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Glenn Dranoff, MD

Publications

  • Ott PA, Fritsch EF, Wu CJ, Dranoff G.Vaccines and Melanoma.Hematol Oncol Clin North Am. 2014 Jun;28(3):559-569.
    24880947
  • Xu C, Fillmore CM, Koyama S, Wu H, Zhao Y, Chen Z, Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A, Reibel JB, Walton Z, Ji H, Watanabe H, Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, Dranoff G, Hammerman PS, Kim CF, Wong KK.Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.Cancer Cell. 2014 May 12;25(5):590-604.
    24794706
  • Alvarez Arias DA, Kim HJ, Zhou P, Holderried TA, Wang X, Dranoff G, Cantor H.Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity.Cancer Immunol Res. 2014 Mar;2(3):207-16.
    24778317
  • Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL.OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy.Immunol Cell Biol. 2014 Apr 15.
    24732076
  • Selvarajah S, Pyne S, Chen E, Sompallae R, Ligon AH, Nielsen GP, Dranoff G, Stack E, Loda M, Flavin R.High-Resolution Array CGH and Gene Expression Profiling of Alveolar Soft Part Sarcoma.Clin Cancer Res. 2014 Mar 15;20(6):1521-30.
    24493828
  • Ali OA, Verbeke C, Johnson C, Sands RW, Lewin SA, White D, Doherty E, Dranoff G, Mooney DJ.Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants.Cancer Res. 2014 Mar 15;74(6):1670-81.
    24480625
  • Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC.A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.J Hematol Oncol. 2014;7:15.
    24565018
  • Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW.In vivo discovery of immunotherapy targets in the tumour microenvironment.Nature. 2014 Feb 6;506(7486):52-7.
    24476824
  • Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, Mikse OR, Cherniack AD, Beauchamp EM, Pugh TJ, Wilkerson MD, Fecci PE, Butaney M, Reibel JB, Soucheray M, Cohoon TJ, Janne PA, Meyerson M, Hayes DN, Shapiro GI, Shimamura T, Sholl LM, Rodig SJ, Freeman GJ, Hammerman PS, Dranoff G, Wong KK.Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.Cancer Discovery. 2013 Dec(12):1355-63.
    24078774
  • Dranoff G.Immunotherapy at large: Balancing tumor immunity and inflammatory pathology.Nat Med. 2013 Sep;19(9):1100-1.
    24013749
  • Burkhardt UE, Hainz U, Stevenson K, Goldstein NR, Pasek M, Naito M, Wu D, Ho VT, Alonso A, Hammond NN, Wong J, Sievers QL, Brusic A, McDonough SM, Zeng W, Perrin A, Brown JR, Canning CM, Koreth J, Cutler C, Armand P, Neuberg D, Lee JS, Antin JH, Mulligan RC, Sasada T, Ritz J, Soiffer RJ, Dranoff G, Alyea EP, Wu CJ.Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells.J Clin Invest. 2013 Sep 3;123(9):3756-65.
    23912587
  • Bulliard Y, Jolicoeur R, Windman M, Rue SM, Ettenberg S, Knee DA, Wilson NS, Dranoff G, Brogdon JL.Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies.J Exp Med. 2013 Aug 26;210(9):1685-93.
    23897982
  • Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT, Mitchell DA, Fecci PE, Sampson JH, Dranoff G.An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma.Expert Review Of Vaccines. 2013 Jun;12(6):597-615.
    23750791
  • Dranoff G, Fearon D.Tumour immunology.Curr Opin Immunol. 2013 Mar 17.
    23510648
  • Brusic A, Hainz U, Wadleigh M, Neuberg D, Su M, Canning CM, Deangelo DJ, Stone RM, Lee JS, Mulligan RC, Ritz J, Dranoff G, Sasada T, Wu CJ.Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.Oncoimmunology. 2012 Oct 1;1(7):1095-1103.
    23170257
  • Dranoff G.Tailor-made renal cell carcinoma vaccines.Cancer Cell. 2012 Sep 11;22(3):287-9.
    22975372
  • Schoenfeld J, Jinushi M, Nakazaki Y, Wiener D, Park J, Soiffer R, Neuberg D, Mihm M, Hodi FS, Dranoff G.Active immunotherapy induces antibody responses that target tumor angiogenesis.Cancer Res. 2010 Dec 15;70(24):10150-60.
    21159637
  • Zilberberg J, Friedman TM, Dranoff G, Korngold R.Treatment with GM-CSF secreting myeloid leukemia cell vaccine prior to autologous-BMT improves the survival of leukemia challenged mice.Biol Blood Marrow Transplant. 2010 Oct 12.
    20946965
  • Nosho K, Baba Y, Tanaka N, Shima K, Hayashi M, Meyerhardt JA, Giovannucci E, Dranoff G, Fuchs CS, Ogino S.Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review.J Pathol. 2010 Dec;222(4):350-66.
    20927778
  • Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G.IAP inhibitors enhance co-stimulation to promote tumor immunity.J Exp Med. 2010 Sep 27;207(10):2195-206.
    20837698
  • Ferrone C, Dranoff G.Dual roles for immunity in gastrointestinal cancers.J Clin Oncol. 2010 Sep 10;28(26):4045-51. Review.
    20644090
  • Hodi FS, Dranoff G.The biologic importance of tumor-infiltrating lymphocytes.J Cutan Pathol. 2010 Apr;37 Suppl 1:48-53.
    20482675
  • Wong KK, Jacks T, Dranoff G.NF-kappaB fans the flames of lung carcinogenesis.Cancer Prev Res (Phila Pa). 2010 Apr;3(4):403-5. Review.
    20354166
  • Ali OA, Emerich D, Dranoff G, Mooney DJ.In situ regulation of DC subsets and T cells mediates tumor regression in mice.Sci Transl Med. 2009 Nov 25;1(8):8ra19.
    20368186
  • Ogino S, Nosho K, Irahara N, Meyerhardt JA, Baba Y, Shima K, Glickman JN, Ferrone CR, Mino-Kenudson M, Tanaka N, Dranoff G, Giovannucci EL, Fuchs CS.Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype.Clin Cancer Res. 2009 Oct 15;15(20):6412-20.
    19825961
  • Ho VT, Vanneman M, Kim H, Sasada T, Kang YJ, Pasek M, Cutler C, Koreth J, Alyea E, Sarantopoulos S, Antin JH, Ritz J, Canning C, Kutok J, Mihm MC, Dranoff G, Soiffer R.Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation.Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15825-30.
    19717467
  • Dranoff G.Targets of protective tumor immunity.Ann N Y Acad Sci. 2009 Sep;1174:74-80. Review.
    19769739
  • Zarei S,Schwenter F,Luy P,Aurrand-Lions M,Morel P,Kopf M,Dranoff G,Mach N.Role of GM-CSF signaling in cell-based tumor immunization.Blood. 2009 Jun 25;113(26):6658-68.
    19282460
  • Jinushi M,Sato M,Kanamoto A,Itoh A,Nagai S,Koyasu S,Dranoff G,Tahara H.Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms.J Exp Med. 2009 Jun 8;206(6):1317-26.
    19433619
  • Dougan M,Dranoff G.The immune response to tumors.Curr Protoc Immunol. 2009 Apr;Chapter 20:Unit 20.11.
    19347848
  • Mirshahidi S,Kramer VG,Whitney JB,Essono S,Lee S,Dranoff G,Anderson KS,Ruprecht RM.Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival.Vaccine. 2009 Mar 13;27(12):1825-33.
    19201387
  • Ali OA,Huebsch N,Cao L,Dranoff G,Mooney DJ.Infection-mimicking materials to program dendritic cells in situ.Nat Mater. 2009 Feb;8(2):151-8.
    19136947
  • Dougan M,Dranoff G.Immune therapy for cancer.Annu Rev Immunol. 2009;27:83-117. Review.
    19007331
  • Fonseca C,Soiffer R,Ho V,Vanneman M,Jinushi M,Ritz J,Neuberg D,Stone R,DeAngelo D,Dranoff G.Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction.Blood. 2009 Feb 19;113(8):1681-8.
    19008459
  • Lantz CS,Min B,Tsai M,Chatterjea D,Dranoff G,Galli SJ.IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro.Lab Invest. 2008 Nov;88(11):1134-42.
    18975389
  • Jinushi M,Nakazaki Y,Carrasco DR,Draganov D,Souders N,Johnson M,Mihm MC,Dranoff G.Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.Cancer Res. 2008 Nov 1;68(21):8889-98.
    18974133
  • Lantz CS,Min B,Tsai M,Chatterjea D,Dranoff G,Galli SJ.IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro.Lab Invest. 2008 Sep 22.
    18810250
  • Sittler T,Zhou J,Park J,Yuen NK,Sarantopoulos S,Mollick J,Salgia R,Giobbie-Hurder A,Dranoff G,Hodi FS.Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity.Clin Cancer Res. 2008 Jun 15;14(12):3896-905.
    18559611
  • Oble DA,Mino-Kenudson M,Goldsmith J,Hodi FS,Seliem RM,Dranoff G,Mihm M,Hasserjian R,Lauwers GY.Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis.Am J Surg Pathol. 2008 Aug;32(8):1130-7.
    18545145
  • Jinushi M, Hodi FS, Dranoff G.Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines.Immunol Rev. 2008 Apr;222:287-98. Review.
    18364009
  • Fonseca C, Dranoff G.Capitalizing on the immunogenicity of dying tumor cells.Clin Cancer Res. 2008 Mar 15;14(6):1603-8. Review.
    18347160
  • Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, Korman A, Lautz D, Russell S, Jaklitsch MT, Ramaiya N, Chen TC, Neuberg D, Allison JP, Mihm MC, Dranoff G.Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3005-10.
    18287062
  • Dougan M, Dranoff G.Inciting inflammation: the RAGE about tumor promotion.J Exp Med. 2008 Feb 18;205(2):267-70.
    18268042
  • Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA.Modeling genomic diversity and tumor dependency in malignant melanoma.Cancer Res. 2008 Feb 1;68(3):664-73.
    18245465
  • Jinushi M, Vanneman M, Munshi NC, Tai YT, Prabhala RH, Ritz J, Neuberg D, Anderson KC, Carrasco DR, Dranoff G.MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1285-90.
    18202175
  • Kobayashi N, Karisola P, Pea-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ.TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells.Immunity. 2007 Dec;27(6):927-40.
    18082433
  • Jinushi M, Dranoff G.Triggering tumor immunity through angiogenesis targeting.Clin Cancer Res. 2007 Jul 1;13(13):3762-4.
    17606704
  • Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G.MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.J Clin Invest. 2007 Jul;117(7):1902-13.
    17557120
  • Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G.Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.Blood. 2007 Aug 1;110(3):954-61.
    17483299
  • Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery .Corrigendum: High-throughput oncogene mutation profiling in human cancer.Nat Genet. 2007 Apr;39(4):567.
    17392811
  • Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA.High-throughput oncogene mutation profiling in human cancer.Nat Genet. 2007 Mar;39(3):347-351.
    17293865
  • Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK.IL-7 induces myelopoiesis and erythropoiesis.J Immunol. 2007 Feb 1;178(3):1553-63.
    17237404
  • Kimura K, Song CH, Rastogi A, Dranoff G, Galli SJ, Lantz CS.Interleukin-3 and c-Kit/stem cell factor are required for normal eosinophil responses in mice infected with Strongyloides venezuelensis.Lab Invest. 2006 Oct;86(10):987-96.
    16894356
  • Jinushi M, Hodi FS, Dranoff G.Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity.Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9190-5.
    16754847
  • Hodi FS, Dranoff G.Combinatorial cancer immunotherapy.Adv Immunol. 2006;90:341-68. Review.
    16730268
  • Fecci PE, Mitchell DA, Whitesides JF, Xie W, Friedman AH, Archer GE, Herndon JE, Bigner DD, Dranoff G, Sampson JH.Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.Cancer Res. 2006 Mar 15;66(6):3294-302.
    16540683
  • Dranoff G.The therapeutic implications of intratumoral regulatory T cells.Clin Cancer Res. 2005 Dec 1;11(23):8226-9.
    16322278
  • Nieuwenhuis EE, Gillessen S, Scheper RJ, Exley MA, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Blumberg RS, Wilson SB.CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.Exp Dermatol. 2005 Apr;14(4):250-8.
    15810882
  • Katsumoto TR, Duda J, Kim A, Wardak Z, Dranoff G, Clapp DW, Shannon K.Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells.J Exp Med. 2005 Mar 21;201(6):853-8.
    15781578
  • Dranoff G.CTLA-4 blockade: unveiling immune regulation.J Clin Oncol. 2005 Feb 1;23(4):662-4.
    15613692
  • Schmollinger JC, Dranoff G.Targeting melanoma inhibitor of apoptosis protein with cancer immunotherapy.Apoptosis. 2004 May;9(3):309-13.
    15258462
  • Dranoff G.Cytokines in cancer pathogenesis and cancer therapy.Nat Rev Cancer. 2004 Jan;4(1):11-22.
    14708024
  • Bellucci R, Wu CJ, Chiaretti S, Weller E, Davies FE, Alyea EP, Dranoff G, Anderson KC, Munshi NC, Ritz J.Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens.Blood. 2004 Jan 15;103(2):656-63.
    14563636
  • Soiffer R, Hodi FS, Haluska F, Jung K, Gillessen S, Singer S, Tanabe K, Duda R, Mentzer S, Jaklitsch M, Bueno R, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Mihm M, Dranoff G.Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma.J Clin Oncol. 2003 Sep 1;21(17):3343-50.
    12947071
  • Gillessen S, Naumov YN, Nieuwenhuis EE, Exley MA, Lee FS, Mach N, Luster AD, Blumberg RS, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Wilson SB.CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion.Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8874-9.
    12847287
  • Dranoff G.GM-CSF-secreting melanoma vaccines.Oncogene. 2003 May 19;22(20):3188-92.
    12789295
  • Mollick JA, Hodi FS, Soiffer RJ, Nadler LM, Dranoff G.MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients.Cancer Immun. 2003 Mar 17;3:3.
    12747745
  • Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G.Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.J Exp Med. 2003 May 5;197(9):1213-9.
    12732663
  • Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, Davis T, Henry-Spires R, MacRae S, Willman A, Padera R, Jaklitsch MT, Shankar S, Chen TC, Korman A, Allison JP, Dranoff G.Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4712-7.
    12682289
  • Dranoff G.Coordinated tumor immunity.J Clin Invest. 2003 Apr;111(8):1116-8.
    12697728
  • Schmollinger JC, Vonderheide RH, Hoar KM, Maecker B, Schultze JL, Hodi FS, Soiffer RJ, Jung K, Kuroda MJ, Letvin NL, Greenfield EA, Mihm M, Kutok JL, Dranoff G.Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3398-403.
    12626761
  • Salgia R, Lynch T, Skarin A, Lucca J, Lynch C, Jung K, Hodi FS, Jaklitsch M, Mentzer S, Swanson S, Lukanich J, Bueno R, Wain J, Mathisen D, Wright C, Fidias P, Donahue D, Clift S, Hardy S, Neuberg D, Mulligan R, Webb I, Sugarbaker D, Mihm M, Dranoff G.Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma.J Clin Oncol. 2003 Feb 15;21(4):624-30.
    12586798
  • Dranoff G.GM-CSF-based cancer vaccines.Immunol Rev. 2002 Oct;188:147-54.
    12445288
  • Yang XF, Wu CJ, Chen L, Alyea EP, Canning C, Kantoff P, Soiffer RJ, Dranoff G, Ritz J.CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells.Cancer Res. 2002 Oct 1;62(19):5517-22.
    12359762
  • Frossard JL, Saluja AK, Mach N, Lee HS, Bhagat L, Hadenque A, Rubbia-Brandt L, Dranoff G, Steer ML.In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury.Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L541-8.
    12169573
  • Hodi FS, Schmollinger JC, Soiffer RJ, Salgia R, Lynch T, Ritz J, Alyea EP, Yang J, Neuberg D, Mihm M, Dranoff G.ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.Proc Natl Acad Sci U S A. 2002 May 14;99(10):6919-24.
    11983866
  • Dranoff G.Immune recognition and tumor protection.Curr Opin Immunol. 2002 Apr;14(2):161-164.
  • Jegalian AG, Acurio A, Dranoff G, Wu H.Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3.Blood. 2002 Apr 1;99(7):2603-5.
    11895800
  • Teshima T, Liu C, Lowler KP, Dranoff G, Ferrara JL.Donor leukocyte infusion from immunized donors increases tumor vaccine efficacy after allogeneic bone marrow transplantation.Cancer Res. 2002 Feb 1;62(3):796-800.
    11830535
  • Yang XF, Wu CJ, McLaughlin S, Chillemi A, Wang KS, Canning C, Alyea EP, Kantoff P, Soiffer RJ, Dranoff G, Ritz J.CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia.Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7492-7.
    11416219
  • Li S, Gillessen S, Tomasson MH, Dranoff G, Gilliland DG, Van Etten RA.Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.Blood. 2001 Mar 1;97(5):1442-50.
    11222392
  • Tomasson MH, Williams IR, Li S, Kutok J, Cain D, Gillessen S, Dranoff G, Van Etten RA, Gilliland DG.Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3.Blood. 2001 Mar 1;97(5):1435-41.
    11222391
  • Teshima T, Mach N, Hill GR, Pan L, Gillessen S, Dranoff G, Ferrara JL.Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation.Cancer Res. 2001 Jan 1;61(1):162-71.
    11196155
  • Gillessen S, Mach N, Small C, Mihm M, Dranoff G.Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity.Blood. 2001 Feb 15;97(4):922-8.
    11159518
  • Wynn AA, Miyakawa K, Miyata E, Dranoff G, Takeya M, Takahashi K.Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation.Am J Pathol. 2001 Jan;158(1):131-45.
    11141486
  • Dranoff G.Genetically engineered cytokine secreting turmor cell vaccines.Harrison's Principles of Internal Medicine. 2000 Dec;12:571-575.
  • Mach N, Dranoff G.Cytokine-secreting tumor cell vaccines.Curr Opin Immunol. 2000 Oct;12(5):571-5.
    11007361
  • Wu CJ, Yang XF, McLaughlin S, Neuberg D, Canning C, Stein B, Alyea EP, Soiffer RJ, Dranoff G, Ritz J.Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia.J Clin Invest. 2000 Sep;106(5):705-14.
    10974024
  • Dranoff G.Targeting gene therapy--a reality?.Mol Ther. 2000 Feb;1(2):117-8.
    10933921
  • Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, Dranoff G.Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.Cancer Res. 2000 Jun 15;60(12):3239-46.
    10866317
  • Sampson JH, Crotty LE, Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD.Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7503-8.
    10852962
  • Dranoff G.Interpreting cancer vaccine clinical trials.J Gene Med. 1999 Mar-Apr;1(2):80-3.
    10738571
  • Birnbaum RA, O'Marcaigh A, Wardak Z, Zhang YY, Dranoff G, Jacks T, Clapp DW, Shannon KM.Nf1 and Gmcsf interact in myeloid leukemogenesis.Mol Cell. 2000 Jan;5(1):189-95.
    10678181
  • Heimberger AB, Crotty LE, Archer GE, McLendon RE, Friedman A, Dranoff G, Bigner DD, Sampson JH.Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma.J Neuroimmunol. 2000 Feb 1;103(1):16-25.
    10674985
  • Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA.Cathepsin S required for normal MHC class II peptide loading and germinal center development.Immunity. 1999 Feb;10(2):197-206.
    10072072
  • Dranoff G.The use of gene transfer in cancer immunotherapy.Forum (Genova). 1998 Oct-Dec;8(4):357-64.
    9863030
  • Evans R, Shultz LD, Dranoff G, Fuller JA, Kamdar SJ.CSF-1 regulation of Il6 gene expression by murine macrophages: a pivotal role for GM-CSF.J Leukoc Biol. 1998 Dec;64(6):810-6.
    9850165
  • Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Dranoff G.Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13141-6.
    9789055
  • Chen LZ, Hochwald GM, Huang C, Dakin G, Tao H, Cheng C, Simmons WJ, Dranoff G, Thorbecke GJ.Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-beta1.Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12516-21.
    9770517
  • Dranoff G.Cancer gene therapy: connecting basic research with clinical inquiry.J Clin Oncol. 1998 Jul;16(7):2548-56.
    9667277
  • Hodi FS, Dranoff G.Genetically modified tumor cell vaccines.Surg Oncol Clin N Am. 1998 Jul;7(3):471-85.
    9624213
  • Gainsford T, Roberts AW, Kimura S, Metcalf D, Dranoff G, Mulligan RC, Begley CG, Robb L, Alexander WS.Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production.Blood. 1998 Apr 15;91(8):2745-52.
    9531584
  • Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ.Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites.Nature. 1998 Mar 5;392(6671):90-3.
    9510253
  • Schultze JL, Michalak S, Seamon MJ, Dranoff G, Jung K, Daley J, Delgado JC, Gribben JG, Nadler LM.CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy.J Clin Invest. 1997 Dec 1;100(11):2757-65.
    9389740
  • Dunussi-Joannopoulos K, Dranoff G, Weinstein HJ, Ferrara JL, Bierer BE, Croop JM.Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines.Blood. 1998 Jan 1;91(1):222-30.
    9414288
  • Mach N, Lantz CS, Galli SJ, Reznikoff G, Mihm M, Small C, Granstein R, Beissert S, Sadelain M, Mulligan RC, Dranoff G.Involvement of interleukin-3 in delayed-type hypersensitivity.Blood. 1998 Feb 1;91(3):778-83.
    9446636
  • Huffman Reed JA, Rice WR, Zsengellr ZK, Wert SE, Dranoff G, Whitsett JA.GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice.Am J Physiol. 1997 Oct;273(4 Pt 1):L715-25.
    9357845
  • Mackey MF, Gunn JR, Ting PP, Kikutani H, Dranoff G, Noelle RJ, Barth RJ.Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154.Cancer Res. 1997 Jul 1;57(13):2569-74.
    9205055
  • Yu JS, Burwick JA, Dranoff G, Breakefield XO.Gene therapy for metastatic brain tumors by vaccination with granulocyte-macrophage colony-stimulating factor-transduced tumor cells.Hum Gene Ther. 1997 Jun 10;8(9):1065-72.
    9189764
  • Dranoff G.Gene therapy 1996.Biochim Biophys Acta. 1997 Apr 18;1332(2):R21-4.
    9141465
  • Simons JW, Jaffee EM, Weber CE, Levitsky HI, Nelson WG, Carducci MA, Lazenby AJ, Cohen LK, Finn CC, Clift SM, Hauda KM, Beck LA, Leiferman KM, Owens AH, Piantadosi S, Dranoff G, Mulligan RC, Pardoll DM, Marshall FF.Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer.Cancer Res. 1997 Apr 15;57(8):1537-46.
    9108457
  • Shen Z, Reznikoff G, Dranoff G, Rock KL.Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.J Immunol. 1997 Mar 15;158(6):2723-30.
    9058806
  • Ellem KA, O'Rourke MG, Johnson GR, Parry G, Misko IS, Schmidt CW, Parsons PG, Burrows SR, Cross S, Fell A, Li CL, Bell JR, Dubois PJ, Moss DJ, Good MF, Kelso A, Cohen LK, Dranoff G, Mulligan RC.A case report: immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy.Cancer Immunol Immunother. 1997 Mar;44(1):10-20.
    9111579
  • Dranoff G, Soiffer R, Lynch T, Mihm M, Jung K, Kolesar K, Liebster L, Lam P, Duda R, Mentzer S, Singer S, Tanabe K, Johnson R, Sober A, Bhan A, Clift S, Cohen L, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Mulligan RC.A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor.Hum Gene Ther. 1997 Jan 1;8(1):111-23.
    8990000
  • Sampson JH, Archer GE, Ashley DM, Fuchs HE, Hale LP, Dranoff G, Bigner DD.Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10399-404.
    8816812
  • Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA.Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice.J Clin Invest. 1996 Feb 1;97(3):649-55.
    8609219
  • Hurford RK, Dranoff G, Mulligan RC, Tepper RI.Gene therapy of metastatic cancer by in vivo retroviral gene targeting.Nat Genet. 1995 Aug;10(4):430-5.
    7670493
  • Berns AJ, Clift S, Cohen LK, Donehower RC, Dranoff G, Hauda KM, Jaffee EM, Lazenby AJ, Levitsky HI, Marshall FF.Phase I study of non-replicating autologous tumor cell injections using cells prepared with or without GM-CSF gene transduction in patients with metastatic renal cell carcinoma.Hum Gene Ther. 1995 Mar;6(3):347-68.
    7779918
  • Dranoff G, Mulligan RC.Gene transfer as cancer therapy.Adv Immunol. 1995;58:417-54.
    7741031
  • Dranoff G, Crawford AD, Sadelain M, Ream B, Rashid A, Bronson RT, Dickersin GR, Bachurski CJ, Mark EL, Whitsett JA.Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.Science. 1994 Apr 29;264(5159):713-6.
    8171324
  • Sanda MG, Ayyagari SR, Jaffee EM, Epstein JI, Clift SL, Cohen LK, Dranoff G, Pardoll DM, Mulligan RC, Simons JW.Demonstration of a rational strategy for human prostate cancer gene therapy.J Urol. 1994 Mar;151(3):622-8.
    8308972
  • Dranoff G, Mulligan RC.Activities of granulocyte-macrophage colony-stimulating factor revealed by gene transfer and gene knockout studies.Stem Cells. 1994;12 Suppl 1:173-82; discussion 182-4.
    7696961
  • Jaffee EM, Dranoff G, Cohen LK, Hauda KM, Clift S, Marshall FF, Mulligan RC, Pardoll DM.High efficiency gene transfer into primary human tumor explants without cell selection.Cancer Res. 1993 May 15;53(10 Suppl):2221-6.
    8485707
  • Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC.Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3539-43.
    8097319