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Jonathan M. Higgins, DPhil

Publications

  • Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM.Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.J Cell Biol. 2012 Oct 15;199(2):251-68.
    23071152
  • Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT.Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogs at inner centromeres.Mol Biol Cell. 2012 Feb 22.
    22357620
  • Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM.Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.Bioorg Med Chem Lett. 2012 Mar 1;22(5):2015-9.
    22335895
  • Czakai K, Müller K, Mosesso P, Pepe G, Schulze M, Gohla A, Patnaik D, Dekant W, Higgins JM, Mally A.Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity?.Toxicol Sci. 2011 Aug;122(2):317-29.
    21551354
  • Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM.A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.Curr Biol. 2011 Jun 21;21(12):1061-9.
    21658950
  • Varier RA, Outchkourov NS, de Graaf P, van Schaik FM, Ensing HJ, Wang F, Higgins JM, Kops GJ, Timmers HM.A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.EMBO J. 2010 Dec 1;29(23):3967-78.
    20953165
  • Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM.Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.Science. 2010 Oct 8;330(6001):231-5.
    20705812
  • Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM.Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.
    20836251
  • Higgins JM.Haspin: a newly discovered regulator of mitotic chromosome behavior.Chromosoma. 2010 Apr;119(2):137-47. Review.
    19997740
  • Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JM, Knapp S.Structure and functional characterization of the atypical human kinase haspin.Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20198-203.
    19918057
  • Dai J, Kateneva AV, Higgins JM.Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.J Cell Sci. 2009 Nov 15;122(Pt 22):4168-76.
    19910498
  • Kateneva AV, Higgins JM.Shugoshin and PP2A: collaborating to keep chromosomes connected.Dev Cell. 2009 Sep;17(3):303-5.
    19758553
  • Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, Buettner R, Schüle R.Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.Nat Cell Biol. 2008 Jan;10(1):53-60.
    18066052
  • Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH.The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.J Mol Biol. 2007 Oct 19;373(2):401-11.
    17850815
  • Dai J, Sullivan BA, Higgins JM.Regulation of mitotic chromosome cohesion by Haspin and Aurora B.Dev Cell. 2006 Nov;11(5):741-50.
    17084365
  • Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB.The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility.Mol Biol Cell. 2006 May;17(5):2366-76.
    16525026
  • Dai J, Higgins JM.Haspin: a mitotic histone kinase required for metaphase chromosome alignment.Cell Cycle. 2005 May;4(5):665-8.
    15846065
  • Dai J, Sultan S, Taylor SS, Higgins JM.The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.Genes Dev. 2005 Feb 15;19(4):472-88.
    15681610
  • Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, Watts GF, Mizoguchi E, Simmons B, Patel DD, Bhan AK, Brenner MB.Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes.J Exp Med. 2004 Dec 20;200(12):1673-9.
    15611293
  • Hintermann E, Yang N, O'Sullivan D, Higgins JM, Quaranta V.Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes.J Biol Chem. 2005 Mar 4;280(9):8004-15.
    15579904
  • Higgins JM.Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases.Cell Mol Life Sci. 2003 Mar;60(3):446-62.
    12737306
  • Kilshaw PJ, Higgins JM.Alpha E: no more rejection?.J Exp Med. 2002 Oct 7;196(7):873-5.
    12370249
  • Higgins JM.Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases.Protein Sci. 2001 Aug;10(8):1677-84.
    11468364
  • Higgins JM.The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells.Gene. 2001 Apr 4;267(1):55-69.
    11311556
  • Bono P, Rubin K, Higgins JM, Hynes RO.Layilin, a novel integral membrane protein, is a hyaluronan receptor.Mol Biol Cell. 2001 Apr;12(4):891-900.
    11294894
  • Strauch UG, Mueller RC, Li XY, Cernadas M, Higgins JM, Binion DG, Parker CM.Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction.J Immunol. 2001 Mar 1;166(5):3506-14.
    11207310
  • Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM.T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.Curr Opin Cell Biol. 2000 Oct;12(5):563-8.
    10978890
  • Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB.The role of alpha and beta chains in ligand recognition by beta 7 integrins.J Biol Chem. 2000 Aug 18;275(33):25652-64.
    10837471
  • Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB.Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.J Exp Med. 2000 May 1;191(9):1555-67.
    10790430
  • Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB.IQGAP1 and calmodulin modulate E-cadherin function.J Biol Chem. 1999 Dec 31;274(53):37885-92.
    10608854
  • Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB.Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin.J Cell Biol. 1998 Jan 12;140(1):197-210.
    9425167
  • Higgins JM, Wiedemann H, Timpl R, Reid KB.Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.J Immunol. 1995 Dec 15;155(12):5777-85.
    7499866
  • Nolan KF, Kaluz S, Higgins JM, Goundis D, Reid KB.Characterization of the human properdin gene.Biochem J. 1992 Oct 1;287 ( Pt 1):291-7.
    1417780