Vijay K. Kuchroo, DVM, PhD

Publications

• Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK.Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell deat
  22863785
• Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK.Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.
  22773818
• Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Jul 8.
  22772464
• Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP.Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.Mol Cell Biol. 2011 Oct;31(19):3963-74.
  21807895
• Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK.Emerging Tim-3 functions in antimicrobial and tumor immunity.Trends Immunol. 2011 Aug;32(8):345-9. Review.
  21697013
• Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR.Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.Blood
  21385853
• Zhu C, Anderson AC, Kuchroo VK.TIM-3 and its regulatory role in immune responses.Curr Top Microbiol Immunol. 2011;350:1-15. Review.
  20700701
• Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, Dekruyff RH, Kuchroo VK.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Eur J Immunol. 2011 Mar 18.
  21469101
• Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM.Tim3 binding to galectin-9 stimulates antimicrobial immunity.J Exp Med. 2010 Oct 25;207(11):2343-54.
  20937702
• Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC.Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity.J Exp Med. 2010 Sep 27;207(10):2187-94.
  20819927
• Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R.Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14733-8.
  20679213
• Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK.T-bet, a Th1 transcription factor regulates the expression of Tim-3.Eur J Immunol. 2010 Mar;40(3):859-66.
  20049876