Spyridon Artavanis-Tsakonas, PhD

Publications

• Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S.Trp53 regulates Notch 4 signaling through Mdm2.J Cell Sci. 2011 Apr 1;124(Pt 7):1067-76.
  21402876
• Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.Conserved genes act as modifiers of invertebrate SMN loss of function defects.PLoS Genet. 2010 Oct;
  21124729
• Artavanis-Tsakonas S, Muskavitch MA.Notch: the past, the present, and the future.Curr Top Dev Biol. 2010;92:1-29.
  20816391
• Kelly DF, Lake RJ, Middelkoop TC, Fan HY, Artavanis-Tsakonas S, Walz T.Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.PLoS ONE. 2010;5(5):e10532.
  20479883
• Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.Proc
  20194747
• Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S.In vivo analysis of the Notch receptor S1 cleavage.PLoS ONE. 2009;4(8):e6728.
  19701455
• Fre S, Pallavi SK, Huyghe M, Laé M, Janssen KP, Robine S, Artavanis-Tsakonas S, Louvard D.Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6309-14.
  19251639
• Hurlbut GD, Kankel MW, Artavanis-Tsakonas S.Nodal points and complexity of Notch-Ras signal integration.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2218-23.
  19171888
• Kankel MW, Hurlbut GD, Upadhyay G, Yajnik V, Yedvobnick B, Artavanis-Tsakonas S.Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.Genetics. 2007 Dec;177(4):2493-505.
  18073442
• Fleming RJ, Purcell K, Artavanis-Tsakonas S.The NOTCH receptor and its ligands.Trends Cell Biol. 1997 Nov;7(11):437-41.
  17709001
• Kelly DF, Lake RJ, Walz T, Artavanis-Tsakonas S.Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9591-6.
  17535912
• Hurlbut GD, Kankel MW, Lake RJ, Artavanis-Tsakonas S.Crossing paths with Notch in the hyper-network.Curr Opin Cell Biol. 2007 Apr;19(2):166-75. Review.
  17317139
• Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7.
  16751266
• Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S.CADASIL: a critical look at a Notch disease.Dev Neurosci. 2006;28(1-2):5-12. Review.
  16508299
• Mourikis P, Hurlbut GD, Artavanis-Tsakonas S.Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1307-12.
  16434470
• Louvi A, Artavanis-Tsakonas S.Notch signalling in vertebrate neural development.Nat Rev Neurosci. 2006 Feb;7(2):93-102. Review.
  16429119
• Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S.Regulation of Notch signalling by non-visual beta-arrestin.Nat Cell Biol. 2005 Dec;7(12):1091-101.
  16284625
• Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S.Notch signals control the fate of immature progenitor cells in the intestine.Nature. 2005 Jun 16;435(7044):964-8.
  15959516
• Veraksa A, Bauer A, Artavanis-Tsakonas S.Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry.Dev Dyn. 2005 Mar;232(3):827-34.
  15704125
• Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S.Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.Am J Pathol. 2004 Aug;165(2):695-705.
  15277242
• Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK.The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.Curr Biol. 2004 Jun 8;14(11):965-74.
  15182669
• Artavanis-Tsakonas S.Accessing the Exelixis collection.Nat Genet. 2004 Mar;36(3):207.
  14981522
• Beltran S, Blanco E, Serras F, Pérez-Villamil B, Guigó R, Artavanis-Tsakonas S, Corominas M.Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster.Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3293-8.
  12626737
• Grandbarbe L, Bouissac J, Rand M, Hrabé de Angelis M, Artavanis-Tsakonas S, Mohier E.Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.Development. 2003 Apr;130(7):1391-402.
  12588854
• Mishra-Gorur K, Rand MD, Perez-Villamil B, Artavanis-Tsakonas S.Down-regulation of Delta by proteolytic processing.J Cell Biol. 2002 Oct 28;159(2):313-24.
  12403816
• Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artavanis-Tsakonas S, Okano H.Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.Development. 2002 Feb;129(4):1049-59.
  11861487
• Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL.Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):196-200.
  11773624
• Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K.Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.Int J D
  11226752
• Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Nat Genet. 2000 Dec;26(4):484-9.
  11101851
• Kurata S, Go MJ, Artavanis-Tsakonas S, Gehring WJ.Notch signaling and the determination of appendage identity.Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2117-22.
  10681430
• Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC.Calcium depletion dissociates and activates heterodimeric notch receptors.Mol Cell Biol. 2000 Mar;20(5):1825-35.
  10669757
• Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S.Human ligands of the Notch receptor.Am J Pathol. 1999 Mar;154(3):785-94.
  10079256
• Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S.Processing of the notch ligand delta by the metalloprotease Kuzbanian.Science. 1999 Jan 1;283(5398):91-4.
  9872749
• Go MJ, Artavanis-Tsakonas S.A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development.Genetics. 1998 Sep;150(1):211-20.
  9725840
• Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID.The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.Blood. 1998 J
  9596653
• Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S.Human deltex is a conserved regulator of Notch signalling.Nat Genet. 1998 May;19(1):74-8.
  9590294
• Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T.Notch inhibition of E47 supports the existence of a novel signaling pathway.Mol Cell Biol. 1998 Apr;18(4):2230-9.
  9528794
• Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM.Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.Mol Cell Biol. 1997 Nov;17(11):6265-73.
  9343387
• Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S.Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.Development. 1997 Nov;124(21):4265-73.
  9334275
• Frankel S, Sigel EA, Craig C, Elgin SC, Mooseker MS, Artavanis-Tsakonas S.An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin.J Cell Sci. 1997 Sep;110 ( Pt 17):1999-2012.
  9378752
• Sun X, Artavanis-Tsakonas S.Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Development. 1997 Sep;124(17):3439-48.
  9310338
• Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S.Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.Cell. 1997 Jul 25;90(2):281-91.
  9244302
• Artavanis-Tsakonas S.Alagille syndrome--a notch up for the Notch receptor.Nat Genet. 1997 Jul;16(3):212-3.
  9207778
• Blaumueller CM, Artavanis-Tsakonas S.Comparative aspects of Notch signaling in lower and higher eukaryotes.Perspect Dev Neurobiol. 1997;4(4):325-43.
  9171446
• Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S.Analysis of dominant enhancers and suppressors of activated Notch in Drosophila.Genetics. 1996 Nov;144(3):1127-41.
  8913755
• Sun X, Artavanis-Tsakonas S.The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.Development. 1996 Aug;122(8):2465-74.
  8756291
• Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N.Interaction between Wingless and Notch signaling pathways mediated by dishevelled.Science. 1996 Mar 29;271(5257):1826-32.
  8596950
• Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S.Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.Genomics. 1996 Jan 1;31(1):58-64.
  8808280
• Ahmad I, Zaqouras P, Artavanis-Tsakonas S.Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells.Mech Dev. 1995 Sep;53(1):73-85.
  8555113
• Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S.Alterations in Notch signaling in neoplastic lesions of the human cervix.Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6414-8.
  7604005
• Dawson IA, Roth S, Artavanis-Tsakonas S.The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.J Cell Biol. 1995 May;129(3):725-37.
  7730407