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Daniel P. Cahill, MD, PhD

Publications

  • Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE.Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.Science. 2014 Jun 12.
    24925914
  • Kim BY, Jiang W, Beiko J, Prabhu SS, Demonte F, Gilbert MR, Sawaya R, Aldape KD, Cahill DP, McCutcheon IE.Diagnostic discrepancies in malignant astrocytoma due to limited small pathological tumor sample can be overcome by IDH1 testing.J. Neurooncol. 2014 Apr 29.
    24777756
  • Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE.Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.Cell. 2014 Apr 24;157(3):580-94.
    24726434
  • Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden M, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS.Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.Clin Cancer Res. 2014 Apr 8.
    24714777
  • Huse JT, Wallace M, Aldape KD, Berger MS, Bettegowda C, Brat DJ, Cahill DP, Cloughesy T, Haas-Kogan DA, Marra M, Miller CR, Nelson SJ, Salama SR, Soffietti R, Wen PY, Yip S, Yen K, Costello JF, Chang S.Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) low-grade glioma research workshop.Neuro Oncology. 2014 Jan;16(2):173-8.
    24305708
  • Beiko J, Suki D, Hess KR, Fox BD, Cheung V, Cabral M, Shonka N, Gilbert MR, Sawaya R, Prabhu SS, Weinberg J, Lang FF, Aldape KD, Sulman EP, Rao G, McCutcheon IE, Cahill DP.IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection.Neuro Oncology. 2014 Jan;16(1):81-91.
    24305719
  • Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K.Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.Cancer Cell. 2013 Sep 9;24(3):331-46.
    23993863
  • Taylor JW, Chi AS, Cahill DP.Tailored therapy in diffuse gliomas: using molecular classifiers to optimize clinical management.Oncology (Huntingt). 2013 Jun;27(6):504-14. Review.
    23909061
  • Dunn GP, Andronesi OC, Cahill DP.From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma.Neurosurg Focus. 2013 Feb;34(2):E2.
    23373447
  • Jones PS, Dunn GP, Barker FG, Curry WT, Hochberg FH, Cahill DP.Molecular genetics of low-grade gliomas: genomic alterations guiding diagnosis and therapeutic intervention. 11th Annual Frye-Halloran Brain Tumor Symposium.Neurosurg Focus. 2013 Feb;34(2):E9.
    23373454
  • Dziurzynski K, Blas-Boria D, Suki D, Cahill DP, Prabhu SS, Puduvalli V, Levine N.Butterfly glioblastomas: a retrospective review and qualitative assessment of outcomes.J. Neurooncol. 2012 Sep;109(3):555-63.
    22806339
  • Likhacheva A, Pinnix CC, Parikh NR, Allen PK, McAleer MF, Chiu MS, Sulman EP, Mahajan A, Guha-Thakurta N, Prabhu SS, Cahill DP, Luo D, Shiu AS, Brown PD, Chang EL.Predictors of Survival in Contemporary Practice After Initial Radiosurgery for Brain Metastases.Int J Radiat Oncol Biol Phys. 2012 Aug 14.
    22898384
  • Raghunathan A, Olar A, Vogel H, Parker JR, Coventry SC, Debski R, Albarracin CT, Aldape KD, Cahill DP, Powell SZ, Fuller GN.Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma.Ann Diagn Pathol. 2012 Aug;16(4):255-9.
    22445362
  • Olar A, Raghunathan A, Albarracin CT, Aldape KD, Cahill DP, Powell SZ, Goodman JC, Fuller GN.Absence of IDH1-R132H mutation predicts rapid progression of nonenhancing diffuse glioma in older adults.Ann Diagn Pathol. 2012 Jun;16(3):161-70.
    22197544
  • Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, Yan H, Papadopoulos N, Kinzler KW.Mutations in CIC and FUBP1 contribute to human oligodendroglioma.Science. 2011 Sep 9;333(6048):1453-5.
    21817013
  • Cahill DP, Barker FG, Davis KR, Kalva SP, Sahai I, Frosch MP.Case records of the Massachusetts General Hospital. Case 10-2010. A 37-year-old woman with weakness and a mass in the brain.N Engl J Med. 2010 Apr 8;362(14):1326-33.
    20375410
  • Yip S, Miao J, Cahill DP, Iafrate AJ, Aldape K, Nutt CL, Louis DN.MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.Clin Cancer Res. 2009 Jul 15;15(14):4622-9.
    19584161
  • Cahill DP, Codd PJ, Batchelor TT, Curry WT, Louis DN.MSH6 inactivation and emergent temozolomide resistance in human glioblastomas.Clin Neurosurg. 2008;55:165-71.
    19248684
  • Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN.Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Clin Cancer Res. 2007 Apr 1;13(7):2038-45.
    17404084
  • Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR.Patterns of somatic mutation in human cancer genomes.Nature. 2007 Mar 8;446(7132):153-8.
    17344846
  • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.Cancer Cell. 2007 Jan;11(1):83-95.
    17222792
  • Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Richardson D, Shepherd R, Small A, Solomon H, Tofts C, Varian J, West S, Widaa S, Yates A, Easton DF, Riggins G, Roy JE, Levine KK, Mueller W, Batchelor TT, Louis DN, Stratton MR, Futreal PA, Wooster R.A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.Cancer Res. 2006 Apr 15;66(8):3987-91.
    16618716
  • Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, Karess R, Kinzler KW, Vogelstein B, Velculescu VE, Lengauer C.Three classes of genes mutated in colorectal cancers with chromosomal instability.Cancer Res. 2004 May 1;64(9):2998-3001.
    15126332