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Alejandro Gutierrez, MD

Publications

  • Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT.TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.Cancer Discovery. 2013 May;3(5):564-77.
    23471820
  • Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL.Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.Blood. 2012 Nov 1;120(18):3764-73.
    22976955
  • Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT.Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.Cancer Cell. 2012 Aug 14;22(2):209-21.
    22897851
  • Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH.NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.PLoS ONE. 2012;7(6):e39725.
    22768113
  • Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT.The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.Blood. 2011 Oct 13;118(15):4169-73.
    21878675
  • Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang YX, Sioletic S, Kozakewich E, Grebliunaite R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CD, Look AT.Aberrant AKT activation drives well-differentiated liposarcoma.Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16386-91.
    21930930
  • Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT.Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.J Exp Med. 2011 Aug 1;208(8):1595-603.
    21727187
  • Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.Nature. 2011 Mar 3;471(7336):104-9.
    21368833
  • Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT.T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.Cancer Cell. 2010 Oct 19;18(4):353-66.
    20951945
  • Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT.Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.J Clin Oncol. 2010 Aug 20;28(24):3816-23.
    20644084
  • Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA.Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.J Steroid Biochem Mol Biol. 2010 Aug;121(3-5):546-55.
    20083198
  • Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter SS, Larson RS, Borowitz MJ, Silverman LB, Chin L, Hunger SP, Jamieson C, Sallan SE, Look AT.Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.Blood. 2010 Apr 8;115(14):2845-51.
    20124220
  • Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.Blood. 2010 Mar 4;115(9):1735-45.
    20007543
  • Grace RF, Su H, Sena L, Poussaint TY, Heeney MM, Gutierrez A.Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea.Am J Hematol. 2010 Feb;85(2):135-7.
    20052745
  • Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.Mol Cell Biol. 2009 Nov;29(21):5911-22.
    19704007
  • Gutierrez A,Sanda T,Grebliunaite R,Carracedo A,Salmena L,Ahn Y,Dahlberg S,Neuberg D,Moreau LA,Winter SS,Larson R,Zhang J,Protopopov A,Chin L,Pandolfi PP,Silverman LB,Hunger SP,Sallan SE,Look AT.High frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia.Blood. 2009 Jul 16;114(3):647-50.
    19458356
  • O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT.Alu elements mediate MYB gene tandem duplication in human T-ALL.J Exp Med. 2007 Dec 24;204(13):3059-66.
    18070937
  • Gutierrez A, Look AT.NOTCH and PI3K-AKT pathways intertwined.Cancer Cell. 2007 Nov;12(5):411-3.
    17996644
  • Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT.Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.British Journal of Haematology. 2007 Jul;138(2):169-75.
    17593023
  • Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA.Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.Nature. 2007 Jun 21;447(7147):966-71.
    17515920
  • Singh G, Gutierrez A, Xu K, Blair IA.Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range.Anal Chem. 2000 Jul 15;72(14):3007-13.
    10939360