Richard Blumberg, MD

Publications

Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang Y-H, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS .CEACAM1 dampens anti-timor immunity by downregulation of NKG2D ligand expression on tumor cells and NKG2D function on NK cells.J Exp Med..
Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, va
21760897
Kamat A, Ancuta P, Blumberg RS, Gabuzda D.Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation.PLoS ONE. 2010;5(11):e15533.
21125014
Kaser A, Zeissig S, Blumberg RS.Inflammatory bowel disease.Annu Rev Immunol. 2010 Mar;28:573-621. Review.
20192811
Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, Miura Y, Koyanagi Y, Nakajima A, Blumberg RS, Takahashi H, Hayami M, Igarashi T, Miura T.Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infec
19889928
Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T.Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate
19572372
Blumberg RS.Inflammation in the intestinal tract: pathogenesis and treatment.Dig Dis. 2009;27(4):455-64. Review.
19897960
Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP.Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesi
19633655
Chen Z, Chen L, Blumberg RS.Editorial: CEACAM1: fine-tuned for fine-tuning.J Leukoc Biol. 2009 Aug;86(2):195-7.
19643737
Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.Am J Resp
19097991
Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J.The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6.
19073936
Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS.CEACAM1 and the regulation of mucosal inflammation.Mucosal Immunol. 2008 Nov;1 Suppl 1:S39-42. Review.
19079227
Blumberg RS, Li L, Nusrat A, Parkos CA, Rubin DC, Carrington JL.Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease.Mucosal Immunol. 2008 Sep;1(5):330-4.
19079196
Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S.Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.J Immunol. 2008 Nov 1;181(9):6148-57.
18941205
Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki T, Blumberg RS, Nakajima A.Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases.Allergy. 2008 Sep;63(9):1136-47.
18547288
Blumberg RS.Crohn disease.JAMA. 2008 Jul 23;300(4):439-40.
18647989
Kaser A, Blumberg RS.Adaptive immunity in inflammatory bowel disease: state of the art.Curr Opin Gastroenterol. 2008 Jul;24(4):455-61. Review.
18622159
Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS.Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithe
18391483
Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS.Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.J Immunol. 2008 May 1;180(9):6085-93.
18424730
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.The inhibitory cytokine IL-35 contributes to regulatory T-cell function.Nature. 2007 Nov 22;450(7169):566-9.
18033300
Stern-Ginossar N, Nedvetzki S, Markel G, Gazit R, Betser-Cohen G, Achdout H, Aker M, Blumberg RS, Davis DM, Appelmelk B, Mandelboim O.Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.J Immunol. 2007 Oct 1;179(7):4424-34.
17878338
Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S.Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental
17506035
Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L.Expression of nonclassical class I molecules by intestinal epithelial cells.Inflamm Bowel Dis. 2007 Mar;13(3):298-307.
17238179
Mizoguchi A, Ogawa A, Takedatsu H, Sugimoto K, Shimomura Y, Shirane K, Nagahama K, Nagaishi T, Mizoguchi E, Blumberg RS, Bhan AK.Dependence of intestinal granuloma formation on unique myeloid DC-like cells.J Clin Invest. 2007 Mar;117(3):605-15.
17318261
Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS.SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.Immunity. 2006 Nov;25(5):769-81.
17081782
Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.J Immunol. 200
17082597
Markel G, Seidman R, Stern N, Cohen-Sinai T, Izhaki O, Katz G, Besser M, Treves AJ, Blumberg RS, Loewenthal R, Mandelboim O, Orenstein A, Schachter J.Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic c
17056532
Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS.Role of CEACAM1 as a regulator of T cells.Ann N Y Acad Sci. 2006 Aug;1072:155-75. Review.
17057197
Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF.Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.J Exp Med. 2006 Aug 7;203(8):1875-81.
16880260
Gray-Owen SD, Blumberg RS.CEACAM1: contact-dependent control of immunity.Nat Rev Immunol. 2006 Jun;6(6):433-46. Review.
16724098
Wada K, Nakajima A, Katayama K, Kudo C, Shibuya A, Kubota N, Terauchi Y, Tachibana M, Miyoshi H, Kamisaki Y, Mayumi T, Kadowaki T, Blumberg RS.Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and diffe
16524877
Nieuwenhuis EE, Blumberg RS.The role of the epithelial barrier in inflammatory bowel disease.Adv Exp Med Biol. 2006;579:108-16. Review.
16620014
Utku N, Heinemann T, Winter M, Bulwin CG, Schlawinsky M, Fraser P, Nieuwenhuis EE, Volk HD, Blumberg RS.Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice.Clin Exp Immunol. 2006 Apr;144(1):142-51.
16542376
Brozovic S, Sahoo R, Barve S, Shiba H, Uriarte S, Blumberg RS, Kinane DF.Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells.Microb
16514159
Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O.The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells.J Immunol
15356119
Markel G, Achdout H, Katz G, Ling KL, Salio M, Gruda R, Gazit R, Mizrahi S, Hanna J, Gonen-Gross T, Arnon TI, Lieberman N, Stren N, Nachmias B, Blumberg RS, Steuer G, Blau H, Cerundolo V, Mussaffi H, Mandelboim O.Biological function of the soluble CEACAM1
15259011
Chen D, Iijima H, Nagaishi T, Nakajima A, Russell S, Raychowdhury R, Morales V, Rudd CE, Utku N, Blumberg RS.Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function.J Immunol. 2004
15004154
Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN, Becker C, Gallagher TM, Holmes KV, Blumberg RS.Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1.J Exp Med. 2004 Feb 16
14970176
Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA.Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site.Blood. 2001 Sep 1;98(5):1469-7
11520797

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Richard Blumberg, MD Publications Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang Y-H, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS .CEACAM1 dampens anti-timor immunity by downregulation of NKG2D ligand expression on tumor cells and NKG2D function on NK cells.J Exp Med.. Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, va 21760897 Kamat A, Ancuta P, Blumberg RS, Gabuzda D.Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation.PLoS ONE. 2010;5(11):e15533. 21125014 Kaser A, Zeissig S, Blumberg RS.Inflammatory bowel disease.Annu Rev Immunol. 2010 Mar;28:573-621. Review. 20192811 Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K, Miura Y, Koyanagi Y, Nakajima A, Blumberg RS, Takahashi H, Hayami M, Igarashi T, Miura T.Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infec 19889928 Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T.Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate 19572372 Blumberg RS.Inflammation in the intestinal tract: pathogenesis and treatment.Dig Dis. 2009;27(4):455-64. Review. 19897960 Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP.Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesi 19633655 Chen Z, Chen L, Blumberg RS.Editorial: CEACAM1: fine-tuned for fine-tuning.J Leukoc Biol. 2009 Aug;86(2):195-7. 19643737 Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA.High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice.Am J Resp 19097991 Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J.The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6. 19073936 Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS.CEACAM1 and the regulation of mucosal inflammation.Mucosal Immunol. 2008 Nov;1 Suppl 1:S39-42. Review. 19079227 Blumberg RS, Li L, Nusrat A, Parkos CA, Rubin DC, Carrington JL.Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease.Mucosal Immunol. 2008 Sep;1(5):330-4. 19079196 Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S.Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.J Immunol. 2008 Nov 1;181(9):6148-57. 18941205 Tachibana M, Wada K, Katayama K, Kamisaki Y, Maeyama K, Kadowaki T, Blumberg RS, Nakajima A.Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases.Allergy. 2008 Sep;63(9):1136-47. 18547288 Blumberg RS.Crohn disease.JAMA. 2008 Jul 23;300(4):439-40. 18647989 Kaser A, Blumberg RS.Adaptive immunity in inflammatory bowel disease: state of the art.Curr Opin Gastroenterol. 2008 Jul;24(4):455-61. Review. 18622159 Fujisawa T, Nakajima A, Fujisawa N, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, Blumberg RS.Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithe 18391483 Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS.Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.J Immunol. 2008 May 1;180(9):6085-93. 18424730 Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.The inhibitory cytokine IL-35 contributes to regulatory T-cell function.Nature. 2007 Nov 22;450(7169):566-9. 18033300 Stern-Ginossar N, Nedvetzki S, Markel G, Gazit R, Betser-Cohen G, Achdout H, Aker M, Blumberg RS, Davis DM, Appelmelk B, Mandelboim O.Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.J Immunol. 2007 Oct 1;179(7):4424-34. 17878338 Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S.Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental 17506035 Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L.Expression of nonclassical class I molecules by intestinal epithelial cells.Inflamm Bowel Dis. 2007 Mar;13(3):298-307. 17238179 Mizoguchi A, Ogawa A, Takedatsu H, Sugimoto K, Shimomura Y, Shirane K, Nagahama K, Nagaishi T, Mizoguchi E, Blumberg RS, Bhan AK.Dependence of intestinal granuloma formation on unique myeloid DC-like cells.J Clin Invest. 2007 Mar;117(3):605-15. 17318261 Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS.SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.Immunity. 2006 Nov;25(5):769-81. 17081782 Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.J Immunol. 200 17082597 Markel G, Seidman R, Stern N, Cohen-Sinai T, Izhaki O, Katz G, Besser M, Treves AJ, Blumberg RS, Loewenthal R, Mandelboim O, Orenstein A, Schachter J.Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic c 17056532 Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS.Role of CEACAM1 as a regulator of T cells.Ann N Y Acad Sci. 2006 Aug;1072:155-75. Review. 17057197 Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF.Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.J Exp Med. 2006 Aug 7;203(8):1875-81. 16880260 Gray-Owen SD, Blumberg RS.CEACAM1: contact-dependent control of immunity.Nat Rev Immunol. 2006 Jun;6(6):433-46. Review. 16724098 Wada K, Nakajima A, Katayama K, Kudo C, Shibuya A, Kubota N, Terauchi Y, Tachibana M, Miyoshi H, Kamisaki Y, Mayumi T, Kadowaki T, Blumberg RS.Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and diffe 16524877 Nieuwenhuis EE, Blumberg RS.The role of the epithelial barrier in inflammatory bowel disease.Adv Exp Med Biol. 2006;579:108-16. Review. 16620014 Utku N, Heinemann T, Winter M, Bulwin CG, Schlawinsky M, Fraser P, Nieuwenhuis EE, Volk HD, Blumberg RS.Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice.Clin Exp Immunol. 2006 Apr;144(1):142-51. 16542376 Brozovic S, Sahoo R, Barve S, Shiba H, Uriarte S, Blumberg RS, Kinane DF.Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells.Microb 16514159 Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O.The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells.J Immunol 15356119 Markel G, Achdout H, Katz G, Ling KL, Salio M, Gruda R, Gazit R, Mizrahi S, Hanna J, Gonen-Gross T, Arnon TI, Lieberman N, Stren N, Nachmias B, Blumberg RS, Steuer G, Blau H, Cerundolo V, Mussaffi H, Mandelboim O.Biological function of the soluble CEACAM1 15259011 Chen D, Iijima H, Nagaishi T, Nakajima A, Russell S, Raychowdhury R, Morales V, Rudd CE, Utku N, Blumberg RS.Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function.J Immunol. 2004 15004154 Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN, Becker C, Gallagher TM, Holmes KV, Blumberg RS.Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1.J Exp Med. 2004 Feb 16 14970176 Watt SM, Teixeira AM, Zhou GQ, Doyonnas R, Zhang Y, Grunert F, Blumberg RS, Kuroki M, Skubitz KM, Bates PA.Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site.Blood. 2001 Sep 1;98(5):1469-7 11520797
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