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Michelle S. Hirsch, MD, PhD


  • Cabral FC, Krajewski KM, Rosenthal MH, Hirsch MS, Howard SA.Teratoma with malignant transformation: report of three cases and review of the literature.Clin Imaging. 2014 Apr 28.
  • Guancial EA, Werner L, Bellmunt J, Bamias A, Choueiri TK, Ross R, Schutz FA, Park RS, O'Brien RJ, Hirsch MS, Barletta JA, Berman DM, Lis R, Loda M, Stack EC, Garraway LA, Riester M, Michor F, Kantoff PW, Rosenberg JE.FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.Cancer Med. 2014 May 21.
  • Rose BS, Chen MH, Zhang D, Hirsch MS, Richie JP, Chang SL, Hegde JV, Loffredo MJ, D'Amico AV.Maximum Tumor Diameter and the Risk of Prostate-Specific Antigen Recurrence After Radical Prostatectomy.Clin Genitourin Cancer. 2014 Mar 28.
  • Phillips JG, Aizer AA, Chen MH, Zhang D, Hirsch MS, Richie JP, Tempany CM, Williams S, Hegde JV, Loffredo MJ, D'Amico AV.The Effect of Differing Gleason Scores at Biopsy on the Odds of Upgrading and the Risk of Death From Prostate Cancer.Clin Genitourin Cancer. 2014 Mar 3.
  • Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R.Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.Cancer Res. 2014 Feb 15;74(4):1141-52.
  • Elias KM, Labidi-Galy SI, Vitonis AF, Hornick JL, Doyle LA, Hirsch MS, Cramer DW, Drapkin R.Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms.Gynecol Oncol. 2014 Feb;132(2):328-33.
  • Schoolmeester JK, Howitt BE, Hirsch MS, Dal Cin P, Quade BJ, Nucci MR.Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: clinicopathologic and immunohistochemical characterization of 16 cases.Am J Surg Pathol. 2014 Feb;38(2):176-88.
  • Perets R, Wyant GA, Muto KW, Bijron JG, Poole BB, Chin KT, Chen JY, Ohman AW, Stepule CD, Kwak S, Karst AM, Hirsch MS, Setlur SR, Crum CP, Dinulescu DM, Drapkin R.Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.Cancer Cell. 2013 Dec 9;24(6):751-65.
  • Aizer AA, Paly JJ, Zietman AL, Nguyen PL, Beard CJ, Rao SK, Kaplan ID, Niemierko A, Hirsch MS, Wu CL, Olumi AF, Michaelson MD, D'Amico AV, Efstathiou JA.Models of care and NCCN guideline adherence in very-low-risk prostate cancer.J Natl Compr Canc Netw. 2013 Nov;11(11):1364-72.
  • Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, Van Hummelen P, Macconaill LE, Shoni M, Wagle N, Jones RT, Quick CM, Laury A, Katz IT, Hahn WC, Matulonis UA, Hirsch MS.Oncogenic mutations in cervical cancer: Genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.Cancer. 2013 Nov 1;119(21):3776-83.
  • Ning G, Bijron JG, Yuan J, Hirsch MS, McKeon FD, Nucci MR, Crum CP, Xian W.Differential expression of p-ERM, a marker of cell polarity, in benign and neoplastic oviductal epithelium.Int J Gynecol Pathol. 2013 Jul;32(4):345-52.
  • Zhang C, Berney DM, Hirsch MS, Cheng L, Ulbright TM.Evidence Supporting the Existence of Benign Teratomas of the Postpubertal Testis: A Clinical, Histopathologic, and Molecular Genetic Analysis of 25 Cases.Am J Surg Pathol. 2013 Apr 16.
  • Schutz FA, Pomerantz MM, Gray KP, Atkins MB, Rosenberg JE, Hirsch MS, McDermott DF, Lampron ME, Lee GS, Signoretti S, Kantoff PW, Freedman ML, Choueiri TK.Single nucleotide polymorphisms and risk of recurrence of renal-cell carcinoma: a cohort study.Lancet Oncol. 2013 Jan;14(1):81-7.
  • Howitt BE, Nucci MR, Drapkin R, Crum CP, Hirsch MS.Stathmin-1 expression as a complement to p16 helps identify high-grade cervical intraepithelial neoplasia with increased specificity.Am J Surg Pathol. 2013 Jan;37(1):89-97.
  • Morgan EA, Pozdnyakova O, Nascimento AF, Hirsch MS.PAX8 and PAX5 are differentially expressed in B-cell and T-cell lymphomas.Histopathology. 2012 Aug 29.
  • Sahni VA, Hirsch MS, Silverman SG.Renal angiomyoadenomatous tumour: Imaging features.Can Urol Assoc J. 2012 Aug;6(4):E140-3.
  • Choueiri TK, Cheville J, Palescandolo E, Fay AP, Kantoff PW, Atkins MB, McKenney JK, Brown V, Lampron ME, Zhou M, Hirsch MS, Signoretti S.BRAF mutations in metanephric adenoma of the kidney.Eur Urol. 2012 Nov;62(5):917-22.
  • Aizer AA, Paly JJ, Zietman AL, Nguyen PL, Beard CJ, Rao SK, Kaplan ID, Niemierko A, Hirsch MS, Wu CL, Olumi AF, Michaelson MD, D'Amico AV, Efstathiou JA.Multidisciplinary care and pursuit of active surveillance in low-risk prostate cancer.J Clin Oncol. 2012 Sep 1;30(25):3071-6.
  • Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, Fogal V, Ruoslahti E, Hahn WC, Bhatia SN.Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.Sci Transl Med. 2012 Aug 15;4(147):147ra112.
  • Williams SB, Hirsch MS, Kantoff PW, Richie JP.Neuroepithelial Tumor Arising in a Testicular Teratoma With Retroperitoneal Metastasis.J Clin Oncol. 2012 Jun 11.
  • Bentink S, Haibe-Kains B, Risch T, Fan JB, Hirsch MS, Holton K, Rubio R, April C, Chen J, Wickham-Garcia E, Liu J, Culhane A, Drapkin R, Quackenbush J, Matulonis UA.Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer.PLoS ONE. 2012;7(2):e30269.
  • Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A.Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.Science. 2011 Nov 25;334(6059):1129-33.
  • Karst AM, Levanon K, Duraisamy S, Liu JF, Hirsch MS, Hecht JL, Drapkin R.Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas.Gynecol Oncol. 2011 Oct;123(1):5-12.
  • Mosquera JM, Dal Cin P, Mertz KD, Perner S, Davis IJ, Fisher DE, Rubin MA, Hirsch MS.Validation of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinomas.Diagn Mol Pathol. 2011 Sep;20(3):129-37.
  • Laury AR, Perets R, Piao H, Krane JF, Barletta JA, French C, Chirieac LR, Lis R, Loda M, Hornick JL, Drapkin R, Hirsch MS.A comprehensive analysis of PAX8 expression in human epithelial tumors.Am J Surg Pathol. 2011 Jun;35(6):816-26.
  • Pinto AP, Crum CP, Hirsch MS.MOLECULAR MARKERS OF EARLY CERVICAL NEOPLASIA.Diagn Histopathol. 2010 Oct 1;16(10):445-454.
  • Williams SB, Chen MH, D'Amico AV, Weinberg AC, Kacker R, Hirsch MS, Richie JP, Hu JC.Radical Retropubic Prostatectomy and Robotic-assisted Laparoscopic Prostatectomy: Likelihood of Positive Surgical Margin(s).Urology. 2010 Nov;76(5):1097-101.
  • Choueiri TK, Lim ZD, Hirsch MS, Tamboli P, Jonasch E, McDermott DF, Cin PD, Corn P, Vaishampayan U, Heng DY, Tannir NM.Vascular endothelial growth factor-targeted therapy for the treatment of adult metastatic Xp11.2 translocation renal cell carcinoma.Cancer. 2010 Nov 15;116(22):5219-25.
  • Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, Mckeon FD, Hirsch MS, Wa X, Crum CP.High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression.Mod Pathol. 2010 Oct;23(10):1316-24.
  • Campos SM, Berlin ST, Parker LM, Chen WY, Bunnell CA, Atkinson T, Lee J, Matulonis U, Hirsch MS, Harris L, Krasner CN.Phase I trial of liposomal doxorubicin and ZD1839 in patients with refractory gynecological malignancies or metastatic breast cancer.Int J Clin Oncol. 2010 Aug;15(4):390-8.
  • Folkins AK, Nevadunsky NS, Saleemuddin A, Jarboe EA, Muto MG, Feltmate CM, Crum CP, Hirsch MS.Evaluation of vascular space involvement in endometrial adenocarcinomas: laparoscopic vs abdominal hysterectomies.Mod Pathol. 2010 Aug;23(8):1073-9.
  • Chen EY, Tran A, Raho CJ, Birch CM, Crum CP, Hirsch MS.Histological 'progression' from low (LSIL) to high (HSIL) squamous intraepithelial lesion is an uncommon event and an indication for quality assurance review.Mod Pathol. 2010 Aug;23(8):1045-51.
  • Jarboe EA, Venkat P, Hirsch MS, Cibas ES, Crum CP, Garner EI.A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology.J Low Genit Tract Dis. 2010 Jul;14(3):174-8.
  • Carlson JW, Jarboe EA, Kindelberger D, Nucci MR, Hirsch MS, Crum CP.Serous tubal intraepithelial carcinoma: diagnostic reproducibility and its implications.Int J Gynecol Pathol. 2010 Jul;29(4):310-4.
  • Laury AR, Hornick JL, Perets R, Krane JF, Corson J, Drapkin R, Hirsch MS.PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma.Am J Surg Pathol. 2010 May;34(5):627-35.
  • Long KB, Srivastava A, Hirsch MS, Hornick JL.PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors.Am J Surg Pathol. 2010 May;34(5):723-9.
  • Levanon K, Ng V, Piao HY, Zhang Y, Chang MC, Roh MH, Kindelberger DW, Hirsch MS, Crum CP, Marto JA, Drapkin R.Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis.Oncogene. 2010 Feb 25;29(8):1103-13.
  • Clauss A, Ng V, Liu J, Piao H, Russo M, Vena N, Sheng Q, Hirsch MS, Bonome T, Matulonis U, Ligon AH, Birrer MJ, Drapkin R.Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.Neoplasia. 2010 Feb;12(2):161-72.
  • Coco DP, Hirsch MS, Hornick JL.Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract.Am J Surg Pathol. 2009 Dec;33(12):1795-801.
  • Liu JF, Hirsch MS, Lee H, Matulonis UA.Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma.Gynecol Oncol. 2009 Dec;115(3):401-6.
  • Choueiri TK, Mosquera JM, Hirsch MS.A case of adult metastatic Xp11 translocation renal cell carcinoma treated successfully with sunitinib.Clin Genitourin Cancer. 2009 Oct;7(3):E93-4.
  • Semmel DR,Folkins AK,Hirsch MS,Nucci MR,Crum CP.Intercepting early pelvic serous carcinoma by routine pathological examination of the fimbria.Mod Pathol. 2009 Aug;22(8):985-8.
  • Chang MC,Vargas SO,Hornick JL,Hirsch MS,Crum CP,Nucci MR.Embryonic Stem Cell Transcription Factors and D2-40 (Podoplanin) as Diagnostic Immunohistochemical Markers in Ovarian Germ Cell Tumors.Int J Gynecol Pathol. 2009 Jul;28(4):347-55.
  • Jarboe EA,Miron A,Carlson JW,Hirsch MS,Kindelberger D,Mutter GL,Crum CP,Nucci MR.Coexisting Intraepithelial Serous Carcinomas of the Endometrium and Fallopian Tube: Frequency and Potential Significance.Int J Gynecol Pathol. 2009 Jul;28(4):308-15.
  • Callahan MJ,Nagymanyoki Z,Bonome T,Johnson ME,Litkouhi B,Sullivan EH,Hirsch MS,Matulonis UA,Liu J,Birrer MJ,Berkowitz RS,Mok SC.Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.Clin Cancer Res. 2008 Dec 1;14(23):7667-73.
  • Carlson JW, Miron A, Jarboe EA, Parast MM, Hirsch MS, Lee Y, Muto MG, Kindelberger D, Crum CP.Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention.J Clin Oncol. 2008 Sep 1;26(25):4160-5.
  • Lomo L,Nucci MR,Lee KR,Lin MC,Hirsch MS,Crum CP,Mutter GL.Histologic and immunohistochemical decision-making in endometrial adenocarcinoma.Mod Pathol. 2008 Aug;21(8):937-42.
  • Lomo L, Nucci MR, Lee KR, Lin MC, Hirsch MS, Crum CP, Mutter GL.Histologic and immunohistochemical decision-making in endometrial adenocarcinoma.Mod Pathol.;21:937-42.
  • Mertz KD,Demichelis F,Sboner A,Hirsch MS,Dal Cin P,Struckmann K,Storz M,Scherrer S,Schmid DM,Strebel RT,Probst-Hensch NM,Gerstein M,Moch H,Rubin MA.Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer.Int J Cancer. 2008 Aug 1;123(3):569-76.
  • Hill SJ, Berkowitz R, Granter SR, Hirsch MS.Pagetoid lesions of the vulva: a collision between malignant melanoma and extramammary Paget disease.Int J Gynecol Pathol. 2008 Apr;27(2):292-6.
  • Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zembowicz A, Mihm MC, McKee PH, Brenn T.Atypical genital nevi. A clinicopathologic analysis of 56 cases.Am J Surg Pathol. 2008 Jan;32(1):51-7.
  • Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS.Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis.Histopathology. 2007 Sep;51(3):305-12.
  • McCluggage WG, Sumathi VP, Nucci MR, Hirsch M, Dal Cin P, Wells M, Flanagan AM, Fisher C.Ewing family of tumours involving the vulva and vagina: report of a series of four cases.J Clin Pathol. 2007 Jun;60(6):674-80. Review.
  • Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP.Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship.Am J Surg Pathol. 2007 Feb;31(2):161-9.
  • Hirsch MS, Dal Cin P, Fletcher CD.ALK expression in pseudosarcomatous myofibroblastic proliferations of the genitourinary tract.Histopathology. 2006 Apr;48(5):569-78.
  • Browne TJ, Hirsch MS, Brodsky G, Welch WR, Loda MF, Rubin MA.Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens.Hum Pathol. 2004 Dec;35(12):1462-8.
  • Hirsch MS, Faquin WC, Krane JF.Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid.Mod Pathol. 2004 Jun;17(6):631-6.
  • Hirsch MS, Weinstein MH, Thomas A, Dal Cin P.Identical karyotypes in synchronous bilateral clear cell renal cell carcinomas.Cancer Genet Cytogenet. 2002 Nov;139(1):86-7.
  • Nascimento AF, Hirsch MS, Cviko A, Quade BJ, Nucci MR.The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosis.Mod Pathol. 2003 Jan;16(1):22-7.