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Spyridon Artavanis-Tsakonas, PhD

Publications

  • Sale S, Lafkas D, Artavanis-Tsakonas S.Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages.Nat Cell Biol. 2013 Apr 21.
    23604318
  • Fleming RJ, Hori K, Sen A, Filloramo GV, Langer JM, Obar RA, Artavanis-Tsakonas S, Maharaj-Best AC.An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling.Development. 2013 May;140(9):2039-49.
    23571220
  • Guruharsha KG, Obar RA, Mintseris J, Aishwarya K, Krishnan RT, Vijayraghavan K, Artavanis-Tsakonas S.Drosophila protein interaction map (DPiM): a paradigm for metazoan protein complex interactions.Fly (Austin).;6(4):246-53.
    23222005
  • Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.Regulation of ligand-independent Notch signal through intracellular trafficking.Commun Integr Biol. 2012 Jul 1;5(4):374-6.
    23060962
  • Pallavi SK, Ho DM, Hicks C, Miele L, Artavanis-Tsakonas S.Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.EMBO J. 2012 Jun 29;31(13):2895-907.
    22580825
  • Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S.Trp53 regulates Notch 4 signaling through Mdm2.J Cell Sci. 2011 Apr 1;124(Pt 7):1067-76.
    21402876
  • Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.Conserved genes act as modifiers of invertebrate SMN loss of function defects.PLoS Genet. 2010 Oct;6(10):e1001172.
    21124729
  • Artavanis-Tsakonas S, Muskavitch MA.Notch: the past, the present, and the future.Curr Top Dev Biol. 2010;92:1-29.
    20816391
  • Kelly DF, Lake RJ, Middelkoop TC, Fan HY, Artavanis-Tsakonas S, Walz T.Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.PLoS ONE. 2010;5(5):e10532.
    20479883
  • Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5012-7.
    20194747
  • Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S.In vivo analysis of the Notch receptor S1 cleavage.PLoS ONE. 2009;4(8):e6728.
    19701455
  • Fre S, Pallavi SK, Huyghe M, Laé M, Janssen KP, Robine S, Artavanis-Tsakonas S, Louvard D.Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6309-14.
    19251639
  • Hurlbut GD, Kankel MW, Artavanis-Tsakonas S.Nodal points and complexity of Notch-Ras signal integration.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2218-23.
    19171888
  • Kankel MW, Hurlbut GD, Upadhyay G, Yajnik V, Yedvobnick B, Artavanis-Tsakonas S.Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector.Genetics. 2007 Dec;177(4):2493-505.
    18073442
  • Fleming RJ, Purcell K, Artavanis-Tsakonas S.The NOTCH receptor and its ligands.Trends Cell Biol. 1997 Nov;7(11):437-41.
    17709001
  • Kelly DF, Lake RJ, Walz T, Artavanis-Tsakonas S.Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9591-6.
    17535912
  • Hurlbut GD, Kankel MW, Lake RJ, Artavanis-Tsakonas S.Crossing paths with Notch in the hyper-network.Curr Opin Cell Biol. 2007 Apr;19(2):166-75. Review.
    17317139
  • Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7.
    16751266
  • Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S.CADASIL: a critical look at a Notch disease.Dev Neurosci. 2006;28(1-2):5-12. Review.
    16508299
  • Mourikis P, Hurlbut GD, Artavanis-Tsakonas S.Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1307-12.
    16434470
  • Louvi A, Artavanis-Tsakonas S.Notch signalling in vertebrate neural development.Nat Rev Neurosci. 2006 Feb;7(2):93-102. Review.
    16429119
  • Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S.Regulation of Notch signalling by non-visual beta-arrestin.Nat Cell Biol. 2005 Dec;7(12):1091-101.
    16284625
  • Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S.Notch signals control the fate of immature progenitor cells in the intestine.Nature. 2005 Jun 16;435(7044):964-8.
    15959516
  • Veraksa A, Bauer A, Artavanis-Tsakonas S.Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry.Dev Dyn. 2005 Mar;232(3):827-34.
    15704125
  • Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S.Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.Am J Pathol. 2004 Aug;165(2):695-705.
    15277242
  • Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK.The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.Curr Biol. 2004 Jun 8;14(11):965-74.
    15182669
  • Artavanis-Tsakonas S.Accessing the Exelixis collection.Nat Genet. 2004 Mar;36(3):207.
    14981522
  • Beltran S, Blanco E, Serras F, Pérez-Villamil B, Guigó R, Artavanis-Tsakonas S, Corominas M.Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster.Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3293-8.
    12626737
  • Grandbarbe L, Bouissac J, Rand M, Hrabé de Angelis M, Artavanis-Tsakonas S, Mohier E.Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.Development. 2003 Apr;130(7):1391-402.
    12588854
  • Mishra-Gorur K, Rand MD, Perez-Villamil B, Artavanis-Tsakonas S.Down-regulation of Delta by proteolytic processing.J Cell Biol. 2002 Oct 28;159(2):313-24.
    12403816
  • Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artavanis-Tsakonas S, Okano H.Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.Development. 2002 Feb;129(4):1049-59.
    11861487
  • Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL.Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):196-200.
    11773624
  • Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K.Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.Int J Dev Neurosci. 2001 Feb;19(1):21-35.
    11226752
  • Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.Nat Genet. 2000 Dec;26(4):484-9.
    11101851
  • Kurata S, Go MJ, Artavanis-Tsakonas S, Gehring WJ.Notch signaling and the determination of appendage identity.Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2117-22.
    10681430
  • Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC.Calcium depletion dissociates and activates heterodimeric notch receptors.Mol Cell Biol. 2000 Mar;20(5):1825-35.
    10669757
  • Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S.Human ligands of the Notch receptor.Am J Pathol. 1999 Mar;154(3):785-94.
    10079256
  • Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S.Processing of the notch ligand delta by the metalloprotease Kuzbanian.Science. 1999 Jan 1;283(5398):91-4.
    9872749
  • Go MJ, Artavanis-Tsakonas S.A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development.Genetics. 1998 Sep;150(1):211-20.
    9725840
  • Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID.The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.Blood. 1998 Jun 1;91(11):4084-91.
    9596653
  • Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S.Human deltex is a conserved regulator of Notch signalling.Nat Genet. 1998 May;19(1):74-8.
    9590294
  • Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T.Notch inhibition of E47 supports the existence of a novel signaling pathway.Mol Cell Biol. 1998 Apr;18(4):2230-9.
    9528794
  • Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM.Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.Mol Cell Biol. 1997 Nov;17(11):6265-73.
    9343387
  • Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S.Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.Development. 1997 Nov;124(21):4265-73.
    9334275
  • Frankel S, Sigel EA, Craig C, Elgin SC, Mooseker MS, Artavanis-Tsakonas S.An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin.J Cell Sci. 1997 Sep;110 ( Pt 17):1999-2012.
    9378752
  • Sun X, Artavanis-Tsakonas S.Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Development. 1997 Sep;124(17):3439-48.
    9310338
  • Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S.Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.Cell. 1997 Jul 25;90(2):281-91.
    9244302
  • Artavanis-Tsakonas S.Alagille syndrome--a notch up for the Notch receptor.Nat Genet. 1997 Jul;16(3):212-3.
    9207778
  • Blaumueller CM, Artavanis-Tsakonas S.Comparative aspects of Notch signaling in lower and higher eukaryotes.Perspect Dev Neurobiol. 1997;4(4):325-43.
    9171446
  • Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S.Analysis of dominant enhancers and suppressors of activated Notch in Drosophila.Genetics. 1996 Nov;144(3):1127-41.
    8913755
  • Sun X, Artavanis-Tsakonas S.The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.Development. 1996 Aug;122(8):2465-74.
    8756291
  • Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N.Interaction between Wingless and Notch signaling pathways mediated by dishevelled.Science. 1996 Mar 29;271(5257):1826-32.
    8596950
  • Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S.Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.Genomics. 1996 Jan 1;31(1):58-64.
    8808280
  • Ahmad I, Zaqouras P, Artavanis-Tsakonas S.Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells.Mech Dev. 1995 Sep;53(1):73-85.
    8555113
  • Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S.Alterations in Notch signaling in neoplastic lesions of the human cervix.Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6414-8.
    7604005
  • Dawson IA, Roth S, Artavanis-Tsakonas S.The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.J Cell Biol. 1995 May;129(3):725-37.
    7730407