DF/HCC Program Affiliation

Breast Cancer
Biostatistics

DF/HCC Associations

Associate Director, Biostatistics

Research Abstract

My oncology research is related to breast cancer, biostatistics, and immunology. The breast cancer research includes studies of long-term toxicity (e.g. cardiac events after doxorubicin and/or radiation to left chest, MDS after alkylating agents), a recent grant submission on mathematical models of the effects of current and new breast cancer imaging methodology and therapy changes on national survival statistics, and studies of prognostic factors, most recently in DCIS patients. The immunology research includes studies of immunogenetics in mice and studies of patient and assay technique factors which influence the variability of tests such as lymphoproliferative assays, cytotoxic T lymphocyte assays, and immunophenotyping. The biostatistics research is related to breast cancer (e.g., competing risks methodology, analysis of non-proportional hazards, computing methods for SAGE analysis) or to immunology (e.g., interval censoring in animal studies, robust estimates of coefficient of variation in lab studies).

Publications

• Mitsuyasu R, Gelman R, Cherng DW, Landay A, Fahey J, Reichman R, Erice A, Bucy RP, Kilby JM, Lederman MM, Hamilton CD, Lertora J, White BL, Tebas P, Duliege AM, Pollard RB,.The virologic, immunologic, and clinical effects of interleukin 2 with potent anti
  17389292
• Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak
  17349583
• Carlson RW, Moench SJ, Hammond ME, Perez EA, Burstein HJ, Allred DC, Vogel CL, Goldstein LJ, Somlo G, Gradishar WJ, Hudis CA, Jahanzeb M, Stark A, Wolff AC, Press MF, Winer EP, Paik S, Ljung BM,.HER2 testing in breast cancer: NCCN Task Force report and re
  16813731
• Wüthrich C, Kesari S, Kim WK, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ.Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infe
  16798673
• Lim M, Bellon JR, Gelman R, Silver B, Recht A, Schnitt SJ, Harris JR.A prospective study of conservative surgery without radiation therapy in select patients with Stage I breast cancer.Int J Radiat Oncol Biol Phys 2006 Jul 15;65(4):1149-54.
  16750330
• Yao J, Weremowicz S, Feng B, Gentleman RC, Marks JR, Gelman R, Brennan C, Polyak K.Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression.Cancer Res 2006 Apr 15;66(8):4065-78.
  16618726
• Lin NU, Gelman R, Winer EP.Dose density in breast cancer: a simple message?.J Natl Cancer Inst 2005 Dec 7;97(23):1712-4.
  16333021
• Burstein HJ, Bellon JR, Galper S, Lu HM, Kuter I, Taghian AG, Wong J, Gelman R, Bunnell CA, Parker LM, Garber JE, Winer EP, Harris JR, Powell SN.Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophos
  16243442
• Gelman R, Harris JR.Editorial comment on "the link between local recurrence and distant metastasis in human breast cancer" by Serge Koscielny and Maurice Tubiana.Int J Radiat Oncol Biol Phys 1999 Jan 1;43(1):7-9.
  9989509
• Shapiro CL, Hardenbergh PH, Gelman R, Blanks D, Hauptman P, Recht A, Hayes DF, Harris J, Henderson IC.Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients.J Clin Oncol 1998 Nov;16(11):3493-501.
  9817266
• Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K.Regulation of in situ to invasive breast carcinoma transition.Cancer
  18455123
• Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris GJ, Bullitt E, Van den Abbeele AD, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Kirsch DG, Crawford A, Hochberg F, Winer EP.Phase II trial of lapatinib for brain metastases in patients
  18421051
• Wong JS, Ho AY, Kaelin CM, Bishop KL, Silver B, Gelman R, Harris JR, Hergrueter CA.Incidence of major corrective surgery after post-mastectomy breast reconstruction and radiation therapy.Breast J 2008 Jan-Feb;14(1):49-54.
  18186865
• Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, Assmann V, Elshamy WM, Rual JF, Levine D, Rozek LS, Gelman RS, Gunsalus KC, Greenberg RA, Sobhian B, Bertin N, Venkatesan K, Ayivi-Guedehoussou N, Sole
  17922014
• Burstein HJ, Keshaviah A, Baron AD, Hart RD, Lambert-Falls R, Marcom PK, Gelman R, Winer EP.Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study.Cancer 2007 S
  17614302
• Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM.Further evidence for BRCA1 communication with the inactive X chromosome.Cel
  17350581
• Lin NU, Parker LM, Come SE, Burstein HJ, Haldoupis M, Ryabin N, Gelman R, Winer EP, Shulman LN.Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: unexpected incidence of hypersensitivity reactions.In
  17345004
• Harris LN, You F, Schnitt SJ, Witkiewicz A, Lu X, Sgroi D, Ryan PD, Come SE, Burstein HJ, Lesnikoski BA, Kamma M, Friedman PN, Gelman R, Iglehart JD, Winer EP.Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early bre
  17317830
• Landis DM, Luo W, Song J, Bellon JR, Punglia RS, Wong JS, Killoran JH, Gelman R, Harris JR.Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity.Int J Radiat Oncol Biol Phys 2007 Apr 1;67(5):1299-308.
  17275202
• Burstein HJ, Overmoyer B, Gelman R, Silverman P, Savoie J, Clarke K, Dumadag L, Younger J, Ivy P, Winer EP.Rebeccamycin analog for refractory breast cancer: a randomized phase II trial of dosing schedules.Invest New Drugs 2007 Apr;25(2):161-4.
  16969707
• Margolin DH, Saunders EH, Bronfin B, de Rosa N, Axthelm MK, Goloubeva OG, Eapen S, Gelman RS, Letvin NL.Germinal center function in the spleen during simian HIV infection in rhesus monkeys.J Immunol 2006 Jul 15;177(2):1108-19.
  16818768
• Krop I, März A, Carlsson H, Li X, Bloushtain-Qimron N, Hu M, Gelman R, Sabel MS, Schnitt S, Ramaswamy S, Kleer CG, Enerbäck C, Polyak K.A putative role for psoriasin in breast tumor progression.Cancer Res 2005 Dec 15;65(24):11326-34.
  16357139
• Burstein HJ, Parker LM, Keshaviah A, Doherty J, Partridge AH, Schapira L, Ryan PD, Younger J, Harris LN, Moy B, Come SE, Schumer ST, Bunnell CA, Haldoupis M, Gelman R, Winer EP.Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for do
  16293865
• Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC, Silverman LB, Sallan SE, Guinan EC, Nadler LM.Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leu
  15920008
• Bellon JR, Come SE, Gelman RS, Henderson IC, Shulman LN, Silver BJ, Harris JR, Recht A.Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial.J Clin Oncol 2005 Mar 20;23(9):1934-40.
  15774786
• Partridge AH, Wong JS, Knudsen K, Gelman R, Sampson E, Gadd M, Bishop KL, Harris JR, Winer EP.Offering participants results of a clinical trial: sharing results of a negative study.Lancet 2005 Mar 12-18;365(9463):963-4.
  15766998
• Thurman SA, Schnitt SJ, Connolly JL, Gelman R, Silver B, Harris JR, Recht A.Outcome after breast-conserving therapy for patients with stage I or II mucinous, medullary, or tubular breast carcinoma.Int J Radiat Oncol Biol Phys 2004 May 1;59(1):152-9.
  15093911
• Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K.A neural survival factor is a candidate o
  12953101
• Burstein HJ, Harris LN, Marcom PK, Lambert-Falls R, Havlin K, Overmoyer B, Friedlander RJ, Gargiulo J, Strenger R, Vogel CL, Ryan PD, Ellis MJ, Nunes RA, Bunnell CA, Campos SM, Hallor M, Gelman R, Winer EP.Trastuzumab and vinorelbine as first-line therapy
  12885806
• Bendell JC, Domchek SM, Burstein HJ, Harris L, Younger J, Kuter I, Bunnell C, Rue M, Gelman R, Winer E.Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma.Cancer 2003 Jun 15;97(12):2972-7.
  12784331
• Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K.Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.Cancer Res 2003 May 1;
  12727813
• DiGianni LM, Kim HT, Emmons K, Gelman R, Kalkbrenner KJ, Garber JE.Complementary medicine use among women enrolled in a genetic testing program.Cancer Epidemiol Biomarkers Prev 2003 Apr;12(4):321-6.
  12692106
• Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K.Molecular markers in ductal carcinoma in situ of the breast.Mol Cancer Res 2003 Mar;1(5):362-
  12651909
• Partridge AH, Burstein HJ, Gelman RS, Marcom PK, Winer EP.Do patients participating in clinical trials want to know study results?.J Natl Cancer Inst 2003 Mar 19;95(6):491-2.
  12644548
• Burstein HJ, Harris LN, Gelman R, Lester SC, Nunes RA, Kaelin CM, Parker LM, Ellisen LW, Kuter I, Gadd MA, Christian RL, Kennedy PR, Borges VF, Bunnell CA, Younger J, Smith BL, Winer EP.Preoperative therapy with trastuzumab and paclitaxel followed by sequ
  12506169
• Chen WY, Garber JE, Higham S, Schneider KA, Davis KB, Deffenbaugh AM, Frank TS, Gelman RS, Li FP.BRCA1/2 genetic testing in the community setting.J Clin Oncol 2002 Nov 15;20(22):4485-92.
  12431973
• Galper S, Gelman R, Recht A, Silver B, Kohli A, Wong JS, Van Buren T, Baldini EH, Harris JR.Second nonbreast malignancies after conservative surgery and radiation therapy for early-stage breast cancer.Int J Radiat Oncol Biol Phys 2002 Feb 1;52(2):406-14.
  11872286
• Burstein HJ, Kuter I, Campos SM, Gelman RS, Tribou L, Parker LM, Manola J, Younger J, Matulonis U, Bunnell CA, Partridge AH, Richardson PG, Clarke K, Shulman LN, Winer EP.Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing m
  11352965
• Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, Bilska M, Craiu A, Zheng XX, Krivulka GR, Beaudry K, Lifton MA, Nickerson CE, Trigona WL, Punt K, Freed DC, Guan L, Dubey S, Casimiro D, Simon A, Davies ME, Chastain M, Strom TB, Gelman RS, Mon
  11039923
• Galper S, Recht A, Silver B, Bernardo MV, Gelman R, Wong J, Schnitt SJ, Connolly JL, Harris JR.Is radiation alone adequate treatment to the axilla for patients with limited axillary surgery? Implications for treatment after a positive sentinel node biopsy
  10924981
• Park CC, Mitsumori M, Nixon A, Recht A, Connolly J, Gelman R, Silver B, Hetelekidis S, Abner A, Harris JR, Schnitt SJ.Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and syste
  10764427
• Peiro G, Bornstein BA, Connolly JL, Gelman R, Hetelekidis S, Nixon AJ, Recht A, Silver B, Harris JR, Schnitt SJ.The influence of infiltrating lobular carcinoma on the outcome of patients treated with breast-conserving surgery and radiation therapy.Breast
  10752679
• Burstein HJ, Manola J, Younger J, Parker LM, Bunnell CA, Scheib R, Matulonis UA, Garber JE, Clarke KD, Shulman LN, Winer EP.Docetaxel administered on a weekly basis for metastatic breast cancer.J Clin Oncol 2000 Mar;18(6):1212-9.
  10715290
• Hetelekidis S, Schnitt SJ, Silver B, Manola J, Bornstein BA, Nixon AJ, Recht A, Gelman R, Harris JR, Connolly JL.The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer.Int J Radiat Oncol Biol Phys 2000 J
  10656369
• Shafman TD, Levitz S, Nixon AJ, Gibans LA, Nichols KE, Bell DW, Ishioka C, Isselbacher KJ, Gelman R, Garber J, Harris JR, Haber DA.Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contra
  10612799
• Shapiro CL, Keating J, Angell JE, Janicek M, Gelman R, Hayes D, LeBoff MS.Monitoring therapeutic response in skeletal metastases using dual-energy x-ray absorptiometry: a prospective feasibility study in breast cancer patients.Cancer Invest 1999;17(8):566
  10592763
• Dubey A, Recht A, Come SE, Gelman RS, Silver B, Harris JR, Shulman LN.Concurrent CMF and radiation therapy for early stage breast cancer: results of a pilot study.Int J Radiat Oncol Biol Phys 1999 Nov 1;45(4):877-84.
  10571193
• Hetelekidis S, Collins L, Silver B, Manola J, Gelman R, Cooper A, Lester S, Lyons JA, Harris JR, Schnitt SJ.Predictors of local recurrence following excision alone for ductal carcinoma in situ.Cancer 1999 Jan 15;85(2):427-31.
  10023711
• Karlsson GB, Halloran M, Schenten D, Lee J, Racz P, Tenner-Racz K, Manola J, Gelman R, Etemad-Moghadam B, Desjardins E, Wyatt R, Gerard NP, Marcon L, Margolin D, Fanton J, Axthelm MK, Letvin NL, Sodroski J.The envelope glycoprotein ectodomains determine t
  9743534
• Schmitz JE, Forman MA, Lifton MA, Concepción O, Reimann KA, Crumpacker CS, Daley JF, Gelman RS, Letvin NL.Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immuno
  9639517
• Chabner E, Nixon A, Gelman R, Hetelekidis S, Recht A, Bornstein B, Connolly J, Schnitt S, Silver B, Manola J, Harris J, Garber J.Family history and treatment outcome in young women after breast-conserving surgery and radiation therapy for early-stage brea
  9626202
• Chen MH, Chuang ML, Bornstein BA, Gelman R, Harris JR, Manning WJ.Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals.Circulation 1997 Nov 18;96(10):3269-72.
  9396414
• Recht A, Come SE, Henderson IC, Gelman RS, Silver B, Hayes DF, Shulman LN, Harris JR.The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer.N Engl J Med 1996 May 23;334(21):1356-61.
  8614420