. 2009;27(4):455-64. Review.
    19897960
  • Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP.Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.Nat Med. 2009 Aug;15(8):940-5.
    19633655
  • Chen Z, Chen L, Blumberg RS.Editorial: CEACAM1: fine-tuned for fine-tuning.J Leukoc Biol. 2009 Aug;86(2):195-7.
    19643737
  • Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.Am J Respir Cell Mol Biol. 2009 Aug;41(2):129-35.
    19097991
  • Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J.The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6.
    19073936
  • Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS.CEACAM1 and the regulation of mucosal inflammation.Mucosal Immunol. 2008 Nov;1 Suppl 1:S39-42. Review.
    19079227
  • Blumberg RS, Li L, Nusrat A, Parkos CA, Rubin DC, Carrington JL.Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease.Mucosal Immunol. 2008 Sep;1(5):330-4.
    19079196
  • Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S.Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.J Immunol. 2008 Nov 1;181(9):6148-57.
    18941205
  • Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki T, Blumberg RS, Nakajima A.Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases.Allergy. 2008 Sep;63(9):1136-47.
    18547288
  • Blumberg RS.Crohn disease.JAMA. 2008 Jul 23;300(4):439-40.
    18647989
  • Kaser A, Blumberg RS.Adaptive immunity in inflammatory bowel disease: state of the art.Curr Opin Gastroenterol. 2008 Jul;24(4):455-61. Review.
    18622159
  • Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS.Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.J Pharmacol Sci. 2008 Apr;106(4):627-38.
    18391483
  • Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS.Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.J Immunol. 2008 May 1;180(9):6085-93.
    18424730
  • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.The inhibitory cytokine IL-35 contributes to regulatory T-cell function.Nature. 2007 Nov 22;450(7169):566-9.
    18033300
  • Stern-Ginossar N, Nedvetzki S, Markel G, Gazit R, Betser-Cohen G, Achdout H, Aker M, Blumberg RS, Davis DM, Appelmelk B, Mandelboim O.Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.J Immunol. 2007 Oct 1;179(7):4424-34.
    17878338
  • Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S.Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma.Eur J Immunol. 2007 Jun;37(6):1663-77.
    17506035
  • Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L.Expression of nonclassical class I molecules by intestinal epithelial cells.Inflamm Bowel Dis. 2007 Mar;13(3):298-307.
    17238179
  • Mizoguchi A, Ogawa A, Takedatsu H, Sugimoto K, Shimomura Y, Shirane K, Nagahama K, Nagaishi T, Mizoguchi E, Blumberg RS, Bhan AK.Dependence of intestinal granuloma formation on unique myeloid DC-like cells.J Clin Invest. 2007 Mar;117(3):605-15.
    17318261
  • Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS.SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.Immunity. 2006 Nov;25(5):769-81.
    17081782
  • Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.J Immunol. 2006 Nov 15;177(10):6833-41.
    17082597
  • Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS.Role of CEACAM1 as a regulator of T cells.Ann N Y Acad Sci. 2006 Aug;1072:155-75. Review.
    17057197
  • Markel G, Seidman R, Stern N, Cohen-Sinai T, Izhaki O, Katz G, Besser M, Treves AJ, Blumberg RS, Loewenthal R, Mandelboim O, Orenstein A, Schachter J.Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions.J Immunol. 2006 Nov 1;177(9):6062-71.
    17056532
  • Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF.Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.J Exp Med. 2006 Aug 7;203(8):1875-81.
    16880260
  • Gray-Owen SD, Blumberg RS.CEACAM1: contact-dependent control of immunity.Nat Rev Immunol. 2006 Jun;6(6):433-46. Review.
    16724098
  • Wada K, Nakajima A, Katayama K, Kudo C, Shibuya A, Kubota N, Terauchi Y, Tachibana M, Miyoshi H, Kamisaki Y, Mayumi T, Kadowaki T, Blumberg RS.Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation.J Biol Chem. 2006 May 5;281(18):12673-81.
    16524877
  • Nieuwenhuis EE, Blumberg RS.The role of the epithelial barrier in inflammatory bowel disease.Adv Exp Med Biol. 2006;579:108-16. Review.
    16620014
  • Utku N, Heinemann T, Winter M, Bulwin CG, Schlawinsky M, Fraser P, Nieuwenhuis EE, Volk HD, Blumberg RS.Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice.Clin Exp Immunol. 2006 Apr;144(1):142-51.
    16542376
  • Brozovic S, Sahoo R, Barve S, Shiba H, Uriarte S, Blumberg RS, Kinane DF.Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells.Microbiology. 2006 Mar;152(Pt 3):797-806.
    16514159
  • Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O.The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells.J Immunol. 2004 Sep 15;173(6):3732-9.
    15356119
  • Markel G, Achdout H, Katz G, Ling KL, Salio M, Gruda R, Gazit R, Mizrahi S, Hanna J, Gonen-Gross T, Arnon TI, Lieberman N, Stren N, Nachmias B, Blumberg RS, Steuer G, Blau H, Cerundolo V, Mussaffi H, Mandelboim O.Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients.Eur J Immunol. 2004 Aug;34(8):2138-48.
    15259011
  • Chen D, Iijima H, Nagaishi T, Nakajima A, Russell S, Raychowdhury R, Morales V, Rudd CE, Utku N, Blumberg RS.Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function.J Immunol. 2004 Mar 15;172(6):3535-43.
    15004154
  • Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN, Becker C, Gallagher TM, Holmes KV, Blumberg RS.Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1.J Exp Med. 2004 Feb 16;199(4):471-82.
    14970176
  • Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA.Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site.Blood. 2001 Sep 1;98(5):1469-79.
    11520797