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Ronny I. Drapkin, MD, PhD

Publications

  • Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, Levanon K, Sougnez C, Tsherniak A, Gomez S, Onofrio R, Gabriel S, Chin L, Zhang N, Spellman PT, Zhang Y, Akbani R, Hoadley KA, Kahn A, K√∂bel M, Huntsman D, Soslow RA, Defazio A, Birrer MJ, Gray JW, Weinstein JN, Bowtell DD, Drapkin R, Mesirov JP, Getz G, Levine DA, Meyerson M, .Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.J Clin Invest. 2013 Jan 2;123(1):517-25.
    23257362
  • Howitt BE, Nucci MR, Drapkin R, Crum CP, Hirsch MS.Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity.Am J Surg Pathol. 2013 Jan;37(1):89-97.
    23211296
  • O'Neal RL, Nam KT, Lafleur BJ, Barlow B, Nozaki K, Lee HJ, Kim WH, Yang HK, Shi C, Maitra A, Montgomery E, Washington MK, El Rifai W, Drapkin RI, Goldenring JR.Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas.Hum Pathol. 2012 Oct 16.
    23084584
  • Sung CK, Yim H, Gu H, Li D, Andrews E, Duraisamy S, Li C, Drapkin R, Benjamin T.The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC.PLoS ONE. 2012;7(9):e46486.
    23029531
  • Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, Fogal V, Ruoslahti E, Hahn WC, Bhatia SN.Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.Sci Transl Med. 2012 Aug 15;4(147):147ra112.
    22896676
  • Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A.Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.Science. 2011 Nov 25;334(6059):1129-33.
    22033517
  • Manchanda R, Drapkin R, Jacobs I, Menon U.The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer.Gynecol Oncol. 2011 Oct 20.
    22019526
  • Kalogera E, Scholler N, Powless C, Weaver A, Drapkin R, Li J, Jiang SW, Podratz K, Urban N, Dowdy SC.Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer.Gynecol Oncol. 2011 Oct 28.
    22037318
  • Karst AM, Drapkin R.The new face of ovarian cancer modeling: better prospects for detection and treatment.F1000 Med Rep. 2011;3:22.
    22076125
  • Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD, Balkwill FR.Rethinking ovarian cancer: recommendations for improving outcomes.Nat Rev Cancer. 2011 Oct;11(10):719-25.
    21941283
  • Kondratiev S, Duraisamy S, Unitt CL, Green MR, Pinkus GS, Shipp MA, Kutok JL, Drapkin RI, Rodig SJ.Aberrant Expression of the Dendritic Cell Marker TNFAIP2 by the Malignant Cells of Hodgkin Lymphoma and Primary Mediastinal Large B-Cell Lymphoma Distinguishes These Tumor Types From Morphologically and Phenotypically Similar Lymphomas.Am J Surg Pathol. 2011 Oct;35(10):1531-9.
    21921781
  • Matulonis UA, Hirsch M, Palescandolo E, Kim E, Liu J, van Hummelen P, Macconaill L, Drapkin R, Hahn WC.High throughput interrogation of somatic mutations in high grade serous cancer of the ovary.PLoS ONE. 2011;6(9):e24433.
    21931712
  • Karst AM, Levanon K, Duraisamy S, Liu JF, Hirsch MS, Hecht JL, Drapkin R.Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas.Gynecol Oncol. 2011 Oct;123(1):5-12.
    21683992
  • Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC.Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12372-7.
    21746896
  • Fotheringham S, Levanon K, Drapkin R.Ex vivo culture of primary human fallopian tube epithelial cells.Journal Of Visualized Experiments : Jo Ve. 2011(51).
    21610668
  • Laury AR, Perets R, Piao H, Krane JF, Barletta JA, French C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin R, Hirsch MS.A comprehensive analysis of PAX8 expression in human epithelial tumors.Am J Surg Pathol. 2011 Jun;35(6):816-26.
    21552115
  • Karst AM, Levanon K, Drapkin R.Modeling high-grade serous ovarian carcinogenesis from the fallopian tube.Proc Natl Acad Sci U S A. 2011 May 3;108(18):7547-52.
    21502498
  • Mehra K, Mehrad M, Ning G, Drapkin R, McKeon FD, Xian W, Crum CP.STICS, SCOUTs and p53 signatures; a new language for pelvic serous carcinogenesis.Front Biosci (Elite Ed). 2011;3:625-34.
    21196340
  • Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J.53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.Nat Struct Mol Biol. 2010 Jun;17(6):688-95.
    20453858
  • Laury AR, Hornick JL, Perets R, Krane JF, Corson J, Drapkin R, Hirsch MS.PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma.Am J Surg Pathol. 2010 May;34(5):627-35.
    20414098
  • Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, Kung AL, Hahn WC, Drapkin R, Livingston DM, Liu JF.An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.Cancer Cell. 2010 Mar 16;17(3):298-310.
    20227043
  • Levanon K, Ng V, Piao HY, Zhang Y, Chang MC, Roh MH, Kindelberger DW, Hirsch MS, Crum CP, Marto JA, Drapkin R.Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis.Oncogene. 2010 Feb 25;29(8):1103-13.
    19935705
  • Clauss A, Ng V, Liu J, Piao H, Russo M, Vena N, Sheng Q, Hirsch MS, Bonome T, Matulonis U, Ligon AH, Birrer MJ, Drapkin R.Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.Neoplasia. 2010 Feb;12(2):161-72.
    20126474
  • Jarboe EA, Folkins AK, Drapkin R, Ince TA, Agoston ES, Crum CP.Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective.Histopathology. 2009 Nov;55(5):619.
    19912369
  • Karst AM, Drapkin R.Ovarian cancer pathogenesis: a model in evolution.J Oncol. 2010;2010:932371.
    19746182
  • Garrett LA, Vargas SO, Drapkin R, Laufer MR.Does the fimbria have an embryologic origin distinct from that of the rest of the fallopian tube?.Fertil Steril. 2008 Nov;90(5):2008.e5-8.
    18353321
  • Levanon K, Crum C, Drapkin R.New insights into the pathogenesis of serous ovarian cancer and its clinical impact.J Clin Oncol. 2008 Nov 10;26(32):5284-93. Review.
    18854563
  • Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK.Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.Clin Cancer Res. 2008 Oct 15;14(20):6478-86.
    18927287
  • Drapkin R, Clauss A, Skates S.Urokinase-type plasminogen activator receptor: a beacon of malignancy?.Clin Cancer Res. 2008 Sep 15;14(18):5643-5.
    18794069
  • Jarboe EA, Folkins AK, Drapkin R, Ince TA, Agoston ES, Crum CP.Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective.Histopathology. 2008 Aug;53(2):127-38. Review.
    18298580
  • De Nicolo A, Tancredi M, Lombardi G, Flemma CC, Barbuti S, Di Cristofano C, Sobhian B, Bevilacqua G, Drapkin R, Caligo MA.A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function.Clin Cancer Res. 2008 Jul 15;14(14):4672-80.
    18628483
  • Bossuyt V,Medeiros F,Drapkin R,Folkins AK,Crum CP,Nucci MR.Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma.Int J Gynecol Pathol. 2008 Jul;27(3):390-7.
    18580316
  • Scholler N, Lowe KA, Bergan LA, Kampani AV, Ng V, Forrest RM, Thorpe JD, Gross JA, Garvik BM, Drapkin R, Anderson GL, Urban N.Use of yeast-secreted in vivo biotinylated recombinant antibodies (Biobodies) in bead-based ELISA.Clin Cancer Res. 2008 May 1;14(9):2647-55.
    18451228
  • Folkins AK, Jarboe EA, Saleemuddin A, Lee Y, Callahan MJ, Drapkin R, Garber JE, Muto MG, Tworoger S, Crum CP.A candidate precursor to pelvic serous cancer (p53 signature) and its prevalence in ovaries and fallopian tubes from women with BRCA mutations.Gynecol Oncol. 2008 May;109(2):168-73.
    18342932
  • Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR.A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.Gastroenterology. 2008 Feb;134(2):511-22.
    18242217
  • Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR.A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.Gastroenterology.;134:511-22.
  • Jarboe E, Folkins A, Nucci MR, Kindelberger D, Drapkin R, Miron A, Lee Y, Crum CP.Serous carcinogenesis in the fallopian tube: a descriptive classification.Int J Gynecol Pathol. 2008 Jan;27(1):1-9.
    18156967
  • Nucci MR, Drapkin R, Cin PD, Fletcher CD, Fletcher JA.Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications.Am J Surg Pathol. 2007 May;31(5):737-743.
    17460458
  • Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y.Lessons from BRCA: The Tubal Fimbria Emerges as an Origin for Pelvic Serous Cancer.Clin Med Res. 2007 Mar;5(1):35-44. Review.
    17456833
  • Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM.Further evidence for BRCA1 communication with the inactive X chromosome.Cell. 2007 Mar 9;128(5):991-1002.
    17350581
  • Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW, Lee Y.The distal fallopian tube: a new model for pelvic serous carcinogenesis.Curr Opin Obstet Gynecol.;19:3-9.
  • Erkko H, Xia B, Nikkila J, Schleutker J, Syrjakoski K, Mannermaa A, Kallioniemi A, Pylkas K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R.A recurrent mutation in PALB2 in Finnish cancer families.Nature. 2007 Mar 15;446(7133):316-9.
    17287723
  • Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW, Lee Y.The distal fallopian tube: a new model for pelvic serous carcinogenesis.Curr Opin Obstet Gynecol. 2007 Feb;19(1):3-9. Review.
    17218844
  • Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP.A candidate precursor to serous carcinoma that originates in the distal fallopian tube.J Pathol. 2007 Jan;211(1):26-35.
    17117391
  • Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL.Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.Cancer Res. 2005 Mar 15;65(6):2162-9.
    15781627
  • Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, Rajewsky K.Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.Genes Dev. 2005 Feb 15;19(4):489-501.
    15713842
  • Drapkin R, Crum CP, Hecht JL.Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia.Hum Pathol. 2004 Aug;35(8):1014-21.
    15297969
  • Ganesan S, Silver DP, Drapkin R, Greenberg R, Feunteun J, Livingston DM.Association of BRCA1 with the inactive X chromosome and XIST RNA.Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29;359(1441):123-8.
    15065664
  • Cantor S, Drapkin R, Zhang F, Lin Y, Han J, Pamidi S, Livingston DM.The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2357-62.
    14983014
  • Drapkin RI, Genest DR, Holmes LB, Huang T, Vargas SO.Unilateral transverse arm defect with subterminal digital nubbins.Pediatr Dev Pathol. 2003 Jul-Aug;6(4):348-54.
    14692649
  • Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y.The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.Cell. 2003 May 2;113(3):357-67.
    12732143
  • Ganesan S, Silver DP, Greenberg RA, Avni D, Drapkin R, Miron A, Mok SC, Randrianarison V, Brodie S, Salstrom J, Rasmussen TP, Klimke A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM.BRCA1 supports XIST RNA concentration on the inactive X chromosome.Cell. 2002 Nov 1;111(3):393-405.
    12419249
  • Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM.The p400 complex is an essential E1A transformation target.Cell. 2001 Aug 10;106(3):297-307.
    11509179
  • Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM.BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.Cell. 2001 Apr 6;105(1):149-60.
    11301010
  • Reinberg D, Orphanides G, Ebright R, Akoulitchev S, Carcamo J, Cho H, Cortes P, Drapkin R, Flores O, Ha I, Inostroza JA, Kim S, Kim TK, Kumar P, Lagrange T, LeRoy G, Lu H, Ma DM, Maldonado E, Merino A, Mermelstein F, Olave I, Sheldon M, Shiekhattar R, Zawel L, et al.The RNA polymerase II general transcription factors: past, present, and future.Cold Spring Harb Symp Quant Biol. 1998;63:83-103.
    10384273
  • LeRoy G, Drapkin R, Weis L, Reinberg D.Immunoaffinity purification of the human multisubunit transcription factor IIH.J Biol Chem. 1998 Mar 20;273(12):7134-40.
    9507027
  • Selby CP, Drapkin R, Reinberg D, Sancar A.RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repair.Nucleic Acids Res. 1997 Feb 15;25(4):787-93.
    9016630
  • Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D.Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6488-93.
    8692842
  • Maldonado E, Shiekhattar R, Sheldon M, Cho H, Drapkin R, Rickert P, Lees E, Anderson CW, Linn S, Reinberg D.A human RNA polymerase II complex associated with SRB and DNA-repair proteins.Nature. 1996 May 2;381(6577):86-9.
    8609996
  • Maldonado E, Drapkin R, Reinberg D.Purification of human RNA polymerase II and general transcription factors.Methods Enzymol. 1996;274:72-100.
    8902797
  • Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E.The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.Mol Cell Biol. 1995 Sep;15(9):4735-44.
    7651391
  • Tong X, Drapkin R, Reinberg D, Kieff E.The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2.Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3259-63.
    7724549
  • Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D.Cdk-activating kinase complex is a component of human transcription factor TFIIH.Nature. 1995 Mar 16;374(6519):283-7.
    7533895
  • Drapkin R, Reinberg D.The multifunctional TFIIH complex and transcriptional control.Trends Biochem Sci. 1994 Nov;19(11):504-8.
    7855896
  • Drapkin R, Reinberg D.Transcription. The essential twist.Nature. 1994 Jun 16;369(6481):523-4.
    8202151
  • Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D.Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.Nature. 1994 Apr 21;368(6473):769-72.
    8152490
  • Drapkin R, Sancar A, Reinberg D.Where transcription meets repair.Cell. 1994 Apr 8;77(1):9-12.
    8156601
  • Drapkin R, Merino A, Reinberg D.Regulation of RNA polymerase II transcription.Curr Opin Cell Biol. 1993 Jun;5(3):469-76.
    8352965