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Dai Fukumura, MD, PhD

Publications

  • Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK.Benefits of vascular normalization are dose and time dependent--letter.Cancer Res. 2013 Dec 1;73(23):7144-6.
    24265277
  • Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK.Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.Journal of the National Cancer Institute. 2013 Aug 21;105(16):1188-201.
    23899555
  • Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R.Transgenic mice for cGMP imaging.Circ Res. 2013 Aug 2;113(4):365-71.
    23801067
  • Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK.Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12774-9.
    23861493
  • Jain RK, Munn LL, Fukumura D.Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.Cold Spring Harb Protoc. 2013 Jul;2013(7):678-80.
    23818670
  • Jain RK, Munn LL, Fukumura D.Measuring interstitial pH and pO2 in mouse tumors.Cold Spring Harb Protoc. 2013 Jul;2013(7):675-7.
    23818669
  • Jain RK, Munn LL, Fukumura D.Measuring leukocyte-endothelial interactions in mice.Cold Spring Harb Protoc. 2013 Jun;2013(6):561-3.
    23734020
  • Jain RK, Munn LL, Fukumura D.Measuring angiogenesis and hemodynamics in mice.Cold Spring Harb Protoc. 2013;2013(4).
    23547161
  • Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK.Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.Cell. 2013 Feb 28;152(5):1065-76.
    23452854
  • Huang Y, Goel S, Duda DG, Fukumura D, Jain RK.Vascular normalization as an emerging strategy to enhance cancer immunotherapy.Cancer Res. 2013 Feb 25.
    23440426
  • Han HS, Martin JD, Lee J, Harris DK, Fukumura D, Jain RK, Bawendi M.Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo.Angew Chem Int Ed Engl. 2013 Jan 28;52(5):1414-9.
    23255143
  • Jain RK, Munn LL, Fukumura D.Lung window preparation in mice.Cold Spring Harb Protoc. 2013 Jan;2013(1).
    23282642
  • Jain RK, Munn LL, Fukumura D.Pancreatic tumor preparation in mice.Cold Spring Harb Protoc. 2012 Dec;2012(12).
    23209145
  • Jain RK, Munn LL, Fukumura D.Liver tumor preparation in mice.Cold Spring Harb Protoc. 2012 Dec;2012(12).
    23209146
  • Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK.Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3119-27.
    23071298
  • Jain RK, Munn LL, Fukumura D.Lymphangiography of the mouse ear.Cold Spring Harb Protoc. 2012;2012(11).
    23118365
  • Jain RK, Munn LL, Fukumura D.Lymphangiography of the mouse tail.Cold Spring Harb Protoc. 2012;2012(11).
    23118364
  • Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC.Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6.
    23045683
  • Jain RK, Munn LL, Fukumura D.Mammary fat pad chamber preparation in mice.Cold Spring Harb Protoc. 2012;2012(10).
    23028075
  • Jain RK, Munn LL, Fukumura D.Mammary fat pad tumor preparation in mice.Cold Spring Harb Protoc. 2012;2012(10).
    23028076
  • Jain RK, Munn LL, Fukumura D.Corneal pocket assay in rabbits.Cold Spring Harb Protoc. 2012 Sep;2012(9):1017-8.
    22949714
  • Stylianopoulos T, Soteriou K, Fukumura D, Jain RK.Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model.Ann Biomed Eng. 2012 Aug 2.
    22855118
  • Jain RK, Munn LL, Fukumura D.Rabbit ear chambers.Cold Spring Harb Protoc. 2012 Jul;2012(7):813-14.
    22753607
  • Chauhan VP, Stylianopoulos T, Martin JD, Popović Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK.Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.Nat Nanotechnol. 2012 Jun;7(6):383-8.
    22484912
  • Goel S, Fukumura D, Jain RK.Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology.Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1214.
    22550180
  • Vakoc BJ, Fukumura D, Jain RK, Bouma BE.Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.Nat Rev Cancer. 2012 May;12(5):363-8. Review.
    22475930
  • Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D.Multistage nanoparticles for improved delivery into tumor tissue.Methods Enzymol. 2012;508:109-30.
    22449923
  • Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG.Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.Nat Protoc. 2012;7(4):756-62.
    22441294
  • Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK.An isolated tumor perfusion model in mice.Nat Protoc. 2012;7(4):749-55.
    22441293
  • Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D.A transient parabiosis skin transplantation model in mice.Nat Protoc. 2012;7(4):763-70.
    22441295
  • Chauhan VP, Popović Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK.Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11417-20.
    22113800
  • Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP.Impaired lymphatic contraction associated with immunosuppression.Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18784-9.
    22065738
  • Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL.Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.Blood. 2011 Oct 27;118(17):4740-9.
    21835951
  • Huang P, Westmoreland SV, Jain RK, Fukumura D.Spontaneous nonthymic tumors in SCID mice.Comp Med. 2011 Jun;61(3):227-34.
    21819692
  • Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK.Normalization of the vasculature for treatment of cancer and other diseases.Physiol. Rev. 2011 Jul;91(3):1071-121. Review.
    21742796
  • Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L.PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.Clin Cancer Res. 2011 Jun 1;17(11):3638-48.
    21459800
  • Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK.The biology of brain metastases-translation to new therapies.Nat Rev Clin Oncol. 2011 Jun;8(6):344-56. Review.
    21487419
  • Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK.Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3725-30.
    21321210
  • Duda DG, Kozin S, Kirkpatrick ND, Xu L, Fukumura D, Jain RK.CXCL12 (SDF1α) - CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anti-Cancer Therapies?.Clin Cancer Res. 2011 Feb 24.
    21349998
  • Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D.Multistage nanoparticle delivery system for deep penetration into tumor tissue.Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2426-31.
    21245339
  • Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK.Scaling rules for diffusive drug delivery in tumor and normal tissues.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1799-803.
    21224417
  • Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK.C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):302-7.
    21173223
  • Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK.Malignant cells facilitate lung metastasis by bringing their own soil.Proc Natl Acad Sci U S A. 2010 Nov 22.
    21098274
  • Popović Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG.A Nanoparticle Size Series for In Vivo Fluorescence Imaging.Angew Chem Int Ed Engl. 2010 Nov 8;49(46):8649-52.
    20886481
  • Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK.Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.Biophys J. 2010 Sep 8;99(5):1342-9.
    20816045
  • Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL.Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.Nat Methods. 2010 Aug;7(8):655-60.
    20581828
  • Brown E, Munn LL, Fukumura D, Jain RK.In vivo imaging of tumors.Cold Spring Harb Protoc. 2010 Aug;2010(8):pdb.prot5452.
    20647356
  • Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D.Angiopoietin-2 Interferes with Anti-VEGFR-2- Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas.Clin Cancer Res. 2010 Jul 15;16(14):3618-27.
    20501615
  • Fukumura D, Duda DG, Munn LL, Jain RK.Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.Microcirculation. 2010 Apr;17(3):206-25. Review.
    20374484
  • Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH.In vivo wide-area cellular imaging by side-view endomicroscopy.Nat Methods. 2010 Apr;7(4):303-5.
    20228814
  • Choi B, Bouma B, Fukumura D, Jain RK.Optical methods in vascular biology and medicine.J Biomed Opt.;15(1):011001.
    20210426
  • Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG.InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.J Am Chem Soc. 2010 Jan 20;132(2):470-1.
    20025222
  • Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG.Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.J Am Chem Soc. 2010 Jan 20;132(2):472-83.
    20025223
  • Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK.Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.PLoS ONE. 2009;4(12):e8316.
    20016816
  • Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE.Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.Nat Med. 2009 Oct;15(10):1219-23.
    19749772
  • Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK.VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.PLoS ONE. 2009;4(9):e6525.
    19763275
  • Dawson MR, Duda DG, Fukumura D, Jain RK.VEGFR1-activity-independent metastasis formation.Nature. 2009 Sep 17;461(7262):E4; discussion E5.
    19759568
  • Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA.Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.Opt Lett. 2009 Jul 1;34(13):2066-8.
    19572001
  • Au P,Tam J,Duda DG,Lin PC,Munn LL,Fukumura D,Jain RK.Paradoxical Effects of PDGF-BB Overexpression in Endothelial Cells on Engineered Blood Vessels In Vivo.Am J Pathol. 2009 Jul;175(1):294-302.
    19477947
  • Kamoun WS,Ley CD,Farrar CT,Duyverman AM,Lahdenranta J,Lacorre DA,Batchelor TT,di Tomaso E,Duda DG,Munn LL,Fukumura D,Sorensen AG,Jain RK.Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.J Clin Oncol. 2009 May 20;27(15):2542-52.
    19332720
  • Tam J,Duda DG,Perentes JY,Quadri RS,Fukumura D,Jain RK.Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.PLoS ONE. 2009;4(3):e4974.
    19333381
  • Lahdenranta J,Hagendoorn J,Padera TP,Hoshida T,Nelson G,Kashiwagi S,Jain RK,Fukumura D.Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.Cancer Res. 2009 Apr 1;69(7):2801-8.
    19318557
  • Luong MX,Tam J,Lin Q,Hagendoorn J,Moore KJ,Padera TP,Seed B,Fukumura D,Kucherlapati R,Jain RK.Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.J Cell Physiol. 2009 May;219(2):430-7.
    19170073
  • Tam J,Fukumura D,Jain RK.A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.Cell Metab. 2009 Jan 7;9(1):52-63.
    19117546
  • Fukumura D,Jain RK.Imaging angiogenesis and the microenvironment.APMIS. 2008 Jul-Aug;116(7-8):695-715. Review.
    18834413
  • Padera TP,Kuo AH,Hoshida T,Liao S,Lobo J,Kozak KR,Fukumura D,Jain RK.Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.Mol Cancer Ther. 2008 Aug;7(8):2272-9.
    18687659
  • Huang P,Duda DG,Jain RK,Fukumura D.Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.Comp Med. 2008 Jun;58(3):253-63.
    18589867
  • Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D.Perivascular nitric oxide gradients normalize tumor vasculature.Nat Med. 2008 Mar;14(3):255-7.
    18278052
  • Au P, Tam J, Fukumura D, Jain RK.Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.Blood. 2008 May 1;111(9):4551-8.
    18256324
  • Jain RK, Lahdenranta J, Fukumura D.Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.PLoS Med. 2008 Jan 29;5(1):e24.
    18232729
  • Au P, Tam J, Fukumura D, Jain RK.Small blood vessel engineering.Methods Mol. Med. 2007;140:183-95.
    18085210
  • Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK.Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.Blood. 2008 Feb 1;111(3):1302-5.
    17993613
  • Fukumura D, Jain RK.Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.Microvasc Res.;74(2-3):72-84. Review.
    17560615
  • Fukumura D, Jain RK.Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.J Cell Biochem. 2007 Jul 1;101(4):937-49. Review.
    17171643
  • Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK.Data Do Not Support Benefits of Anti-VEGFR3 Therapy.Cancer Res. 2007 May 15;67(10):5055.
    17510438
  • Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE.Influence of tumor cell and stroma sensitivity on tumor response to radiation.Cancer Res. 2007 May 1;67(9):4016-21.
    17483312
  • Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT.Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.Nat Biotechnol. 2007 Mar;25(3):317-8.
    17322871
  • Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK.Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.Cancer Res. 2006 Aug 15;66(16):8065-75.
    16912183
  • Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK.Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.Ann Biomed Eng. 2006 Aug;34(8):1247-58.
    16832606
  • Fukumura D, Kashiwagi S, Jain RK.The role of nitric oxide in tumour progression.Nat Rev Cancer. 2006 Jul;6(7):521-34. Review.
    16794635
  • Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D.Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.Cancer Res. 2006 Apr 15;66(8):3971-7.
    16618713
  • Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK.Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.Cancer Res. 2006 Apr 1;66(7):3360-4.
    16585153
  • Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK.Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.Blood. 2006 Apr 1;107(7):2774-6.
    16339405
  • Hagendoorn J, Padera TP, Fukumura D, Jain RK.Molecular regulation of microlymphatic formation and function: role of nitric oxide.Trends Cardiovasc. Med. 2005 Jul;15(5):169-73. Review.
    16165013
  • Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P.Genetic evidence for a tumor suppressor role of HIF-2alpha.Cancer Cell. 2005 Aug;8(2):131-41.
    16098466
  • Huang P, McKee TD, Jain RK, Fukumura D.Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.Comp Med. 2005 Jun;55(3):236-43.
    16089171
  • Jain RK,Au P,Tam J,Duda DG,Fukumura D.Engineering vascularized tissue.Nat Biotechnol. 2005 Jul;23(7):821-3.
    16003365
  • Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D.NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.J Clin Invest. 2005 Jul;115(7):1816-27.
    15951843
  • Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK.Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.Nat Med. 2005 Jun;11(6):678-82.
    15880117
  • Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK.Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.Cancer Cell. 2004 Dec;6(6):553-63.
    15607960
  • Duda DG,Fukumura D,Munn LL,Booth MF,Brown EB,Huang P,Seed B,Jain RK.Differential transplantability of tumor-associated stromal cells.Cancer Res. 2004 Sep 1;64(17):5920-4.
    15342367
  • Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK.Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.Circ Res. 2004 Jul 23;95(2):204-9.
    15192027
  • Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK.Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.Cancer Res. 2004 Jul 1;64(13):4400-4.
    15231646
  • Duda DG,Fukumura D,Jain RK.Role of eNOS in neovascularization: NO for endothelial progenitor cells.Trends Mol Med. 2004 Apr;10(4):143-5.
    15162796
  • Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK.Tissue engineering: creation of long-lasting blood vessels.Nature. 2004 Mar 11;428(6979):138-9.
    15014486
  • Gohongi T, Todoroki T, Fukumura D, Jain RK.Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.Oncol Rep. 2004 Apr;11(4):803-7.
    15010876
  • Xu L, Pathak PS, Fukumura D.Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells.Clin Cancer Res. 2004 Jan 15;10(2):701-7.
    14760093
  • Fukumura D,Ushiyama A,Duda DG,Xu L,Tam J,Krishna V,Chatterjee K,Garkavtsev I,Jain RK.Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.Circ Res. 2003 Oct 31;93(9):e88-97.
    14525808
  • Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D.Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.Clin Cancer Res. 2003 Sep 15;9(11):4221-6.
    14519649
  • Forbes NS, Munn LL, Fukumura D, Jain RK.Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.Cancer Res. 2003 Sep 1;63(17):5188-93.
    14500342
  • Dolmans DE, Fukumura D, Jain RK.Photodynamic therapy for cancer.Nat Rev Cancer. 2003 May;3(5):380-7. Review.
    12724736
  • Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD.Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.Cancer Res. 2003 Feb 15;63(4):747-51.
    12591719
  • Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL.Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.Cancer Res. 2002 Dec 1;62(23):6831-6.
    12460895
  • Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D.Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.Cancer Res. 2002 Aug 1;62(15):4289-94.
    12154031
  • Jain RK, Munn LL, Fukumura D.Dissecting tumour pathophysiology using intravital microscopy.Nat Rev Cancer. 2002 Apr;2(4):266-76.
    12001988
  • Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK.Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.Clin Cancer Res. 2002 Apr;8(4):1008-13.
    11948107
  • Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK.Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.Cancer Res. 2002 Apr 1;62(7):2151-6.
    11929837
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