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M. Amin Arnaout


  • Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA.Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin.Nat Struct Mol Biol. 2014 Apr;21(4):383-8.
  • Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA.Atomic basis for the species-specific inhibition of αV integrins by mAb 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.J Biol Chem. 2014 Apr 1.
  • Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA.Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.Stem Cells. 2014 Mar;32(3):791-801.
  • Frohlich EM, Alonso JL, Borenstein JT, Zhang X, Arnaout MA, Charest JL.Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers.Lab Chip. 2013 May 2.
  • Adair BD, Xiong JP, Alonso JL, Hyman BT, Arnaout MA.EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.PLoS ONE. 2013;8(2):e57951.
  • Mahalingam B, Ajroud K, Alonso JL, Anand S, Adair BD, Horenstein AL, Malavasi F, Xiong JP, Arnaout MA.Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.J Immunol. 2011 Dec 15;187(12):6393-401.
  • Xiong JP, Mahalingham B, Alonso JL, Borrelli LA, Rui X, Anand S, Hyman BT, Rysiok T, Müller-Pompalla D, Goodman SL, Arnaout MA.Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.J Cell Biol. 2009 Aug 24;186(4):589-600.
  • Arnaout MA, Goodman SL, Xiong JP.Structure and mechanics of integrin-based cell adhesion.Curr Opin Cell Biol. 2007 Oct;19(5):495-507. Review.
  • Li X, Xiong JW, Shelley CS, Park H, Arnaout MA.The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells.Development. 2006 Sep;133(18):3641-50.
  • Adair BD, Xiong JP, Maddock C, Goodman SL, Arnaout MA, Yeager M.Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.J Cell Biol. 2005 Mar 28;168(7):1109-18.
  • Alonso JL, Essafi M, Xiong JP, Stehle T, Arnaout MA.Does the integrin alphaA domain act as a ligand for its betaA domain?.Curr Biol. 2002 May 14;12(10):R340-2.
  • Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA.Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.Science. 2002 Apr 5;296(5565):151-5.
  • Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, and Arnaout MA.Crystal structure of the extracellular segment of integrin alphaVbeta3. .Science. 2001 Oct12;294(5541):339-345.