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Galit Lahav

Publications

  • Liu JC, Lerou PH, Lahav G.Stem cells: balancing resistance and sensitivity to DNA damage.Trends Cell Biol. 2014 May;24(5):268-274.
    24721782
  • Loewer A, Karanam K, Mock C, Lahav G.The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.BMC Biol. 2013;11:114.
    24252182
  • Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Agarwal V, Letai A, Lerou PH, Lahav G.High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.Cell Stem Cell. 2013 Oct 3;13(4):483-91.
    23954752
  • Gaglia G, Guan Y, Shah JV, Lahav G.Activation and control of p53 tetramerization in individual living cells.Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15497-501.
    24006363
  • Karanam K, Loewer A, Lahav G.Dynamics of the DNA damage response: insights from live-cell imaging.Brief Funct Genomics. 2013 Mar;12(2):109-17.
    23292635
  • Ikeda F, Lahav G.Signal transduction and signaling networks.Mol Biol Cell. 2013 Mar;24(6):676.
    23486400
  • Purvis JE, Lahav G.Encoding and decoding cellular information through signaling dynamics.Cell. 2013 Feb 28;152(5):945-56.
    23452846
  • Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW.Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.Nature. 2013 Feb 28;494(7438):480-3.
    23446419
  • Karanam K, Kafri R, Loewer A, Lahav G.Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.Mol Cell. 2012 Jul 27;47(2):320-9.
    22841003
  • Purvis JE, Lahav G.Decoding the insulin signal.Mol Cell. 2012 Jun 29;46(6):715-6.
    22749395
  • Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G.p53 dynamics control cell fate.Science. 2012 Jun 15;336(6087):1440-4.
    22700930
  • Orth JD, Loewer A, Lahav G, Mitchison TJ.Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.Mol Biol Cell. 2012 Feb;23(4):567-76.
    22171325
  • Loewer A, Lahav G.We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.Curr Opin Genet Dev. 2011 Dec;21(6):753-8. Review.
    22005655
  • Batchelor E, Loewer A, Mock C, Lahav G.Stimulus-dependent dynamics of p53 in single cells.Mol Syst Biol. 2011 May 10;7:488.
    21556066
  • Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G.A synthetic-natural hybrid oscillator in human cells.Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17047-52.
    20837528
  • Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W.Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.Cancer Cell. 2010 Aug 9;18(2):147-59.
    20708156
  • Geva-Zatorsky N, Dekel E, Batchelor E, Lahav G, Alon U.Fourier analysis and systems identification of the p53 feedback loop.Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13550-5.
    20622152
  • Loewer A, Batchelor E, Gaglia G, Lahav G.Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.Cell. 2010 Jul 9;142(1):89-100.
    20598361
  • Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW.Cell growth and size homeostasis in proliferating animal cells.Science. 2009 Jul 10;325(5937):167-71.
    19589995
  • Batchelor E, Loewer A, Lahav G.The ups and downs of p53: understanding protein dynamics in single cells.Nat Rev Cancer. 2009 May;9(5):371-7.
    19360021
  • Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G.Distinct mechanisms act in concert to mediate cell cycle arrest.Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):785-90.
    19139404
  • Lahav G.Oscillations by the p53-Mdm2 feedback loop.Adv Exp Med Biol. 2008;641:28-38. Review.
    18783169
  • Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G.Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.Mol Cell. 2008 May 9;30(3):277-89.
    18471974
  • Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Alaluf I, Swerdlin N, Perzov N, Danon T, Liron Y, Raveh T, Carpenter AE, Lahav G, Alon U.Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.Nat Methods. 2006 Jul;3(7):525-31.
    16791210
  • Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U.Oscillations and variability in the p53 system.Mol Syst Biol. 2006;2:2006.0033.
    16773083
  • Loewer A, Lahav G.Cellular conference call: external feedback affects cell-fate decisions.Cell. 2006 Mar 24;124(6):1128-30. Review.
    16564006
  • Lahav G.The strength of indecisiveness: oscillatory behavior for better cell fate determination.Sci STKE. 2004 Dec 21;2004(264):pe55. Review.
    15613687
  • Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U.Dynamics of the p53-Mdm2 feedback loop in individual cells.Nat Genet. 2004 Feb;36(2):147-50.
    14730303