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Zhirui Wang, PhD

Publications

  • Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z.Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells.J Immunol Methods. 2014 Mar;405:57-66.
    24462799
  • Wamala I, Matar AJ, Farkash E, Wang Z, Huang CA, Sachs DH.Recombinant anti-monkey CD3 immunotoxin depletes peripheral lymph node T lymphocytes more effectively than rabbit anti-thymocyte globulin in na├»ve baboons.Transpl Immunol. 2013 Dec;29(1-4):60-3.
    24157659
  • Peraino JS, Schenk M, Li G, Zhang H, Farkash EA, Sachs DH, Huang CA, Duran-Struuck R, Wang Z.Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells.J Immunol Methods. 2013 Dec 15;398-399:33-43.
    24055128
  • Peraino JS, Schenk M, Zhang H, Li G, Hermanrud CE, Neville DM, Sachs DH, Huang CA, Duran-Struuck R, Wang Z.A truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin.J Immunol Methods. 2013 Mar 5.
    23470981
  • Matar AJ, Pathiraja V, Wang Z, Duran-Struuck R, Gusha A, Crepeau R, Tasaki M, Sachs DH, Huang CA.Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment.Transpl Immunol. 2012 Aug;27(1):52-4.
    22676970
  • Peraino JS, Hermanrud CE, Springett L, Zhang H, Li G, Srinivasan S, Gusha A, Sachs DH, Huang CA, Wang Z.Expression and characterization of recombinant soluble porcine CD3 ectodomain molecules: mapping the epitope of an anti-porcine CD3 monoclonal antibody 898H2-6-15.Cell Immunol.;276(1-2):162-7.
    22672968
  • Peraino J, Zhang H, Hermanrud CE, Li G, Sachs DH, Huang CA, Wang Z.Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris.Protein Expr Purif. 2012 Feb 2;82(2):270-278.
    22326797
  • Hermanrud CE, Pathiraja V, Matar A, Duran-Struuck R, Crepeau RL, Srinivasan S, Sachs DH, Huang CA, Wang Z.Expression and purification of non-N-glycosylated porcine interleukin 3 in yeast Pichia pastoris.Protein Expr Purif. 2012 Mar;82(1):70-4.
    22154875
  • Wang Z, Duran-Struuck R, Crepeau R, Matar A, Hanekamp I, Srinivasan S, Neville DM, Sachs DH, Huang CA.Development of a diphtheria toxin based antiporcine CD3 recombinant immunotoxin.Bioconjug Chem. 2011 Oct 19;22(10):2014-20.
    21866954
  • Nishimura H, Scalea J, Wang Z, Shimizu A, Moran S, Gillon B, Sachs DH, Yamada K.First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome.Transplantation. 2011 Sep 27;92(6):641-7.
    21822171
  • Hermanrud CE, Lucas CL, Sykes M, Huang CA, Wang Z.Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris.Protein Expr Purif. 2011 Mar;76(1):115-20.
    21074618
  • Kim GB, Wang Z, Liu YY, Stavrou S, Mathias A, Goodwin KJ, Thomas JM, Neville DM.A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin.Protein Eng. Des. Sel. 2007 Sep;20(9):425-32.
    17693455
  • Liu YY, Wang Z, Thomas J, Goodwin KJ, Stavrou S, Neville DM.Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins.Immunol Cell Biol. 2007 Jul;85(5):357-62.
    17325695
  • Wang Z, Kim GB, Woo JH, Liu YY, Mathias A, Stavrou S, Neville DM.Improvement of a recombinant anti-monkey anti-CD3 diphtheria toxin based immunotoxin by yeast display affinity maturation of the scFv.Bioconjug Chem.;18(3):947-55.
    17352456
  • Wang Z, Neville DM.Expression and characterization of recombinant soluble monkey CD3 molecules: mapping the FN18 polymorphic epitope.Mol Immunol. 2004 Mar;40(16):1179-88.
    15104123
  • Woo JH, Liu YY, Mathias A, Stavrou S, Wang Z, Thompson J, Neville DM.Gene optimization is necessary to express a bivalent anti-human anti-T cell immunotoxin in Pichia pastoris.Protein Expr Purif. 2002 Jul;25(2):270-82.
    12135560