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Katia Georgopoulos, PhD

Publications

  • Joshi I, Yoshida T, Jena N, Qi X, Zhang J, Van Etten RA, Georgopoulos K.Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.Nat Immunol. 2014 Mar;15(3):294-304.
    24509510
  • Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F.β-Catenin induces T-cell transformation by promoting genomic instability.Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6.
    24371308
  • Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K.Transcriptional regulation of the Ikzf1 locus.Blood. 2013 Oct 31;122(18):3149-59.
    24002445
  • Yoshida T, Georgopoulos K.GATA-3 controls self-renewal in stressed HSCs.Nat Immunol. 2013 Oct;14(10):1032-3.
    24048133
  • Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK.Aiolos promotes TH17 differentiation by directly silencing Il2 expression.Nat Immunol. 2012 Aug;13(8):770-7.
    22751139
  • Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K.Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.Immunity. 2010 Nov 24;33(5):685-98.
    21093322
  • Yoshida T, Ng SY, Georgopoulos K.Awakening lineage potential by Ikaros-mediated transcriptional priming.Curr Opin Immunol. 2010 Apr;22(2):154-60. Review.
    20299195
  • Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein JL, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, Canals JM.Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons.J Comp Neurol. 2010 Feb 1;518(3):329-51.
    19950118
  • Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR.Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.Nat Immunol. 2009 Oct;10(10):1110-7.
    19734904
  • Ng SY,Yoshida T,Zhang J,Georgopoulos K.Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells.Immunity. 2009 Apr;30(4):493-507.
    19345118
  • Georgopoulos K.Acute lymphoblastic leukemia--on the wings of IKAROS.N Engl J Med. 2009 Jan 29;360(5):524-6.
    19131438
  • Georgopoulos K.From immunity to tolerance through HDAC.Nat Immunol. 2009 Jan;10(1):13-4.
    19088734
  • Naito T, Gomez-Del Arco P, Williams CJ, Georgopoulos K.Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.Immunity. 2007 Nov;27(5):723-34.
    17980631
  • Agoston DV, Szemes M, Dobi A, Palkovits M, Georgopoulos K, Gyorgy A, Ring MA.Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation.J Neurochem. 2007 Sep;102(6):1805-16.
    17504264
  • Kioussis D, Georgopoulos K.Epigenetic flexibility underlying lineage choices in the adaptive immune system.Science. 2007 Aug 3;317(5838):620-2.
    17673651
  • Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M.Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.Immunity. 2007 Mar;26(3):335-44.
    17363301
  • Kashiwagi M, Morgan BA, Georgopoulos K.The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.Development. 2007 Apr;134(8):1571-82.
    17360773
  • Ng SY, Yoshida T, Georgopoulos K.Ikaros and chromatin regulation in early hematopoiesis.Curr Opin Immunol. 2007 Apr;19(2):116-22. Review.
    17307348
  • Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K.Early hematopoietic lineage restrictions directed by Ikaros.Nat Immunol. 2006 Apr;7(4):382-91.
    16518393
  • Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E.Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.Development. 2006 Mar;133(6):1183-92.
    16501171
  • Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival.Mol Cell Biol. 2005 Dec;25(24):11145-55.
    16314534
  • Georgopoulos K.Gene regulation and cancer. AACR meeting review, the Homestead, Hot Springs, VA, USA, 14-18 October 1998.Biochim Biophys Acta. 1999 May 31;1423(3):R75-9.
    10382542
  • Koipally J, Renold A, Kim J, Georgopoulos K.Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.EMBO J. 1999 Jun 1;18(11):3090-100.
    10357820
  • Cortes M, Wong E, Koipally J, Georgopoulos K.Control of lymphocyte development by the Ikaros gene family.Curr Opin Immunol. 1999 Apr;11(2):167-71.
    10322160
  • Avitahl N, Winandy S, Friedrich C, Jones B, Ge Y, Georgopoulos K.Ikaros sets thresholds for T cell activation and regulates chromosome propagation.Immunity. 1999 Mar;10(3):333-43.
    10204489
  • Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K.Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.Immunity. 1999 Mar;10(3):345-55.
    10204490
  • Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K.Aiolos regulates B cell activation and maturation to effector state.Immunity. 1998 Oct;9(4):543-53.
    9806640
  • Nichogiannopoulou A, Trevisan M, Friedrich C, Georgopoulos K.Ikaros in hemopoietic lineage determination and homeostasis.Semin Immunol. 1998 Apr;10(2):119-25.
    9618757
  • Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA.Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.Curr Biol. 1998 Apr 23;8(9):508-15.
    9560339
  • Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K.Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage.Immunity. 1997 Oct;7(4):483-92.
    9354469
  • Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K.Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.EMBO J. 1997 Apr 15;16(8):2004-13.
    9155026
  • Georgopoulos K.Transcription factors required for lymphoid lineage commitment.Curr Opin Immunol. 1997 Apr;9(2):222-7.
    9099800
  • Georgopoulos K, Winandy S, Avitahl N.The role of the Ikaros gene in lymphocyte development and homeostasis.Annu Rev Immunol. 1997;15:155-76.
    9143685
  • Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K.Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.Immunity. 1996 Dec;5(6):537-49.
    8986714
  • Sun L, Liu A, Georgopoulos K.Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.EMBO J. 1996 Oct 1;15(19):5358-69.
    8895580
  • Molnr A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K.The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.J Immunol. 1996 Jan 15;156(2):585-92.
    8543809
  • Winandy S, Wu P, Georgopoulos K.A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Cell. 1995 Oct 20;83(2):289-99.
    7585946
  • Clevers HC, Oosterwegel MA, Georgopoulos K.Transcription factors in early T-cell development.Immunol Today. 1993 Dec;14(12):591-6.
    7905739
  • Georgopoulos K, Moore DD, Derfler B.Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.Science. 1992 Oct 30;258(5083):808-12.
    1439790
  • Georgopoulos K, Morgan BA, Moore DD.Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer.Mol Cell Biol. 1992 Feb;12(2):747-57.
    1531087
  • Oosterwegel M, van de Wetering M, Dooijes D, Klomp L, Winoto A, Georgopoulos K, Meijlink F, Clevers H.Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.J Exp Med. 1991 May 1;173(5):1133-42.
    1827138
  • Georgopoulos K, Galson D, Terhorst C.Tissue-specific nuclear factors mediate expression of the CD3 delta gene during T cell development.EMBO J. 1990 Jan;9(1):109-15.
    2136828
  • Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P.c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.Cell. 1988 Dec 2;55(5):917-24.
    3142692
  • Georgopoulos K, van den Elsen P, Bier E, Maxam A, Terhorst C.A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene.EMBO J. 1988 Aug;7(8):2401-7.
    2847918
  • Saito H, Koyama T, Georgopoulos K, Clevers H, Haser WG, LeBien T, Tonegawa S, Terhorst C.Close linkage of the mouse and human CD3 gamma- and delta-chain genes suggests that their transcription is controlled by common regulatory elements.Proc Natl Acad Sci U S A. 1987 Dec;84(24):9131-4.
    2827170
  • van den Elsen P, Georgopoulos K, Shepley BA, Orkin S, Terhorst C.Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.Proc Natl Acad Sci U S A. 1986 May;83(9):2944-8.
    2939461
  • Terhorst C, de Vries J, Georgopoulos K, Gold D, Oettgen H, Pettey C, Spits H, Ucker D, van den Elsen P, Wileman T.The T cell receptor/T3 complex.Year Immunol. 1986;2:245-53.
    2437726