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Maria Kontaridis, PhD

Publications

  • Overman JP, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J, Bennett AM.PZR coordinates Noonan and LEOPARD syndrome signaling in zebrafish and mice.Mol Cell Biol. 2014 May 27.
    24865967
  • Kontaridis MI.How to get a K award: it is not just about the science.Circ Res. 2014 Mar 14;114(6):941-3.
    24625724
  • Dolmatova E, Spagnol G, Boassa D, Baum JR, Keith K, Ambrosi C, Kontaridis MI, Sorgen PL, Sosinsky GE, Duffy HS.Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.Am J Physiol Heart Circ Physiol. 2012 Nov 15;303(10):H1208-18.
    22982782
  • Lauriol J, Kontaridis MI.PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?.Trends Cardiovasc. Med. 2011 May;21(4):97-104. Review.
    22681964
  • Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, Wu X, Lauriol J, Wang B, Bauer M, Bronson R, Franchini KG, Neel BG, Kontaridis MI.Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.J Clin Invest. 2011 Mar;121(3):1026-43.
    21339643
  • Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG.Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.Dev Cell. 2010 May 18;18(5):750-62.
    20493809
  • Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG.Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.Circulation. 2008 Mar 18;117(11):1423-35.
    18316486
  • Bentires-Alj M, Kontaridis MI, Neel BG.Stops along the RAS pathway in human genetic disease.Nat Med. 2006 Mar;12(3):283-5.
    16520774
  • Kontaridis MI, Swanson KD, David FS, Barford D, Neel BG.PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.J Biol Chem. 2006 Mar 10;281(10):6785-92.
    16377799
  • Haider UG, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM.Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.Mol Pharmacol. 2005 Jul;68(1):41-8.
    15849355
  • Kontaridis MI, Eminaga S, Fornaro M, Zito CI, Sordella R, Settleman J, Bennett AM.SHP-2 positively regulates myogenesis by coupling to the Rho GTPase signaling pathway.Mol Cell Biol. 2004 Jun;24(12):5340-52.
    15169898
  • Ivins Zito C, Kontaridis MI, Fornaro M, Feng GS, Bennett AM.SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis.J Cell Physiol. 2004 May;199(2):227-36.
    15040005
  • Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG.Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.Mol Cell. 2004 Feb 13;13(3):341-55.
    14967142
  • Kontaridis MI, Liu X, Zhang L, Bennett AM.Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts.Mol Cell Biol. 2002 Jun;22(11):3875-91.
    11997521