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G. Paolo Dotto, MD, PhD


  • Brooks YS, Ostano P, Jo SH, Dai J, Getsios S, Dziunycz P, Hofbauer GF, Cerveny K, Chiorino G, Lefort K, Dotto GP.Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer.J Clin Invest. 2014 May 1;124(5):2260-76.
  • Dotto GP.Multifocal epithelial tumors and field cancerization: stroma as a primary determinant.J Clin Invest. 2014 Apr 1;124(4):1446-53. Review.
  • Dotto GP, Karine L.miR-34a/SIRT6 in squamous differentiation and cancer.Cell Cycle. 2014 Apr 1;13(7):1055-6.
  • Dziunycz PJ, Lefort K, Wu X, Freiberger SN, Neu J, Djerbi N, Iotzowa-Weiss G, French LE, Dotto GP, Hofbauer GF.The Oncogene ATF3 Is Potentiated by Cyclosporine A and Ultraviolet Light A.J Invest Dermatol. 2014 Feb 7.
  • Goruppi S, Dotto GP.Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.Trends Cell Biol. 2013 Dec;23(12):593-602. Review.
  • Lefort K, Brooks Y, Ostano P, Cario-André M, Calpini V, Guinea-Viniegra J, Albinger-Hegyi A, Hoetzenecker W, Kolfschoten I, Wagner EF, Werner S, Dotto GP.A miR-34a-SIRT6 axis in the squamous cell differentiation network.EMBO J. 2013 Aug 14;32(16):2248-63.
  • Kim JE, Won CH, Bak H, Kositratna G, Manstein D, Dotto GP, Chang SE.Gene Profiling Analysis of the Early Effects of Ablative Fractional Carbon Dioxide Laser Treatment on Human Skin.Dermatol Surg. 2013 Mar 14.
  • Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP.Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.Cell. 2012 Jun 8;149(6):1207-20.
  • Ferrándiz N, Caraballo JM, García-Gutierrez L, Devgan V, Rodriguez-Paredes M, Lafita MC, Bretones G, Quintanilla A, Muñoz-Alonso MJ, Blanco R, Reyes JC, Agell N, Delgado MD, Dotto GP, León J.p21 as a transcriptional co-repressor of S-phase and mitotic control genes.PLoS ONE. 2012;7(5):e37759.
  • Dotto GP.p63 and FGFR: when development meets proliferation.EMBO Mol Med. 2012 Mar;4(3):165-7.
  • Restivo G, Nguyen BC, Dziunycz P, Ristorcelli E, Ryan RJ, Ozuysal OY, Di Piazza M, Radtke F, Dixon MJ, Hofbauer GF, Lefort K, Dotto GP.IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.EMBO J. 2011 Sep 9.
  • Dotto GP.Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis.Cancer Res. 2011 Mar 15;71(6):2029-33.
  • Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP.Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.Genes Dev. 2010 Jul 15;24(14):1519-32.
  • Kang J, Yoo J, Lee S, Tang W, Aguilar B, Ramu S, Choi I, Otu HH, Shin JW, Dotto GP, Koh CJ, Detmar M, Hong YK.An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells.Blood. 2010 Jul 8;116(1):140-50.
  • Wu, X. Nguyen, B. C. Dziunycz, P. Chang, S. Brooks, Y. Lefort, K. Hofbauer, G. F. Dotto, G. P.Opposing roles for calcineurin and ATF3 in squamous skin cancer.Nature. 2010-05-20;465(7296):368-72.
  • Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB.Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.J Clin Invest. 2010 Feb 1;120(2):446-56.
  • Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin MJ, Pazin M, Ostano P, Dummer R, Brissette JL, Dotto GP.A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.J Clin Invest. 2009 Oct;119(10):3127-37.
  • Dotto GP.Notch tumor suppressor function.Oncogene. 2008 Sep 1;27(38):5115-23. Review.
  • Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP.EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.Nat Cell Biol. 2008 Aug;10(8):902-11.
  • Mandinova A, Lefort K, Tommasi di Vignano A, Stonely W, Ostano P, Chiorino G, Iwaki H, Nakanishi J, Dotto GP.The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.EMBO J. 2008 Apr 23;27(8):1243-54.
  • Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F.Notch1 functions as a tumor suppressor in mouse skin.Nat Genet. 2003 Mar;33(3):416-21.
  • Talora C, Sgroi DC, Crum CP, Dotto GP.Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.Genes Dev. 2002 Sep 1;16(17):2252-63.
  • Oh H, Mammucari C, Nenci A, Cabodi S, Cohen SN, Dotto GP.Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1).Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5430-5.
  • Calautti E, Grossi M, Mammucari C, Aoyama Y, Pirro M, Ono Y, Li J, Dotto GP.Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.J Cell Biol. 2002 Jan 7;156(1):137-48.
  • Cabodi S, Calautti E, Talora C, Kuroki T, Stein PL, Dotto GP.A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.Mol Cell. 2000 Nov;6(5):1121-9.
  • Topley GI, Okuyama R, Gonzales JG, Conti C, Dotto GP.p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential.Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9089-94.
  • Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G.Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.J Cell Biol. 1998 Jun 15;141(6):1449-65.
  • Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, Dotto GP.Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.Science. 1998 May 15;280(5366):1069-72.