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Zhenfeng Duan, MD, PhD


  • Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, Wang Y, Mankin H, Hornicek FJ, Duan Z.Programmed Cell Death Ligand 1 Expression in Osteosarcoma.Cancer Immunol Res. 2014 Apr 21.
  • Osaka E, Yang X, Shen JK, Yang P, Feng Y, Mankin HJ, Hornicek FJ, Duan Z.MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug.J Orthop Res. 2014 Apr 24.
  • Guo S, Lopez-Marquez H, Fan KC, Choy E, Cote G, Harmon D, Nielsen GP, Yang C, Zhang C, Mankin H, Hornicek FJ, Borger DR, Duan Z.Synergistic Effects of Targeted PI3K Signaling Inhibition and Chemotherapy in Liposarcoma.PLoS ONE. 2014;9(4):e93996.
  • Iyer AK, Duan Z, Amiji MM.Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors.Mol Pharm. 2014 Apr 1.
  • Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F.Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.J Orthop Res. 2014 May;32(5):695-701.
  • Cipriani NA, Letovanec I, Hornicek FJ, Mullen JT, Duan Z, Borger DR, Nielsen GP.BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas.Histopathology. 2014 Apr;64(5):639-46.
  • Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z.Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.Cancer Lett. 2014 Jan 1;342(1):104-12.
  • Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z.Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.PLoS ONE. 2013;8(9):e75851.
  • Kerr DA, Lopez HU, Deshpande V, Hornicek FJ, Duan Z, Zhang Y, Rosenberg AE, Borger DR, Nielsen GP.Molecular Distinction of Chondrosarcoma From Chondroblastic Osteosarcoma Through IDH1/2 Mutations.Am J Surg Pathol. 2013 Apr 16.
  • Lin M, Zhao Y, Wang S, Liu M, Duan Z, Chen Y, Li F, Xu F, Lu T.Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications.Biotechnol Adv. 2012 Nov;30(6):1551-61.
  • Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z.Lipid-functionalized Dextran Nanosystems to Overcome Multidrug Resistance in Cancer: A Pilot Study.Clin Orthop Relat Res. 2012 Sep 21.
  • Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z.Targeting hedgehog-GLI-2 pathway in osteosarcoma.J Orthop Res. 2012 Sep 11.
  • Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS, Hornicek FJ.Systematic Kinome shRNA Screening Identifies CDK11 (PITSLRE) Kinase Expression Is Critical for Osteosarcoma Cell Growth and Proliferation.Clin Cancer Res. 2012 Sep 1;18(17):4580-8.
  • Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ.Establishment and characterization of a novel chordoma cell line: CH22.J Orthop Res. 2012 Oct;30(10):1666-73.
  • Kobayashi E, Hornicek FJ, Duan Z.MicroRNA Involvement in Osteosarcoma.Sarcoma. 2012;2012:359739.
  • Duan Z, Li X, Huang H, Yuan W, Zheng SL, Liu X, Zhang Z, Choy E, Harmon D, Mankin H, Hornicek F.Synthesis and Evaluation of (2-(4-Methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) Isomers To Reverse Multidrug Resistance in Cancer.J Med Chem. 2012 Mar 22.
  • Choy E, Hornicek F, Macconaill L, Harmon D, Tariq Z, Garraway L, Duan Z.High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.Cancer. 2011 Oct 17.
  • Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z.Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.Anti Cancer Drugs. 2011 Mar 10.
  • Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z.ROCK1 as a potential therapeutic target in osteosarcoma.J Orthop Res. 2011 Mar 8.
  • Milane L, Duan Z, Amiji M.Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning.Cancer Cell Int. 2011;11:3.
  • Susa M, Choy E, Liu X, Schwab JH, Hornicek FJ, Mankin H, Duan Z.Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.Mol Cancer Ther. 2010 Dec;9(12):3342-50.
  • Guo Y, Nemeth JA, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek FJ, Duan Z.Effects of Siltuximab on the IL-6 Induced Signaling Pathway in Ovarian Cancer.Clin Cancer Res. 2010 Dec 1;16(23):5759-69.
  • Milane LJ, Duan Z, Amiji MM.Development of EGFR-Targeted Polymer Blend Nanocarriers for Paclitaxel/Lonidamine Delivery to Treat Multi-Drug Resistance in Human Breast and Ovarian Tumor Cells.Mol Pharm. 2010 Nov 24.
  • DeLaney TF, Duan Z, Hornicek FJ.Proteomic profiling of chordoma.J Surg Oncol. 2010 Dec 1;102(7):719.
  • Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z.Blockage of Stat3 With CDDO-Me Inhibits Tumor Cell Growth in Chordoma.Spine. 2010 Aug 15;35(18):1668-75.
  • Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM, Duan Z.Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma.PLoS ONE. 2010;5(5):e10764.
  • Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z.Characterization and analysis of human chordoma cell lines.Spine. 2010 Jun 1;35(13):1257-64.
  • Susa M, Milane L, Amiji MM, Hornicek FJ, Duan Z.Nanoparticles: A Promising Modality in the Treatment of Sarcomas.Pharmaceutical Research. 2010 May 27.
  • Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H, Duan Z.Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis.J Orthop Res. 2010 Jul;28(7):971-8.
  • Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z.Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.BMC Cancer. 2010;10:187.
  • Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z.Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells.Cancer Chemother Pharmacol. 2010 May 12.
  • Duan Z, Ji D, Weinstein EJ, Liu X, Susa M, Choy E, Yang C, Mankin H, Hornicek FJ.Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma.Cancer Lett. 2010 Jul 28;293(2):220-9.
  • Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ.Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.J Orthop Res. 2010 Jun;28(6):746-52.
  • Yang C, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z.The Kinase Mirk is a Potential Therapeutic Target in Osteosarcoma.Carcinogenesis. 2010 Apr;31(4):552-8.
  • van Vlerken LE, Duan Z, Little SR, Seiden MV, Amiji MM.Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems.The Aaps Journal. 2010 Jun;12(2):171-80.
  • Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z.Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay.J Biomol Screen. 2010 Mar;15(3):287-96.
  • Susa M, Iyer AK, Ryu K, Hornicek FJ, Mankin H, Amiji MM, Duan Z.Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma.BMC Cancer. 2009;9:399.
  • Duan Z, Choy E, Hornicek FJ.NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.PLoS ONE. 2009;4(10):e7415.
  • Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z.A novel target for treatment of chordoma: signal transducers and activators of transcription 3.Mol Cancer Ther. 2009 Sep;8(9):2597-605.
  • Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ.ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.PLoS ONE. 2009;4(9):e6967.
  • Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ.Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.Mol Cancer Ther. 2009 Aug;8(8):2122-30.
  • Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z.Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.Anticancer Res. 2009 Jun;29(6):1867-71.
  • Yang C,Yang S,Wood KB,Hornicek FJ,Schwab JH,Fondren G,Mankin H,Duan Z.Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression.Apoptosis. 2009 Jan;14(1):124-33.
  • Duan Z,Choy E,Jimeno JM,Cuevas Cdel M,Mankin HJ,Hornicek FJ.Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines.Cancer Chemother Pharmacol. 2009 May;63(6):1121-9.
  • Miao J,Mu D,Ergel B,Singavarapu R,Duan Z,Powers S,Oliva E,Orsulic S.Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model.Int J Cancer. 2008 Nov 1;123(9):2041-7.
  • Duan Z,Weinstein EJ,Ji D,Ames RY,Choy E,Mankin H,Hornicek FJ.Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.Mol Cancer Ther. 2008 Aug;7(8):2377-85.
  • Devalapally H,Duan Z,Seiden MV,Amiji MM.Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles.Clin Cancer Res. 2008 May 15;14(10):3193-203.
  • Devalapally H, Duan Z, Seiden MV, Amiji MM.Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer.Int J Cancer. 2007 Oct 15;121(8):1830-8.
  • Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.Mol Pharmacol. 2007 Nov;72(5):1137-45.
  • van Vlerken LE, Duan Z, Seiden MV, Amiji MM.Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer.Cancer Res. 2007 May 15;67(10):4843-50.
  • Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.Clin Cancer Res. 2006 Nov 15;12(22):6844-52.
  • Duan Z, Foster R, Bell DA, Mahoney J, Wolak K, Vaidya A, Hampel C, Lee H, Seiden MV.Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer.Clin Cancer Res. 2006 Sep 1;12(17):5055-63.
  • Duan Z, Foster R, Brakora KA, Yusuf RZ, Seiden MV.GBP1 overexpression is associated with a paclitaxel resistance phenotype.Cancer Chemother Pharmacol. 2006 Jan;57(1):25-33.
  • Duan Z, Lamendola DE, Duan Y, Yusuf RZ, Seiden MV.Description of paclitaxel resistance-associated genes in ovarian and breast cancer cell lines.Cancer Chemother Pharmacol. 2005 Mar;55(3):277-85.
  • Duan Z, Duan Y, Lamendola DE, Yusuf RZ, Naeem R, Penson RT, Seiden MV.Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.Clin Cancer Res. 2003 Jul;9(7):2778-85.
  • Lamendola DE, Duan Z, Yusuf RZ, Seiden MV.Molecular description of evolving paclitaxel resistance in the SKOV-3 human ovarian carcinoma cell line.Cancer Res. 2003 May 1;63(9):2200-5.
  • Duan Z, Feller AJ, Penson RT, Chabner BA, Seiden MV.Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.Clin Cancer Res. 1999 Nov;5(11):3445-53.
  • Duan Z, Feller AJ, Toh HC, Makastorsis T, Seiden MV.TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line.Gene. 1999 Mar 18;229(1-2):75-81.