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David R. Beier, MD, PhD


  • Tao J, Koster MI, Harrison W, Moran JL, Beier DR, Roop DR, Overbeek PA.A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.PLoS ONE. 2012;7(11):e50634.
  • Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T.Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus.J Virol. 2012 Nov;86(21):11541-7.
  • Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR.Mutation mapping and identification by whole-genome sequencing.Genome Res. 2012 Aug;22(8):1541-8.
  • Bjork BC, Fujiwara Y, Davis SW, Qiu H, Saunders TL, Sandy P, Orkin S, Camper SA, Beier DR.A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development.PLoS ONE. 2010;5(12):e14375.
  • Beier DR.New genetic resources for mammalian developmental biologists.F1000 Biol Rep. 2010;2:72.
  • Hellman NE, Liu Y, Merkel E, Austin C, Le Corre S, Beier DR, Sun Z, Sharma N, Yoder BK, Drummond IA.The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch.Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18499-504.
  • Stottmann RW, Beier DR.Using ENU mutagenesis for phenotype-driven analysis of the mouse.Methods Enzymol. 2010;477:329-48.
  • Shiba D, Manning DK, Koga H, Beier DR, Yokoyama T.Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia.Cytoskeleton. 2010 Feb;67(2):112-9.
  • Bjork BC, Turbe-Doan A, Prysak M, Herron BJ, Beier DR.Prdm16 is required for normal palatogenesis in mice.Hum Mol Genet. 2010 Mar 1;19(5):774-89.
  • Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR.Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.N Engl J Med. 2010 Jan 21;362(3):206-16.
  • Heydemann A, Ceco E, Lim JE, Hadhazy M, Ryder P, Moran JL, Beier DR, Palmer AA, McNally EM.Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice.J Clin Invest. 2009 Dec;119(12):3703-12.
  • Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR, Lloyd KC, Bradley A, Skarnes WC.Agouti C57BL/6N embryonic stem cells for mouse genetic resources.Nat Methods. 2009 Jul;6(7):493-5.
  • Beckstead WA,Bjork BC,Stottmann RW,Sunyaev S,Beier DR.SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs.Mamm Genome. 2008 Oct-Dec;19(10-12):687-90.
  • Seale P,Bjork B,Yang W,Kajimura S,Chin S,Kuang S,Scime A,Devarakonda S,Conroe HM,Erdjument-Bromage H,Tempst P,Rudnicki MA,Beier DR,Spiegelman BM.PRDM16 controls a brown fat/skeletal muscle switch.Nature. 2008 Aug 21;454(7207):961-7.
  • Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR.THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.Nat Genet. 2008 Apr;40(4):403-10.
  • Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J.Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.J Am Soc Nephrol. 2008 Mar;19(3):469-76.
  • Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P.Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency.Oncogene. 2008 Apr 10;27(17):2456-65.
  • Moran JL, Qiu H, Turbe-Doan A, Yun Y, Boeglin WE, Brash AR, Beier DR.A Mouse Mutation in the 12R-Lipoxygenase, Alox12b, Disrupts Formation of the Epidermal Permeability Barrier.J Invest Dermatol. 2007 Aug;127(8):1893-7.
  • Matera I, Cockroft JL, Moran JL, Beier DR, Goldowitz D, Pavan WJ.A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3.Pigment Cell Res. 2007 Jun;20(3):210-5.
  • Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR.Gata4 is necessary for normal pulmonary lobar development.Am J Respir Cell Mol Biol. 2007 Apr;36(4):391-7.
  • Ideraabdullah FY, Kim K, Pomp D, Moran JL, Beier D, Villena FP.Rescue of the Mouse DDK Syndrome by Parent-of-Origin-Dependent Modifiers.Biol Reprod. 2007 Feb;76(2):286-293.
  • Holland KD, Fleming MT, Cheek S, Moran JL, Beier DR, Meisler MH.De novo exon duplication in a new allele of mouse Glra1 (spasmodic).Genetics. 2006 Dec;174(4):2245-7.
  • Lehoczky JA, Cai WW, Douglas JA, Moran JL, Beier DR, Innis JW.Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations.Mamm Genome. 2006 Sep;17(9):903-13.
  • Smith LA, Bukanov NO, Husson H, Russo RJ, Barry TC, Taylor AL, Beier DR, Ibraghimov-Beskrovnaya O.Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease.J Am Soc Nephrol. 2006 Oct;17(10):2821-31.
  • Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Bjork BC, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR.Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.Genome Res. 2006 Mar;16(3):436-40.
  • Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR.Fog2 is required for normal diaphragm and lung development in mice and humans.PLoS Genet. 2005 Jul;1(1):58-65.
  • Herron BJ, Rao C, Liu S, Laprade L, Richardson JA, Olivieri E, Semsarian C, Millar SE, Stubbs L, Beier DR.A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice.Hum Mol Genet. 2005 Mar 1;14(5):667-77.
  • Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR.Interacting genetic loci cause airway hyperresponsiveness.Physiol Genomics. 2005 Mar 21;21(1):105-11.
  • Schmausser B, Endrich S, Brändlein S, Schär J, Beier D, Müller-Hermelink HK, Eck M.The chemokine receptor CCR7 is expressed on epithelium of non-inflamed gastric mucosa, Helicobacter pylori gastritis, gastric carcinoma and its precursor lesions and up-regulated by H. pylori.Clin Exp Immunol. 2005 Feb;139(2):323-7.
  • Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR.A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.Development. 2003 Oct;130(19):4665-72.
  • Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR.A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.Development. 2002 Dec;129(24):5839-46.
  • Herron BJ, Lu W, Rao C, Liu S, Peters H, Bronson RT, Justice MJ, McDonald JD, Beier DR.Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.Nat Genet. 2002 Feb;30(2):185-9.
  • Cho Y, Ramer J, Rivailler P, Quink C, Garber RL, Beier DR, Wang F.An Epstein-Barr-related herpesvirus from marmoset lymphomas.Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1224-9.
  • Iakoubova O, Dushkin H, Pacella L, Beier DR.Genetic analysis of modifying loci on mouse chromosome 1 that affect disease severity in a model of recessive PKD.Physiol Genomics. 1999 Aug 31;1(2):101-5.
  • Kuida S, Beier DR.Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease.Genome Res. 2000 Jan;10(1):49-54.
  • Förnzler D, Her H, Knapik EW, Clark M, Lehrach H, Postlethwait JH, Zon LI, Beier DR.Gene mapping in zebrafish using single-strand conformation polymorphism analysis.Genomics. 1998 Jul 15;51(2):216-22.
  • Neuhaus IM, Beier DR.Efficient localization of mutations by interval haplotype analysis.Mamm Genome. 1998 Feb;9(2):150-4.
  • Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P.The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Cell. 1990 Oct 5;63(1):225-33.