Alexandros Tzatsos, MD, PhD

Publications

• Gao T, Zhou D, Yang C, Singh T, Penzo-Méndez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ.Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas.Gastroenterology. 2013 Feb 27.
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• Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N.KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.J Clin Invest. 2013 Jan 16.
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• Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N.Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells.J Biol Chem. 2011 Sep 23;286(38):33061-9.
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• Tzatsos A.Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.J Biol Chem. 2009 Aug 21;284(34):22525-34.
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• Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN.Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6.
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• Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN.Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12.
  18250326
• Tzatsos A, Tsichlis PN.Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.J Biol Chem. 2007 Jun 22;282(25):18069-82.
  17459875
• Tzatsos A, Kandror KV.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.Mol Cell Biol. 2006 Jan;26(1):63-76.
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