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Fred H. Hochberg, MD


  • Gonda DD, Akers JC, Kim R, Kalkanis SN, Hochberg FH, Chen CC, Carter BS.Neuro-oncologic Applications of Exosomes, Microvesicles, and Other Nano-Sized Extracellular Particles.Neurosurgery. 2013 Apr;72(4):501-10.
  • Hu J, Wen PY, Abrey LE, Fadul CE, Drappatz J, Salem N, Supko JG, Hochberg F.A phase II trial of oral gimatecan for recurrent glioblastoma.J. Neurooncol. 2013 Feb;111(3):347-53.
  • Jones PS, Dunn GP, Barker FG, Curry WT, Hochberg FH, Cahill DP.Molecular genetics of low-grade gliomas: genomic alterations guiding diagnosis and therapeutic intervention. 11th Annual Frye-Halloran Brain Tumor Symposium.Neurosurg Focus. 2013 Feb;34(2):E9.
  • Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H.Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.Nat Med. 2012 Dec;18(12):1835-40.
  • Momen-Heravi F, Balaj L, Alian S, Trachtenberg AJ, Hochberg FH, Skog J, Kuo WP.Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles.Front Physiol. 2012;3:162.
  • Stacy RC, Jakobiec FA, Hochberg FH, Hochberg EP, Cestari DM.Orbital involvement in Bing-Neel syndrome.J Neuroophthalmol. 2010 Sep;30(3):255-9.
  • Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK.Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.J Clin Oncol. 2010 Jun 10;28(17):2817-23.
  • Ozsunar Y, Mullins ME, Kwong K, Hochberg FH, Ament C, Schaefer PW, Gonzalez RG, Lev MH.Glioma recurrence versus radiation necrosis? A pilot comparison of arterial spin-labeled, dynamic susceptibility contrast enhanced MRI, and FDG-PET imaging.Acad Radiol. 2010 Mar;17(3):282-90.
  • Pe'er J, Hochberg FH, Foster CS.Clinical review: treatment of vitreoretinal lymphoma.Ocul Immunol Inflamm.;17(5):299-306. Review.
  • Fintelmann F,Forghani R,Schaefer PW,Hochberg EP,Hochberg FH.Bing-Neel Syndrome revisited.Clin Lymphoma Myeloma. 2009 Mar;9(1):104-6.
  • Baehring JM,Hochberg EP,Raje N,Ulrickson M,Hochberg FH.Neurological manifestations of Waldenstrom macroglobulinemia.Nat Clin Pract Neurol. 2008 Oct;4(10):547-56. Review.
  • Zhu JJ,Gerstner ER,Engler DA,Mrugala MM,Nugent W,Nierenberg K,Hochberg FH,Betensky RA,Batchelor TT.High-dose methotrexate for elderly patients with primary CNS lymphoma.Neuro-oncol. 2009 Apr;11(2):211-5.
  • Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris GJ, Bullitt E, Van den Abbeele AD, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Kirsch DG, Crawford A, Hochberg F, Winer EP.Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer.J Clin Oncol. 2008 Apr 20;26(12):1993-9.
  • Sher DJ, Henson JW, Avutu B, Hochberg FH, Batchelor TT, Martuza RL, Barker FG 2nd, Loeffler JS, Chakravarti A.The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma.J Neurooncol. 2008 May;88(1):43-50.
  • Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg FH, Weissleder R, Carson W, Chiocca EA, Kaur B.Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy.Journal of the National Cancer Institute. 2007 Dec 5;99(23):1768-81.
  • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA.Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.Cancer Res. 2007 Oct 1;67(19):9398-406.
  • Voloschin AD, Betensky R, Wen PY, Hochberg F, Batchelor T.Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma.J Neurooncol. 2008 Jan;86(2):211-5.
  • Hochberg FH, Baehring JM, Hochberg EP.Primary CNS lymphoma.Nat Clin Pract Neurol. 2007 Jan;3(1):24-35. Review.
  • Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J.Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes.J Neurol Sci. 2006 Sep 25;247(2):208-16.
  • Baehring JM, Hochberg FH.Primary lymphoma of the nervous system.Cancer J. 2006 Jan-Feb;12(1):1-13. Review.
  • Stern BV, Baehring JM, Kleopa KA, Hochberg FH.Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system.J Neurooncol. 2006 May;78(1):81-4.
  • Shah GD, Kesari S, Xu R, Batchelor TT, O'Neill AM, Hochberg FH, Levy B, Bradshaw J, Wen PY.Comparison of linear and volumetric criteria in assessing tumor response in adult high-grade gliomas.Neuro-oncol. 2006 Jan;8(1):38-46.
  • Nguyen P, Chakravarti A, Batchelor T, Hochberg F, Loeffler J.Results of Whole-Brain Radiation as Salvage of Methotrexate Failure in Patients with Primary Central Nervous System Lymphoma.J Am Diet Assoc.;In press.
  • Baehring JM, Henchcliffe C, Ledezma CJ, Fulbright R, Hochberg FH.Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system.J Neurol Neurosurg Psychiatry. 2005 Apr;76(4):540-4.
  • Chiocca EA, Abbed KM, Tatter S, Louis DN, Hochberg FH, Barker F, Kracher J, Grossman SA, Fisher JD, Carson K, Rosenblum M, Mikkelsen T, Olson J, Markert J, Rosenfeld S, Nabors LB, Brem S, Phuphanich S, Freeman S, Kaplan R, Zwiebel J.A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.Mol Ther. 2004 Nov;10(5):958-66.
  • Plotkin SR, Betensky RA, Hochberg FH, Grossman SA, Lesser GJ, Nabors LB, Chon B, Batchelor TT.Treatment of relapsed central nervous system lymphoma with high-dose methotrexate.Clin Cancer Res. 2004 Sep 1;10(17):5643-6.
  • Nestler U, Wakimoto H, Siller-Lopez F, Aguilar LK, Chakravarti A, Muzikansky A, Stemmer-Rachamimov A, Chiocca EA, Aguilar-Cordova E, Hochberg FH.The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.J Neurooncol. 2004 Mar-Apr;67(1-2):177-88.
  • Lev MH, Ozsunar Y, Henson JW, Rasheed AA, Barest GD, Harsh GR, Fitzek MM, Chiocca EA, Rabinov JD, Csavoy AN, Rosen BR, Hochberg FH, Schaefer PW, Gonzalez RG.Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected].AJNR Am J Neuroradiol. 2004 Feb;25(2):214-21.
  • Kirsch DG, Hochberg FH.Targeting HER2 in brain metastases from breast cancer.Clin Cancer Res. 2003 Nov 15;9(15):5435-6.
  • Deisboeck TS, Wakimoto H, Nestler U, Louis DN, Sehgal PK, Simon M, Chiocca EA, Hochberg FH.Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study.Gene Ther. 2003 Aug;10(15):1225-33.
  • Baehring JM, Longtine J, Hochberg FH.A new approach to the diagnosis and treatment of intravascular lymphoma.J Neurooncol. 2003 Feb;61(3):237-48.
  • Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH.Neurolymphomatosis.Neuro-oncol. 2003 Apr;5(2):104-15.
  • Batchelor T, Carson K, O'Neill A, Grossman SA, Alavi J, New P, Hochberg F, Priet R.Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: a report of NABTT 96-07.J Clin Oncol. 2003 Mar 15;21(6):1044-9.
  • Braaten KM, Betensky RA, de Leval L, Okada Y, Hochberg FH, Louis DN, Harris NL, Batchelor TT.BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma.Clin Cancer Res. 2003 Mar;9(3):1063-9.
  • Wu CJ, Neuberg D, Chillemi A, McLaughlin S, Hochberg EP, Galinsky I, DeAngelo D, Soiffer RJ, Alyea EP, Capdeville R, Stone RM, Ritz J.Quantitative monitoring of BCR/ABL transcript during STI-571 therapy.Leuk Lymphoma. 2002 Dec;43(12):2281-9.
  • Hochberg EP, Miklos DB, Neuberg D, Eichner DA, McLaughlin SF, Mattes-Ritz A, Alyea EP, Antin JH, Soiffer RJ, Ritz J.A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation.Blood. 2003 Jan 1;101(1):363-9.
  • Selker RG, Shapiro WR, Burger P, Blackwood MS, Arena VC, Gilder JC, Malkin MG, Mealey JJ, Neal JH, Olson J, Robertson JT, Barnett GH, Bloomfield S, Albright R, Hochberg FH, Hiesiger E, Green S,.The Brain Tumor Cooperative Group NIH Trial 87-01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine.Neurosurgery. 2002 Aug;51(2):343-55; discussion 355-7.
  • Bellucci R, Alyea EP, Weller E, Chillemi A, Hochberg E, Wu CJ, Canning C, Schlossman R, Soiffer RJ, Anderson KC, Ritz J.Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma.Blood. 2002 Jun 15;99(12):4610-7.
  • Wakimoto H, Ikeda K, Abe T, Ichikawa T, Hochberg FH, Ezekowitz RA, Pasternack MS, Chiocca EA.The complement response against an oncolytic virus is species-specific in its activation pathways.Mol Ther. 2002 Mar;5(3):275-82.
  • Fitzek MM, Thornton AF, Rabinov JD, Lev MH, Pardo FS, Munzenrider JE, Okunieff P, Bussière M, Braun I, Hochberg FH, Hedley-Whyte ET, Liebsch NJ, Harsh GR.Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial.J Neurosurg. 1999 Aug;91(2):251-60.
  • Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA.Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses.Nat Med. 1999 Aug;5(8):881-7.
  • Ostergaard L, Hochberg FH, Rabinov JD, Sorensen AG, Lev M, Kim L, Weisskoff RM, Gonzalez RG, Gyldensted C, Rosen BR.Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors.J Neurosurg. 1999 Feb;90(2):300-5.
  • Alderson L, Fetell MR, Sisti M, Hochberg F, Cohen M, Louis DN.Sentinel lesions of primary CNS lymphoma.J Neurol Neurosurg Psychiatry. 1996 Jan;60(1):102-5.
  • Aronen HJ, Glass J, Pardo FS, Belliveau JW, Gruber ML, Buchbinder BR, Gazit IE, Linggood RM, Fischman AJ, Rosen BR.Echo-planar MR cerebral blood volume mapping of gliomas. Clinical utility.Acta Radiol. 1995 Sep;36(5):520-8.
  • Glass J, Gruber ML, Cher L, Hochberg FH.Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.J Neurosurg. 1994 Aug;81(2):188-95.
  • Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TK, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA.Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.Hum Gene Ther. 1994 Aug;5(8):969-78.
  • Loeffler JS, Alexander E, Hochberg FH, Wen PY, Morris JH, Schoene WC, Siddon RL, Morse RH, Black PM.Clinical patterns of failure following stereotactic interstitial irradiation for malignant gliomas.Int J Radiat Oncol Biol Phys. 1990 Dec;19(6):1455-62.