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Iain A. Drummond, PhD

Publications

  • Pathak N, Austin-Tse CA, Liu Y, Vasilyev A, Drummond IA.Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function.Mol Biol Cell. 2014 Apr 17.
    24743595
  • Tomar R, Mudumana SP, Pathak N, Hukreide NA, Drummond IA.osr1 Is Required for Podocyte Development Downstream of wt1a.J Am Soc Nephrol. 2014 Apr 10.
    24722440
  • Le Corre S, Eyre D, Drummond IA.Modulation of the Secretory Pathway Rescues Zebrafish Polycystic Kidney Disease Pathology.J Am Soc Nephrol. 2014 Mar 13.
    24627348
  • Thomas S, Wright KJ, Le Corre S, Micalizzi A, Romani M, Abhyankar A, Saada J, Perrault I, Amiel J, Litzler J, Filhol E, Elkhartoufi N, Kwong M, Casanova JL, Boddaert N, Baehr W, Lyonnet S, Munnich A, Burglen L, Chassaing N, Encha-Ravazi F, Vekemans M, Gleeson JG, Valente EM, Jackson PK, Drummond IA, Saunier S, Attié-Bitach T.A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.Hum Mutat. 2014 Jan;35(1):137-46.
    24166846
  • Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA, Haber DA.A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.Dis Model Mech. 2013 Dec 5.
    24311731
  • Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA.odd-skipped related 2 is required for fin chondrogenesis in zebrafish.Dev Dyn. 2013 Nov;242(11):1284-92.
    23913342
  • Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F.Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.Am J Hum Genet. 2013 Oct 3;93(4):672-86.
    24094744
  • Drummond IA.The cilium in lights: new views of an ancient organelle.BMC Biol. 2013;11:74.
    23822867
  • Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR.Mutation mapping and identification by whole-genome sequencing.Genome Res. 2012 Aug;22(8):1541-8.
    22555591
  • Vasilyev A, Liu Y, Hellman N, Pathak N, Drummond IA.Mechanical stretch and PI3K signaling link cell migration and proliferation to coordinate epithelial tubule morphogenesis in the zebrafish pronephros.PLoS ONE. 2012;7(7):e39992.
    22815719
  • Panizzi JR, Becker-Heck A, Castleman VH, Al-Mutairi DA, Liu Y, Loges NT, Pathak N, Austin-Tse C, Sheridan E, Schmidts M, Olbrich H, Werner C, Häffner K, Hellman N, Chodhari R, Gupta A, Kramer-Zucker A, Olale F, Burdine RD, Schier AF, O'Callaghan C, Chung EM, Reinhardt R, Mitchison HM, King SM, Omran H, Drummond IA.CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.Nat Genet. 2012 Jun;44(6):714-9.
    22581229
  • Pathak N, Austin CA, Drummond IA.Tubulin Tyrosine Ligase-like Genes ttll3 and ttll6 Maintain Zebrafish Cilia Structure and Motility.J Biol Chem. 2011 Apr 1;286(13):11685-95.
    21262966
  • Drummond IA.Polycystins, focal adhesions and extracellular matrix interactions.Biochim Biophys Acta. 2011 Mar 15.
    21396443
  • Chen LM, Zhao J, Musa-Aziz R, Pelletier MF, Drummond IA, Boron WF.Cloning and characterization of a zebrafish homologue of human AQP1: A bifunctional water and gas channel.Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1163-74.
    20739606
  • Hellman NE, Liu Y, Merkel E, Austin C, Le Corre S, Beier DR, Sun Z, Sharma N, Yoder BK, Drummond IA.The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch.Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18499-504.
    20937855
  • Vasilyev A, Drummond IA.Fluid flow and guidance of collective cell migration.Cell Adh Migr.;4(3):353-7.
    20234192
  • Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA.The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation.Dis Model Mech.;3(5-6):354-65.
    20335443
  • Pathak NH, Drummond IA.Polyglutamylation and the fleer gene.Methods Cell Biol. 2009;94:317-32. Review.
    20362098
  • Sussman CR, Zhao J, Plata C, Lu J, Daly C, Angle N, DiPiero J, Drummond IA, Liang JO, Boron WF, Romero MF, Chang MH.Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish.Am J Physiol Cell Physiol. 2009 Oct;297(4):C865-75.
    19625604
  • Vasilyev A,Liu Y,Mudumana S,Mangos S,Lam PY,Majumdar A,Zhao J,Poon KL,Kondrychyn I,Korzh V,Drummond IA.Collective cell migration drives morphogenesis of the kidney nephron.PLoS Biol. 2009 Jan 6;7(1):e9.
    19127979
  • Mudumana SP,Hentschel D,Liu Y,Vasilyev A,Drummond IA.odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate.Development. 2008 Oct;135(20):3355-67.
    18787069
  • Moller CC, Mangos S, Drummond IA, Reiser J.Expression of trpC1 and trpC6 orthologs in zebrafish.Gene Expr Patterns. 2008 May;8(5):291-296.
    18378501
  • Insinna C, Pathak N, Perkins B, Drummond I, Besharse JC.The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development.Dev Biol. 2008 Apr 1;316(1):160-70.
    18304522
  • Pathak N, Obara T, Mangos S, Liu Y, Drummond IA.The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.Mol Biol Cell. 2007 Nov;18(11):4353-64.
    17761526
  • Liu Y, Pathak N, Kramer-Zucker A, Drummond IA.Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros.Development. 2007 Mar;134(6):1111-22.
    17287248
  • Panizzi JR, Jessen JR, Drummond IA, Solnica-Krezel L.New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia.Development. 2007 Mar;134(5):921-31.
    17267448
  • Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Muller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nurnberg P, Hildebrandt F.Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.Nat Genet. 2006 Dec;38(12):1397-405.
    17086182
  • Obara T, Mangos S, Liu Y, Zhao J, Wiessner S, Kramer-Zucker AG, Olale F, Schier AF, Drummond IA.Polycystin-2 immunolocalization and function in zebrafish.J Am Soc Nephrol. 2006 Oct;17(10):2706-18.
    16943304
  • Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F.The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.Nat Genet. 2006 Jun;38(6):674-81.
    16682973
  • Kramer-Zucker AG, Wiessner S, Jensen AM, Drummond IA.Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes.Dev Biol. 2005 Sep 15;285(2):316-29.
    16102746
  • Kramer-Zucker AG, Olale F, Haycraft CJ, Yoder BK, Schier AF, Drummond IA.Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis.Development. 2005 Apr;132(8):1907-21.
    15790966
  • Drummond IA.Zebrafish kidney development.Methods Cell Biol. 2004;76:501-30.
    15602890
  • Majumdar A, Drummond IA.Podocyte differentiation in the absence of endothelial cells as revealed in the zebrafish avascular mutant, cloche.Dev Genet. 1999;24(3-4):220-9.
    10322630
  • Kim E, Arnould T, Sellin LK, Benzing T, Fan MJ, Grning W, Sokol SY, Drummond I, Walz G.The polycystic kidney disease 1 gene product modulates Wnt signaling.J Biol Chem. 1999 Feb 19;274(8):4947-53.
    9988738
  • Drummond IA, Majumdar A, Hentschel H, Elger M, Solnica-Krezel L, Schier AF, Neuhauss SC, Stemple DL, Zwartkruis F, Rangini Z, Driever W, Fishman MC.Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function.Development. 1998 Dec;125(23):4655-67.
    9806915