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Vijay K. Kuchroo, DVM, PhD

Publications

  • Lee Y, Collins M, Kuchroo VK.Unexpected targets and triggers of autoimmunity.J Clin Immunol. 2014 Jul;34 Suppl 1:56-60.
    24789684
  • Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA.Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.J Clin Invest. 2014 Jun 2;124(6):2513-22.
    24812667
  • da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N.Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.Cancer Immunol Res. 2014 May;2(5):410-22.
    24795354
  • Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK.Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.Immunity. 2014 Apr 17;40(4):569-81.
    24745333
  • Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK.Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms.Immunity. 2014 Apr 17;40(4):477-89.
    24745332
  • Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G.TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity.Immunity. 2014 Apr 17;40(4):542-53.
    24703780
  • Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, Tarhini AA, Tawbi HA, Kirkwood JM, Moschos S, Wang H, Guillaume P, Luescher IF, Krieg A, Anderson AC, Kuchroo VK, Zarour HM.PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines.Cancer Res. 2014 Feb 15;74(4):1045-55.
    24343228
  • Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M.Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.J Immunol. 2013 Oct 1;191(7):3753-63.
    23975864
  • Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ.IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.Nat Immunol. 2013 Oct;14(10):1054-63.
    23995234
  • Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV.Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.J Clin Invest. 2013 Sep 3;123(9):4023-35.
    23979159
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Aug(8):1248-53.
    22772464
  • Sakuishi K, Ngiow SF, Sullivan JM, Teng MW, Kuchroo VK, Smyth MJ, Anderson AC.TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer.Oncoimmunology. 2013 Apr 1;2(4):e23849.
    23734331
  • Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK.Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7.
    23630250
  • Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A.Dynamic regulatory network controlling TH17 cell differentiation.Nature. 2013 Mar 6.
    23467089
  • Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK.Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.Nature. 2013 Mar 6.
    23467085
  • Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ.IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet.J Immunol. 2013 Apr 15;190(8):3977-84.
    23479229
  • Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM.IL-1β Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation.J Immunol. 2013 Apr 15;190(8):4196-204.
    23487424
  • Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF.Regulatory T cells: recommendations to simplify the nomenclature.Nat Immunol. 2013 Apr;14(4):307-8.
    23507634
  • Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH.MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2270-5.
    23341605
  • Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X.The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.Nat Immunol. 2013 Jan;14(1):72-81.
    23202271
  • Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB.TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.Sci Signal. 2012 Dec 11;5(254):ra90.
    23233528
  • Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK.Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.Nat Med. 2012 Sep;18(9):1394-400.
    22863785
  • Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK.Induction and molecular signature of pathogenic TH17 cells.Nat Immunol. 2012 Oct;13(10):991-9.
    22961052
  • Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK.Aiolos promotes TH17 differentiation by directly silencing Il2 expression.Nat Immunol. 2012 Aug;13(8):770-7.
    22751139
  • Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK.Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10.
    22773818
  • Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR.Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.Blood. 2012 Jul 19;120(3):682-90.
    22677125
  • Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB.Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.J Clin Invest. 2012 Jul 2;122(7):2395-404.
    22684103
  • Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP.Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.Mol Cell Biol. 2011 Oct;31(19):3963-74.
    21807895
  • Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK.Emerging Tim-3 functions in antimicrobial and tumor immunity.Trends Immunol. 2011 Aug;32(8):345-9. Review.
    21697013
  • Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR.Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.Blood. 2011 Apr 28;117(17):4501-10.
    21385853
  • Zhu C, Anderson AC, Kuchroo VK.TIM-3 and its regulatory role in immune responses.Curr Top Microbiol Immunol. 2011;350:1-15. Review.
    20700701
  • Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, Dekruyff RH, Kuchroo VK.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Eur J Immunol. 2011 Mar 18.
    21469101
  • Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM.Tim3 binding to galectin-9 stimulates antimicrobial immunity.J Exp Med. 2010 Oct 25;207(11):2343-54.
    20937702
  • Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC.Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.J Exp Med. 2010 Sep 27;207(10):2187-94.
    20819927
  • Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R.Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8.
    20679213
  • Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK.T-bet, a Th1 transcription factor regulates the expression of Tim-3.Eur J Immunol. 2010 Mar;40(3):859-66.
    20049876